Vitamin D Decreases Adipocyte Size of Pericardial Adipose Tissue in Obese Female Wistar Rat: A Preliminary Study

Abstrac t—Obesity is also associated with the accumulation of fat mass both in subcutaneous and visceral. Pericardial adipose tissue (PAT) is one of the visceral fat tissue that increases when obesity occurs. In previous study, Vitamin D deficiency in obesity was associated with increased thickness of epicardial adipose tissue (EAT). PAT and EAT are associated in anatomical conjunction. This study wants to prove whether the administration of vitamin D can reduce the size of adipocytes in paracardial fat of obese female wistar rat. In this preliminary study, 3 obese female wistar rat (275, 278, 280 grams) were divided into 3 treatments: control, 800 IU of vitamin D, 2400 IU of vitamin D. Vitamin D were administered by oral gavage for 8 weeks. All of rats were sacrificed on week 8 and pericardial fat were extracted for stereology analysis. Our histologis examination showed that the total size of adipocytes pericardial fat were decreased in 2400 IU vit D, in comparison to the 800 IU and control treatment. It showed that vitamin D could decrease the size of adipocyte of pericardial fat in obese female wistar rat.