Chemistry and Physics of Lipids最新文献

{"title":"The small-molecule kinase inhibitor ceritinib, unlike imatinib, causes a significant disturbance of lipid membrane integrity: A combined experimental and MD study","authors":"Markus Fischer ,&nbsp;Meike Luck ,&nbsp;Max Werle ,&nbsp;Alexander Vogel ,&nbsp;Mohammad Bashawat ,&nbsp;Kai Ludwig ,&nbsp;Holger A. Scheidt ,&nbsp;Peter Müller","doi":"10.1016/j.chemphyslip.2023.105351","DOIUrl":"10.1016/j.chemphyslip.2023.105351","url":null,"abstract":"<div><p><span>Ceritinib<span><span><span> and imatinib are small-molecule </span>protein kinase inhibitors<span> which are applied as therapeutic agents against various diseases. The fundamentals of their clinical use, i.e. their pharmacokinetics as well as the mechanisms of the inhibition of the respective kinases, are relatively well studied. However, the interaction of the drugs with membranes, which can be a possible cause of side effects, has hardly been investigated so far. Therefore, we have characterized the interaction of both drugs with </span></span>lipid membranes consisting of 1-palmitoyl-2-oleoyl-</span></span><em>sn</em><span><span>-glycero-3-phosphocholine (POPC) in the absence and in the presence of cholesterol. For determining the membrane impact of both drugs on a molecular level, different experimental (NMR, ESR, fluorescence) and theoretical (MD simulations) approaches were applied. The data show that ceritinib, in contrast to imatinib, interacts more effectively with membranes significantly affecting various physico-chemical membrane parameters like membrane order and transmembrane permeation of polar solutes. The pronounced membrane impact of ceritinib can be explained by a strong affinity of the drug towards POPC which competes with the POPC-cholesterol interaction by that attenuating the ordering effect of cholesterol. The data are relevant for understanding putative toxic and cytotoxic side effects of these drugs such as the triggering of </span>cell lysis or apoptosis.</span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"257 ","pages":"Article 105351"},"PeriodicalIF":3.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49672249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saturation of fatty acids in phosphatidic acid uniquely alters transthyretin stability changing morphology and toxicity of amyloid fibrils","authors":"Abid Ali ,&nbsp;Kiryl Zhaliazka ,&nbsp;Tianyi Dou ,&nbsp;Aidan P. Holman ,&nbsp;Dmitry Kurouski","doi":"10.1016/j.chemphyslip.2023.105350","DOIUrl":"10.1016/j.chemphyslip.2023.105350","url":null,"abstract":"<div><p><span>Transthyretin (TTR) is a small, β-sheet-rich </span>tetrameric protein<span><span> that transports thyroid hormone thyroxine<span> and retinol. </span></span>Phospholipids<span>, including phosphatidic acid<span><span> (PA), can uniquely alter the stability of amyloidogenic proteins. However, the role of PA in TTR aggregation remains unclear. In this study, we investigated the effect of saturation of fatty acids (FAs) in PA on the rate of TTR aggregation. We also reveal the extent to which PAs with different length and saturation of FAs altered the morphology and secondary structure of TTR aggregates. Our results showed that TTR aggregation in the equimolar presence of PAs with different length and saturation of FAs yielded structurally and morphologically different fibrils compared to those formed in the lipid-free environment. We also found that PAs drastically lowered the toxicity of TTR aggregates formed in the presence of this phospholipid. These results shed light on the role of PA in the stability of TTR and transthyretin </span>amyloidosis.</span></span></span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"257 ","pages":"Article 105350"},"PeriodicalIF":3.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49672250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic synthesis of 1,2-dipalmitoyl-rac-glycero-3-phosphatidylethanolamine and its effect on the induction of apoptosis in normal human lung fibroblasts","authors":"Beatriz Tlatelpa-Romero ,&nbsp;David Atahualpa Contreras-Cruz ,&nbsp;Gabriel Guerrero-Luna ,&nbsp;María Guadalupe Hernández-Linares ,&nbsp;Sinuhé Ruiz-Salgado ,&nbsp;Criselda Mendoza-Milla ,&nbsp;Yair Romero ,&nbsp;René de-la-Rosa Paredes ,&nbsp;Luis F. Oyarzábal ,&nbsp;Diego Alejandro Mendoza-Sámano ,&nbsp;Jiovani Alfredo Galván-León ,&nbsp;Luis G. Vázquez-de-Lara","doi":"10.1016/j.chemphyslip.2023.105349","DOIUrl":"10.1016/j.chemphyslip.2023.105349","url":null,"abstract":"<div><h3>Background /objective</h3><p>The phospholipid 1,2-dipalmitoyl-<em>rac</em>-glycero-3-phosphatidylethanolamine (PE) comprises two fatty acid chains: glycerol, phosphate, and ethanolamine. PE participates in critical cellular processes such as apoptosis and autophagy, which places it as a target for designing new therapeutic alternatives in diseases such as pulmonary fibrosis. Therefore, this study aimed obtain PE through a six-step organic synthesis pathway and determine its biological effect on apoptosis induction in normal human lung fibroblasts (NHLF).</p></div><div><h3>Methodology</h3><p>The first step of the organic synthesis route began with protected glycerol that was benzylated at <em>sn</em>-3; later, it was deprotected to react with palmitic acid at <em>sn</em>-1, <em>sn</em>-2. To remove the benzyl group, hydrogenation was performed with palladium on carbon (Pd/C); subsequently, the molecule was phosphorylated in <em>sn</em>-3 with phosphorus oxychloride and triethylamine, and the intermediate was hydrolyzed in an acid medium to obtain the final compound. After PE synthesis, apoptosis assessment was performed: apoptosis was induced using exposure to annexin V-FITC/propidium iodide-ECD (PI) and quantified using flow cytometry. The experiments were performed in three NHLF cell lines with different concentrations of PE 10, 100 and 1000 µg/mL for 24 and 48 h.</p></div><div><h3>Results</h3><p>The PE obtained by organic synthesis presented a melting point of 190–192 °C, a purity of 95%, and a global yield of 8%. The evaluation of apoptosis with flow cytometry showed that at 24 h, exposure to PE 10, 100, and 1000 µg/mL induces early apoptosis in 19.42%− 25.54%, while late apoptosis was only significant <em>P &lt;</em> 0.05 in cells challenged with 100 µg/mL PE. At 48 h, NHLF exposed to PE 10, 100, and 1000 µg/mL showed decreasing early apoptosis: 28.69–32.16%, 12.59–18.84%, and 10.91–12.61%, respectively. The rest of the NHLF exposed to PE showed late apoptosis: 12.03–16–42%, 11.04–15.94%, and 49.23–51.28%. Statistical analysis showed a significance <em>P &lt;</em> 0.05 compared to the control.</p></div><div><h3>Conclusion</h3><p>The organic synthesis route of PE allows obtaining <em>rac</em>-1,2-<em>O</em>-Dipalmitoyl-glycero-3-phosphoethanolamine (<strong>1</strong>), which showed an apoptotic effect on NHLF.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"257 ","pages":"Article 105349"},"PeriodicalIF":3.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0009308423000713/pdfft?md5=6fc80b27b1609f8fc8647a5bd1aa75f7&pid=1-s2.0-S0009308423000713-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41186897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of Leucidal – eco-preservative from radish – on model lipid membranes and selected pathogenic bacteria","authors":"Beata Wyżga ,&nbsp;Magdalena Skóra ,&nbsp;Katarzyna Hąc-Wydro","doi":"10.1016/j.chemphyslip.2023.105338","DOIUrl":"10.1016/j.chemphyslip.2023.105338","url":null,"abstract":"<div><p>In this work the effect of Leucidal - a natural preservative from radish dedicated to be used in cosmetics - on bacteria cells and model bacteria membranes was investigated. To get insight into the mechanism of action of this formulation the lipid Langmuir monolayers imitating <em>Escherichia coli</em> (<em>E. coli</em>) and <em>Staphylococcus aureus</em> (<em>S. aureus</em>) membranes were prepared. Then, the influence of Leucidal on model systems was investigated by means of the surface pressure/area measurements, penetration studies and Brewster Angle Microscopy (BAM) visualization. Similar experiments were done also for one component monolayers formed from the model membrane lipids. The in vitro tests were done on five different bacteria species (<em>E. coli, Enterococcus faecalis, S. aureus, Salmonella enterica, Pseudomonas aeruginosa</em>). Leucidal was found to decrease packing of the monolayers, however, it was excluded from the films at higher concentrations. Model membrane experiments evidenced also a stronger affinity of the components of this eco-preservative to <em>E. coli</em> vs <em>S. aureus</em> membrane. Among one component films, those formed from phosphatidylglycerols and cardiolipins were more sensitive to the presence of Leucidal. However, in vitro tests evidenced that Leucidal exerts stronger inhibitory effect against <em>S. aureus</em> bacteria as compared to <em>E. coli</em> strain. These findings were discussed from the point of view of the role of Leucidal components and the lipid membrane properties in the membrane - based mechanism of action of this preservative. The results allow one to suggest that the membrane may not be the main site of action of Leucidal on bacteria. Moreover, since high concentration of the tested preparation exerted antibacterial activity in relation to all tested bacteria, a low selectivity of Leucidal can be postulated, which may be problematic from the point of view of its effect on the skin microbiome.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105338"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0009308423000609/pdfft?md5=baed64a17ac71d98e0ded7f957fbc620&pid=1-s2.0-S0009308423000609-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ionic liquids on biomembranes: A review on recent biophysical studies","authors":"Saheli Mitra ,&nbsp;Veerendra K. Sharma ,&nbsp;Sajal K. Ghosh","doi":"10.1016/j.chemphyslip.2023.105336","DOIUrl":"10.1016/j.chemphyslip.2023.105336","url":null,"abstract":"<div><p>Ionic liquids<span><span><span> (ILs) have been emerged as a versatile class of compounds that can be easily tuned to achieve desirable properties for various applications. The ability of ILs to interact with biomembranes has attracted significant interest, as they have been shown to modulate membrane properties in ways that may have implications for various </span>biological processes. This review provides an overview of recent studies that have investigated the interaction between ILs and biomembranes. We discuss the effects of ILs on the physical and chemical properties of biomembranes, including changes in membrane </span>fluidity<span>, permeability, and stability. We also explore the mechanisms underlying the interaction of ILs with biomembranes, such as electrostatic interactions<span>, hydrogen bonding<span>, and van der Waals forces. Additionally, we discuss the future prospects of this field.</span></span></span></span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105336"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-plane and out-of-plane gigahertz sound velocities of saturated and unsaturated phospholipid bilayers from cryogenic to room temperatures","authors":"E.A. Dobrynina,&nbsp;V.A. Zykova,&nbsp;N.V. Surovtsev","doi":"10.1016/j.chemphyslip.2023.105335","DOIUrl":"10.1016/j.chemphyslip.2023.105335","url":null,"abstract":"<div><p><span><span>Here, we examined the gigahertz sound velocities of hydrated multibilayers of saturated (1,2-dimyristoyl-sn-glycero-3-phosphocholine, DMPC) and unsaturated (1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC) </span>phospholipids<span> by Brillouin spectroscopy. Out-of-plane and in-plane (lateral) phonons were studied independently of each other. Similar strong temperature dependences of the sound velocities were found for phonons of both types. The sound velocities in the low-temperature limit were two-fold higher than that at physiological temperatures; a significant part of the changes in sound velocity occurs in the solid-like gel phase. The factors that may be involved in the peculiar behavior of sound velocity include changes in the chain conformational state, relaxation susceptibility, changes in the </span></span>elastic modulus at infinite frequencies, and lateral packing of molecules.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105335"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman imaging and chemometric methods in human normal bronchial and cancer lung cells: Raman biomarkers of lipid reprogramming","authors":"Monika Kopec,&nbsp;Karolina Beton-Mysur,&nbsp;Halina Abramczyk","doi":"10.1016/j.chemphyslip.2023.105339","DOIUrl":"https://doi.org/10.1016/j.chemphyslip.2023.105339","url":null,"abstract":"<div><p>This paper presents an approach to study biochemical changes in human normal bronchial cells (BEpiC) and human cancer lung cells (A549) by Raman spectroscopy and Raman imaging combined with chemometric methods. Based on Raman spectra and Raman imaging combined with chemometric methods we have proved that peaks at 845 cm⁻¹, 2845 cm⁻¹, 2936 cm⁻¹, 1444 cm⁻¹, 750 cm⁻¹, 1126 cm⁻¹, 1584 cm⁻¹, can be treated as Raman biomarkers probing phosphorylation, lipid reprogramming, oxidative phosphorylation and changes in cholesterol and cytochrome in normal and cancer cells. Raman analysis of the bands at 845 cm⁻¹, 2845 cm⁻¹, 1444 cm⁻¹, and 1126 cm⁻¹ in human cancer lung cells and human normal bronchial cells demonstrate enhanced phosphorylation and triglycerides <em>de novo</em> synthesis, reduced levels of cholesterol and cytochrome <em>c</em> in cancer cells. The sensitivity is equal to 100% (nucleus), 87.5% (mitochondria), 100% (endoplasmic reticulum), 87.5% (lipid droplets), 87.5% (cytoplasm), 87.5% (cell membrane) for A549 cell line and 83.3% (nucleus), 100% (mitochondria), 83.3% (endoplasmic reticulum), 100% (lipid droplets), 100% (cytoplasm), 83.3% (cell membrane) for BEpiC. The values of specificity for cross-validation equal 93.4% (nucleus), 85.5% (mitochondria), 89.5% (endoplasmic reticulum), 90.8% (lipid droplets), 61.8% (cytoplasm), 94.7% (cell membrane) for A549 cell line and 88.5% (nucleus), 85.9% (mitochondria), 85.9% (endoplasmic reticulum), 97.4% (lipid droplets), 75.6% (cytoplasm), 92.3% (cell membrane) for BEpiC. We have confirmed that Raman spectroscopy methods combined with PLS-DA are useful tools to monitor changes in human cancer lung cells and human normal bronchial cells.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"257 ","pages":"Article 105339"},"PeriodicalIF":3.4,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41080907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of amphiphilic carbosilane dendrons on lipid model membranes","authors":"Dominika Wrobel ,&nbsp;Antonin Edr ,&nbsp;Eliska Zemanova ,&nbsp;Tomáš Strašák ,&nbsp;Alena Semeradtova ,&nbsp;Jan Maly","doi":"10.1016/j.chemphyslip.2023.105314","DOIUrl":"10.1016/j.chemphyslip.2023.105314","url":null,"abstract":"<div><p><span>Amphiphilic dendrons represent a relatively novel class of molecules which may show many unique properties suitable for applications in a field of molecular biology and </span>nanomedicine<span><span>. They were frequently studied as platforms suitable for drug delivery systems as were, e.g. polymersomes or hybrid lipid-polymer nanoparticles. Recently, natural extracellular </span>lipid vesicles<span> (EVs), called exosomes (EXs), were shown to be a promising candidate in drug delivery applications. Formation of hybrid exosome-dendron nanovesicles could bring benefits in their simple conjugation with selective targeting moieties. Unfortunately, the complex architecture of biological membranes, EXs included, makes obstacles in elucidating the important parameters and mechanisms of interaction with the artificial amphiphilic structures.</span></span></p><p><span>The aim of the presented work was to study the interaction of two types of amphiphilic carbosilane dendritic structures (denoted as DDN-1 and DDN-2) suitable for further modification with streptavidin<span> (DDN-1) or using click-chemistry approach (DDN-2), with selected neutral and negatively charged lipid<span> model membranes<span>, partially mimicking the basic properties of natural EXs biomembranes. To meet the goal, a number of biophysical methods<span> were used for determination of the degree and mechanisms of the interaction. The results showed that the strength of interactions of amphiphilic dendrons with liposomes was related with surface charge of liposomes. Several steps of interactions were disclosed. The initialization step was mainly coupled with amphiphilic dendrons - liposomes surface interaction resulting in destabilization of large self-assembled amphiphilic dendrons structures. Such destabilization was more significant with liposomes of higher negative charge. With increasing concentration of amphiphilic dendrons in a solution the interactions were taking place also in the hydrophobic part of bilayer. Further increase of nanoparticle concentration resulted in a gradual dendritic cluster formation in a </span></span></span></span></span>lipid bilayer structure.</p><p>Due to high affinity of amphiphilic dendrons to model lipid bilayers the conclusion can be drawn that they represent promising platforms also for decoration of exosomes or other kinds of natural lipid vehicles. Such organized hybrid dendron-lipid biomembranes may be advantageous for their subsequent post-functionalization with small molecules, large biomacromolecules or polymers suitable for targeted drug-delivery or theranostic applications.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105314"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solubilization of biomimetic lipid mixtures by some commonly used non-ionic detergents","authors":"Amanda C. Caritá ,&nbsp;Rafaela R.M. Cavalcanti,&nbsp;Mariana S.S. Oliveira,&nbsp;Karin A. Riske","doi":"10.1016/j.chemphyslip.2023.105327","DOIUrl":"10.1016/j.chemphyslip.2023.105327","url":null,"abstract":"<div><p><span><span>Detergents are amphiphilic molecules often used to solubilize biological membranes<span> and separate their components. Here we investigate the solubilization of </span></span>lipid vesicles by the commonly used non-ionic detergents polyoxyethylene (20) oleyl ether (Brij 98), n-octyl-β-</span><span>D</span><span><span>-glucoside (OG), and n-dodecyl β-D maltoside<span><span> (DDM) and compare the results with the standard detergent Triton X-100 (TX-100). The vesicles were composed of palmitoyl oleoyl phosphatidylcholine<span> (POPC) or of a biomimetic<span> ternary mixture of POPC, egg </span></span></span>sphingomyelin<span> (SM) and cholesterol (2:1:2 molar ratio). To follow the solubilization profile of large unilamellar vesicles (LUVs), 90° light scattering measurements were done along the titration of LUVs with the detergents. Then, giant unilamellar vesicles (GUVs) were observed with </span></span></span>optical microscopy<span> during exposure to the detergents, to allow direct visualization of the solubilization process. Isothermal titration calorimetry<span> (ITC) was used to assess the binding constant<span> of the detergents in POPC bilayers<span>. The results show that the incorporation of TX-100, Brij 98 and, to a lesser extent, OG in the pure POPC liposomes leads to an increase in the vesicle area, which indicates their ability to redistribute between the two leaflets of the membrane in a short scale of time. On the other hand, DDM incorporates mainly in the external leaflet causing an increase in vesicle curvature/tension leading ultimately to vesicle burst. Only TX-100 and OG were able to completely solubilize the POPC vesicles, whereas the biomimetic ternary mixture was partially insoluble in all detergents tested. TX-100 and OG were able to incorporate in the bilayer of the ternary mixture and induce macroscopic phase separation of liquid-ordered (</span></span></span></span></span><em>Lo</em>) and liquid-disordered (<em>Ld</em><span>) domains, with selective solubilization of the latter. Combination of ITC data with turbidity results showed that TX-100 and OG can be incorporated up to almost 0.3 detergent/lipid, significantly more than Brij 98 and DDM. This fact seems to be directly related to their higher capacity to solubilize POPC membranes and their ability to induce macroscopic phase separation in the biomimetic lipid mixture.</span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105327"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9986853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transethosome: An ultra-deformable ethanolic vesicle for enhanced transdermal drug delivery","authors":"Alan Raj ,&nbsp;Kamal Dua ,&nbsp;Rajesh Sreedharan Nair ,&nbsp;C. Sarath Chandran ,&nbsp;Angel Treasa Alex","doi":"10.1016/j.chemphyslip.2023.105315","DOIUrl":"10.1016/j.chemphyslip.2023.105315","url":null,"abstract":"<div><p><span>Drug delivery through the skin improves solubility, bioavailability, and unwanted systemic side effects of the drug. The selection of a suitable carrier is a challenging process. The conventional lipid vesicles<span> have some limitations. They deliver the drug in the stratum corneum and have poor colloidal stability. Here comes the need for ultra-deformable lipid vesicles to provide the drug beyond the stratum corneum. Transethosomes are novel ultra-deformable vesicles that can deliver drugs into deeper tissues. The composition of transethosomes includes </span></span>phospholipid, ethanol and surfactants. Each ingredient has a pivotal role in the properties of the carrier. This review covers the design, preparation method, characterisation, and characteristics of the novel vesicle. Also, we cover the impact of surfactants on vesicular properties and the skin permeation behaviour of novel vesicles.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105315"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10204998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}