ASTRAKHAN MEDICAL JOURNAL最新文献

{"title":"COST-UTILITY ANALYSIS OF PERSONALIZED ANTIPLATELET THERAPY","authors":"M. Abdullaev, B. Kantemirova, E. Chernysheva, A. Romanova","doi":"10.29039/2712-8164-2023-1-17-26","DOIUrl":"https://doi.org/10.29039/2712-8164-2023-1-17-26","url":null,"abstract":"The article contains the results of a comparison pharmacoeconomical cost-utility analysis of several options for dual antiplatelet therapy in patients with acute coronary syndrome after stent implanting. The costs for treatment alternatives with and without prior pharmacogenetic testing for CYP2C19 were calculated. According to the results of the analysis the most cost-effective treatment option for patients with acute coronary syndrome is prior pharmacogenetic testing and the choice of the antiplatelet drug prasugrel in slow and intermediate metabolizers (CUA: 289,111.00 rubles per QALY).","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131351700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHALLENGES IN EARLY DIAGNOSIS OF JUVENILE DERMATOMYOSITIS: A BRIEF REVIEW OF THE LITERATURE AND A CASE STUDY","authors":"S. Mamedova, N. Surkhay","doi":"10.29039/1992-6499-2023-1-106-115","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-106-115","url":null,"abstract":"Juvenile dermatomyositis (JDM) is an autoimmune, relatively rare multisystem disease of unknown etiology, of which late diagnosis and late initiation of therapy can lead to a child's disability and even lethal outcome. The disease begins in most cases at the age of 5–12 years though can manifest itself both in earlier, and at more advanced age. This disease has a pronounced clinical polymorphism, which complicates early diagnosis and therapy. The article provides a brief overview of research car-ried out in recent years. A rare case of development of juvenile dermatomyositis in a teenager is con-sidered. Attention is drawn to the complexity of staging this disease during the initial treatment for medical care. A positive dynamics of the course of the disease was shown against the background of correctly selected therapy. The importance of adherence to the prescribed treatment is indicated, the refusal of which can lead to adverse outcomes","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130892658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL «MASKS» OF PYELONEPHRITIS IN CHILDREN (CASE STUDIES)","authors":"G. R. Sagitova, A.A. Antonova, V. Sereda, Marina Gerner","doi":"10.29039/1992-6499-2023-1-116-120","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-116-120","url":null,"abstract":"Various variants of the clinical manifestation of the development of acute pyelonephritis in children are presented. Attention is drawn to the need for a detailed survey and examination of a sick child with suspected acute pyelonephritis. It is shown that laboratory diagnostics helps in making the speci-fied diagnosis and prescribing the necessary therapy. In differential diagnosis, it is important to under-stand the causes of the development of clinical manifestations of various diseases.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116266631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTION OF DAMAGES OF THE GASTRIC AND DUODENAL MUCOSA DURING CHEMOTHERAPY","authors":"Yaroslav Yakimenko, V. Kutukov, V. Antonyan, Svetlana Gavrilova, E. Gasanova, D. Bogomolov, M. Gaziev, E. Andreeva","doi":"10.29039/1992-6499-2023-1-97-105","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-97-105","url":null,"abstract":"Abstract. The main goal of the study was to prevent the development of gastric and duodenal ulcers in patients with colorectal cancer receiving adjuvant therapy with 5-fluorouracil. Materials and methods. The study included 60 patients with a verified diagnosis of localized or locally advanced colon and rectosigmoid cancer after radical surgical treatment. The patients are divided into two groups. The first group included 28 people who were found to have Helicobacter pylori during fibro-gastroduodenoscopy and 13C-respiratory urease test. Patients underwent anti-Helicobacter and gastro-protective therapy before adjuvant chemotherapy with 5-fluorouracil according to the developed scheme. The second group included 32 people. Tests for infection with Helicobacter pylori in these patients were negative, they did not receive gastroprotective therapy. Research results. The study showed the effectiveness of prophylactic therapy administered to patients from the first group before the start of the adjuvant chemotherapy program, since ulcerative lesions of the mucous membranes of the stomach and duodenum in patients were detected less frequently, responded better to conservative therapy, and also did not cause a delay in the next course of drug treatment. including 5-fluorouracil. When preventive antiulcer treatment was administered, the chance of developing ulcer complications in patients decreased by 5.08 times. The most vulnerable in terms of mucosal damage were female pa-tients of elderly and senile age, complications developed even against the background of antiulcer treatment.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117079204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF DIABETIC RETINOPATHY IN THE POPULATION OF PEOPLE WITH DIABETES IN ASTRAKHAN","authors":"Mekher Skandrani, L. Ramazanova, Khazem Alui, R. Shamratov, Mariya Ploskonos","doi":"10.29039/1992-6499-2023-1-81-87","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-81-87","url":null,"abstract":"The purpose of the study: analysis of examination and treatment data of patients with diabetic reti-nopathy in the adult population of the city of Astrakhan. Materials and methods. The medical records of 1111 patients with type 1 and type 2 diabetes mellitus who were treated in the ophthalmological and endocrinological departments of the Aleksandro-Mariinsky Regional Clinical Hospital from January to August 2022 were studied. All patients were examined using standard clinical, laboratory, and instru-mental examination methods. Research results. According to our data, in recent years, the incidence of diabetes mellitus among the adult population of Astrakhan has more than doubled. Of the 1111 ex-amined patients, 185 were diagnosed with type 1 diabetes mellitus (16,7 %), and the remaining 926 patients were diagnosed with type 2 diabetes (83,3 %). The diagnosis of diabetic retinopathy of vary-ing severity during the examination of patients with diabetes mellitus was established in 77 out of 185 examined patients with diabetes mellitus type 1 (41,6 %) and in 665 out of 926 with diabetes mellitus type 2 (71,8 %). Thus, against the background of an increase in the incidence of diabetes, there is a tendency to reduce the incidence of diabetic retinopathy among the adult population of Astrakhan, which can be explained not only by the widespread use of transretinal laser photocoagulation and vitrectomy, but also by new methods for monitoring blood glucose, hypertension and serum lipids. Conclusion. Diabetic retinopathy is a highly specific vascular complication of both type 1 and type 2 diabetes mellitus. The prevalence of retinopathy is closely related to the duration of diabetes. After 20 years of diabetes, almost all patients with type 1 diabetes and more than 60 % of patients with type 2 diabetes have some degree of retinopathy. The best screening method for diabetic retinopathy is an extended eye examination performed by an ophthalmologist. Modern ophthalmic diagnostic and treatment methods can prevent or delay the onset of diabetic retinopathy, as well as prevent vision loss in a significant proportion of diabetic patients.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125881470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE DYNAMICS OF SPIROMETRY INDICATORS IN PATIENTS WITH DIFFERENT OCCUPATIONAL PATHOLOGIES OF THE BRONCHOPULMONARY SYSTEM","authors":"V. Fedotov","doi":"10.29039/1992-6499-2023-1-88-96","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-88-96","url":null,"abstract":"","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130732097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IRON INDICATORS IN THE UMBILICAL BLOOD OF PREMATURE CHILDREN BORN USING IVF TECHNOLOGY","authors":"N.P. Provatar, E. Kashirskaya, A. A. Nikolaev, A. Kashirskiy","doi":"10.29039/1992-6499-2023-1-66-71","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-66-71","url":null,"abstract":"The paper presents the results of a study of iron metabolism in full-term infants conceived naturally and using in vitro fertilization (IVF) technology. The data obtained allowed us to conclude that there were no statistically significant differences in the studied indicators in the groups and did not reveal the effect of IVF technology on the iron metabolism of full-term newborns. The purpose of the study. To study and compare the data of iron metabolism - hemoglobin, serum iron, serum transferrin recep-tor (sTfR), ferritin, ferritin index (sTfR/logFer), transferrin saturation, zinc protoporphyrin/ heme ratio in full-term infants conceived using IVF technology and children born by natural conception. Materi-als and methods. Clinical, biochemical and statistical methods were used in the work. The indicators of hemogram and ferrokinetics were determined in 20 full-term children conceived by observation, and in 18 children born using the technology of in vitro fertilization. Research results. In full-term children born as a result of IVF procedure, the level of Hb it was 17,03 ± 0,82 g/dl. The level of serum iron was comparable in the study groups (in full–term children conceived naturally, it is 26,09 ± 0,68 μmol/l, in children conceived by IVF – 25,24 ± 0,5 μmol/l). Studies of the ferritin level in full–term children conceived in the traditional way showed values of 175,73 ± 11,63 μg/l, in children after IVF procedure – 177,04 ± 11,21 μg/l. When calculating the ferritin index (sTfR / log10 Ferritin), data were obtained - in full-term children, the ferritin index is 3,72 ± 0,28 and 4,03 ± 0,36 mg/l depending on the method of conception, the differences are not statistically significant. In full-term children conceived naturally, the TS level was determined to be 61,18 ± 4,11 %, and in full-term children born as a result of traditional conception – 61,77 ± 5,3 %. Conclusion. The study allowed us to conclude that there is no statistically significant effect of the IVF method on iron metabolism and ferrokinetic factors in full-term newborns conceived by this method.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128398607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLUSTER ANALYSIS AS AN INTEGRATOR OF DIFFERENT TECHNIQUES FOR ASSESSING THE PHYSICAL DEVELOPMENT OF HEALTHY ADOLESCENTS","authors":"A. Semenov, I. Gayvoronskiy, V. Krishtop","doi":"10.29039/1992-6499-2023-1-72-80","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-72-80","url":null,"abstract":"The influence of external factors can significantly deviate the distribution of somatotypes from the indicators of the general population, which makes researchers select the most suitable scheme of so-matotyping from the already known ones or construct their own. Applicants of military universities are a particular case of such samples, formed as a result of a complex of factors, including the work of military medical commissions. The aim was to use cluster analysis to develop an integrative classifica-tion for assessing the physical development of practically healthy adolescents. Materials and meth-ods. The object of the study was 280 applicants (234 boys and 46 girls), who were examined by spe-cialists in the medical commissions of military commissariats and were considered to be practically healthy. Anthropometric data were analyzed: body length, body weight, length of the torso, limbs, girth dimensions of the torso and limbs, as well as body component composition. Hierarchical cluster analysis by the Ward method and Kendall's correlation coefficient were used in the study. Results. By means of cluster analysis of the physical development indicators of the virtually healthy individuals, we identified a significant contribution of body mass index, weight, body length in the formation of three major groups, which we characterized as: the male macrosomatic phenotype, the male mesoso-matic phenotype, and the female phenotype. Based on the proportion of muscle and fat tissue, visceral fat, distal diameter of the forearm as an indicator of bone development, body mass index and thick-ness of the skin-fat fold of the anterior abdominal wall, the following subgroups were identified: male macrosomatic phenotype, with hyperstenic features, male macrosomatic phenotype, with normosthen-ic features, male mesosomatic phenotype with digestive features, male mesosomatic phenotype with mesotonic features, male mesosomatic muscle phenotype, female megalosomic athletic and subathletic phenotype, female stenoplastic phenotype. Conclusion. The used statistical approach allows to change the classical paradigm of searching for a universal methodology of somatotyping, to the creation of algorithms of compilation of well-known schemes of physical development evaluation in the selected population groups.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133249991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND ANAMNESTIC FACTORS OF PREGNANT WOMEN WITH DIFFER-ENT COURSE OF A NEW CORONAVIRUS INFECTION","authors":"Nasri Onsi, Mariya Marina V. Kuzmina Kuzmina Marina V. Kuzmina, S. Sinchihin, O. Nagaeva, Georgiy Gviniashvili, Anakhanum Muratova","doi":"10.29039/1992-6499-2023-1-59-65","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-59-65","url":null,"abstract":"Pregnant women infected with SARS-CoV-2 are considered as a risk group for the development of severe complications and an unfavorable outcome of a new coronavirus infection. At the same time, various non-gestational factors may be an additional unfavorable background that determines the course of this disease in pregnant women. The purpose of the study was to evaluate the clinical and anamnestic data of pregnant women with different course of a new coronavirus infection. Material and research methods. A retrospective analysis of the history and comorbidity data of 360 pregnant women infected with SARS-CoV-2 was carried out. The features of the reproductive history and ex-tragenital pathology of pregnant women with different course of Coronavirus Disease 2019 (COVID-19) were revealed. The standard collection of anamnesis and clinical examination was carried out, which is required to fill in the medical records of an outpatient and inpatient patient. Statistical pro-cessing of the obtained results was carried out using Microsoft Excel 2010 and Statistica (version 6.0). Research results. It has been established that among pregnant women with a severe course of this dis-ease, patients who use nicotine-containing products and have such concomitant somatic pathologies as diabetes mellitus, obesity, hypothyroidism, iron deficiency anemia, chronic arterial hypertension and varicose veins are significantly more common. Unfavorable factors of the reproductive history in-clude: abortion, non-developing pregnancy, preeclampsia. Conclusion. To predict the course of a new coronavirus disease in the gestational period, it is necessary to take into account the listed clinical and anamnestic data of the patient.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130874901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATHOLOGY OF THE URINARY SYSTEM AND ITS FREQUENCY IN CHILDREN WITH COVID-19","authors":"D. Yarovaya, O. Bashkina, Elena V. Krasilova, M. Samotrueva, E. Kasymova","doi":"10.29039/1992-6499-2023-1-39-49","DOIUrl":"https://doi.org/10.29039/1992-6499-2023-1-39-49","url":null,"abstract":"This review presents data on endothelial dysfunction and the mechanisms of its development in coro-navirus disease. The possible pathology of the urinary system and its frequency in children against the background of COVID-19, which is mainly due to endothelial dysfunction, is described. Displayed studies on the frequency of urinary tract infections in children and adolescents during a pandemic, which depended on the level of quarantine measures, which in turn affect the neuro-psychological causes of bladder dysfunction, limited timely access to medical care, etc. A systematic review of stud-ies published in English from 2000 to 2019 was performed (with predominant inclusion (84,6 %) of data for the last 2 years) using PubMed, ScienceDirect, ProQuest, GoogleScholar, Cochrane, Medline, AMED databases., EMBASE, CINHAL, SportDiscus, Scopus and PEDro. The review included review articles, meta-analyses, qualitative studies, retrospective and prospective studies.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124602416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}