PREVENTION OF DAMAGES OF THE GASTRIC AND DUODENAL MUCOSA DURING CHEMOTHERAPY

Yaroslav Yakimenko, V. Kutukov, V. Antonyan, Svetlana Gavrilova, E. Gasanova, D. Bogomolov, M. Gaziev, E. Andreeva
{"title":"PREVENTION OF DAMAGES OF THE GASTRIC AND DUODENAL MUCOSA DURING CHEMOTHERAPY","authors":"Yaroslav Yakimenko, V. Kutukov, V. Antonyan, Svetlana Gavrilova, E. Gasanova, D. Bogomolov, M. Gaziev, E. Andreeva","doi":"10.29039/1992-6499-2023-1-97-105","DOIUrl":null,"url":null,"abstract":"Abstract. The main goal of the study was to prevent the development of gastric and duodenal ulcers in patients with colorectal cancer receiving adjuvant therapy with 5-fluorouracil. Materials and methods. The study included 60 patients with a verified diagnosis of localized or locally advanced colon and rectosigmoid cancer after radical surgical treatment. The patients are divided into two groups. The first group included 28 people who were found to have Helicobacter pylori during fibro-gastroduodenoscopy and 13C-respiratory urease test. Patients underwent anti-Helicobacter and gastro-protective therapy before adjuvant chemotherapy with 5-fluorouracil according to the developed scheme. The second group included 32 people. Tests for infection with Helicobacter pylori in these patients were negative, they did not receive gastroprotective therapy. Research results. The study showed the effectiveness of prophylactic therapy administered to patients from the first group before the start of the adjuvant chemotherapy program, since ulcerative lesions of the mucous membranes of the stomach and duodenum in patients were detected less frequently, responded better to conservative therapy, and also did not cause a delay in the next course of drug treatment. including 5-fluorouracil. When preventive antiulcer treatment was administered, the chance of developing ulcer complications in patients decreased by 5.08 times. The most vulnerable in terms of mucosal damage were female pa-tients of elderly and senile age, complications developed even against the background of antiulcer treatment.","PeriodicalId":269283,"journal":{"name":"ASTRAKHAN MEDICAL JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ASTRAKHAN MEDICAL JOURNAL","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29039/1992-6499-2023-1-97-105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract. The main goal of the study was to prevent the development of gastric and duodenal ulcers in patients with colorectal cancer receiving adjuvant therapy with 5-fluorouracil. Materials and methods. The study included 60 patients with a verified diagnosis of localized or locally advanced colon and rectosigmoid cancer after radical surgical treatment. The patients are divided into two groups. The first group included 28 people who were found to have Helicobacter pylori during fibro-gastroduodenoscopy and 13C-respiratory urease test. Patients underwent anti-Helicobacter and gastro-protective therapy before adjuvant chemotherapy with 5-fluorouracil according to the developed scheme. The second group included 32 people. Tests for infection with Helicobacter pylori in these patients were negative, they did not receive gastroprotective therapy. Research results. The study showed the effectiveness of prophylactic therapy administered to patients from the first group before the start of the adjuvant chemotherapy program, since ulcerative lesions of the mucous membranes of the stomach and duodenum in patients were detected less frequently, responded better to conservative therapy, and also did not cause a delay in the next course of drug treatment. including 5-fluorouracil. When preventive antiulcer treatment was administered, the chance of developing ulcer complications in patients decreased by 5.08 times. The most vulnerable in terms of mucosal damage were female pa-tients of elderly and senile age, complications developed even against the background of antiulcer treatment.
化疗期间胃和十二指肠黏膜损伤的预防
摘要该研究的主要目的是预防接受5-氟尿嘧啶辅助治疗的结直肠癌患者胃和十二指肠溃疡的发展。材料和方法。该研究包括60例经根治性手术治疗后确诊为局部或局部晚期结肠癌和直肠乙状结肠癌的患者。病人被分为两组。第一组包括28名在纤维-胃十二指肠镜检查和13c -呼吸脲酶测试中发现幽门螺杆菌的人。根据制定的方案,患者在5-氟尿嘧啶辅助化疗前接受抗幽门螺杆菌和胃保护治疗。第二组有32人。这些患者的幽门螺杆菌感染试验均为阴性,未接受胃保护治疗。研究的结果。该研究表明,在开始辅助化疗计划之前,对第一组患者进行预防性治疗是有效的,因为患者胃和十二指肠粘膜溃疡病变的检测频率较低,对保守治疗的反应更好,并且也没有造成下一个疗程药物治疗的延迟。包括5 -氟尿嘧啶。给予预防性抗溃疡治疗后,患者发生溃疡并发症的几率降低5.08倍。最易发生粘膜损伤的是老年女性患者,即使在抗溃疡治疗的背景下也会出现并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信