IRON INDICATORS IN THE UMBILICAL BLOOD OF PREMATURE CHILDREN BORN USING IVF TECHNOLOGY

N.P. Provatar, E. Kashirskaya, A. A. Nikolaev, A. Kashirskiy
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Abstract

The paper presents the results of a study of iron metabolism in full-term infants conceived naturally and using in vitro fertilization (IVF) technology. The data obtained allowed us to conclude that there were no statistically significant differences in the studied indicators in the groups and did not reveal the effect of IVF technology on the iron metabolism of full-term newborns. The purpose of the study. To study and compare the data of iron metabolism - hemoglobin, serum iron, serum transferrin recep-tor (sTfR), ferritin, ferritin index (sTfR/logFer), transferrin saturation, zinc protoporphyrin/ heme ratio in full-term infants conceived using IVF technology and children born by natural conception. Materi-als and methods. Clinical, biochemical and statistical methods were used in the work. The indicators of hemogram and ferrokinetics were determined in 20 full-term children conceived by observation, and in 18 children born using the technology of in vitro fertilization. Research results. In full-term children born as a result of IVF procedure, the level of Hb it was 17,03 ± 0,82 g/dl. The level of serum iron was comparable in the study groups (in full–term children conceived naturally, it is 26,09 ± 0,68 μmol/l, in children conceived by IVF – 25,24 ± 0,5 μmol/l). Studies of the ferritin level in full–term children conceived in the traditional way showed values of 175,73 ± 11,63 μg/l, in children after IVF procedure – 177,04 ± 11,21 μg/l. When calculating the ferritin index (sTfR / log10 Ferritin), data were obtained - in full-term children, the ferritin index is 3,72 ± 0,28 and 4,03 ± 0,36 mg/l depending on the method of conception, the differences are not statistically significant. In full-term children conceived naturally, the TS level was determined to be 61,18 ± 4,11 %, and in full-term children born as a result of traditional conception – 61,77 ± 5,3 %. Conclusion. The study allowed us to conclude that there is no statistically significant effect of the IVF method on iron metabolism and ferrokinetic factors in full-term newborns conceived by this method.
体外受精技术早产儿脐血铁指标的研究
本文介绍了利用体外受精(IVF)技术自然受孕的足月婴儿铁代谢的研究结果。根据所获得的数据,我们得出的结论是,所研究的指标在两组之间没有统计学上的显著差异,也没有揭示体外受精技术对足月新生儿铁代谢的影响。研究的目的。研究比较体外受精和自然受孕足月婴儿的铁代谢指标——血红蛋白、血清铁、血清转铁蛋白受体(sTfR)、铁蛋白、铁蛋白指数(sTfR/logFer)、转铁蛋白饱和度、锌原卟啉/血红素比值。材料和方法。采用临床、生化、统计学等方法。对20例观察妊娠足月患儿和18例体外受精患儿的血象和铁动力学指标进行了测定。研究的结果。在IVF手术后出生的足月儿童中,Hb水平为17.03±0.82 g/dl。各研究组血清铁水平具有可比性(自然妊娠足月患儿为26、09±0.68 μmol/l,体外受精妊娠患儿为- 25、24±0.5 μmol/l)。传统方法妊娠足月儿铁蛋白水平分别为175、73±11、63 μg/l,体外受精后足月儿铁蛋白水平分别为- 177、04±11、21 μg/l。在计算铁蛋白指数(sTfR / log10铁蛋白)时,获得数据-足月儿铁蛋白指数分别为3,72±0,28和4,03±0,36 mg/l,根据受孕方法不同,差异无统计学意义。在自然受孕的足月儿童中,TS水平为61,18±4.11%,而在传统受孕的足月儿童中,TS水平为61,77±5.3%。结论。该研究使我们得出结论,IVF方法对通过该方法受孕的足月新生儿的铁代谢和铁动力学因子没有统计学意义的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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