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Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases tRNA队列苷修饰及其糖基化衍生物在人类健康和疾病中的生物发生和作用
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-02-20 DOI: 10.1016/j.chembiol.2024.11.004
Tsutomu Suzuki , Atsuya Ogizawa , Kensuke Ishiguro , Asuteka Nagao
{"title":"Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases","authors":"Tsutomu Suzuki ,&nbsp;Atsuya Ogizawa ,&nbsp;Kensuke Ishiguro ,&nbsp;Asuteka Nagao","doi":"10.1016/j.chembiol.2024.11.004","DOIUrl":"10.1016/j.chembiol.2024.11.004","url":null,"abstract":"<div><div>Various types of post-transcriptional modifications contribute to physiological functions by regulating the abundance and function of RNAs. In particular, tRNAs have the widest variety and largest number of modifications, with crucial roles in protein synthesis. Queuosine (Q) is a characteristic tRNA modification with a 7-deazaguanosine core structure bearing a bulky side chain with a cyclopentene group. Q and its derivatives are found in the anticodon of specific tRNAs in both bacteria and eukaryotes. In metazoan tRNAs, Q is further glycosylated with galactose or mannose. The functions of these glycosylated Qs remained unknown for nearly half a century since their discovery. Recently, our group identified the glycosyltransferases responsible for these tRNA modifications and elucidated their biological roles. We, here, review the biochemical and physiological functions of Q and its glycosylated derivatives as well as their associations with human diseases, including cancer and inflammatory and neurological diseases.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 2","pages":"Pages 227-238"},"PeriodicalIF":6.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next steps for targeted protein degradation 定向降解蛋白质的下一步行动
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-02-20 DOI: 10.1016/j.chembiol.2024.10.004
Mackenzie W. Krone , Craig M. Crews
{"title":"Next steps for targeted protein degradation","authors":"Mackenzie W. Krone ,&nbsp;Craig M. Crews","doi":"10.1016/j.chembiol.2024.10.004","DOIUrl":"10.1016/j.chembiol.2024.10.004","url":null,"abstract":"<div><div>Targeted protein degradation (TPD) has greatly advanced as a therapeutic strategy in the past two decades, and we are on the cusp of rationally designed protein degraders reaching clinical approval. Offering pharmacological advantages relative to occupancy-driven protein inhibition, chemical methods for regulating biomolecular proximity have provided opportunities to tackle disease-related targets that were undruggable. Despite the pre-clinical success of designed degraders and existence of clinical therapies that serendipitously utilize TPD, expansion of the TPD toolbox is necessary to identify and characterize the next generation of molecular degraders. Here we highlight three areas for continued growth in the field that should be prioritized: expansion of TPD platform with greater spatiotemporal precision, increased throughput of degrader synthesis, and optimization of cooperativity in chemically induced protein complexes. The future is bright for TPD in medicine, and we expect that innovative approaches will increase therapeutic applications of proximity-induced pharmacology.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 2","pages":"Pages 219-226"},"PeriodicalIF":6.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation 靶向选择性PCK1和PGC-1α赖氨酸乙酰化的小分子通过增加乳酸氧化引起抗糖尿病作用
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-02-20 DOI: 10.1016/j.chembiol.2025.01.005
Beste Mutlu, Kfir Sharabi, Jee Hyung Sohn, Bo Yuan, Pedro Latorre-Muro, Xin Qin, Jin-Seon Yook, Hua Lin, Deyang Yu, João Paulo G. Camporez, Shingo Kajimura, Gerald I. Shulman, Sheng Hui, Theodore M. Kamenecka, Patrick R. Griffin, Pere Puigserver
{"title":"Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation","authors":"Beste Mutlu,&nbsp;Kfir Sharabi,&nbsp;Jee Hyung Sohn,&nbsp;Bo Yuan,&nbsp;Pedro Latorre-Muro,&nbsp;Xin Qin,&nbsp;Jin-Seon Yook,&nbsp;Hua Lin,&nbsp;Deyang Yu,&nbsp;João Paulo G. Camporez,&nbsp;Shingo Kajimura,&nbsp;Gerald I. Shulman,&nbsp;Sheng Hui,&nbsp;Theodore M. Kamenecka,&nbsp;Patrick R. Griffin,&nbsp;Pere Puigserver","doi":"10.1016/j.chembiol.2025.01.005","DOIUrl":"10.1016/j.chembiol.2025.01.005","url":null,"abstract":"","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 2","pages":"Page 379"},"PeriodicalIF":6.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells 外排泵ABCC1/MRP1组成性地限制癌细胞中PROTAC的敏感性
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-02-20 DOI: 10.1016/j.chembiol.2024.11.009
Gernot Wolf , Conner Craigon , Shao Thing Teoh , Patrick Essletzbichler , Svenja Onstein , Diane Cassidy , Esther C.H. Uijttewaal , Vojtech Dvorak , Yuting Cao , Ariel Bensimon , Ulrich Elling , Alessio Ciulli , Giulio Superti-Furga
{"title":"The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells","authors":"Gernot Wolf ,&nbsp;Conner Craigon ,&nbsp;Shao Thing Teoh ,&nbsp;Patrick Essletzbichler ,&nbsp;Svenja Onstein ,&nbsp;Diane Cassidy ,&nbsp;Esther C.H. Uijttewaal ,&nbsp;Vojtech Dvorak ,&nbsp;Yuting Cao ,&nbsp;Ariel Bensimon ,&nbsp;Ulrich Elling ,&nbsp;Alessio Ciulli ,&nbsp;Giulio Superti-Furga","doi":"10.1016/j.chembiol.2024.11.009","DOIUrl":"10.1016/j.chembiol.2024.11.009","url":null,"abstract":"<div><div>Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins, and several PROTACs have reached the stage of clinical candidates. However, the roles of cellular transmembrane transporters in PROTAC uptake and efflux remain underexplored. Here, we utilized transporter-focused genetic screens to identify the ATP-binding cassette transporter ABCC1/MRP1 as a key PROTAC resistance factor. Unlike the previously identified inducible PROTAC exporter ABCB1/MDR1, ABCC1 is highly expressed among cancers of various origins and constitutively restricts PROTAC bioavailability. Moreover, in a genome-wide PROTAC resistance screen, we identified candidates involved in processes such as ubiquitination, mTOR signaling, and apoptosis as genetic factors involved in PROTAC resistance. In summary, our findings reveal ABCC1 as a crucial constitutively active efflux pump limiting PROTAC efficacy in various cancer cells, offering insights for overcoming drug resistance.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 2","pages":"Pages 291-306.e6"},"PeriodicalIF":6.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covalent targeting of splicing in T cells T 细胞剪接的共价靶向作用
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-01-16 DOI: 10.1016/j.chembiol.2024.10.010
Kevin A. Scott , Hiroyuki Kojima , Nathalie Ropek , Charles D. Warren , Tiffany L. Zhang , Simon J. Hogg , Henry Sanford , Caroline Webster , Xiaoyu Zhang , Jahan Rahman , Bruno Melillo , Benjamin F. Cravatt , Jiankun Lyu , Omar Abdel-Wahab , Ekaterina V. Vinogradova
{"title":"Covalent targeting of splicing in T cells","authors":"Kevin A. Scott ,&nbsp;Hiroyuki Kojima ,&nbsp;Nathalie Ropek ,&nbsp;Charles D. Warren ,&nbsp;Tiffany L. Zhang ,&nbsp;Simon J. Hogg ,&nbsp;Henry Sanford ,&nbsp;Caroline Webster ,&nbsp;Xiaoyu Zhang ,&nbsp;Jahan Rahman ,&nbsp;Bruno Melillo ,&nbsp;Benjamin F. Cravatt ,&nbsp;Jiankun Lyu ,&nbsp;Omar Abdel-Wahab ,&nbsp;Ekaterina V. Vinogradova","doi":"10.1016/j.chembiol.2024.10.010","DOIUrl":"10.1016/j.chembiol.2024.10.010","url":null,"abstract":"<div><div>Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric acrylamide EV96 and its analogues lead to a selective T cell state-dependent loss of interleukin 2-inducible T cell kinase (ITK) by targeting one of the core splicing factors SF3B1. Mechanistic investigations suggest that the state-dependency stems from a combination of differential protein turnover rates and extensive ITK mRNA alternative splicing. We further introduce the most comprehensive list to date of proteins involved in splicing and leverage cysteine- and protein-directed activity-based protein profiling with electrophilic scout fragments to demonstrate covalent ligandability for many classes of splicing factors and splicing regulators in T cells. Taken together, our findings show how chemical perturbation of splicing can lead to immune state-dependent changes in protein expression and provide evidence for the broad potential to target splicing factors with covalent chemistry.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 1","pages":"Pages 201-218.e17"},"PeriodicalIF":6.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New opportunities in mechanistic and functional microbiome studies 机制和功能微生物组研究的新机遇
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-01-16 DOI: 10.1016/j.chembiol.2024.12.012
Judith Behnsen, Kerwyn Casey Huang, Matthew T. Sorbara, Meng C. Wang, Jun Yu, Melody Y. Zeng
{"title":"New opportunities in mechanistic and functional microbiome studies","authors":"Judith Behnsen,&nbsp;Kerwyn Casey Huang,&nbsp;Matthew T. Sorbara,&nbsp;Meng C. Wang,&nbsp;Jun Yu,&nbsp;Melody Y. Zeng","doi":"10.1016/j.chembiol.2024.12.012","DOIUrl":"10.1016/j.chembiol.2024.12.012","url":null,"abstract":"<div><div>The field of microbiome research has experienced remarkable growth, leading to unprecedented discoveries of the molecular mechanisms that dictate host-microbiota interactions and their crucial roles in human health. In this “chemical biology of the microbiome” focus issue from <em>Cell Chemical Biology</em>, this Voices piece asks researchers from a range of backgrounds to share their insights on the most exciting recent developments in the microbiome field.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 1","pages":"Pages 5-8"},"PeriodicalIF":6.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss 认识一下作者：卡特琳娜·琼斯、卡米拉·贝尔纳多·德·布里托和玛丽安娜·泽维尔·拜德罗斯
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-01-16 DOI: 10.1016/j.chembiol.2024.12.009
Katerina Jones, Camila Bernardo de Brito, Mariana Xavier Byndloss
{"title":"Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss","authors":"Katerina Jones,&nbsp;Camila Bernardo de Brito,&nbsp;Mariana Xavier Byndloss","doi":"10.1016/j.chembiol.2024.12.009","DOIUrl":"10.1016/j.chembiol.2024.12.009","url":null,"abstract":"<div><div>In an interview with Samantha Nelson, a scientific editor of <em>Cell Chemical Biology</em>, the authors of the review entitled “<span><span>Metabolic tug-o-war: Microbial metabolism shapes colonization resistance against enteric pathogens</span><svg><path></path></svg></span>” share their perspectives on the field and their lives as scientists.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 1","pages":"Pages 3-4"},"PeriodicalIF":6.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway 人类 AKR1C3 与 GPR84 的激动剂结合，并参与扩展的多胺途径。
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-01-16 DOI: 10.1016/j.chembiol.2024.07.011
Natavan Dudkina , Hyun Bong Park , Deguang Song , Abhishek Jain , Sajid A. Khan , Richard A. Flavell , Caroline H. Johnson , Noah W. Palm , Jason M. Crawford
{"title":"Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway","authors":"Natavan Dudkina ,&nbsp;Hyun Bong Park ,&nbsp;Deguang Song ,&nbsp;Abhishek Jain ,&nbsp;Sajid A. Khan ,&nbsp;Richard A. Flavell ,&nbsp;Caroline H. Johnson ,&nbsp;Noah W. Palm ,&nbsp;Jason M. Crawford","doi":"10.1016/j.chembiol.2024.07.011","DOIUrl":"10.1016/j.chembiol.2024.07.011","url":null,"abstract":"<div><div>Altered human aldo-keto reductase family 1 member C3 (AKR1C3) expression has been associated with poor prognosis in diverse cancers, ferroptosis resistance, and metabolic diseases. Despite its clinical significance, the endogenous biochemical roles of AKR1C3 remain incompletely defined. Using untargeted metabolomics, we identified a major transformation mediated by AKR1C3, in which a spermine oxidation product “sperminal” is reduced to “sperminol.” Sperminal causes DNA damage and activates the DNA double-strand break response, whereas sperminol induces autophagy <em>in vitro</em>. AKR1C3 also pulls down acyl-pyrones and pyrone-211 inhibits AKR1C3 activity. Through G protein-coupled receptor ligand screening, we determined that pyrone-211 is also a potent agonist of the semi-orphan receptor GPR84. Strikingly, mammalian fatty acid synthase produces acyl-pyrones <em>in vitro</em>, and this production is modulated by NADPH. Taken together, our studies support a regulatory role of AKR1C3 in an expanded polyamine pathway and a model linking fatty acid synthesis and NADPH levels to GPR84 signaling.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 1","pages":"Pages 126-144.e18"},"PeriodicalIF":6.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The right tool for the job: Chemical biology and microbiome science 这项工作的正确工具：化学生物学和微生物组科学
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-01-16 DOI: 10.1016/j.chembiol.2024.12.004
Christopher Whidbey
{"title":"The right tool for the job: Chemical biology and microbiome science","authors":"Christopher Whidbey","doi":"10.1016/j.chembiol.2024.12.004","DOIUrl":"10.1016/j.chembiol.2024.12.004","url":null,"abstract":"<div><div>Microbiomes exist in ecological niches ranging from the ocean and soil to inside of larger organisms like plants and animals. Within these niches, microbes play key roles in biochemical processes that impact larger phenomena, such as biogeochemical cycling or health. By understanding of how these processes occur at the molecular level, it may be possible to develop new interventions to address global problems. The complexity of these systems poses challenges to more traditional techniques. Chemical biology can help overcome these challenges by providing tools that are broadly applicable and can obtain molecular-level information about complex systems. This primer is intended to serve as a brief introduction to chemical biology and microbiome science, to highlight some of the ways that these two disciplines complement each other, and to encourage dialog and collaboration between these fields.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 1","pages":"Pages 83-97"},"PeriodicalIF":6.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden 基于酵母的口服疗法可提供免疫检查点抑制剂，减轻肠道肿瘤负担
IF 6.6 1区 生物学
Cell Chemical Biology Pub Date : 2025-01-16 DOI: 10.1016/j.chembiol.2024.10.013
Olivia N. Rebeck , Miranda J. Wallace , Jerome Prusa , Jie Ning , Esse M. Evbuomwan , Sunaina Rengarajan , LeMoyne Habimana-Griffin , Suryang Kwak , David Zahrah , Jason Tung , James Liao , Bejan Mahmud , Skye R.S. Fishbein , Erick S. Ramirez Tovar , Rehan Mehta , Bin Wang , Mark G. Gorelik , Beth A. Helmink , Gautam Dantas
{"title":"A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden","authors":"Olivia N. Rebeck ,&nbsp;Miranda J. Wallace ,&nbsp;Jerome Prusa ,&nbsp;Jie Ning ,&nbsp;Esse M. Evbuomwan ,&nbsp;Sunaina Rengarajan ,&nbsp;LeMoyne Habimana-Griffin ,&nbsp;Suryang Kwak ,&nbsp;David Zahrah ,&nbsp;Jason Tung ,&nbsp;James Liao ,&nbsp;Bejan Mahmud ,&nbsp;Skye R.S. Fishbein ,&nbsp;Erick S. Ramirez Tovar ,&nbsp;Rehan Mehta ,&nbsp;Bin Wang ,&nbsp;Mark G. Gorelik ,&nbsp;Beth A. Helmink ,&nbsp;Gautam Dantas","doi":"10.1016/j.chembiol.2024.10.013","DOIUrl":"10.1016/j.chembiol.2024.10.013","url":null,"abstract":"<div><div>Engineered probiotics are an emerging platform for <em>in situ</em> delivery of therapeutics to the gut. Herein, we developed an orally administered, yeast-based therapeutic delivery system to deliver next-generation immune checkpoint inhibitor (ICI) proteins directly to gastrointestinal tumors. We engineered <em>Saccharomyces cerevisiae</em> var. <em>boulardii</em> (<em>Sb</em>), a probiotic yeast with high genetic tractability and innate anticancer activity, to secrete “miniature” antibody variants that target programmed death ligand 1 (<em>Sb</em>_haPD-1). When tested in an ICI-refractory colorectal cancer (CRC) mouse model, <em>Sb</em>_haPD-1 significantly reduced intestinal tumor burden and resulted in significant shifts to the immune cell profile and microbiome composition. This oral therapeutic platform is modular and highly customizable, opening new avenues of targeted drug delivery that can be applied to treat a myriad of gastrointestinal malignancies.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 1","pages":"Pages 98-110.e7"},"PeriodicalIF":6.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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