D-aring to explore: New approaches to gasdermin D targeting

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-12-19 DOI:10.1016/j.chembiol.2024.11.006

Lei Wang , Wen Zhou

引用次数: 0

Abstract

Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.¹ identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.

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D-正在探索：gasdermin D靶向的新方法

新型焦亡抑制剂有望在治疗炎性疾病和恶性肿瘤方面取得突破。在这一期的《细胞化学生物学》中，Hu等人1确定了两种靶向气皮蛋白D （GSDMD）低聚物的靶向药物，有效抑制焦亡，同时减少半胱氨酸抑制剂的脱靶效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.