2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)最新文献_第3页

A novel live cell imaging method with sub-cellular resolution for cell-based assays 一种新型的活细胞成像方法，具有亚细胞分辨率，用于基于细胞的检测

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820894

Chengxiong Wu, Q. Fang

引用次数: 0

Gold microelectrode arrays with monolithically-integrated circuits for label-free monitoring of bio-molecule interaction in-situ 带单片集成电路的金微电极阵列用于生物分子相互作用的无标记监测

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820921

Yu-Chieh Lee, Hsin Chen

引用次数: 0

An 802.15.4a wide band frequency synthesizer for 5GHz ISM band health care applications 一种用于5GHz ISM频段医疗保健应用的802.15.a宽带频率合成器

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820932

Ko-Chi Kuo, Chi-Wei Wu

{"title":"An 802.15.4a wide band frequency synthesizer for 5GHz ISM band health care applications","authors":"Ko-Chi Kuo, Chi-Wei Wu","doi":"10.1109/ISBB.2014.6820932","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820932","url":null,"abstract":"This paper presents a wide tuning, low phase noise, and fast locking CMOS integer-N frequency synthesizer with 1.8V power supply. The proposed design can be used for the IEEE 802.15.4a unlicensed ultra-wideband healthcare applications such as body sensor network. The operating frequency range of the proposed design is ranged from 4.6 GHz to 5.6 GHz for the local oscillator of the RF front-end circuits. The proposed frequency synthesizer consists of a fast-phase-frequency detector charge pump (Fast-PFDCP), a dual mode low-pass loop filter (Dual_Mode_LPF), a voltage control oscillator, an auto-band selection (ABS), an optimum-band selection (OBS), a lock detector, and a pulse-swallow divider. By adapting the Auto Band Selection (ABS), the proposed design can reduce the calibration time by using the binary search algorithm to select the calibration word. In addition, the Optimal Band Selection (OBS) algorithm is proposed to acquire the optimum band which exhibits the minimum VCOμ gainμ variation which can affect the performance of phase noise of overall frequency synthesizer significantly. Furthermore, the design of the voltage-controlled oscillator with the switch-capacitor technique can achieve the wide tuning range and the low phase noise in order to cover the desired operating frequency bands and to accommodate process, voltage, and temperature (PVT) variations. The frequency synthesizer is designed by using the TSMC 0.18μm CMOS 1P6M technology.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132857816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Profiling mitochondrial complex I inhibitors by combining mitochondrial morphological features and maximum common chemical substructures 结合线粒体形态特征和最常见的化学亚结构分析线粒体复合体I抑制剂

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820948

Chung-Chih Lin, Jyh-Ying Peng, Y. Tseng, C. Chou, F. Chang, Y. Wu, L. Kao, Chun-Nan Hsu

{"title":"Profiling mitochondrial complex I inhibitors by combining mitochondrial morphological features and maximum common chemical substructures","authors":"Chung-Chih Lin, Jyh-Ying Peng, Y. Tseng, C. Chou, F. Chang, Y. Wu, L. Kao, Chun-Nan Hsu","doi":"10.1109/ISBB.2014.6820948","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820948","url":null,"abstract":"Studies on the mechanism of toxins are important to reveal the etiology of Parkinson's disease (PD). Complex I inhibitors are a main group of PD toxins, and their chemical features have been intensively studied. However, the chemical structures specific to mitochondrial morphological changes are still unknown. We developed a drug profiling system that combines mitochondrial morphological quantification and chemical substructure computation, which allows us to discover chemical substructures specific to mitochondrial morphological changes. Using this system, we quantified the mitochondrial morphology induced by annonaceous acetogenins, and calculated the maximum common substructure of acetogenins inducing similar cell responses. We discovered that (1) the hydroxyl groups close to γ-lactone in annonacin may result in stronger effects on nuclear size reduction and mitochondrial aggregation; (2) bis-THF acetogenins may have less mitochondria aggregation than those of mono-THF acetogenins; (3) less hydroxyl group at the alkyl chain opposite from γ-lactone end may result in less mitochondrial fission.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121481624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D image processing for mitochondria morphology variation analysis 线粒体形态变异分析的三维图像处理

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820953

Han-Wei Dan, Wan-Chi Hung, Y.‐S. Tsai, Chung-Chih Lin

{"title":"3D image processing for mitochondria morphology variation analysis","authors":"Han-Wei Dan, Wan-Chi Hung, Y.‐S. Tsai, Chung-Chih Lin","doi":"10.1109/ISBB.2014.6820953","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820953","url":null,"abstract":"Mitochondria play an important role in producing energy of cell, aging and cell death. Previous investigations suggest that mitochondrial dysfunctions are associated with neurodegenerative, and the peripheral blood cells of those patients have validation of mitochondrial morphology. This study presents an analysis system of automated 3D mitochondrial morphology of lymphocytes in 3D images to reveal morphological features of mitochondria, and this system is specific for analyzing mice T lymphocyte precursors in thymus and mature lymphocytes in spleen. Mitochondria in original confocal and deconvoluted wild-field micrographs are segmented by Support Vector Machine, and then image features are extracted for morphological subtype clustering. The distribution of subtypes in individual lymphocytes is used to classify precursors and mature lymphocytes by decision tree. There are more short tubules in spleen lymphocyte, and more globules in thymus lymphocyte. The accuracy of cell classified from confocal and wild-field images in this system are both over 96% for training set, and for testing set, the accuracy for confocal and wild-field micrographs are 79% and 71% respectively. In conclusions, this new system can be used for investigations of lymphocyte development and drug discovery for inflammation and immunity.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122613414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Bluetooth-based Low-Energy Qi-compliant battery charger for implantable medical devices 基于蓝牙的低能量qi兼容电池充电器，用于植入式医疗设备

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820911

S. Hached, Aref Trigui, Imane El Khalloufi, M. Sawan, Oleg Loutochin, J. Corcos

引用次数: 21

Implementation of a real-time ECG signal processor 实现了一个实时心电信号处理器

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820941

Shih-Yu Chang Chien, Cheng-Han Hsieh, Mark Po-Hung Lin, Q. Fang, Shuenn-Yuh Lee

引用次数: 10

Using ECG surface electrodes in measurement of respiration rate for preterm infants 使用ECG表面电极测量早产儿呼吸速率

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820926

H. Kuo, Ning-Huei Peng, T. Kao, Weichih Hu

引用次数: 5

Measurement and parameter characterization of pseudo-resistor based CCIA for biomedical applications 生物医学应用中基于伪电阻的CCIA测量与参数表征

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820938

Chih-Chan Tu, Tsung-Hsien Lin

引用次数: 9

X-ray image enhancement using a modified anisotropic diffusion 使用改进的各向异性扩散的x射线图像增强

2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820940

L. Septiana, Kang-Ping Lin

引用次数: 10