Gold microelectrode arrays with monolithically-integrated circuits for label-free monitoring of bio-molecule interaction in-situ

This paper presents a CMOS chip integrating EGFETs (extended-gate field-effect transistors) with gold microelectrodes for label-free monitoring of the DNA amplification. The accumulation of intrinsic charges of DNAs causes the surface potential of microelectrodes to change gradually, and the potential change is detected by the readout circuit integrated with the microelectrodes. A second-order Bessel low pass filter is further employed to eliminate both high-frequency noise and ground interferences.