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2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)最新文献

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A multichannel analog front-end for recording neural electrical signals 用于记录神经电信号的多通道模拟前端
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820944
Yuan Feng, Zhigong Wang, Xiaoying Lu, A. Shuai, L. Xian
{"title":"A multichannel analog front-end for recording neural electrical signals","authors":"Yuan Feng, Zhigong Wang, Xiaoying Lu, A. Shuai, L. Xian","doi":"10.1109/ISBB.2014.6820944","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820944","url":null,"abstract":"Recent work in the field of neurophysiology has demonstrated that it is possible to reveal the nature of “memory” and “thinking” which helps to understand how brain works, by means of observing the firing characteristic of action potentials (AP) and the exchange pattern of signals between neurons. To address these needs, we have developed a prototype of a fully integrated circuit for neural recording on a Micro-Electrode Array (MEA). In this scheme, the MEA is composed by 64 electrodes and 2 reference electrodes. The proposed integrated circuit has an area of 5×5 mm2, including 8 recording channels. Each channel can operate independently to execute amplifying, filtering, etc. The circuits are designed and simulated in a standard 0.5μm CMOS technology. According to the simulation results, this chip is able to record AP signal from neurons.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115888744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A 1.6uW Gm-C coninuous-time sigma-delta modulator with increasing linearity technology for bio-signal acquisitions 一种1.6uW Gm-C连续时间σ - δ调制器，采用线性度增加技术，用于生物信号采集
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820920
Chih-Pei Hsueh, Ming-Chun Liang, Jia-Hua Hong, Shuenn-Yuh Lee
{"title":"A 1.6uW Gm-C coninuous-time sigma-delta modulator with increasing linearity technology for bio-signal acquisitions","authors":"Chih-Pei Hsueh, Ming-Chun Liang, Jia-Hua Hong, Shuenn-Yuh Lee","doi":"10.1109/ISBB.2014.6820920","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820920","url":null,"abstract":"This paper present a low-pass sigma delta modulator (LPSDM), which can be used for electroencephalogram (EEG) or electrocardiogram (ECG) signal acquisition systems. The LPSDM is implemented in continuous time Gm-C architecture and the systematic design flow is introduced. The power consumption of LPSDM is 1.614uW. According to the post-layout simulation under the bandwidth of ECG, a signal-to-noise and harmonic distortion ratio (SNDR) of 57.9 dB can be achieved.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123850199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A study of an energy harvesting device based on photosystem-II protein complex 基于光系统ii蛋白复合物的能量收集装置的研究
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820900
P. Huang, Ting-Ru Lin, H. Chu, Chih-Ting Lin
{"title":"A study of an energy harvesting device based on photosystem-II protein complex","authors":"P. Huang, Ting-Ru Lin, H. Chu, Chih-Ting Lin","doi":"10.1109/ISBB.2014.6820900","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820900","url":null,"abstract":"In this study, we accomplished a solid-state photosystem-II (PSII) device for bio-inherited solar energy-harvesting device. With solid-state PSII embedded, this is an innovative device with better life time and stable performance than previous photosystem based devices. To demonstrate the potential of the proposed method, we measured the photocurrent and discussed the mechanism of this device. Furthermore, we compared photo-induced currents generated by the proposed device with another traditional method. Experimentally, the life time of its energy-harvesting mechanism can be enhanced by 10 times. This work demonstrates the potential of different pathway toward bio-inherited devices.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121471919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A reconfigurable overlapping FFT/IFFT filter for ECG signal de-noising 用于心电信号去噪的可重构重叠FFT/IFFT滤波器
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820925
Nannan Zhang, Ze-dong Nie, Yu Luo, Leilei Du, Xiaohui Wang, Lei Wang
{"title":"A reconfigurable overlapping FFT/IFFT filter for ECG signal de-noising","authors":"Nannan Zhang, Ze-dong Nie, Yu Luo, Leilei Du, Xiaohui Wang, Lei Wang","doi":"10.1109/ISBB.2014.6820925","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820925","url":null,"abstract":"Dynamic Electrocardiograph (ECG) monitoring (known as Holter) plays an important role in the earlier detection and diagnosis of various cardiovascular diseases. ECG signals obtained from Holter systems normally contain a lot of noises and artifacts. These noises degrade signal quality, which may be critical for routine monitoring and diagnosis. To solve the problem, a reconfigurable overlapping fast Fourier transform/ inverse fast Fourier transform (FFT/IFFT) filter for suppressing the power-line interference and the high-frequency noise is presented in this paper. The filter is based on a 12-lead Holter system with a high-performance analogue front-end and a field-programmable gate array (FPGA) for enhanced digital processing. This paper analyzes the performance of the reconfigurable overlapping FFT/IFFT filter in ECG de-noising applications and validate it by real-world emulations. Furthermore, the de-noising performance of the reconfigurable overlapping FFT filter was evaluated.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"544 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123109168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
An efficient Multi-Directional Lossless Recompression for video coding systems 一种高效的多方向无损再压缩视频编码系统
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820916
Yi-Guo Chen, Yu-Hsuan Lee, Chao-Chyun Chen
{"title":"An efficient Multi-Directional Lossless Recompression for video coding systems","authors":"Yi-Guo Chen, Yu-Hsuan Lee, Chao-Chyun Chen","doi":"10.1109/ISBB.2014.6820916","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820916","url":null,"abstract":"Video coding systems suffer from tremendous memory bandwidth requirement on external memory. This bandwidth is directly proportional to display resolution and frame rate. The aspiration of high-end visual quality drives display resolution and frame rate upgraded to a certain level. That also causes a design bottleneck on the memory bandwidth of external memory in video coding systems. In this paper, the Multi-Direction Lossless Recompression (MDLR) is proposed to alleviate above issue. It includes two core techniques: (1) Multi-Directional Prediction and (2) Direction-Adaptive Golomb-Rice code. The Multi-Directional Prediction can obtain an efficient residual. Then, Direction-Adaptive Golomb-Rice code converts it into an efficient codeword. The experiment result shows that the proposed MDLR can save the memory bandwidth of the video coding system as high as 42% on average.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129734911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A novel infrared microbolometer in standard CMOS-MEMS process 一种标准CMOS-MEMS工艺的新型红外微热计
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820898
Meng-Lieh Sheu, Ji-Yi Chen, M. Li, L. Tsao
{"title":"A novel infrared microbolometer in standard CMOS-MEMS process","authors":"Meng-Lieh Sheu, Ji-Yi Chen, M. Li, L. Tsao","doi":"10.1109/ISBB.2014.6820898","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820898","url":null,"abstract":"A novel infrared micro-bolometer realized in CMOS with MEMS post process is proposed. The micro-bolometer is constructed as a metal micro-cavity to enhance its absorptivity of incident infrared energy. Three testkeys with different cavity structure are presented. The measured sensitivity of the testkeys, in the temperature range of 5-75°C, are 9.56 Ω/°C, 8.78 Ω/°C and 9.89 Ω/°C, respectively. The micro-bolometer occupies a chip area of 439×370 μm<sup>2</sup> in 0.18 μm process. It is suitable for application on smart biomedical sensor.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121115027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Design and optimization of a generalized wide-bandwidth white light system for Light-Eye Technology (LeyeT) 光眼技术(LeyeT)通用宽带白光系统的设计与优化
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820950
P. Lin, Wei-Lee Chen, Yeeu-Chang Lee, Ming Chang, Yu-Cheng Chou, Chang-Chun Lee
{"title":"Design and optimization of a generalized wide-bandwidth white light system for Light-Eye Technology (LeyeT)","authors":"P. Lin, Wei-Lee Chen, Yeeu-Chang Lee, Ming Chang, Yu-Cheng Chou, Chang-Chun Lee","doi":"10.1109/ISBB.2014.6820950","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820950","url":null,"abstract":"The Light-Eye Technology (LeyeT) has been developed to provide a generalized light source for various biomedical applications. The LeyeT system is designed for the purposes of uniform light, light with specific wavelength, controllable size of light, etc. Multiple high-directionality single-Watt light-emitting diodes (LED) are packed together and integrated to deliver a wide-bandwidth white light source. The light uniformity is optimized with respect to the arrangement of LEDs and the controlled currents. The mixed light is then directed to a series of optical devices, including lenses, filters, grating, etc., to synthesize the light of the system. A system optimization is necessary to maintain the performance of system light. The light spectrum is analyzed numerically using a Monte Carlo ray tracing method and verified experimentally using an integrated sphere with a spectrometer. Each optical component is designed and built separately but every local performance is mutually coupled with each other. The system is therefore decomposed into several subsystems while the system target is assigned to each subsystem. Each subsystem finds the new design point along the gradient direction of the local constraint and responds back to the system. Using this Gradient-based Transformation Method (GTM), the optimal design variables are to be found efficiently due to the monotonic characteristics of the gradient-based transformed formulations. The design and optimization of the LeyeT system is been developing to provide the desired generalized light source, which is controllable and optimized for various biomedical applications. In this paper, the design and optimization of the generalized wide-bandwidth white light source is investigated.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"65 Suppl 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125822873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis 高糖诱导内皮细胞凋亡的时间过程基因表达谱
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820924
Julia Tzu-Ya Weng, Yi-Cheng Chen, C. Ma, Tzung-Shian Lai, F. Ho
{"title":"Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis","authors":"Julia Tzu-Ya Weng, Yi-Cheng Chen, C. Ma, Tzung-Shian Lai, F. Ho","doi":"10.1109/ISBB.2014.6820924","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820924","url":null,"abstract":"Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128226310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alveolar bone-loss area localization in periapical radiographs by texture analysis based on fBm model and GLC matrix 基于fBm模型和GLC矩阵的牙槽骨丢失区定位
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820947
P. Lin, P. Huang, P. Huang, H. Hsu, Ping Chen
{"title":"Alveolar bone-loss area localization in periapical radiographs by texture analysis based on fBm model and GLC matrix","authors":"P. Lin, P. Huang, P. Huang, H. Hsu, Ping Chen","doi":"10.1109/ISBB.2014.6820947","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820947","url":null,"abstract":"We propose an effective method to detect alveolar bone-loss areas in dental periapical radiographs in this paper. By analyzing the texture of alveolar bone tissues measured by Gray Level Co-occurrence Matrix (GLCM) or the H-value of fractal Brownian motions (fBm) model, we transfer radiograph images into bone-texture images. Then by auto-thresholding, we segment the bone-texture images into normal and bone-loss regions. Experimental results on six periapical images demonstrate that our method using fBm-H value as the texture feature can detect bone-loss areas best conforming to the areas marked by a dentist both visually and quantitatively among all the features used.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130974094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
A quantification method for radial artery pulsation device 一种桡动脉搏动装置的定量方法
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014) Pub Date : 2014-04-11 DOI: 10.1109/ISBB.2014.6820922
L. Septiana, Wen-Chen Lin, Sheng-Cheng Huang, Kang-Ping Lin
{"title":"A quantification method for radial artery pulsation device","authors":"L. Septiana, Wen-Chen Lin, Sheng-Cheng Huang, Kang-Ping Lin","doi":"10.1109/ISBB.2014.6820922","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820922","url":null,"abstract":"In this study we present a multi-step constant pressure pulse measurement system based on the technology and operating principles of electronic sphygmomanometer. We approach pulse diagnosis in a way that's comparable to pulse diagnosis practiced by traditional Chinese medicine (TCM) physicians, in particular where the administration of superficial, middle, and deep pressure were applied during pulsation measurement. We capture radial artery pulse signals as quantitative vascular pressure fluctuations (in mmHg) all the while pressure cuff step-up pressure over the measurement site, from 30mmHg to 180mmHg, using a 10mmHg step, and 10 seconds hold of constant pressure between the steps to capture pulse signals for respective pressures. We intend this work to lend TCM physicians a quantitative and visual supplement during a pulse diagnosis, and to enrich cardiovascular and clinical analysis applications from pulsation measurement.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130502650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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