Biosensors and Bioelectronics: X最新文献

{"title":"Preface of special issue: Recent advances in cancer biosensors & diagnostics","authors":"Ahu Arslan Yildiz , Onur Parlak , Arzum Erdem Gürsan","doi":"10.1016/j.biosx.2025.100694","DOIUrl":"10.1016/j.biosx.2025.100694","url":null,"abstract":"","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100694"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible gold nanoparticle SERS tape for rapid, label-free and ultrasensitive detection and differentiation of Shiga toxin variants","authors":"A. D'Avino ,&nbsp;A. Milano ,&nbsp;V. Marchesano ,&nbsp;B. Guilcapi ,&nbsp;D. Sagnelli ,&nbsp;M. Rippa ,&nbsp;L. Zhou ,&nbsp;G. Rossi ,&nbsp;L. Consagra ,&nbsp;M. Brigotti ,&nbsp;S. Morabito ,&nbsp;L. Petti","doi":"10.1016/j.biosx.2025.100696","DOIUrl":"10.1016/j.biosx.2025.100696","url":null,"abstract":"<div><div>Surface-Enhanced Raman Spectroscopy (SERS) is a highly sensitive technique that enhances Raman signals using plasmonic nanomaterials, enabling the detection of trace biomolecules. Flexible SERS substrates offer advantages such as low cost, adaptability to various surfaces, and reliable performance in complex environments, making them ideal for real-time applications in food safety, environmental monitoring, and diagnostics. In this work, we present a flexible SERS sensor based on Kapton film coated with gold nanoparticles, fabricated through a simple bottom-up method. As a case study, we evaluated, for the first time to the best of our knowledge, its performance in detecting Shiga toxins (Stxs), which are produced by Shiga toxin-producing Escherichia coli (STEC) and are responsible for severe illnesses such as hemorrhagic colitis and hemolytic uremic syndrome. Early and accurate detection of Stxs is critical for outbreak control and timely treatment. We focused on three variants: Shiga toxin 1 (Stx1), Shiga toxin 2 (Stx2), and cleaved Stx2, which are structurally similar but differ in pathogenicity. The SERS spectra collected from each toxin revealed subtle but consistent differences, and Principal Component Analysis (PCA) successfully discriminated between them. Notably, our sensor achieved an outstanding enhancement factor of 7 × 10⁶ and reached an ultra-low limit of detection (LOD) of 15 pM for Stx2 representing, to our knowledge, the lowest LOD reported to date for this toxin using a flexible SERS platform. We also evaluated the LOD in clinically relevant concentrations measured in sera, demonstrating that our system provides a sensitivity suitable for application in real diagnostic settings in the earlier stages of the disease. These results demonstrate the high sensitivity and discriminative power of our sensor, highlighting its strong potential for real-time, on-site monitoring of hazardous biomolecules in fields such as environmental surveillance, food safety, and clinical diagnostics.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100696"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chip-scale optical detection of lung cancer with engineered photodetector based on distributed semiconductor heterojunctions","authors":"Ashutosh Kumar ,&nbsp;Santosh Kumar ,&nbsp;Nikita Mohanta ,&nbsp;Siddharth Singh ,&nbsp;Manoj K. Pal ,&nbsp;Hem Chandra Jha ,&nbsp;Mukesh Kumar","doi":"10.1016/j.biosx.2025.100701","DOIUrl":"10.1016/j.biosx.2025.100701","url":null,"abstract":"<div><div>Early detection of lung cancer is crucial because of the lower survival rate for improving treatment outcomes. Chip-scale photonic biosensors offer a promising label-free and non-invasive diagnostic approach by analyzing intercellular properties. Here, we demonstrate a chip-scale photonic platform based on semiconductor heterojunctions of n-type ZnO/TiO₂ with a comb-like structure to enable label-free detection of lung cancer cells. The lung cancer cells are detected using the engineered structure of the proposed photodetector through distinct fluctuations in the cells' electrical signature. The proposed voltage-controlled device configuration enhances interband transitions within the ZnO/TiO₂ depletion region with strong light-matter interaction, particularly in the UV spectrum. The proposed biosensor results in an enhanced photocurrent response in the presence of A549 cells, demonstrating its high sensitivity towards lung cancer detection. The photocurrent in PBS increases from 45 μA to 80 μA when a small concentration of A549 cells (500 cells/μl) is added at a low bias of 1.6 V, demonstrating label-free detection capability. The proposed device with its engineered structure combines ZnO's efficient charge carrier transport with TiO₂'s proven biocompatibility, enabling sensitive and non-invasive analysis with an additional flexibility of voltage-controlled operation. The demonstrated on-chip biosensor can be a potential candidate for cancer detection, which can enable future integration with compact biosystems.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100701"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance electrochemical sensors: The impact of hydrodynamic flow and vibration on redox amplification","authors":"Fabian O. Romero-Soto ,&nbsp;Masoud Madadelahi ,&nbsp;Victor H. Perez-Gonzalez ,&nbsp;Sergio O. Martinez-Chapa ,&nbsp;Marc J. Madou","doi":"10.1016/j.biosx.2025.100697","DOIUrl":"10.1016/j.biosx.2025.100697","url":null,"abstract":"<div><div>Interdigitated electrodes (IDEs) enhance analyte diffusion through overlapping concentration profiles, locally renewing analyte and improving signal response. As the IDE gap decreases, redox amplification (RA)—efficiency of the analyte cycling between electrodes—improves exponentially. However, fabricating sub-micron gaps is costly and complex, limiting point-of-care applicability. To address this, we demonstrated that forced convection, i.e., hydrodynamic flow and mechanical vibration, significantly enhances mass transport and signal response in gold IDEs with 10, 5, and 2 μm gaps. Using methylene blue (MB) and potassium ferricyanide/ferrocyanide as redox probes, we examined flow direction (parallel and cross) and mechanical vibration effects. Under hydrodynamic flow, RA values decreased because convection disrupted lateral diffusion; however, the signal response increased due to enhanced analyte replenishment by mass transport. For MB, RA in cross-flow was direction-dependent: one direction reduced analyte depletion, yielding an 11.9 % higher RA. No significant directional effect was observed for the ferricyanide/ferrocyanide couple. Redox cycling under mechanical vibration across a 10 μm gap IDE increased the signal by 8-fold for MB and 4-fold for the ferricyanide/ferrocyanide couple compared to redox cycling under stagnant conditions. The maximum signal enhancement ratio (SER) obtained for MB (19.1) represents the highest vibration-induced value reported to date. To validate biosensing applicability, dopamine detection with redox cycling under mechanical vibration conditions achieved a detection limit (LOD) of 0.52 μM, nearly sixfold lower than in single-mode under stagnant conditions. These results show that large-gap IDEs without surface modification, combined with external convection, can achieve high RA performance and low LOD with minimal liquid volume (&lt;20 μL). This strategy provides a cost-effective and scalable approach in electrochemical sensors for medical diagnostics and water analysis.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100697"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach for enzyme-based glucose detection: The application of non-faradaic electron impedance spectroscopy for PEDOT-PSS/TiO2 nanocomposite","authors":"Ashitosh P. Deshmukh ,&nbsp;Aditya V. Tiwari ,&nbsp;Shailesh P. Tiwari ,&nbsp;Deepika S. Yawale ,&nbsp;Dhananjay P. Deshmukh ,&nbsp;Monica S. Dixit ,&nbsp;Shrikrishna P. Yawale","doi":"10.1016/j.biosx.2025.100712","DOIUrl":"10.1016/j.biosx.2025.100712","url":null,"abstract":"<div><div>This study presents a groundbreaking approach to enzyme-based glucose detection through the innovative application of non-faradaic electron impedance spectroscopy (nf-EIS). A precise <em>in situ</em> chemical oxidative method is used for successfully synthesizing Poly(3,4-ethylenedioxythiophene)-Poly(Sodium 4-styrenesulfonate)/Titanium dioxide (PEDOT-PSS/TiO₂) nanocomposites. Also fabricated them on Whatman Grade-1 (WG-1) filter paper using the Screen-Printed Electrode method. The structural behavior and characteristics of the synthesized PEDOT-PSS polymer matrix have been by using advanced techniques, including Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet–visible (UV–Vis) spectroscopy and Energy Dispersive X-ray Spectroscopy (EDAX) at room temperature (303 K). The analysis of nf-EIS behavior of the fabricated biosensors across varying glucose concentrations demonstrated remarkable insights through impedimetric AC conductivity measurements at a constant voltage (0.3 V). The XRD spectra confirm the presence of the anatase plane in the tetragonal structure of TiO₂ nanoparticles. The average crystallite size and microstrain for all the samples were determined by using the Williamson-Hall (W-H) plot and Debye-Scherrer's formula. Specifically, sample 15 wt% TiO₂ composite with PEDOT-PSS, among other samples, displayed exceptional sensitivity (9.04 × 10⁻⁷ Sm⁻¹mM⁻¹, RSD 1.55 %) with a low detection limit (25.84 μM), a rapid response time of just 20 s, following a linear range of 0–40 mM.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100712"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of transformer-convolutional neural network ensemble for melanoma diagnosis on segmented 3D total body photography data: Cross-Validation stratified K-fold","authors":"Eeshan G. Dandamudi ,&nbsp;Shakeel Abdulkareem ,&nbsp;Mihir Tekal ,&nbsp;Khartik Uppalapati ,&nbsp;Dhruv Karthik Alamuri ,&nbsp;S. Nick Ice ,&nbsp;Kalicharan Sharma ,&nbsp;Aniket Nandi ,&nbsp;Christian L. Lorson ,&nbsp;Kamal Singh","doi":"10.1016/j.biosx.2025.100714","DOIUrl":"10.1016/j.biosx.2025.100714","url":null,"abstract":"<div><div>Skin cancer is one of the most common cancers worldwide, and its early diagnosis is critical for the survival of cancer patients. Many artificial intelligence models have been developed to support early detection; however, limited progress has been made towards a reliable pre-diagnosis of skin cancer types. We developed a deep learning ensemble integrating ConvNeXt-Base, ResNet-50, and Swin Transformer-Base architectures to detect melanoma using images from 3D total body photography (3D-TBP) data. By combining the complementary strengths of individual models coupled with the Quadruple Stratified Leak-Free 5-Fold Cross-Validation (QSLF-KF-CV) approach, the ensemble achieved an Area Under the Curve (AUC) of 0.9208, which is greater than that of individual models. Our strategy demonstrates potential for accurate melanoma detection, as well as broader applications in medical image diagnostics.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100714"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances and future outlooks towards engineered materials and interfaces for PFAS sensing","authors":"Aman Kumar ,&nbsp;Akshay Kumar ,&nbsp;Sonam Kumari ,&nbsp;Nitin Kumar Singhal ,&nbsp;Giovanna Marrazza ,&nbsp;Sandeep Kumar","doi":"10.1016/j.biosx.2025.100706","DOIUrl":"10.1016/j.biosx.2025.100706","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants associated with significant health risks, necessitating sensitive and reliable detection methods across varied matrices. Conventional techniques like liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) provide high sensitivity and specificity but are hampered by their complexity, cost, and limited field applicability. This review critically surveys recent advancements in PFAS sensing, focusing on engineered nanomaterial-based sensors and their integration into practical devices. We categorize sensing materials by structural characteristics, emphasizing nanomaterials functionalized with specific recognition elements to improve selectivity. The review also explores hybrid sensor platforms combining multiple detection modalities. Further, we discuss the role of artificial intelligence and machine learning techniques in enhancing sensor selectivity, data processing, and adaptability to complex environmental samples. Real-world validation studies are analyzed, highlighting sensor performance in matrices including drinking water, serum, and soil, emphasizing strategies to mitigate matrix interferences such as antifouling coatings and sample pretreatment. Challenges in sensor reproducibility, miniaturization, and regulatory compliance for field deployment are also examined. Overall, we provide a comprehensive outlook on the materials innovation, mechanistic understanding, and data-driven approaches that underpin the development of smart, portable PFAS sensors. These advances promise to bridge gaps between laboratory research and real-world applications, supporting regulatory monitoring and environmental protection efforts with scalable, cost-effective sensing solutions.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100706"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-sensitivity biogenic amine detection via engineered binder formulation in resonant microcantilever gas sensors: A case study of cadaverine","authors":"Lawrence Nsubuga ,&nbsp;Tatiana Lisboa Marcondes ,&nbsp;Simon Høegh ,&nbsp;Horst-Günter Rubahn ,&nbsp;Roana de Oliveira Hansen","doi":"10.1016/j.biosx.2025.100698","DOIUrl":"10.1016/j.biosx.2025.100698","url":null,"abstract":"<div><div>Electronic nose (e-nose) technologies rely on functional layers to enable selective detection of target analytes. While previous work has focused on improving repeatability through surface treatments and binder placement, challenges in sensitivity have limited the detection of early-stage spoilage in food applications. In this study, we present an approach to enhance the sensitivity of a piezoelectrically driven microcantilever (PD-MC) based e-nose by engineering the sensing material (binder) composition for cadaverine, while optimizing the sensing mechanism and improving surface application capabilities. Cadaverine is a proven biogenic amine associated with the spoilage of meat. The sensing material is synthesized by complexing Nickel with Cyclam in barium hydroxide, forming a square planar [Ni(cyclam)]²⁺ complex, and modified cyclam with substituted moieties, which forms a viscous glue used as a buffer for the active components and aiding in immobilization on the PD-MC surface. The modified binder formulation is found to enable the detection of cadaverine concentrations as low as 30 μg/kg, allowing for the differentiation between meat freshness on day 1 and day 2. This is a significant improvement over the previously reported detection threshold. Enhanced sensitivity is achieved without compromising repeatability or selectivity, as demonstrated through controlled exposure experiments and resonance frequency analyses. These findings largely advance the development of high-sensitivity, scalable e-nose systems for real-time monitoring of food freshness.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100698"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating mitochondrial metabolism with genetically encoded fluorescent indicators","authors":"C. Aburto ,&nbsp;A. Pinilla ,&nbsp;F. Carrera-Arenas ,&nbsp;A. San Martín","doi":"10.1016/j.biosx.2025.100705","DOIUrl":"10.1016/j.biosx.2025.100705","url":null,"abstract":"<div><div>Mitochondria are recognized as dynamic metabolic hubs that integrate bioenergetic, biosynthetic and signaling functions well beyond ATP production. Their matrix hosts the Krebs cycle, fatty acid β-oxidation, and key branches of amino-acid metabolism, while also supporting heme synthesis, the urea cycle, calcium handling and redox homeostasis. Dissecting these intertwined pathways demands tools that can report metabolite dynamics <em>in situ</em>, where native ion gradients and macromolecular crowding are preserved. Genetically encoded fluorescent indicators are protein-based indicators whose spectroscopic properties shift upon binding the target metabolite. Because they are genetically encoded, these fluorescent indicators can be expressed in specific cell types and targeted to subcellular compartments, allowing real-time, non-invasive tracking of metabolic dynamics in living systems. This systematic review surveys the state-of-the-art in mitochondrial GEFIs, cataloguing fluorescent indicators for monocarboxylates, Krebs-cycle intermediates, amino acids, redox cofactors and energy nucleotides. Additionally, we outline core design principles, summarize strategies that ensure efficient targeting into the mitochondrial matrix, and discuss challenges for their correct application. By charting current capabilities and knowledge gaps, this review aims to guide the next generation of mitochondrial GEFIs and to accelerate quantitative mapping of metabolic networks at subcellular resolution.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100705"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A paper-based chromogenic strip and electrochemical sensor for semi-quantitative estimation of hemoglobin","authors":"Pawankumar Rai ,&nbsp;Srishti Mehrotra ,&nbsp;Ashish K. Singh ,&nbsp;Smriti Priya ,&nbsp;Bhaskar Narayan ,&nbsp;Sandeep K. Sharma","doi":"10.1016/j.biosx.2025.100690","DOIUrl":"10.1016/j.biosx.2025.100690","url":null,"abstract":"<div><div>Anemia and related blood disorders particularly prevalent among children and women in regions of sub-Saharan Africa and South Asia pose a major global health burden. Undiagnosed and untreated anemia often leads to severe health complications making accurate quantification of hemoglobin (Hb) critical for effective management. Conventional laboratory-based methods, though reliable, are often expensive, require expertise and are inaccessible in remote and rural areas, necessitating the need for affordable and easy-to-use diagnostic tools for estimation of hemoglobin. To address these challenges, a QR-code integrated, chromogenic paper-based strip and an electrochemical sensor for estimation of Hb has been developed. The developed chromogenic paper-based Hb-strip demonstrated estimation of Hb in the range of 4–16 g/dL and validated with standard spectrophotometric method. Semi-quantitative Hb estimation was achieved through RGB analysis. Characterization of the developed electrochemical sensor revealed a linear increase in anodic peak current with increasing hemoglobin concentration demonstrating strong correlation (R² = 0.97) and high sensitivity (5.932 μA/g·dL⁻¹), with detection and quantification limits of 0.31 and 1.03 g/dL, respectively. The QR-code embedded on the strip provided multilingual analytical information, enabling user-friendly interpretation. The developed chromogenic Hb-strips offers low-cost, point-of-care and scalable solution for estimation of Hb in low-resource healthcare settings.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"27 ","pages":"Article 100690"},"PeriodicalIF":10.61,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}