Medical Sains : Jurnal Ilmiah Kefarmasian最新文献_第2页

THE INFLUENCE OF EDUCATIONAL INTERVENTIONS ON DRUG CLASSIFICATION KNOWLEDGE IN WANAR VILLAGE COMMUNITIES, PUCUK SUB-DISTRICT, LAMONGAN DISTRICT 教育干预对拉蒙甘县普库克分区瓦纳尔村社区毒品分类知识的影响

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-03 DOI: 10.37874/ms.v9i1.769

Aditya Sindu Sakti, Jazilah Khikmia Suwandi, Devi Ristian Octavia, Djati Wulan Kusumo, Muhammad Syaiful Amin

引用次数: 0

ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT 文章综述：利用姜黄素作为抗癌剂

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-03 DOI: 10.37874/ms.v9i1.1062

Abdul Mulki Irpani, Deden Indra Dinata, Garnadi Jafar

{"title":"ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT","authors":"Abdul Mulki Irpani, Deden Indra Dinata, Garnadi Jafar","doi":"10.37874/ms.v9i1.1062","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1062","url":null,"abstract":"The uncontrolled growth of abnormal cells in one area of the body can spread to other tissues and create more cancer cells, a disease known as cancer. Malignant cancer cells have the potential to become fatal. After cardiovascular disease, cancer is the second most common cause of mortality. Numerous cancer types exist, including stomach, liver, colorectal, lung, breast, and cervical cancers. More than 70% of cancer-related deaths occur in low- and middle-income nations, and the number of cancer-related deaths is predicted to rise steadily, hitting 11.5 million by 2030. Some of the resources utilized to look up information on curcumin's application as an anticancer agent are PubMed, Science Direct, and Google Scholar. Most of the articles that were used were published between 2013 and 2023, or within the last ten years. These journals were found using the following keywords: \"Curcumin,\" \"Cancer,\" \"Curcumin as an Anticancer,\" and \"Utilization of Curcumin as an Anticancer Agent.\" Scholars from many nations have conducted comparable investigations on the application of curcumin as an anticancer agent. Furthermore, it has been established that curcumin directly inhibits cancer cells when used as an anticancer drug. This suggests that curcumin does have anticancer properties.\u0000Keywords: Curcumin, Cancer, Curcumin as an Anticancer agent","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139808565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE INFLUENCE OF EDUCATIONAL INTERVENTIONS ON DRUG CLASSIFICATION KNOWLEDGE IN WANAR VILLAGE COMMUNITIES, PUCUK SUB-DISTRICT, LAMONGAN DISTRICT 教育干预对拉蒙甘县普库克分区瓦纳尔村社区毒品分类知识的影响

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-03 DOI: 10.37874/ms.v9i1.769

Aditya Sindu Sakti, Jazilah Khikmia Suwandi, Devi Ristian Octavia, Djati Wulan Kusumo, Muhammad Syaiful Amin

引用次数: 0

ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT 文章综述：利用姜黄素作为抗癌剂

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-03 DOI: 10.37874/ms.v9i1.1062

Abdul Mulki Irpani, Deden Indra Dinata, Garnadi Jafar

{"title":"ARTICLE REVIEW: UTILIZATION OF CURCUMIN AS AN ANTI-CANCER AGENT","authors":"Abdul Mulki Irpani, Deden Indra Dinata, Garnadi Jafar","doi":"10.37874/ms.v9i1.1062","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1062","url":null,"abstract":"The uncontrolled growth of abnormal cells in one area of the body can spread to other tissues and create more cancer cells, a disease known as cancer. Malignant cancer cells have the potential to become fatal. After cardiovascular disease, cancer is the second most common cause of mortality. Numerous cancer types exist, including stomach, liver, colorectal, lung, breast, and cervical cancers. More than 70% of cancer-related deaths occur in low- and middle-income nations, and the number of cancer-related deaths is predicted to rise steadily, hitting 11.5 million by 2030. Some of the resources utilized to look up information on curcumin's application as an anticancer agent are PubMed, Science Direct, and Google Scholar. Most of the articles that were used were published between 2013 and 2023, or within the last ten years. These journals were found using the following keywords: \"Curcumin,\" \"Cancer,\" \"Curcumin as an Anticancer,\" and \"Utilization of Curcumin as an Anticancer Agent.\" Scholars from many nations have conducted comparable investigations on the application of curcumin as an anticancer agent. Furthermore, it has been established that curcumin directly inhibits cancer cells when used as an anticancer drug. This suggests that curcumin does have anticancer properties.\u0000Keywords: Curcumin, Cancer, Curcumin as an Anticancer agent","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"49 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139868613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANTIOXIDANT ACTIVITY OF Homotrigona fimbriata PROPOLIS EXTRACT Homotrigona fimbriata PROPOLIS EXTRACT 的抗氧化活性

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-01-24 DOI: 10.37874/ms.v9i1.916

Rabiatul Demiati, Rendri Arista Avimaro, P. M. Kustiawan

引用次数: 0

UJI AKTIVITAS ANTIOKSIDAN DENGAN MENGGUNAKAN METODE FRAP PADA EKSTRAK BUTANOL DAUN JATI (Tectona grandis) 用 FRAP 法对教师叶（Tectona grandis）丁醇提取物进行抗氧化活性测试

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-01-23 DOI: 10.37874/ms.v9i1.759

Laeli Fitriyati, Sinta Wahyu Septiani, Muchromin Muchromin

{"title":"UJI AKTIVITAS ANTIOKSIDAN DENGAN MENGGUNAKAN METODE FRAP PADA EKSTRAK BUTANOL DAUN JATI (Tectona grandis)","authors":"Laeli Fitriyati, Sinta Wahyu Septiani, Muchromin Muchromin","doi":"10.37874/ms.v9i1.759","DOIUrl":"https://doi.org/10.37874/ms.v9i1.759","url":null,"abstract":"Indonesia memiliki banyak tanaman yang dapat digunakan sebagai obat tradisional. Pengobatan tradisional dengan menggunakan bahan alam telah dilakukan secara turun. Tanaman daun jati (Tectona grandis) bisa digunakan sebagai antibakteri, antioksidan, dan antitoksik karena mengandung senyawa metabolit sekunder seperti tanin, antrakuinon, fenolik, antosianin, alkaloid, flavonoid, dan naftoquinon. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan ekstrak butanol dari daun jati (Tectona grandis). Penelitian ini merupakan penelitian eksperimental yang melibatkan pembuatan dua ekstrak daun jati menggunakan pelarut butanol dengan metode maserasi. Evaluasi dilakukan secara kualitatif (standarisasi dan uji tabung) dan kuantitatif menggunakan metode antioksidan FRAP (Ferric Reducing Antioxidant Power). Hasil penelitian menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memenuhi persyaratan standarisasi, yaitu memiliki kadar air 9,76% butanol, kadar abu 12,9% butanol, dan kadar abu tidak larut asam 0,7% butanol, serta mengandung saponin, polifenol, dan flavonoid. Nilai Inhibition Concentration 50 (IC50) untuk aktivitas antioksidan adalah 70,848 ppm dan 80,893 ppm, yang termasuk kategori kuat. Oleh karena itu, hasil penelitian ini menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memiliki aktivitas antioksidan yang kuat.\u0000Kata kunci : Daun Jati, Antioksidan, FRAP","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"127 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANTIOXIDANT ACTIVITY OF ROASTED KEDAWUNG SEED (Parkia timoriana) USING SCAVENGER FREE RADICAL DPPH METHOD 用清除自由基 DPPH 法检测烤柚子（Parkia timoriana）的抗氧化活性

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2023-12-31 DOI: 10.37874/ms.v8i4.932

Idmanurrahman Hadi, Teguh Adiyas Putra

{"title":"ANTIOXIDANT ACTIVITY OF ROASTED KEDAWUNG SEED (Parkia timoriana) USING SCAVENGER FREE RADICAL DPPH METHOD","authors":"Idmanurrahman Hadi, Teguh Adiyas Putra","doi":"10.37874/ms.v8i4.932","DOIUrl":"https://doi.org/10.37874/ms.v8i4.932","url":null,"abstract":"Kedawung seeds (Parkia timoriana) contain polyphenolics and flavonoids that can provide pharmacological activities, such as antioxidants. In several regions of Indonesia, kedawung seeds are preserved using the roasting method. This study aimed to analyze the effect of roasting on the content of phytochemical compounds and determine their antioxidant activity using the DPPH method. Roasted kedawung seeds were extracted using a maceration method in ethanol. Phytochemical screening was performed to qualitatively analyze the contents of several phytochemical compounds in the extract. The results showed that roasted kedawung seed extract contained alkaloids, flavonoids, saponins, and terpenoids. Antioxidant testing was performed using the DPPH method with ascorbic acid as a positive control. The IC50 value of ascorbic acid, P. timoriana seed and roasted seed of P. timoriana measured each 12.3 ppm; 20.6 ppm and 9.8 ppm; which categorized as strong antioxidant compounds. These results indicated an increase in the antioxidant effect after roasted seed processing. It concluded that the roasting process could enhance antioxidant effect of P. timoriana seed Keywords: Kedawung seeds, roasted method, antioxidant, DPPH","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"122 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULATION AND EVALUATION OF EFFERVESCENT GRANULE OF WHITE TEMU RHIZOME EXTRACT (Curcuma zedoaria (Christm.) Roscoe.) AS ANTIOXIDANT 作为抗氧化剂的白头翁提取物有效成分的配制和评价

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2023-12-31 DOI: 10.37874/ms.v8i4.1050

Reza Pratama, Deny Puriyani Azhary, S. Muhsinin, Adinda Khumairani

{"title":"FORMULATION AND EVALUATION OF EFFERVESCENT GRANULE OF WHITE TEMU RHIZOME EXTRACT (Curcuma zedoaria (Christm.) Roscoe.) AS ANTIOXIDANT","authors":"Reza Pratama, Deny Puriyani Azhary, S. Muhsinin, Adinda Khumairani","doi":"10.37874/ms.v8i4.1050","DOIUrl":"https://doi.org/10.37874/ms.v8i4.1050","url":null,"abstract":"More than 9,606 plant species have medicinal properties, but only around 3-4% of these have been cultivated commercially and used in traditional medicine in Indonesia. One of the natural ingredients believed to have properties is the white temu rhizome. White Curcuma rhizomes are usually processed into food and drinks. White ginger rhizome has antioxidant activity. Antioxidants are secondary metabolites found in herbal plants and have pharmacological activities that can minimize free radicals. Several studies have shown that white ginger rhizomes have antioxidant activities that can remove free radicals. This research aims to formulate an effervescent granule preparation. for white temu rhizome extract (Curcuma zedoaria (Christm.) Roscoe) using the wet granulation method, which meets the requirements for the physical properties of granules and has antioxidant activity. Several formulae were selected from various combinations. Next, an evaluation was performed to determine the physical properties and activities of the formulated granules. The evaluation results showed that all formulations met the requirements of the physical properties of the granules. Qualitative antioxidant activity testing using TLC plates showed positive antioxidant results in the extract and effervescent granule preparation of white curcuma rhizome extract and in quantitative testing it was found that the IC50 value of white curcuma rhizome extract was in the strong category and in the effervescent granule preparation of white curcuma rhizome extract, the granules were found to be in the strong category. Keywords: Effervescent Granule, Extracts, White Temu Rhizome (Curcuma zedoaria (Christm.) Roscoe), Antioxidants","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"86 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IDENTIFICATION OF MEDICINAL COMPOUND IN URIC ACID JAMU BY THIN LAYER CHROMATOGRAPHY METHOD 薄层色谱法鉴定尿酸果酱中的药用化合物

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2023-12-31 DOI: 10.37874/ms.v8i4.1120

M. Zamzam, Iin Indawati, Nina Karlina, Elsa Tiakomala, Windah Widia Ningrum, Aulia Nurkahfi, Andriana

{"title":"IDENTIFICATION OF MEDICINAL COMPOUND IN URIC ACID JAMU BY THIN LAYER CHROMATOGRAPHY METHOD","authors":"M. Zamzam, Iin Indawati, Nina Karlina, Elsa Tiakomala, Windah Widia Ningrum, Aulia Nurkahfi, Andriana","doi":"10.37874/ms.v8i4.1120","DOIUrl":"https://doi.org/10.37874/ms.v8i4.1120","url":null,"abstract":"Jamu is one of the traditional medicines derived from natural ingredients distributing in Indonesia. In accordance with Permenkes No. 007 of 2012, Medicinal Compound (MC) are prohibited from being added to jamu products. Previous research has found that some of the products in public contain MC. The aim of this study is to determine the presence or absence of allopurinol, piroxicam, and dexamethasone in uric acid jamu. This research used 5 (five) samples of uric acid jamu, both those with and without distribution permits from The Indonesian Food and Drug Authority, randomly selected in Kedawung District, Cirebon Regency, West java, Indonesia. The identification method used in this study is Thin Layer Chromatography (TLC) with the stationary phase being silica gel GF 254. For the identification of allopurinol, the mobile phase is n-butanol: ammonium hydroxide: ethanol; for piroxicam identification, it is ethyl acetate-methanol-ammonia (6:3:1); and for dexamethasone identification, it is chloroform: acetone (1:4). Spot detection is done using ultraviolet (UV) light at 254 nm. The applied solutions are the test solution (A), the test solution with added allopurinol, piroxicam, or dexamethasone (B), and the reference standard solution (C). The research results from the 5 (five) samples of uric acid jamu identified one positive samples containing allopurinol, and all positive samples contained piroxicam and dexamethasone. Keywords: Jamu, thin-layer chromatography, allopurinol, piroxicam, dexamethasone","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"55 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139131061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT 利用天然深层发酵溶剂提取的木瓜叶（Carica papaya L.）和苦苣叶（Ocimum sanctum L.）的分析活性鉴定

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2023-12-31 DOI: 10.37874/ms.v8i4.1079

Renny Amelia, Yuniarty Falya, Tomi, Daryuti, Eka Umi Barkah

{"title":"ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT","authors":"Renny Amelia, Yuniarty Falya, Tomi, Daryuti, Eka Umi Barkah","doi":"10.37874/ms.v8i4.1079","DOIUrl":"https://doi.org/10.37874/ms.v8i4.1079","url":null,"abstract":"Natural deep eutectic solvents (NaDES) are obtained from an adequate mixture of hydrogen bond acceptors (HBA) and donors (HBD), which can bond through the interaction of hydrogen bonds to form a eutectic with a low melting point. NADES has been implemented in several studies as an effective extraction method, but it is still not widely used. C. papaya leaves and O. sanctum leaves have been widely known to have various pharmacological activities. The aim of this study was to determine the best analgesic ability of the NADES extract of C. papaya and O. sanctum leaves. The extraction process used was Microwave-Assisted Extraction (MAE). The liquid extract was tested for antioxidant activity and analgesic activity using doses of 600 mg/kgBW, 800 mg/kgBW, and 1000 mg/kgBW. The results show that The IC50 values of the NADES extract of C. papaya and O. sanctum leaves were 920 ppm and 882 ppm, respectively. Both analgetic percentages are equivalent to the positive control starting from a concentration of 800 mg/kgBW, where the analgetic percentage of the NADES extract of papaya leaves and basil leaves is 59.80% and 54.57% respectively that included in weak category. It can be concluded that both NADES extracts of papaya and basil leaves have analgetic capabilities. Keywords: Natural Deep Eutectic Solvent (NADES), Carica papaya, Ocimum sanctum, analgetic activity.","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"112 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0