Hazena Misgi Damayanti, D. Perwitasari, I. Risdiana, Muhammad Husnul Kuluq
{"title":"REAL WORLD DATA : ANTIVIRUS SELECTION IN COVID-19 PATIENTS AT PKU MUHAMMADIYAH GAMPING HOSPITAL","authors":"Hazena Misgi Damayanti, D. Perwitasari, I. Risdiana, Muhammad Husnul Kuluq","doi":"10.37874/ms.v9i3.1125","DOIUrl":"https://doi.org/10.37874/ms.v9i3.1125","url":null,"abstract":"COVID-19 is a disease that requires antivirals, such as favipiravir and remdesivir, which have been recommended in Indonesia. Choosing the right antiviral agent can affect the length and total cost of hospitalization. The impact of COVID-19 can cause a decline in health and the economy, if not treated effectively. This study aimed to determine the average length of hospitalization and total cost of hospitalization for COVID-19 patients based on the selection of favipiravir and remdesivir antivirals at the PKU Muhammadiyah Gamping Hospital from August 2022-August to 2023 based on real world data. The research method was Observational research with a descriptive research design and retrospective data collection was used. During this period, 306 patients were diagnosed with COVID-19. A total of 171 patients met the inclusion criteria, including 130 patients using favipiravir antivirus and 41 patients using remdesivir antivirus. The results of this study are the average length of hospitalization of the patient group with antiviral favipiravir was 4.1 days and the patient group with antiviral remdesivir was 5 days and the average total cost of hospitalization of the patient group with antiviral favipiravir was IDR 12,377,415 and the average total cost of the patient group with antiviral remdesivir was IDR 14,428,132. The conclusion of this study is that the use of favipiravir antiviral therapy is more effective when viewed from the perspective of length of hospitalization and total cost of hospitalization; therefore, these results can be applied under the same conditions in the treatment of COVID-19.","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"POST-CHEMOTHERAPY TREATMENT IN NATIONAL HEALTH INSURANCE BREAST CANCER PATIENTS AT YOGYAKARTA CITY HOSPITAL","authors":"Dita Putri Anggraeni, Fitriana Yuliastuti","doi":"10.37874/ms.v9i3.939","DOIUrl":"https://doi.org/10.37874/ms.v9i3.939","url":null,"abstract":"Breast cancer accounts for approximately 16.6% of 396,914 cases of cancer and is one of the most fatal and common diseases among women. Treatment of breast cancer mostly has side effects, but the incidence of drug side effects does not always appear because the target drug does not selectively act on the target action. The aim of this study was to find a picture of post-chemotherapy treatment in breast cancer chemotherapy patients participating in the National Health Insurance at RSUD Yogyakarta. Observational method: Retrospective collection of data obtained from patients’ medical records. The subjects included patients with breast cancer at RSUD Yogyakarta who met the inclusion criteria for the primary diagnosis of breast cancer and received chemotherapy medication during the period of 2020. The univariate analysis showed the distribution of frequency and percentage of respondent characteristics, including age, gender, number of patients, single and combination chemotherapy drugs, generic and commercial drugs, and single or combination post-chemotherapy medications. The results were obtained from 72 patients who underwent 4 periods of chemotherapy. The most frequently used chemotherapy regimens for each period were the period 1 combination of Brexel, Epirubicin, Carboplatin. Period 2 combination of the Brexel and Zometa regimes. Periode 3 combination brexel, epirubicine, and carboplatin. The most widely used combination of post-chemotherapy drugs in periods 1-4 was the combination of Ranitidine and Ondansetron.\u0000Keywords: Ca Mamae, Chemotherapy, Regimen, Drugs","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ANTIOXIDANT ACTIVITY, TOTAL PHENOL, AND FLAVONOID CONTENT EXTRACTS AND FRACTIONS MANGO SEEDS (Mangifera indica L.)","authors":"Ratna Anjani, Henny Kasmawati, Yamin, Nina Salamah","doi":"10.37874/ms.v9i3.1196","DOIUrl":"https://doi.org/10.37874/ms.v9i3.1196","url":null,"abstract":"Antioxidants can either stop or slow down the excessive oxidation of a compound. This study aimed to determine the secondary metabolite compounds, antioxidant activity, total flavonoid and phenolic levels, and the correlation between the levels of flavonoid and phenolic compounds in inhibiting free radicals. The DPPH (1,1-diphenyl-2-picrylhydrazyl) method was used to evaluate antioxidant activity. Determination of total flavonoid levels using a UV-Vis spectrophotometer and the aluminum chloride method. The total phenolic content was determined using the Folin-Ciocalteu method. Based on the results of phytochemical screening, mango seed extract (Mangifera indica L.) contains secondary metabolites such as alkaloids, flavonoids, terpenoids, phenolics, and tannins. The relationship between the antioxidant activity of the DPPH method and total flavonoid levels was 91.31%, respectively. The relationship between the antioxidant activity of the DPPH method and the total phenolic content was 99.64%.\u0000Keywords: Mangifera indica L, secondary metabolites, antioxidant activity, DPPH, total flavonoids, total phenolics.","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MISSENSE MUTATIONS IN THE IRAK1 GENE ARE ASSOCIATED WITH AN INCREASED RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS","authors":"Adnan Adnan, Dyah Aryani Perwitasari, Rita Maliza, Nanik Sulistyani","doi":"10.37874/ms.v9i1.1073","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1073","url":null,"abstract":"Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in humans. Missense SNPs can change protein structure and function. This study aimed to determine missense SNPs of the IRAK1 gene that can affect the amino acid sequence and lead to changes in protein structure and function, as well as their relationship as a risk factor for SLE. In this in silico method, several bioinformatics tools have been used to identify missense SNPs, including their properties and impacts, as well as their interaction networks with proteins. The tools used were PolyPhenv2, SIFT, PhD-SNP, PROVEAN, SNAP, Panthers, I-Mutant 3.0, and GeneMania. Four missense SNPs, rs11465830, rs1059702, rs1059703, and 10127175, were obtained from the NCBI SNP database. The SIFT test results showed that all the SNPs were tolerant. In the test results obtained using PolyPhen, the four SNPs were benign. The results of the probe test indicated that the four SNPs were neutral. When tested with SNAP, one SNP was neutral, and three others had an impact. In the PhD-SNP test, all SNPs were neutral. In the panther test, all SNPs were benign. The I-mutant assay showed that the four SNPs could decrease protein stability. Tests with GeneMania have reported that most interactions between genes were between IRAK1 and MYD88, and physical interactions were the most dominant form of interaction. Conclusion. rs10127175, rs11465830, rs1059702, and rs1059703 are missense SNPs in IRAK1, which can disrupt protein stability and be a risk factor for SLE.\u0000Keywords: IRAK1, SNP, Missense, Systemic Lupus Erythematosus","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Faramayuda, S. Riyanti, T. Mariani, Rizka Khoirunnisa Guntina
{"title":"ANALYSIS OF NON-SPECIFIC STANDARDIZED PARAMETERS ON KUMIS KUCING LEAVES (Orthosiphon aristatus (Blume) Miq.) PURPLE VARIETY","authors":"F. Faramayuda, S. Riyanti, T. Mariani, Rizka Khoirunnisa Guntina","doi":"10.37874/ms.v9i1.977","DOIUrl":"https://doi.org/10.37874/ms.v9i1.977","url":null,"abstract":" One of the plants in Indonesia that can be used as a medicine is the purple variety of cat's whiskers (Orthosiphon aristatus (Blume) Miq.). This study aims to examine the quality and safety of the purple variety of Cat’s Whiskers as a raw material for traditional medicine so that it meets the requirements of being free from heavy metal, microbial, and aflatoxin contamination. The results of setting the standardization parameters on the dry material of cat’s whiskers leaves obtained drying losses, water content, total ash content, and acid insoluble ash content, respectively 8.45 ± 0.68%; 6.67 ± 1.15 %; 8.70 ± 0.09 %; 1.31 ± 0.16 %. The results of testing for the heavy metals lead (Pb) and mercury (Hg) on ??dry material and extracts were £ 0.0001 mg/kg. The results of testing the levels of microbial contamination in dry material and extracts obtained total bacteria 1.45x101 and 2.35x101 Cfu/gr, respectively. Test results for aflatoxin contamination on the dry material of Cat’s Whiskers leaves B1, B2, G1, G2 and total aflatoxin £ 0.50 ?g/kg and total aflatoxin £ 2 ?g/kg, respectively. The dried material and leaf extract of the purple variety of cat’s whiskers that were tested met the requirements stated in the regulation of the Food and Drug Supervisory Agency number 32 of 2019 about traditional medicines' safety and quality requirements.","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"131 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Faramayuda, S. Riyanti, T. Mariani, Rizka Khoirunnisa Guntina
{"title":"ANALYSIS OF NON-SPECIFIC STANDARDIZED PARAMETERS ON KUMIS KUCING LEAVES (Orthosiphon aristatus (Blume) Miq.) PURPLE VARIETY","authors":"F. Faramayuda, S. Riyanti, T. Mariani, Rizka Khoirunnisa Guntina","doi":"10.37874/ms.v9i1.977","DOIUrl":"https://doi.org/10.37874/ms.v9i1.977","url":null,"abstract":" One of the plants in Indonesia that can be used as a medicine is the purple variety of cat's whiskers (Orthosiphon aristatus (Blume) Miq.). This study aims to examine the quality and safety of the purple variety of Cat’s Whiskers as a raw material for traditional medicine so that it meets the requirements of being free from heavy metal, microbial, and aflatoxin contamination. The results of setting the standardization parameters on the dry material of cat’s whiskers leaves obtained drying losses, water content, total ash content, and acid insoluble ash content, respectively 8.45 ± 0.68%; 6.67 ± 1.15 %; 8.70 ± 0.09 %; 1.31 ± 0.16 %. The results of testing for the heavy metals lead (Pb) and mercury (Hg) on ??dry material and extracts were £ 0.0001 mg/kg. The results of testing the levels of microbial contamination in dry material and extracts obtained total bacteria 1.45x101 and 2.35x101 Cfu/gr, respectively. Test results for aflatoxin contamination on the dry material of Cat’s Whiskers leaves B1, B2, G1, G2 and total aflatoxin £ 0.50 ?g/kg and total aflatoxin £ 2 ?g/kg, respectively. The dried material and leaf extract of the purple variety of cat’s whiskers that were tested met the requirements stated in the regulation of the Food and Drug Supervisory Agency number 32 of 2019 about traditional medicines' safety and quality requirements.","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"15 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FORMULATION AND CHARACTERIZATION OF ANTI-INFLAMMATORY TRANSDERMAL PATCH PREPARATIONS FROM THE EXTRACT OF PATAH TULANG (Euphorbia tirucalli)","authors":"Shandra Isasi Sutiswa, Syipa Siti Saripah, Nooryza Martihandini","doi":"10.37874/ms.v9i1.998","DOIUrl":"https://doi.org/10.37874/ms.v9i1.998","url":null,"abstract":"Transdermal patches are pharmaceutical preparations that aim to provide a drug delivery system across the surface of the skin and tissue, which is then delivered to the blood. is a plant that contains secondary metabolites with anti-inflammatory activity, such as alkaloids, flavonoids, polyphenols, tannins, steroids, and saponins. This study aimed to determine the characteristics of anti-inflammatory transdermal patch preparations prepared from Euphorbia tirucalli extract. The research method was laboratory experimental by preparing patches using varying concentrations of Euphorbia tirucalli extract, namely F1 (5%), F2 (10%), and F3 (15%). Next, an evaluation of patch preparation was carried out, including organoleptic tests, weight uniformity tests, thickness tests, fold durability tests, pH tests, and moisture tests. From the research results, it can be concluded that Euphorbia tirucalli extract at concentrations of 5%, 10%, and 15% can be made into patch preparations. The best characteristics of the patch preparation were F2 with an extract concentration of 10%, which had a smooth, flexible texture, folding durability >300 folds, pH 4.5, and moisture value of 7.30%.\u0000 Keywords: Anti-inflammatory, Euphorbia tirucalli, Transdermal patch","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FORMULATION AND CHARACTERIZATION OF ANTI-INFLAMMATORY TRANSDERMAL PATCH PREPARATIONS FROM THE EXTRACT OF PATAH TULANG (Euphorbia tirucalli)","authors":"Shandra Isasi Sutiswa, Syipa Siti Saripah, Nooryza Martihandini","doi":"10.37874/ms.v9i1.998","DOIUrl":"https://doi.org/10.37874/ms.v9i1.998","url":null,"abstract":"Transdermal patches are pharmaceutical preparations that aim to provide a drug delivery system across the surface of the skin and tissue, which is then delivered to the blood. is a plant that contains secondary metabolites with anti-inflammatory activity, such as alkaloids, flavonoids, polyphenols, tannins, steroids, and saponins. This study aimed to determine the characteristics of anti-inflammatory transdermal patch preparations prepared from Euphorbia tirucalli extract. The research method was laboratory experimental by preparing patches using varying concentrations of Euphorbia tirucalli extract, namely F1 (5%), F2 (10%), and F3 (15%). Next, an evaluation of patch preparation was carried out, including organoleptic tests, weight uniformity tests, thickness tests, fold durability tests, pH tests, and moisture tests. From the research results, it can be concluded that Euphorbia tirucalli extract at concentrations of 5%, 10%, and 15% can be made into patch preparations. The best characteristics of the patch preparation were F2 with an extract concentration of 10%, which had a smooth, flexible texture, folding durability >300 folds, pH 4.5, and moisture value of 7.30%.\u0000 Keywords: Anti-inflammatory, Euphorbia tirucalli, Transdermal patch","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139850339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE ROLE OF MEDICATION LITERACY IN THE TREATMENT OF HYPERTENSIVE PATIENTS: A REVIEW","authors":"Okti Ratna Mafruhah, Vita Widyasari","doi":"10.37874/ms.v9i1.1071","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1071","url":null,"abstract":"Hypertension, or high blood pressure, has become a major contributor to cardiovascular disease globally. Its prevalence continues to increase, necessitating intensive healthcare efforts. Medication literacy, or the skill of understanding and applying medication information, is crucial for chronic patients, including those with hypertension. However, there has been limited research on this topic, highlighting the need for a literature review of the levels and roles of literacy in the therapy of hypertensive patients. This study used a narrative review approach to analyze the findings of articles on medication literacy in hypertensive patients. This study employs a narrative review approach to analyze findings from various journals. The data were derived from articles focusing on medication literacy in hypertensive patients, identified through literature searches on PubMed from 2013 to 2023. The selected articles were published in international journals, have a full text, can provide data on the role of medication literacy in hypertensive patients, and use quantitative, qualitative, or mixed-methods research designs.Two studies included in the review originated from China. Both articles reported low literacy levels among hypertensive patients. Factors, such as education and income, can also influence literacy. These findings underscore the importance of improving medication literacy in hypertension management, emphasizing the need for better education and more effective development strategies. Both articles also emphasized the significance of medication literacy in the context of hypertension management; that is, they highlighted the need for improved medication literacy and provided evidence of the positive impact of medication literacy on blood pressure control...","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"16 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139865345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE ROLE OF MEDICATION LITERACY IN THE TREATMENT OF HYPERTENSIVE PATIENTS: A REVIEW","authors":"Okti Ratna Mafruhah, Vita Widyasari","doi":"10.37874/ms.v9i1.1071","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1071","url":null,"abstract":"Hypertension, or high blood pressure, has become a major contributor to cardiovascular disease globally. Its prevalence continues to increase, necessitating intensive healthcare efforts. Medication literacy, or the skill of understanding and applying medication information, is crucial for chronic patients, including those with hypertension. However, there has been limited research on this topic, highlighting the need for a literature review of the levels and roles of literacy in the therapy of hypertensive patients. This study used a narrative review approach to analyze the findings of articles on medication literacy in hypertensive patients. This study employs a narrative review approach to analyze findings from various journals. The data were derived from articles focusing on medication literacy in hypertensive patients, identified through literature searches on PubMed from 2013 to 2023. The selected articles were published in international journals, have a full text, can provide data on the role of medication literacy in hypertensive patients, and use quantitative, qualitative, or mixed-methods research designs.Two studies included in the review originated from China. Both articles reported low literacy levels among hypertensive patients. Factors, such as education and income, can also influence literacy. These findings underscore the importance of improving medication literacy in hypertension management, emphasizing the need for better education and more effective development strategies. Both articles also emphasized the significance of medication literacy in the context of hypertension management; that is, they highlighted the need for improved medication literacy and provided evidence of the positive impact of medication literacy on blood pressure control...","PeriodicalId":254294,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"18 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139805455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}