FORMULATION AND CHARACTERIZATION OF ANTI-INFLAMMATORY TRANSDERMAL PATCH PREPARATIONS FROM THE EXTRACT OF PATAH TULANG (Euphorbia tirucalli)

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-09 DOI:10.37874/ms.v9i1.998

Shandra Isasi Sutiswa, Syipa Siti Saripah, Nooryza Martihandini

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Abstract

Transdermal patches are pharmaceutical preparations that aim to provide a drug delivery system across the surface of the skin and tissue, which is then delivered to the blood. is a plant that contains secondary metabolites with anti-inflammatory activity, such as alkaloids, flavonoids, polyphenols, tannins, steroids, and saponins. This study aimed to determine the characteristics of anti-inflammatory transdermal patch preparations prepared from Euphorbia tirucalli extract. The research method was laboratory experimental by preparing patches using varying concentrations of Euphorbia tirucalli extract, namely F1 (5%), F2 (10%), and F3 (15%). Next, an evaluation of patch preparation was carried out, including organoleptic tests, weight uniformity tests, thickness tests, fold durability tests, pH tests, and moisture tests. From the research results, it can be concluded that Euphorbia tirucalli extract at concentrations of 5%, 10%, and 15% can be made into patch preparations. The best characteristics of the patch preparation were F2 with an extract concentration of 10%, which had a smooth, flexible texture, folding durability >300 folds, pH 4.5, and moisture value of 7.30%. Keywords: Anti-inflammatory, Euphorbia tirucalli, Transdermal patch

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用 PATAH TULANG（Euphorbia tirucalli）提取物配制抗炎透皮贴片制剂并对其进行表征

透皮贴剂是一种药物制剂，其目的是在皮肤和组织表面提供一个给药系统，然后将药物输送到血液中。大戟科植物大戟是一种含有具有抗炎活性的次生代谢产物的植物，如生物碱、黄酮类、多酚类、单宁酸、类固醇和皂苷。本研究旨在确定从大戟提取物中制备的抗炎透皮贴剂的特性。研究方法是通过实验室实验，使用不同浓度的大戟提取物制备贴片，即 F1（5%）、F2（10%）和 F3（15%）。接着，对制备的补丁进行了评估，包括感官测试、重量均匀性测试、厚度测试、折叠耐久性测试、pH 值测试和湿度测试。研究结果表明，浓度为 5%、10% 和 15%的大戟提取物可制成贴片制剂。其中，提取物浓度为 10%的贴片制剂 F2 特性最好，其质地光滑、富有弹性，耐折度大于 300 次，pH 值为 4.5，水分值为 7.30%。关键词消炎药桔梗透皮贴片

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Medical Sains : Jurnal Ilmiah Kefarmasian

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