Ukrainian Journal of Pediatric Endocrinology最新文献

{"title":"Features of the physical development of girls with different course of puberty and level of adaptive capabilities","authors":"V. Kashina-Yarmak, Rak L. I.","doi":"10.30978/ujpe2021-4-34","DOIUrl":"https://doi.org/10.30978/ujpe2021-4-34","url":null,"abstract":"The purpose of the study — to establish the features of the physical development of adolescent girls with the different course of puberty and to assess adaptive capabilities depending on the indicators of physical development and the course of puberty.Materials and methods: The examinations involved 57 girls aged 11 to 17 year who were divided into two groups depending on the presence of menstrual disorders. The first group included girls with physiological puberty. The second group consisted of girls with oligo­ or amenorrhea, and in isolated cases, with abnormal uterine bleeding, proio­ or polymenorrhea. The assessments included somatometric parameters, the results of the Ruffier test, the clinoortostatic test, cardiac morphometric indicators, and vascular reactivity according to Doppler ultrasound, the Kerdo index and Baevsky’s adaptive potential.Results and discussion. The significant frequency of tall and higher than average height was established as specific feature of girls regardless of the variant of puberty course (42.4 % with physiological and 42.8 % with pathological puberty). In general, the girls did not differ in height and body weight. In terms of Baevsky’s adaptive potential, 100 % of girls had a satisfactory adaptation level. The significant proportion of adolescent girls showed low exercise tolerance (63.7 % of girls with physiological and 50 % with pathological puberty). The high frequency of initial sympathy and the prevalence of normal vegetative support were recorded. Satisfactory and good results were more likely to be obtained by girls with puberty disorders. Girls with physiological puberty had a high incidence of hyperkinetic hemodynamic (37.5 % compared to 15.0 % in the second group, p < 0.05).The adaptive capabilities of girls with average height did not differ between groups with various puberty course. The tall girls of the first group had the higher frequency of the hyperkinetic type of hemodynamics, combined with best indices of vascular reactivity: two thirds of subjects demonstrated adequate increase in the diameter of the brachial artery in the sample with reactive hyperemia. In girls with menstrual dysfunction, the acceleration of growth was not accompanied by activation of the sympathoadrenal system, but they showed better results of exercise test. It could be assumed that presence of sexual hormones’ imbalance with testosterone prevalence, promotes these results and increases endurance of girls. However, the isolated Ruffier test does not fully reflect the satisfactory adaptation of an adolescent’s body. It is necessary to compare the results of the functional study of adolescent girls with the peculiarities of their hormonal status.Conclusions. A big proportion of girls with tall and higher than average height is the peculiarity of physical development of modern female adolescents. In the absence of pathology of puberty, the adaptive reactions of a body of an adolescent girl are characterized by increased e","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124736450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of type 1 diabetes mellitus on sexual development","authors":"G. Kosovtsova, S. Turchina, L. D. Nikitina, Т. Коstenko, O. V. Shushlypina","doi":"10.30978/ujpe2021-4-15","DOIUrl":"https://doi.org/10.30978/ujpe2021-4-15","url":null,"abstract":"Objective. To determine the peculiarities of sexual development in the adolescents with type 1 diabetes mellitus (DM1).Materials and methods. The puberty pattern was assessed in 52 boys and 64 girls aged 9 to 17 years with DM1 with the disease duration of 1 to 8 years. Sexual development was evaluated according to Tanner using the masculinization index for boys and secondary gender score for girls. The puberty pattern was determined taking into account age standards. Carbohydrate metabolism compensation was assessed by the levels of glycosylated hemoglobin (Hb A1c): values < 6.05 % were defined as ideal compensation level, Hb A1c of 6.05 % — 7.5 % as optimal; values 7.6 %—9.0 % as suboptimal and Hb A1c > 9.0 % was assessed as a high risk for life. The analysis of puberty pattern was carried with account of the age of DM1 manifestation and disease course duration, and compensation of carbohydrate metabolism. Depending on the age of DM1 manifestation, four groups were defined: group 1-at the age of 1 to 8 years, group 2-at 9 — 10 years, group 3-at 11 — 13 years, groups 4 included patients with manifestation later than at 13 years. Based on the DM1 duration, three groups were determined: group I — up to 5 years; group II — from 5 to 10 years; group III-more than 10 years.Results. The evidence has been obtained for the negative DM1 effects on the course of sexual development and formation of the menstrual function. In boys with DM1, which manifested in childhood and prepuberty, there was a later onset of puberty and prolongation of the external genitalia development. The DM1 girls demonstrated a delayed menarche age (13 years 1 month ± 1.7 month) in comparison with the mean menarche age (12 years 9 months ± 1 month). In 38.1 % of female patients, menstrual disorders were diagnosed, mainly in a form of oligomenorrhea and secondary amenorrhea. The delay in sexual development was established in 10.5 % of boys and a 7.5 % of girls, the formation of which was negatively affected by the age of manifestation of type 1 diabetes in children and prepubertal age and unsatisfactory compensation of carbohydrate metabolism.Conclusions. Patients with the onset of diabetes mellitus 1 in childhood and prepuberty with insufficient compensation of carbohydrate metabolism refer to the group with the risk of puberty disorders.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132440717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISPAD’s Clinical Practice Consensus Guidelines 2018. Chapter 4. The Diagnosis and management of monogenic diabetes in children and adolescents","authors":"Translation Ye. V. Globa","doi":"10.30978/ujpe2021-4-40","DOIUrl":"https://doi.org/10.30978/ujpe2021-4-40","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"229 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130924721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of the physical and sexual development disorders in children and adolescents with type 1 diabetes mellitus","authors":"N. Bagatska, L. Glotka","doi":"10.30978/ujpe2021-4-21","DOIUrl":"https://doi.org/10.30978/ujpe2021-4-21","url":null,"abstract":"Objective. To determine hereditary and environmental factors, resulting in the formation of physical and sexual development disorders in children and adolescents with type 1 diabetes mellitus (DM 1).Methods and materials. The genealogical analysis was performed in the families of 50 patients aged 8 to 18 years (22 boys and 28 girls) with DM 1, who were examined at the Institute of Child and Adolescent Health of the NAMS of Ukraine. Harmonious physical development was observed in 16 boys and 10 girls, disharmonious development — in 6 and 18, respectively. The nature of puberty, which corresponded to the normative values, was registered in 19 boys and 23 girls, and puberty disorders were observed in 3 boys and 5 girls.Results. According to the genealogical analysis data, boys with DM 1 with harmonious physical development were more likely to be born with low body weight, they were more likely to undergo surgery compared to the girls with normal sexual development. Mothers of boys with harmonious and disharmonious physical development were significantly less likely to register stress before pregnancy compared to mothers of diabetic girls with different levels of physical development. The DM 1 boys with sexual development disorders significantly more likely to be born with the increased body mass in comparison with the DM 1 girls with sexual development disorders. Hereditary burden of diabetes in the girls with harmonious and disharmonious physical development exceeded in 1.8 and 2.8 times that in boys with corresponding physical development, and in girls with normal sexual development it was in 1.7 times oftener than in the boys. Cardiovascular and gastrointestinal diseases prevailed in the relatives of diabetic boys with harmonious physical development, and in the relatives of boys with disharmonious physical development, the cardiovascular and neurological diseases dominated, and gastrointestinal pathology was rarer than the incidence of these diseases in the relatives of diabetic girls with various levels of physical development. At the same time, relatives of boys with the normal sexual development had predominantly endocrine and neurological diseases, and relatives of boys with sexual development disorders had more often cardiovascular diseases in comparison with the incidence of these pathologies in relatives of girls with various levels of sexual development.Conclusions. It can be assumed that the presence of DM 1, especially diagnosed in childhood, may adversely affect the formation and functioning of the reproductive system in adolescence. Moreover, one should consider the impact of environmental factors and diabetes hereditary burden on their health.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124229570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and autoimmune thyroid diseases (part 2)","authors":"N. V. Volkava, A. Solntsava","doi":"10.30978/ujpe2021-4-6","DOIUrl":"https://doi.org/10.30978/ujpe2021-4-6","url":null,"abstract":"The paper is devoted to the disclosure of mechanisms underlying the ability of vitamin D to modulate inflammatory processes in autoimmune thyroid diseases. Vitamin D receptor (VDR) was found to be expressed in many activated immune cells. Calcitriol affects monocytes and dendritic cells by inhibiting the production of inflammatory cytokines, it has effects on differentiation and maturation of antigen-presenting cells, resulting in the suppression of activation and proliferation of T-lymphocytes. Vitamin D was established to be able to shift the differentiation of CD4+ cells towards type 2 T­helpers (Th2) and T­-regulatory phenotypes and inhibit the development and activity of T-helpers of type 17 (Th17) and type 1 (Th1). In recent years, researchers have drawn attention to the regulatory effect of vitamin D on the balance of Treg /Th17 cells. It has been assumed that mutual Th17 and Treg conversion is feasible due to the tight relationship of the processes of differentiation of these cells and presence of the general key development factor — transforming growth factor­β (TGF­β). Proteins of the Smad family play a crucial role in the transmission of TGFβ signals, and Smad3 is important for Treg cells, while Smad7 is associated with the proinflammatory phenotype of T cells. Experiments have established the ability of vitamin D to suppress Smad7 expression, thus promoting increased Smad3 synthesis. Vitamin D has an inhibitory effect on the expression of Th17 cytokines and the differentiation of Th17 cells into pathogenic types. Results of several investigations demonstrated that cholecalciferol preparations had a beneficial effect on thyroid pathology, but these data are ambiguous. Further research is needed to determine the effectiveness of vitamin D intake in the prevention and treatment of autoimmune thyroid disease.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"35 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132400812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISPAD Clinical Practice Consensus Guidelines 2018. Chapter 2. Stages of type 1 diabetes in children and adolescents Pediatr Diabetes (Ukrainian)","authors":"","doi":"10.30978/ujpe2021-3-26","DOIUrl":"https://doi.org/10.30978/ujpe2021-3-26","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129147439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laurence-Moon-Bardet-Biedl syndrome","authors":"O. O. Fishchuk, M. Ovcharuk, K. S. Biliaeva, N. I. Gurina, V. V. Fishchuk","doi":"10.30978/ujpe2021-3-22","DOIUrl":"https://doi.org/10.30978/ujpe2021-3-22","url":null,"abstract":"Lawrence-Moon-Bardet-Biedl syndrome is a rare autosomal recessive genetic disorder, which may result in a number of multiorgan abnormalities, including impaired brain function, eye diseases, kidney and limbs’ dysfunction. The main symptoms of this syndrome include retinal degeneration, polydactyly, obesity, hypogonadism, congenital kidney abnormalities and mental retardation. However, Lawrence-­Moon­-Barde­-Biedl syndrome may also present with other secondary abnormalities, including ataxia, diabetes insipidus, and dental abnormalities. Clinical changes of the eyes include retinitis pigmentosa, low visual acuity, and vision loss, often due to photoreceptor disorders in the retinal tissue with macular degeneration, leading to night blindness and then, in most cases, can cause complete blindness. In patients with an archetypal manifestation of Lawrence­-Moon­-Barde-­Biedl syndrome, abdominal obesity is common, even if the birth weight is usually normal. In addition, this group of patients has type 2 diabetes mellitus. A distinctive feature of this syndrome is postaxial polydactyly. Hypogonadism, which is a common sign of the disease, as usual can be diagnosed at early age in men in a form of micropenis and testicular hypoplasia).The paper presents clinicalcase of Lawrence­-Moon­-Barde-­Bidle syndrome in a thirteen-year-old boy who referred to endocrinologist with complaints of excessivegain of body weight, memoryloss, visual impairment, difficulties in school, delayedsexual development. Ad ditional investigations enabled to establish the diagnosis of Laurence­-Moon­-Bardet­-Biedl syndrome.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115911368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISPAD Clinical Practice Consensus Guidelines 2018. Chapter 3. Type 2 diabetes mellitus in youth (Ukrainian)","authors":"","doi":"10.30978/ujpe2021-3-35","DOIUrl":"https://doi.org/10.30978/ujpe2021-3-35","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117333027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and autoimmune thyroid diseases (part 1)","authors":"N. Volkova, A. Solntseva","doi":"10.30978/ujpe2021-3-6","DOIUrl":"https://doi.org/10.30978/ujpe2021-3-6","url":null,"abstract":"Autoimmune thyroiditis (AIT) and Graves’ disease (GD) are common autoimmune diseases, and their prevalence assessed as 5 % of general population. Currently, selective immunosuppressive agents for pathogenetic treatment of autoimmune pathology are being developed. Vitamin D with the known anti­inflammatory and immunoregulatory properties, is also of great interest. The first part of the article reviews the roles of various immune cells in the pathogenesis of autoimmune thyroid diseases, which is necessary to reveal the therapeutic potential of calcitriol in these disorders. Classically, AIT was considered to be mediated by T­helpers type 1 (Th1), and GD — by T­helpers type 2 (Th2). This misunderstanding was based on the idea that humoral immunity is controlled by Th2 cytokines, and cellular immunity — by Th1. In the past decades, the role of new subsets of immune cells in the pathogenesis of autoimmune thyroid diseases is being studied, displacing the traditional paradigm of Th1/Th2 dichotomy. It has been established that T­helpers type 17 (Th17) play an important role in the development of various inflammatory and autoimmune diseases, previously classified as Th1­dependent pathologies. The involvement of T­ and B­regulatory lymphocytes in the autoimmune process is also of particular interest. It was found that these cells accumulate in inflamed thyroid tissue in patients with thyroid pathology, but they are unable to suppress the immune response effectively. Further research will help to find out which immune cells can become targets for vitamin D agonists in the complex treatment of autoimmune diseases.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126611593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Part 1","authors":"","doi":"10.30978/ujpe2021-1-40","DOIUrl":"https://doi.org/10.30978/ujpe2021-1-40","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125988436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}