Ukrainian Journal of Pediatric Endocrinology最新文献

{"title":"Essential issues of transfer of knowledge and medical technology in pediatric endocrinology","authors":"M. Vodolazhskyi, O. Budreiko, T. Sydorenko, T. Fomina, T. V. Koshman","doi":"10.30978/UJPE2018-3-4-50","DOIUrl":"https://doi.org/10.30978/UJPE2018-3-4-50","url":null,"abstract":"Objective — improvement of information provision for pediatric endocrinologists. Materials and methods. Abstracts of reports for scientific researches (39) and researches (79) conducted in Ukraine in 2001–2017, research informational and innovational resources provided in record cards, their semantic, informational, scientometric, bibliometric, patent, statistical analysis methods; pediatric endocrinologist surveys (50). Results and discussion. It has been established that, in economic aspect, transfer of technology can be commercial and non-commercial. In the area of children and adolescents health care, non-commercial transfer is primarily used, instrument of which is scientific technical information: scientific and occupational journals, their databases and databanks, patent publications, reference books, reports and contributions to conferences, workshops, symposiums, trade shows, internship of scientists and specialists in universities and organizations; scientific technical information exchange. It has been established that implementation of new methods of prevention, diagnostics, treatment and organizational decision-making in the area of pediatric endocrinology includes three major steps: acquisition of primary information on medical technologies through means of scientific communication; organization of their implementation at a workplace and handling of material, technical, legal, financial and personnel issues as to their use (making an appropriate agreement), as well as designer supervision. We have conducted informational and analytical evaluation of research process and non-commercial transfer of knowledge and technology in pediatric endocrinology in Ukraine in 2001–2017. Analysis of researches indicates an increase in scientific research and research quantity (1.5 times), shows their topical direction, indicates structure of created scientific product (publications, intellectual property items, guidance documents etc.), and establishes ways of scientific result usage by pediatric endocrinologists. Conclusions. In Ukraine, there is a stable process of research in essential directions of pediatric endocrinology. Appropriate informational and innovational resources are being generated. However, their usage by specialists is associated with a number of outstanding issues, including development of a conceptual construct, imperfection of channels for transferring scientific product to the professional community, absence of methodology for assessment of non-commercial transfer of medical technology. Further research of this issue will help to improve transfer of knowledge and technology not only in separate areas of pediatric endocrinology, but in children and adolescents health care in general.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116216232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of vitamin E level in adolescent girls with uterine hypoplasia against the background of hypomenstrual syndrome during follow-up study","authors":"D. Kashkalda, S. Levenets","doi":"10.30978/ujpe2018-3-4-35","DOIUrl":"https://doi.org/10.30978/ujpe2018-3-4-35","url":null,"abstract":"Objective — to assess changes of vitamin E level in adolescent girls with uterine hypoplasia against the background of hypomenstrual syndrome (HMS) during follow-up study. Materials and methods. We examined 40 adolescent girls, aged 14–18 years, with HMS against the background of uterine hypoplasia, particularly those with oligomenorrhea (OM) and secondary amenorrhea (SA), vitamin E level in whose blood serum we had determined before and after the 2 weeks of treatment. Patients were subjected to background therapy and ultraphonophoresis (UP) of vitamin E. Results and discussion. In the process of follow-up study we identified a correction of tocopherol level in blood serum of patients with HMS: increase in frequency of normal indices and decrease in that of low ones. Moreover, during background therapy this is observed mostly in girls with OM, while during treatment with UP of vitamin E it is evident mostly in those with SA. With background therapy positive dynamics of change in tocopherol level are more frequently registered in girls with ineffective treatment, while in case of using UP of vitamin E they are more often registered in patients with effective treatment. Conclusions. Using non-hormonal methods in treatment of adolescent girls with HMS against the background of uterine hypoplasia leads to positive dynamics of change in concentration of vitamin E, which in turn contributes to emergence of menstruations in every third girl in case of background therapy and in 61% of them in case of UP of vitamin E.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128101053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of lipid spectrum in boys with hypoandrogenism","authors":"O. Budreiko, G. Kosovtsova, Т. P. Kostenko","doi":"10.30978/UJPE2018-3-4-45","DOIUrl":"https://doi.org/10.30978/UJPE2018-3-4-45","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132758420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of celiac disease and symptomatic hypothyroidism on progression of type 1 diabetes in children: literature review and researchers’ own observation","authors":"A. V. Solntsеva, N. V. Volkоva, K. Shlimakova","doi":"10.30978/UJPE2018-3-4-5","DOIUrl":"https://doi.org/10.30978/UJPE2018-3-4-5","url":null,"abstract":"Цукровий діабет 1 типу нерідко поєднується з ендокринними і неендокринними імунопатологічними захворюваннями. Найпоширенішими з них є хвороби щитоподібної залози і целіакія. Комбінація кількох автоімунних уражень значно погіршує показники довготривалого метаболічного контролю діабету. У статті представлено огляд літератури про вплив целіакії та автоімунної патології щитоподібної залози на компенсацію вуглеводного обміну у дітей з цукровим діабетом 1 типу. Наведено власне спостереження поєднання цих захворювань у дитини.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133151279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geleophysic dysplasia: one gene, different phenotypes","authors":"E. V. Globa, N. Zelinska","doi":"10.30978/ujpe2018-3-4-56","DOIUrl":"https://doi.org/10.30978/ujpe2018-3-4-56","url":null,"abstract":"Geleophysic dysplasia (GD) is a rare multisystem disorder that affects bones, joints, heart, and skin. Mode of GD inheritance varies and can be autosomal recessive in case of ADAMTSL2 gene mutations and autosomal dominant in case of FBN1 and LTBP3 genes mutations. In the article we present an example of our own examination of two patients from different families, with different GD clinical picture, but with a common trait of pronounced dwarfism resistant to treatment with growth hormone. In the course of usual endocrine tests there has been no primary endocrine pathology detected. We have conducted genetic research in each family by method of exomic sequencing. In both patients we have identified de novo FBN1 heterozygous mutations p.Tyr1696Asp and p.Cys1748Ser. Both children had common clinical symptoms, such as pronounced dwarfism, distinctive facial features, short limbs, as well as joint contractures. However, in one patient we have identified heart pathology, while the other had tracheal stenosis, requiring tracheostomy. Patients with pronounced dwarfism, skeletal anomalies and other specific syndromes (such as tracheal stenosis and heart anomalies) have to undergo genetic testing in order to exclude syndromes of acromelic dysplasia.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122162992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of physical development of school-age children affected by the armed conflict in eastern Ukraine","authors":"S. Turchina, Т. Р. Kostenko","doi":"10.30978/ujpe2018-3-4-20","DOIUrl":"https://doi.org/10.30978/ujpe2018-3-4-20","url":null,"abstract":"Мета роботи — визначити особливості порушень фізичного розвитку (ФР) дітей шкільного віку, які постраждали від збройного конфлікту на сході України. Матеріали та методи. Оцінено характер ФР у дітей та підлітків 6—18 років (179 дівчат і 128 хлопців), які постраждали від збройного конфлікту на сході України і звернулися по медичну допомогу в ДУ «ІОЗДП НАМНУ» протягом 2015—2018 рр. З урахуванням віку та рівня статевого розвитку на початок антитерористичної операції (АТО) сформовано групи: дитинство (6—8 років); препубертат (9—10 років); ранній пубертат (11—13 років); власне пубертат (14—16 років); пізній пубертат (17—18 років). Математична обробка отриманих результатів проведена за допомогою пакетів програм SPSS Statistics 17,0, Excel. Результати та обговорення. Встановлено залежність між характером ФР, статтю і віком на момент початку збройного конфлікту (квітень 2014 р.). У віддаленому катамнезі дисгармонійний ФР найчастіше визначали у дітей, вік яких в 2014 р. склав менше 7 років (66,7 %), за ознаками низького зросту у хлопчиків та надмірної ваги у дівчаток. У хлопчиків, яким у 2014 р. було 9—10 років, навпаки, вдвічі частіше, ніж у дівчаток-однолітків визначали надмірну масу тіла (42,9 % і 27,6 % відповідно). Саме в цій віковій групі в динаміці спостереження діагностовано ускладнений перебіг ожиріння. Встановлено, що найчастішою формою порушення ФР у підлітків обох статей була надмірна вага. Дефіцит маси тіла виявляли значно рідше, переважно у хлопців, яким у 2014 р. було 11—13 років (14,6 %). Висновки. Групою ризику щодо формування порушень ФР є школярі, які зазнали негативного впливу збройного конфлікту у молодшому віці і на початку пубертату, в структурі патології яких переважала надмірна маса тіла.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124956903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional stress and stress-regulating systems indicators in children and adolescents from the Joint forces operation zone","authors":"D. Kashkalda, I. Lebets","doi":"10.30978/DE2018-2-38","DOIUrl":"https://doi.org/10.30978/DE2018-2-38","url":null,"abstract":"Objective — to assess indicators of stress-regulating systems in children of school age from the Joint forces operation (JFO) zone, depending on the presence or absence of stress. Materials and methods. 129 children and adolescents of both sexes aged 7 to 17 years from the JFO zone, including 54 migrant peers, have been examined by us. We researched the state of stress-realizing (cortisol, TBA-active products, diene conjugates, adrenaline, noradrenaline) and stress-limiting (serotonin, melatonin, reduced glutathione, glutathione peroxidase (GPO), superoxide dismutase) systems. Results and discussion. In presence of stress there is a verifiable increase of cortisol concentration in children and adolescents from the JFO zone and in migrants, when compared to adolescents without stress. We have identified in adolescent migrants a decrease of GPO activity and an increase of melatonin level in presence of stress. In absence of stress there is in adolescents from the JFO zone a noted decrease in level of urinary excretion of adrenaline. In migrants we have identified a reverse tendency. Conclusions. In children and adolescents from the JFO zone and in migrants we have established differences in nature of changes in stress-regulating systems, which point to pathogenic peculiarities in development of mechanisms of adaptation to undergone stress.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116615419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical case of pseudohypoparathyroidism in a child","authors":"G. V. Ivanenko, L. O. Iatsun, E. Globa","doi":"10.30978/DE2018-2-43","DOIUrl":"https://doi.org/10.30978/DE2018-2-43","url":null,"abstract":"We have described a clinical case of treatment of a child with pseudohypoparathyroidism — pathology characterized by calcium and phosphate metabolic disorder, specific phenotype, as well as often accompanied by delay in physical and intellectual development. Presented is the case record of a child who consulted an endocrinologist and had been previously diagnosed with congenital hypothyroidism. We have described clinical aspects of disease in the patient, phasing of their emergence, retrospective dynamics of lab values against the background of previous treatment, results of genetic research, which enabled us to confirm the diagnosis of pseudohypoparathyroidism. Emphasis is placed on importance of differential diagnostics of calcium and phosphate metabolic disorders in children, particularly in those with signs of hormone resistance.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114647193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of vitamin D receptor gene polymorphism and its connection with indicators of metabolic status in children with obesity","authors":"H. Mikhno, A. Solntsava, E. Aksyonova, Helena Dashkevich","doi":"10.30978/de2018-2-29","DOIUrl":"https://doi.org/10.30978/de2018-2-29","url":null,"abstract":"Objective — to identify peculiarities of vitamin D receptor gene polymorphism and its connection to indicators of metabolic status in children with obesity and normal body mass. Materials and methods. We have examined 39 children (19 boys and 20 girls) with obesity (body mass index (BMI) (30.6 ± 2.06) kg/m2, age (13.23 ± 2.27) years)). We have determined the main indicators of lipid and phosphorus-calcium metabolism, uric acid, glycated hemoglobin in biochemical analysis of blood. Hormonal state: insulin, leptin, adiponectin, cortisol, thyroid stimulating hormone, free thyroxine, vitamin D. We have conducted genotyping of vitamin D receptor gene by ApaI (A/a) (rs7975232), TaqI (T/t) (rs731236), BsmI (B/b) (rs1544410), FokI (F/f) (rs2228570) polymorphic alleles. Results and discussion. We have identified statistically significant differences by frequency of genotypes and ApaI (A/a) (rs7975232), TaqI (T/t) (rs731236), BsmI (B/b) (rs1544410) VDR alleles between boys with obesity and normal body mass. There have been no identified statistically significant differences by frequency of genotypes and TaqI (T/t) (rs731236), BsmI (B/b) (rs1544410), FokI (F/f) (rs2228570) VDR alleles in girls with obesity. In indicators of biochemical analysis of blood of patients with obesity by ApaI (A/a) (rs7975232) polymorphic locus we have identified statistically significant increase of (р(Аа) = 0.03; р(аа) = 0.006) triglyceride, (р(АА) = 0.004; р(аа) = 0.05) uric acid and (р(Аа) = 0.02) alkaline phosphatase level as to the (р(Аа) = 0.03; р(аа) = 0.006) control group. In patients with AA and Аа genotypes there has been determined a statistically significant increase of insulin indicators in blood serum as to the (р(АА) = 0.002; р(Аа) = 0.002) control group. We have identified a statistically significant difference by HOMA­IR index in children with obesity as to the (р(АА) = 0.007; р(Аа) = 0.03) control group. There has been a noted statistically significant difference by leptin level in children with obesity as to the (р(аа) = 0.007 control group with aa genotype. Conclusions. We have identified a statistically significant increase of triglyceride, HOMA­IR index, leptin and uric acid level in children with obesity by ApaI (A/a) (rs7975232) polymorphic locus as to the control group.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134421513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}