Ukrainian Journal of Pediatric Endocrinology最新文献

{"title":"Disorders of sexual differentiation. A clinical case","authors":"I. Andrikevych, N.I. Sinchuk, V. Pasik","doi":"10.30978/ujpe2023-3-4-25","DOIUrl":"https://doi.org/10.30978/ujpe2023-3-4-25","url":null,"abstract":"The biological sex of a person is anatomical, physiological, and genetic features that help distinguish a male organism from a female one. One distinguishes genetic, gonadal, and phenotypic sex of a person. Sexual differentiation is a process of development, during which the biological male or female sex is formed, it occurs under the influence of genetic and hormonal factors during fetal development. In this regard, any damage at this stage can lead to disorder of sexual development of a newborn. Disorder of sexual differentiation is a complex of medical conditions in which there is a mismatch between a person’s genetic, gonadal and phenotypic sex.Sometimes it is difficult to visually determine the sex of a child born with disorder of the sexual development due to an abnormal, undefined structure of the external genitalia. For example, they may have the appearance of hypertrophied labia majora and/or a hypertrophied clitoris and the absence of testicles, or vice versa, the child’s genitals may have a normal appearance, but at the same time the internal genitals may be improperly developed.To determine which gender to choose for a child with disorder of sexual differentiation, a number of examinations, including genetic ones, should be carried out. Disorder of sexual differentiation is a complex medical and social problem involving a multidisciplinary team of doctors and the patient’s family. This article describes a clinical case of a child with disorder of sexual differentiation at the stage of diagnosis verification. An interdisciplinary approach is an integral part of accompanying a child with disorder of sexual differentiation, where the joint efforts of doctors, psychologists, teachers and other specialists contribute to the creation of inclusive and safe conditions for the development of each person.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"677 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender peculiarities of hepatopathy manifestation in adolescents with type 1 diabetes","authors":"L. Strashok, S. Turchina, M. Isakova, E. Zavelya, A. Yeshchenko, M. Khomenko, O. Buznytska","doi":"10.30978/ujpe2023-3-4-19","DOIUrl":"https://doi.org/10.30978/ujpe2023-3-4-19","url":null,"abstract":"The incidence of diabetes mellitus is steadily increasing worldwide, including in the pediatric population. Type 1 diabetes is a disease that is often accompanied by liver damage in the form of glycogenosis, steatosis, and fibrosis. However, there is paucity of research devoted to this problem. Objective — to determine the gender characteristics of the clinical course of hepatopathy in adolescents with type 1 diabetes. Materials and methods. The study included 86 boys and 87 girls aged 8 to 18 years (school-age children in the period of hormonal puberty adjustment), suffering from type 1 diabetes. Clinical and anamnestic, laboratory and instrumental examinations were carried out in accordance with the current standards. Blood biochemistry examinations included determining the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, total bilirubin and its fractions, total cholesterol, triglycerides, high density lipoprotein, β­lipoproteins. According to the results of ultrasound examinations, adolescents with type 1 diabetes were divided into groups based on the liver size. Results and discussion. The groups did not differ significantly by the nature of dyspeptic complaints. During ultrasound examinations, an increase in the liver size was determined more often in boys; the frequency of steatosis signs did not depend on gender. Absence of positive dynamics of these signs was established in 50 % of patients, regardless of the state of glycemic control. Regardless of gender, functional disorders of the biliary tract were found in almost all of them. The indicators of the lipid panel in girls were slightly higher than in boys, and the difference in β­lipoproteins level was significant. In most adolescents, levels of high density lipoprotein were within the normal ranges, but the frequency of its decrease in boys with enlarged liver was higher compared to girls. ALT activity significantly increased only in girls with enlarged liver, and in boys it only tended to increase; the frequency of increased ALT activity in girls with enlarged liver was 1.5 times higher compared to boys. The AST/ALT ratio in every fifth patient, regardless of gender and liver size, was ≥ 1.3 (a marker of fibrosis formation). Conclusions. The performed investigation revealed the gender peculiarities of clinical, ultrasound and biochemical manifestations of hepatopathy in adolescents with type 1 diabetes, which can be the basis for the administration of patient oriented therapeutic, preventive and rehabilitation measures.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139287954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin and microelement status and somato­sexual development of adolescents with type 1 diabetes","authors":"Yu.V. Volkova, S. Turchina, L. Sukhova","doi":"10.30978/ujpe2023-3-4-14","DOIUrl":"https://doi.org/10.30978/ujpe2023-3-4-14","url":null,"abstract":"Objective — to study peculiarities of the state of vitamin and microelement provision in children and adolescents with type 1 diabetes with the physiological and pathological course of puberty. Materials and methods. The study involved 143 patients (75 boys and 68 girls) with type 1 diabetes aged 10 to 17 years. The level of retinol, tocopherol, 25(OH)D3 and Zn concentration were determined in blood serum.Results and discussion. The gender characteristics of vitamin and microelement imbalance in adolescents with type type 1 diabetes were determined, the nature of which depended on the course of puberty. Among boys with type 1 diabetes under the conditions of harmonious physical development (PD), an increase in the percentage of low levels of vitamin E was recorded more often than in girls (39.1 vs. 12.2 %, рφ < 0.02). In girls with a disharmonious type of PD with increased body weight and high height, there was an increase in the frequency of high levels of vitamin E (48.1 %) under conditions of a normal level of retinol (37.0 %). In boys with high height and body weight disorders, an increased level of Zn (64.3 %) and an increase in the frequency of pronounced vitamin D deficiency (47.6 %) were recorded more often. Only 9.5 % of patients had vitamin D levels that corresponded to the optimal level of provision. In girls with disharmonious PD, the level of 25(OH)D3 was higher than in boys and was (19.06 ± 1.51) and (13.10 ± 1.53) ng/ml, respectively; (рu < 0.002). Under the conditions of disharmonious PD boys had lower values of vitamin A (52.2 vs. 29.6 %, рφ < 0.05) and vitamin E (39.1 vs. 3.7 %, рφ < 0.05) compared to girls. In boys with the physiological course of sexual development (SD), in comparison with girls, a decrease in the level of zinc, retinol and tocopherol was more often registered. Under the conditions of SD disorders, a reduced level of vitamin A was more often registered in girls (66.7 vs. 35.7 %, рφ < 0.03) with a simultaneous decrease in the frequency of its elevated values (8.3 vs. 37.5 %, рφ < 0.01) relative to patients with a physiological course of SD. At the same time, normal levels of vitamin E were recorded more often. Under conditions of sexual development delay in boys, the frequency of normal values of vitamin E was decreased compared to girls. Аt the same time, pronounced deficiency of vitamin D was more often registered in boys with a simultaneous decrease in the frequency of its suboptimal level. Conclusions. Based on the results of the study, a relationship between indicators of vitamin and microelement status and somatic and sexual development in adolescents with type I diabetes was established. The tension of reserves of vitamins A, E, D and the imbalance of zinc concentration were found in boys with disharmonious physical development. Sexual development delay in boys was accompanied by a deterioration in the nature of providing the body with vitamins D and E.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139288145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic signs of the course of puberty in adolescents with type 1 diabetes","authors":"S. Turchina, G. Kosovtsova, Т. Коstenko, S. Chumak, L. Nikitina","doi":"10.30978/ujpe2023-3-4-4","DOIUrl":"https://doi.org/10.30978/ujpe2023-3-4-4","url":null,"abstract":"Objective — to determine significant clinical, anamnestic and hormonal factors on the prognosis of puberty disorders in modern adolescents with type 1 diabetes. Materials and methods. A comprehensive examination involved 233 patients with type 1 diabetes aged 9 to 18 years, who were examined and treated in the Endocrinological Department of the SI «ICAHC NAMS». Based on the results of assessment of the physical and sexual development, the groups of patients with a physiological and pathological course of puberty have been distinguished. To determine significant prognostic clinical, anamnestic, hormonal and metabolic signs regarding the course of puberty in adolescents with type 1 diabetes, the system and information analysis, heterogeneous sequential statistical technique «the Wald test» with the application of the Kullback—Leibler information measure was used. Creating a database and statistical processing of the results were carried out using application packages Microsoft Excel and SPSS 17.0 programs. Results and discussion. The most informative factors have been determined for prognosis of the course of physical and sexual development in adolescents with type 1 diabetes, and the informativeness and predictive coefficients (PC) of initial clinical, anamnestic and hormonal data indicators have been calculated. The most informative signs were combined with the table of physical and sexual development of girls and boys with type 1 diabetes. Despite some gender features of predicting the course of physical and sexual development in boys and girls, it has been proven that the most significant factors in predicting the course of puberty in patients with type 1 diabetes are the period of puberty in which the manifestation of diabetes occurred, the state of compensation carbohydrate metabolism, the level of self-control and the presence of comorbid thyroid gland pathology. Common adverse factors included manifestation of type 1 diabetes in childhood and in the early stages of puberty; the use of short-acting and long-acting human insulins; insufficient or excessive dose of exogenous insulin during puberty; unsatisfactory level of compensation of carbohydrate metabolism with high variability glycaemia during the day and low indicators of the duration of stay in the target range state; low level of diabetes self-control and lack of devices for monitoring of blood glucose; presence of thyropathy with signs thyroid insufficiency. Conclusions. The possibility to predict the course of puberty in an individual patient is the basis for the development of an individual preventive and therapeutic program, aimed at preserving the reproductive potential and social adaptation of adolescents with type 1 diabetes.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139288077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus associated with cystic fibrosis. Clinical cases","authors":"K. Khromykh, T.V. Poteeva, I. V. Chyhir","doi":"10.30978/ujpe2023-2-23","DOIUrl":"https://doi.org/10.30978/ujpe2023-2-23","url":null,"abstract":"Cystic fibrosis is one of the most prevalent orphan monogenic diseases (one case per 2500 newborns). The disease is characterized by violation of the chlorine transport from a cell and an increase in sodium absorption into a cell, which results in the decreased water content in the secretions of all exocrine glands. The reduced volume of periapical epithelial fluid prevents proper mucociliary clearance, and increased sodium chloride concentration and altered pH of fluid decreases enzymatic activity. The most widespread complications of cystic fibrosis are diabetes mellitus, diseases of kidneys and bones, syndrome of distal intestinal obstruction, gastroesophageal reflux disease and depression. Complication of diabetes mellitus develops in about 80 % of patients with cystic fibrosis under 40 years. Diabetes mellitus associated with cystic fibrosis is one of the diabetes forms that require an approach with involvement of multidisciplinary team.Usually, the manifestation and course of diabetes are asymptomatic. Clinical manifestations of diabetes associated with cystic fibrosis in pediatric patients may include constant feeling of fatigue, loss of body weight in the absence of changes in nutrition, delay in physical or sexual development.The authors present clinical cases of diabetes mellitus in patients with cystic fibrosis and perform a comparison of the onset and subsequent course of diabetes, associated with cystic fibrosis, on the example of two pediatric patients.All patients with cystic fibrosis require conduction of screening tests to reveal hyperglycemia, starting from an early school age. The only method to treat diabetes mellitus associated with cystic fibrosis is insulin therapy with the continuation of hypercaloric nutrition and constant monitoring of not only glycemia indices, but also parameters of physical and sexual development, indicators of the function of external respiration, lipid profile, etc.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114528162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric characteristics and indicators of protein-­energy metabolism in adolescent girls with dynamic physical activity","authors":"Vitalii Muzhanovskyi, L. Rak","doi":"10.30978/ujpe2023-2-16","DOIUrl":"https://doi.org/10.30978/ujpe2023-2-16","url":null,"abstract":"Objective — to study the anthropometric characteristics of adolescent girls 12—18 years old, engaged in the have dynamic physical activity, and to determine the indicators of their protein-energy metabolism. \u0000Materials and methods. Examinations involved 37 girls aged 12—18, who were engaged in the dynamic sports 3­4 times a week for 3—8 years. The comparison group included 34 practically healthy girls of the same age with similar weight and height parameters who were physically inactive. All girls were examined by a pediatrician, an endocrinologist, a gynecologist, and a psychiatrist. The following anthropometric parameters were examined: height, body weight, shoulder width, arm length, arm span, chest girth, leg length, waist circumference, hip circumference, body mass index was calculated. The concentration of urea in blood serum was determined by the fluorometric method, the levels of creatinine, lactate, activity of lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase and creatine kinase in the blood serum were determined by the photometric method. The blood analysis of female athletes was carried out after two days of rest after training. Statistical processing of data was carried out with the help of Exсel, SPSS, Statgrafics programs. \u0000Results and discussion. Low physical activity of adolescent girls was associated with a higher risk of primary dysmenorrhea (OR 3.75; CI 95 %) and the presence of gallbladder folds and deformities (OR 2.34; CI 95 %). No significant differences were revealed in the anthropometric characteristics of the girls with different physical activity. This may indicate the physiological nature of their training regime. Underweight of girls was 1.31 times more likely to be associated with sports (risk ratio (RR) 1.31; CI 95 %), and overweight was 1.45 times more common in adynamic teenagers (RR 1.45; CI 95 %). Levels of urea, creatinine, lactate, activity of ALT, LDH, creatine kinase were significantly higher in group of athletically active girls aged 12—14 than in group of inactive ones, and for athletic girls aged 15—18, the higher levels of alanine aminotransferase and lactate dehydrogenase were noticed. \u0000Conclusions. Engagement in the dynamic sports three times a week during 3­8 years does not lead to significant changes in the anthropometric characteristics of adolescent girls compared to physically inactive ones. Sports girls have higher levels of urea, creatinine, lactate, LDH, ALT and creatine kinase, which indicates the intensity of muscle work and the activation of protein­-energy metabolism.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128239945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical manifestations of peripheral vegetative insufficiency in children and adolescents with type 1 diabetes mellitus (retrospective and prospective investigations)","authors":"E. Mykhailova, D. Mitelov","doi":"10.30978/ujpe2023-2-11","DOIUrl":"https://doi.org/10.30978/ujpe2023-2-11","url":null,"abstract":"The variety of complications of type 1 diabetes mellitus (DM) in children and adolescents are often observed in clinical practice. Among them, damage to the central and peripheral nervous system prevails. The term «peripheral vegetative insufficiency» (PVI) refers to a complex of vegetative manifestations that occur in the peripheral (segmental) part of the VNS against the DM background. \u0000Objective — to determine the clinical typology of PVN in children with type 1 DM during the period of the years 1980—1990 (retrospective investigation) and in the period of the years 2012—2022 (prospective study). \u0000Materials and methods. The study was conducted on the basis of the Department of Endocrinology of the SI «Institute of Child and Adolescent Health of the NAMS of Ukraine». Examinations involved 605 pediatric patients: 285 patients (126 children and 159 adolescents) in the retrospective study, and 320 subjects (186 children and 134 adolescents) in the group of prospective study. All patients underwent somatic, neurological, and clinical examinations. \u0000Results and discussion. It haі been determined that in children and adolescents with type 1 diabetes mellitus, PVI clinical manifestations were present in all physiological body systems and often occur under the mask of various somatic diseases. The most typical PVI clinical syndromes in pediatric patients with DM included orthostatic hypotension, tachycardia at rest, hypohidrosis, gastroparesis, constipation, and urinary incontinence. The incidence of PVI syndromes in the groups of patients in the prospective study (years 2012-2022) was lower than in the retrospective study (years 1980—1990) owing to the use of the novel technologies for the DM treatment. \u0000Conclusions. The labile, severe course of type 1 diabetes mellitus in children often triggers the development of autonomic disorders, which are predictors and manifestations of neurological disorders. As the overall duration of the disease increases and carbohydrate metabolism is not compensated properly, the number of functional organic neurological complications increases. Damage to immature brain structures affects their further development and forms the basis for the long-term neurological complications in older age.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122219649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric endocrinology in Ukraine for 2002—2022 years","authors":"N. Zelinska","doi":"10.30978/ujpe2023-2-4","DOIUrl":"https://doi.org/10.30978/ujpe2023-2-4","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129488639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain natriuretic peptide and catecholamines in adolescents with juvenile idiopathic arthritis","authors":"T. Holovko, L. Bogmat, N. Shevchenko, D. Kashkalda, O. Tsura","doi":"10.30978/ujpe2023-1-16","DOIUrl":"https://doi.org/10.30978/ujpe2023-1-16","url":null,"abstract":"Juvenile idiopathic arthritis is a group of chronic diseases of uncertain etiology, in which an immuno­inflammatory process develops with systemic damage to the vascular endothelium, leading to the involvement of vital organs and systems against the background of persistence of the inflammatory process. \u0000Objective — to determine the level of excretion of catecholamines in the daily urine and natriuretic peptide in the blood of adolescents with juvenile idiopathic arthritis. \u0000Materials and methods. The study involved 56 patients with juvenile idiopathic arthritis, aged (13.28 ± 0.38) years, including 17 boys, 39 girls. The polyarticular form of the disease was diagnosed in 48 patients (86 %), the oligoarticular form was in 8 (14 % of patients). The duration of the disease was (68.96 ± 6.29) months (from 12 to 180 months). All patients received methotrexate for more than 12 months, the average dose of which was (11.73 ± 0.39) mg/m2 per week. The control group consisted of 46 (27 boys and 19 girls) practically healthy peers (14.72 ± 0.28) years. The content of catecholamines (adrenaline and norepinephrine) in daily urine was studied by iodine oxidation with the formation of fluorescent trihydroxyindoles (adrenolutin and norepinephrine) and subsequent fluorimetry, as well as the level of brain natriuretic peptide in the blood by competitive immunoassay. \u0000Results and discussions. In patients with juvenile idiopathic arthritis, the level of excretion of catecholamines in the daily urine remains within the age norms, but significantly lower than in healthy peers (p < 0.01), the adrenaline/norepinephrine ratio also decreases (p < 0.05). A significant increase in the level of brain natriuretic peptide in the blood was found in patients with juvenile idiopathic arthritis (p < 0.01), especially in children aged 11—14 years and disease duration up to 5 years (p < 0.05). \u0000Conclusions. The change in the ratio of catecholamine excretion and blood natriuretic peptide level determines the processes of formation of morphofunctional disorders of the cardiovascular system in children with juvenile idiopathic arthritis.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133891381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between comorbid pathology, vitamin D status, and disorders of menstrual function in adolescent girls","authors":"V. Dynnik, O.G. Verchoshanova, H. Havenko, S. Novokhatska","doi":"10.30978/ujpe2023-1-4","DOIUrl":"https://doi.org/10.30978/ujpe2023-1-4","url":null,"abstract":"Objective — to determine the nature of comorbid pathology in modern adolescent girls with disorders of menstrual function, and to establish the relationship between vitamin D status and comorbid pathology. \u0000Materials and methods. The analysis has been performed for the results of clinical and paraclinical examination of 333 adolescent girls aged 11—17 with menstrual disorders (primary oligomenorrhea and abnormal uterine bleeding). Physical and sexual development was determined, body mass index was calculated. The serum levels of vitamin D, prolactin, thyroid­stimulating hormone were evaluated. \u0000Results and discussion. Comorbid pathology was diagnosed in the absolute majority of adolescent girls with disorders of menstrual function, both of abnormal uterine bleeding (AUB) and oligomenorrhea (OM) types. Diseases of the endocrine system were registered mostly often; digestive pathologies and neuropsychological abnormalities were less common. In patients with OM, comorbid conditions of the digestive system and the neuropsychological area were registered significantly more often. Peculiarities of physical, sexual development, and menstrual function were established, which depended on the presence of various comorbid pathologies and the type of menstrual function disorders. Vitamin D insufficiency and its deficiency were observed in the majority of girls with both AUB and OM, and no significant difference was found in various comorbid pathologies. Normative values of vitamin D were noted in no more than 12—18 % of cases and tended to decrease in presence of the diseases of endocrine system. \u0000Conclusions. The obtained results demonstrated the importance of a multidisciplinary approach to the examination of patients with menstrual cycle disorders, as a guarantee of increasing the effectiveness of treatment and preventive measures with the aim of restoring reproductive potential.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130514616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}