Ukrainian Journal of Pediatric Endocrinology最新文献

{"title":"Cytogenetic features in adolescent girls with abnormal uterine bleeding which is comorbid with multi­factor diseases","authors":"N. Bagatska","doi":"10.30978/ujpe2023-1-11","DOIUrl":"https://doi.org/10.30978/ujpe2023-1-11","url":null,"abstract":"Objective — to study the state of chromosomal apparatus in adolescent girls with abnormal uterine bleeding which is comorbid with multi-­factor diseases. \u0000Materials and methods. Cytogenetic analysis has been carried out in 25 girls aged 14 to 17 with abnormal uterine bleeding (AUB) which is comorbid with multifactor diseases (endocrine and nervous). The comparison group included 25 age-matching healthy girls. All the girls have been examined in the Laboratory of Medical Genetics of the Institute. Statistical processing of the study results has been carried out following the Student’s t­test with the use of Excel software package. \u0000Results and discussion. According to the data of cytogenetic analysis, it has been established that the total level of chromosome aberrations in blood lymphocytes of sick girls constituted 5.44 % and exceeded this value by a factor of 2.2 in comparison with the frequency in healthy girls. A 1.8-­fold increase of the number of chromosome aberrations was observed; among them the paired acentric fragments have been recorded twice as often. Chromatid­type aberrations in blood lymphocytes were observed in 2.9 times oftener in girls with AUB, mainly due to an increase in the number of single acentric fragments. The frequency of genomic disorders was 0.60 % that is five times more than their frequency in blood lymphocytes of healthy girls. \u0000Conclusions. Cytogenetic analysis conducted in adolescent girls with abnormal uterine bleeding and comorbid pathology have revealed an increase of the overall level of chromosome aberrations in comparison with healthy girls. Paired acentric fragments prevailed among chromosome aberrations, single acentric fragments prevailed among chromatid-­type aberrations, polyploid cells prevailed among genomic disorders.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"366 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125623089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and nature of thyroid pathology in children and adolescents with type 1 diabetes mellitus and its influence on sexual development","authors":"T. Kostenko","doi":"10.30978/ujpe2022-3-4-21","DOIUrl":"https://doi.org/10.30978/ujpe2022-3-4-21","url":null,"abstract":"Objective — to assess the frequency and nature of thyroid gland pathology in children and adolescents with type 1 diabetes mellitus (DM 1) and to determine its impact on somatic and sexual development. \u0000Materials and methods. Investigation involved 117 children and adolescents with DM 1, aged from 9 to 18 years (54 boys and 63 girls), who were under observation in the clinic of the Institute of Children and Adolescents Health Care. All children underwent thyroid gland (TG) ultrasound examination. The assessments included physical and sexual development of patients, the state of carbohydrate metabolism according to the glycosylated hemoglobin (HbA1c) levels. Creation of the database and statistical processing of the results were carried out using the packages of Microsoft Excel and SPSS 17.0 statistical methods. \u0000Results and discussion. Thyropathies were diagnosed in 41.0 % of DM 1 patients (from the, 20.5 % had diffuse nontoxic goiter, 17.1 % autoimmune thyroiditis (AIT), 3.4 % nodules, cysts). AIT was mostly often determined in girls (22.2 %), and diffuse nontoxic goiter in boys (31.5 %). Among boys with harmonious physical development, 51.6 % had thyroid pathology. In case of sexual development abnormalities, almost half of girls (46.7 %) and a third of boys (33.3 %) had thyropathies. Thyropathies were significantly more often identified in adolescents with the DM 1 onset in childhood (71.4 %) and early puberty (80.0 %), duration of diabetes from 5 to 10 years (48.3 %), and suboptimal compensation (63.3 % in boys and 50.0 % in girls). \u0000Conclusions. The high frequency of thyroid pathology has been established among children and adolescents in whom DM 1 developed at the age of 4—5 years (71.4 %). It has been shown that the increased AIT risk exists in both girls and boys. A significant percentage of thyropathies among children in the early puberty period (80.0 %) was established. The obtained results confirmed the need for careful monitoring of the thyroid gland in children and adolescents with DM1, especially in the period of puberty.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122345056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotonin levels in adolescents with obesity and non­alcoholic fatty liver disease","authors":"L. Strashok, M. Khomenko","doi":"10.30978/ujpe2022-3-4-27","DOIUrl":"https://doi.org/10.30978/ujpe2022-3-4-27","url":null,"abstract":"The prevalence of obesity has reached epidemic proportions not only among adults, but also in the pediatric population. Expectedly the number of obesity-associated diseases, including non­alcoholic fatty liver disease (NAFLD) etc., increases, too. The pathogenesis of these conditions has common links, some of them are well known, others are being investigated. The latter include hormones of the gastrointestinal tract. They are considered as a part of the body’s humoral regulation. These compounds regulate energy balance of a body, and insulin resistance. It is assumed they can affect obesity and NAFLD pathogenesis. \u0000Objective — to determine serotonin levels in adolescents with obesity and NAFLD. \u0000Materials and methods. An examination of 108 adolescents aged 12—17 years with obesity (55 boys and 53 girls) was carried out. The control group consisted of 32 healthy adolescents (18 boys and 14 girls). Depending on the hepatobiliary pathology all patients were divided into two groups: 1st group included 29 (26.9 %) adolescents with functional disorders of the biliary tract (FDBT), and 2nd group consisted of 79 patients (73.1 %) with NAFLD and FDBT.All patients underwent a comprehensive clinical and anamnestic examination, clinical and biochemical blood tests, including determination of the levels of γ-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), total bilirubin and its fractions, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), atherogenic coefficient (AC) value. Levels of fasting glucose and immunoreactive insulin (IRI), HOMA-IR index, and blood serotonin level were also determined. An ultrasound examination of the abdominal cavity was performed. \u0000Results and discussion. According to the clinical and anamnestic data, there were no differences between the groups of adolescents with obesity, depending on the existing hepatobiliary pathology, except for a higher value of the WC/Height in patients with NAFLD and FDBT (p < 0.01). The results of laboratory investigations demonstrated that in patients with NAFLD and FDBT, compared to patients with FDBT, the following parameters were higher: fasting glucose level (p < 0.05), IRI (p < 0.01), the value of the HOMA-IR index and the frequency of its increase (p < 0.01), levels of ALT and AST activity (p < 0.05), the levels of triglycerides and VLDL-­C (p < 0.05). The level of serotonin was higher in the group of patients with NAFLD and FDBT compared to the control group (p < 0.015). \u0000Conclusions. Adolescents with obesity, accompanied by NAFLD and FDBT, had higher rates characterizing abdominal obesity, carbohydrate and lipid metabolism, liver enzyme activity compared to patients with FDBT. Serotonin levels were higher in the group of patients with NAFLD and FDBT compared to the control group.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123670466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 diabetes mellitus in children and adolescents: risk factors","authors":"N. Bagatska, L. Glotka","doi":"10.30978/ujpe2022-3-4-16","DOIUrl":"https://doi.org/10.30978/ujpe2022-3-4-16","url":null,"abstract":"Objective — to study the risk factors for the formation of type 1 diabetes mellitus (DM 1) in children and adolescents. \u0000Materials and methods. Genealogical analysis was carried out in families of 70 children and adolescents with DM 1 of both genders, aged 8 to 18 years, who were examined in the Institute of Children and Adolescents Health Care of the NAMS of Ukraine. The comparison group consisted of pedigrees of 82 healthy peers, residents of Kharkiv and Kharkiv region. The collection of pedigrees was carried out by the generally accepted method. Statistical processing of the obtained data was carried out using the Student’s criterion in the Excel application package. \u0000Results and discussion. Based on genealogical analysis, the predominance of the following endogenous and exogenous factors in families of DM 1 patients was revealed when compared to the similar factors in families of healthy probands: stress before pregnancy and pathological course of childbirth in mothers; tobacco smoking in fathers; artificial feeding, stress, bad habits, surgical interventions, additional load in children. Among the different categories of relatives of DM 1 patients, endocrine diseases prevailed in mothers compared to fathers, in grandmothers in comparison with grandparents and aunts versus uncles. It was determined that 2.9 % of families of patients had hereditary burden for DM 1, 51.4 % of families for type 2 DM, and 4.3 % of families for both type 1 and type 2 diabetes. Relatives of probands with type 1 diabetes demonstrated prevalence of endocrine, cardiovascular, mental and oncological diseases and pathology of the digestive system compared to the frequency of these diseases in relatives of healthy peers. \u0000Conclusions. According to the results of the research, endogenous and exogenous risk factors, and family accumulation of multifactorial diseases (endocrine, cardiovascular, mental and oncological diseases and pathologies of the digestive system) in the pedigrees of children and adolescents with type 1 diabetes have been established.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131499537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of the development of the Department of Endocrine Pathology and Puberty: directions of scientific research, personnel training, prospects","authors":"S. Turchina","doi":"10.30978/ujpe2022-3-4-6","DOIUrl":"https://doi.org/10.30978/ujpe2022-3-4-6","url":null,"abstract":"","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133057643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative balance disorders as a factor of formation and progression of hypoandrogenism in boys","authors":"N. Bagatska, I. Demenkova, V. Volosova","doi":"10.30978/ujpe2022-1-2-17","DOIUrl":"https://doi.org/10.30978/ujpe2022-1-2-17","url":null,"abstract":"Objective — to study the features of the phenotype of adolescent boys with hypoandrogenism and hereditary burdened disorders of the reproductive system.\u0000Materials and methods. The analysis of pedigrees was carried out in 45 families of adolescent boys 12—17 years old with hypoandrogenism (HA) and burdened family history of reproductive system disorders, which were examined in the laboratory of medical genetics of the State Institution «CAHC NAMS». The control group consisted of 47 families of healthy peers, residents of Kharkiv and Kharkiv region.The presence of minor developmental anomalies (MDA) was assessed in adolescent boys with HA. The comparison groups consisted of adolescent boys with systemic connective tissue dysplasia (CTD) and healthy adolescent boys with normal physical and sexual development, examined by specialists of the institute. Mathematical calculations were carried out using statistical programs Excel and SPSS Statistics 17.0. To determine the significance of differences between the groups, the Student’s t-test was used. To assess the likelihood of sexual dysfunction development in younger family members, the odds ratio indicator was calculated.\u0000Results and discussion. Hereditary burden on reproductive system disorders was registered in 66.7 % of families of adolescent boys with HA. Inheritance of pathological traits in generations was observed with the same frequency in the paternal (33.7 %), maternal (30.0 %) and both (paternal and maternal) lines simultaneously (36.2 %). Fathers of boys had delayed sexual development in puberty twice as often as mothers (26.7 vs 13.3 %, p < 0.05), and four times more often in comparison with the frequency in the population (2.5—9.8 %). In the presence of hereditary burden on reproductive diseases, the risk of development of sexual development disorders in other relatives increased in 21.5 times.Assessment of phenotype of adolescent boys with HA showed that 65.0% of patients had an average level of minor developmental abnormalities (from 7 to 10 MDA); high level (more than 14 MDA) was not observed. The majority of MDA were revealed in the craniofacial zone (57.3 %). When compared with healthy peers, boys with HA more often had average and elevated MDA levels. Patients with HA in comparison with boys with MDA less often demonstrated the dysmorphic auricles, spinal deformity, dysplastic tooth growth, up-slanting palpebral fissures and ocular hypertelorism, and more often the sandal gap.\u0000Conclusions. The findings indicate the familial accumulation of reproductive system disorders and increased risk of these disorders development in other children in these families. Among the examined adolescent boys with HA, 65.0 % had an average level of minor developmental abnormalities and an unclassified phenotype, which may indicate a lower severity of connective tissue dysplasia in the patient group.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131699766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipodystrophy in children with type 1 diabetes mellitus and variability of glycemia","authors":"S. Chumak","doi":"10.30978/ujpe2022-1-2-26","DOIUrl":"https://doi.org/10.30978/ujpe2022-1-2-26","url":null,"abstract":"Objective — to optimize the prevention of complications of type 1 diabetes mellitus (DM 1) by diagnosing and preventing insulin­induced lipodystrophy (LD) and studying the effects of injection technique on glycemic variability.\u0000Materials and methods. The study included 235 patients with DM 1 aged 6—17 years (mean age 13.6 years) who were treated in the Department of Endocrinology of the Institute of Health Protection of Children and Adolescents NAMS of Ukraine. From them there were 125 (53.2 %) boys and 110 (46.8 %) girls. The mean DM 1 duration was 5.5 years (1 to 12 years). Patients were divided into two groups: the first consisted of 183 patients with LD (77.9 %), the second group included 52 children without LD (22.2 %). The groups were comparable in the compensation degree, DM duration and gender ratio. The LD was detected visually, by palpation, as well as according to the ultrasound examination (US) of the subcutaneous adipose tissue (SAT) of 385 insulin injection sites using the developed LD screening map. Blood circulation was investigated in the injured sites of SAT. In patients with LD and without it, the glycemic control parameters were calculated taking into account the coefficient of variability (CV) and time when glucose levels corresponded to the target range (time­in­range (TIR)). In case of detection of the pathologically altered SAT, a patient was introduced to the injection technique using short needles (4-5 mm) and indicated the places allowed for insulin injection. The clinical examinations and SAT ultrasound examinations were repeated in 6 months.\u0000Results and discussion. After 6 months, the high glycemia variability was revealed in 70 % of patients with LD (CV = 59.5 vs 38.2 %) and lower TIR parameters (TIR = 35.9 vs 55.7 %). TIR values correlated with HbA1c, and variability (CV) levels with the incidence of hypoglycemia and TBR, which was higher in patients with LD. That is 59.3 % of patients with HbA1c to 8.5 % had this figure greater than 50 % (r = 0.017, p < 0.05). The analysis of ultrasonic data from 385 injection sites revealed LD in 78 % of pediatric patients. The presence of various LD forms, caused by violations of injection technique, has been confirmed.\u0000Conclusions. With the help of ultrasound examinations of insulin injection sites, early diagnosis of the area of the lesion and the form of LD is possible, which additionally motivated 88 % of patients to follow the rules of insulin administration. It has been proven that timely diagnosis, training and implementation of the correct injection technique resulted in the leveling of the diffuse and mixed LD forms in the majority of patients (62 %). The most important risk factors for the development of insulin induced LD is a violation of injection techniques, namely: insufficient rotation of injection sites, injection of insulin into LD sites, small area of injection site, untimely change and excessive length of needles, namely the use of needles longer than 4—5 mm t","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114874703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diseases of the endocrine system in children in Ukraine and specialized care to pediatric patients in 2021","authors":"N. Zelinska, N. Rudenko, E. Globa, O. Rudenko","doi":"10.30978/ujpe2022-1-2-6","DOIUrl":"https://doi.org/10.30978/ujpe2022-1-2-6","url":null,"abstract":"The article provides information on the specialized medical care to children of various ages with endocrine pathology in Ukraine in the year 2021 and presents analysis of its dynamics over the past 8—10 years, based on the data of the official statistics of the Ministry of Health of Ukraine and Ukrainian databases of children with the rare (orphan) endocrine diseases. Information is provided on the provision of pediatric endocrinologists in various regions of Ukraine, the state of inpatient care by region, the indicators of neonatal screening for congenital hypothyroidism and congenital adrenal hyperplasia, and the incidence of endocrine pathology in children under 1 year of age.The article contains data on the dynamics of the prevalence of diabetes mellitus (DM) in children, its various types, malignant diseases of the endocrine glands, in particular thyroid cancer, a database of children with disorders of sexual differentiation (DSD), etc.It is noted that according to the register of children with DM in 2021, 11 193 patients under the age of 18 (15.0 per 10,000 child population) were registered, including 11 014 (14,74) children receiving insulin therapy (with DM type 1, other types of DM with the need for insulin treatment), 51 with DM type 2, 69 children with neonatal DM, of which the diagnosis was genetically confirmed in 40, and MODY was genetically confirmed in 59 children. The prevalence of DM among children aged 0—18 in 2021 increased by 46.2 % compared to 2012. The fastest growing prevalence and incidence of diabetes was among children under 6 years of age.Children with DSD undergo a detailed cytogenetic examination in the world’s leading genetic laboratories by specialists of the Department of Pediatric Endocrinology of the Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine. The database included 682 DSD patients, in particular with chromosomal DSD — 357 (52.3%, in particular 303 patients with Turner syndrome); 46, XY DSD — 119 patients (17.5%); 46,XX — 206 patients (30.2%) (of which 185 patients with DSD due to congenital adrenal hyperplasia).","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126663728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative balance disorders as a factor of formation and progression of hypoandrogenism in boys","authors":"Y. Volkova, K. Sharun, L. L. Sukhova, H. Kosovtsova, S. Turchina, D. Kashkalda","doi":"10.30978/ujpe2022-1-2-21","DOIUrl":"https://doi.org/10.30978/ujpe2022-1-2-21","url":null,"abstract":"Objective — to study the features of the state of oxidative balance (processes of free radical oxidation and antioxidant protection) in boys with hypoandrogenism (HA).\u0000Materials and methods. Examinations involved 103 adolescent boys agreed 14 to 17 years with the delayed sexual development. Serum levels of total testosterone (TT), conjugated dienes (CD), thiobarbituric acid­reactive substance (TBARS), carbonylated proteins, reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activity were determined. The coefficient of oxidative stress was calculated.\u0000Results and discussion. The following indicators have been revealed in patients with the delayed sexual development vs the comparison group: increased CD levels in 84.0 % of patients, elevated levels of carbonylated proteins in 53.7 % of adolescents, one third had raised TBARS levels; 63.0 % of patients demonstrated the increased GSH levels. Decreased activity of GPx and CAT was registered in more than half of the patients. Such changes indicate an imbalance in the ratio of free radical oxidation (FRO) and antioxidant protection, which leads to the state of OS in adolescents with delayed puberty.It was found that the redox balance in adolescents with delayed puberty significantly depends on the degree of androgen deficiency. Half of the patients with a degree I and II HA and 24.5 % of boys with degree III HA had elevated TBARS levels, which is more common in adolescents with normative values of TT. At the highest degree of androgen deficiency, the frequency of normative values of carbonylated proteins decreased. Most boys had elevated levels of CD (80 %), regardless of the degree of HA. An increase in SOD activity was found in patients with degree III HA. Low SOD activity was registered in 28.6 % of patients with degree II HA and 29.6 % with degree III HA, which is much less common compared to patients with normal TT levels. Most patients with HA, regardless of degree, were characterized by low GPx activity. Decreased CAT activity was registered in 76.9 % of patients with degree II HA. The majority of patients with HA (from 60.9 to 90 %) showed elevated levels of GSH, regardless of degree. The progression of HA in adolescents is characterized by the accumulation of products of free radical oxidation of lipids and an imbalance in the enzymatic and low molecular parts of the antioxidant system. This is typical for HA II and III degrees. The largest number of correlations was found in patients with degree III HA, testifying the formation of oxidative stress due to the activation of lipid peroxidation with simultaneous tension of the antioxidant defense system.\u0000Conclusions. The progression of HA is accompanied by the accumulation of products of free radical oxidation of lipids with simultaneous depletion of the enzymatic part of the antioxidant defense system. The activating effect of testosterone deficiency on the formation of oxidative stress in adole","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"8 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120894606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health promotion and nutritional status of adolescents in a large industrial city","authors":"Н. Danylenko, O. H. Avdiievska","doi":"10.30978/ujpe2021-4-27","DOIUrl":"https://doi.org/10.30978/ujpe2021-4-27","url":null,"abstract":"Objective — substantiation of ways to improve the health of students of general secondary education on the basis of determining the nutrition status based on the body mass index (BMI) of adolescents in a large industrial city.Materials and methods. The study was based on a cross-section of a population survey, performed in the period from April to May, 2019, with the use of questionnaire (СС #92695-2019 «Methods for assessing the impact of close social environment on the subjective perception of adolescents’ own health»).Results. The study involved 1191 adolescents aged 11–16 years. Food consumption was estimated by frequency of consumption for one month; body mass index was assessed by WHO standard indicators of physical development (SDS). The following indices of daily consumption have been established: candies (8.03 ± 0.78) %, cakes, pastries (5.8 ± 0.68) %, meat (14.54 ± 1.02) %, sausages (7.62 ± 0.76) %, fish (2.61 ± 0.46) %, milk (11.21 ± 1.9) %, fresh vegetables (19.9 ± 1.15) %. fruits (19.45 ± 1.14) %, mayonnaise, sauces and ketchups (5.47 ± 0.65)%, «fast food» (1.12 ± 0.30)%, street food (steaks, hot dogs) (0.81±0.26)%, snacks (chips, crackers) (1.84 ± 0.38) %, dry pasta «Mivina» (1.43 ± 0.34) %. According to the BMI, (5.3 ± 0.64) % of adolescents had depletion of body weight (BMI <-2SDS); insufficient body weight (BMI <-1 to -2SDS) was registered in (13.6 ± 0.99) % of population; normal body weight (± 1 SDS) was defined in (77.8 ± 1.2) % of adolescents, excessive body weight (BMI from +1 to +2 SDS) in (2,7 ± 0,46) % and obesity (BMI> + 2SDS) in (0.58 ± 0.22) % of children.Conclusions. The priority should be given to promoting health and formation of healthy lifestyle skills among young people. One should pay more attention to the forms and methods of nutrition of children and adolescents, improve the technology of medical, psychological and pedagogical support, and provide recommendations to parents on maintaining good health and proper eating behavior.","PeriodicalId":243962,"journal":{"name":"Ukrainian Journal of Pediatric Endocrinology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132353653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}