IF 1.7 4区生物学

Zygote Pub Date : 2026-02-01 Epub Date: 2026-03-23 DOI: 10.1017/S0967199426100306

Gilad Karavani, Hiila Bauch, Natali Schachter-Safrai, Tal Imbar, Assaf Ban-Meir

{"title":"In vitro fertilization outcomes in young women and their association with male and female infertility aetiology.","authors":"Gilad Karavani, Hiila Bauch, Natali Schachter-Safrai, Tal Imbar, Assaf Ban-Meir","doi":"10.1017/S0967199426100306","DOIUrl":"10.1017/S0967199426100306","url":null,"abstract":"Infertility aetiology has been shown to be related to reproductive outcomes in the wide reproductive age range. The aim of this study was to examine young women in vitro fertilization (IVF) cycle outcomes according to age and infertility cause. This retrospective cohort study was comprised of 305 couples with a female partner aged 17-25 years with either male or female infertility that underwent a fresh IVF cycle between 2003 and 2020. Comparison according to age groups 17-22 years (n = 117) and 23-25 years (n = 188) showed similar outcomes, except for higher rates of 3 pronuclei (PN) embryos in the younger group. However, allocation to groups by infertility aetiology - male factor (MF) (n = 241) vs. female factor (FF) (n = 64) demonstrated lower fertilization rate in the FF vs. MF group (58% vs. 63%, p = 0.049) and higher percent of 1PN and 3PN embryos (0.7% vs. 0.2% and 0.7% vs. 0.1%, p < 0.001 for both). Chemical pregnancy and live-birth rate were significantly higher in the MF vs. FF group (48.9% vs. 29.5%, p = 0.02 and 41.9% vs. 11.0%, p = 0.038). The only parameter associated with live birth rate in a logistic regression analysis was male infertility aetiology (OR = 2.17, p = 0.038). Young couples undergoing IVF cycles due to female factor infertility have poorer reproductive outcomes compared to male factor-related infertility and higher rates of 1PN and 3PN embryos.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"4-11"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embryo morphokinetics and PGT-A outcomes in recurrent pregnancy loss cases. 反复流产病例的胚胎形态动力学和PGT-A结果。

IF 1.7 4区生物学

Zygote Pub Date : 2026-02-01 Epub Date: 2026-04-07 DOI: 10.1017/S0967199426100355

Tutku Melis Aygun, Gulcin Ozkara, Ipek Nur Balin Duzguner, Caroline Pirkevi Cetinkaya, Hakan Kadir Yelke, Yesim Kumtepe, Semra Yildiz, Serkan Selimoglu, Semra Kahraman, Tulay Irez

{"title":"Embryo morphokinetics and PGT-A outcomes in recurrent pregnancy loss cases.","authors":"Tutku Melis Aygun, Gulcin Ozkara, Ipek Nur Balin Duzguner, Caroline Pirkevi Cetinkaya, Hakan Kadir Yelke, Yesim Kumtepe, Semra Yildiz, Serkan Selimoglu, Semra Kahraman, Tulay Irez","doi":"10.1017/S0967199426100355","DOIUrl":"10.1017/S0967199426100355","url":null,"abstract":"Recurrent pregnancy loss (RPL) is a clinically important condition in women undergoing assisted reproductive technologies (ART). This study evaluated embryo morphology and morphokinetic parameters using time-lapse monitoring (TLM) and assessed embryo ploidy by preimplantation genetic testing for aneuploidy (PGT-A) in women with RPL compared with unexplained infertility (UEI) controls. A total of 190 patients (100 RPL, 90 UEI) and 1169 embryos (634 RPL, 535 UEI) cultured under TLM were analyzed. Clinical characteristics, embryo morphology, morphokinetics and ploidy status were compared between groups, and logistic regression was used to identify predictors of aneuploidy. The euploidy rate was significantly lower in the RPL group than in controls (43.5% vs. 52.3%, p = 0.018). Group-wise analysis of all embryos revealed differences in selected morphokinetic parameters (t9 and tSC; p < 0.05). However, morphokinetic timing of euploid embryos did not differ between groups, suggesting that accelerated development alone was not associated with chromosomal abnormality. Embryo morphology was the strongest predictor of aneuploidy in both cohorts. Notably, direct uneven cleavage was associated with a 3.4-fold increased risk of aneuploidy specifically in the RPL group. Although embryos from RPL patients showed relatively faster developmental kinetics, morphokinetic speed alone did not predict chromosomal competence. Instead, embryo quality remained the key determinant of aneuploidy, while the association between direct cleavage and aneuploidy highlights the potential clinical value of TLM when combined with PGT-A. These findings support a complementary role for TLM in embryo assessment in RPL patients.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"20-28"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid supplementation in donor cows (Bos taurus) improves embryo quality. 供体奶牛（Bos taurus）补充脂质可提高胚胎质量。

IF 1.7 4区生物学

Zygote Pub Date : 2026-02-01 Epub Date: 2026-03-27 DOI: 10.1017/S0967199426100331

Christopher Junior Tavares Cardoso, Ana Caroline Bini de Lima, Mirela Brochado Souza-Cáceres, Marcus Vinicius Moraes de Oliveira, Eriklis Nogueira, Fabiana de Andrade Melo Sterza

引用次数: 0

Ovarian stimulation with r-hFSH:r-hLH: a descriptive analysis of embryonic morphokinetic data. 用r-hFSH:r-hLH刺激卵巢：胚胎形态动力学数据的描述性分析。

IF 1.7 4区生物学

Zygote Pub Date : 2025-12-01 Epub Date: 2026-02-02 DOI: 10.1017/S0967199426100276

Edson Borges, Daniela Paes Almeida Ferreira Braga, Assumpto Iaconelli, Amanda Setti

{"title":"Ovarian stimulation with r-hFSH:r-hLH: a descriptive analysis of embryonic morphokinetic data.","authors":"Edson Borges, Daniela Paes Almeida Ferreira Braga, Assumpto Iaconelli, Amanda Setti","doi":"10.1017/S0967199426100276","DOIUrl":"10.1017/S0967199426100276","url":null,"abstract":"The objective of this study was to compare embryonic morphokinetic parameters and clinical outcomes of two controlled ovarian stimulation (COS) protocols in women of advanced maternal age (AMA): Pergoveris (r-hFSH:r-hLH, 2:1 ratio) versus r-hFSH monotherapy (GONAL-f). This retrospective, non-interventional descriptive study was conducted at a private university-affiliated IVF center and included 136 ICSI cycles performed in AMA patients between March 2019 and May 2020. Patients were grouped by COS protocol (GONAL-f, n = 64; Pergoveris, n = 72), and embryo morphokinetics and ICSI outcomes were extracted from the clinic's database; the main outcome was time to complete blastulation (tB, hours). Embryos from the Pergoveris group reached tB earlier than those from the GONAL-f group (mean 109.3 h vs 112.6 h), and all morphokinetic milestones occurred sooner with Pergoveris, alongside lower multinucleation rates at the 2-cell and 4-cell stages. Although blastocyst development was higher in the GONAL-f group, Pergoveris was associated with higher oocyte yield and maturity, higher implantation, clinical and ongoing pregnancy rates, and lower miscarriage and OHSS rates; Pergoveris cycles also required higher gonadotropin doses and longer stimulation. Overall, embryos from the r-hFSH:r-hLH group exhibited faster morphokinetic timings and improved implantation and pregnancy outcomes, and prospective studies are warranted to confirm these observations.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"295-307"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding early development: a detailed study of Clarias dussumieri (Valenciennes, 1840), a near-threatened catfish of the Western Ghats. 了解早期发展：对西高塞山脉一种濒临灭绝的鲶鱼Clarias dussumieri （Valenciennes, 1840）的详细研究。

IF 1.7 4区生物学

Zygote Pub Date : 2025-12-01 Epub Date: 2026-02-18 DOI: 10.1017/S0967199426100288

Sarath Varghese, Charan Ravi, Neethu Z, Abhilash C P, Saikrishnan K R, Chandana B L, Ajith Kumar T T, Uttam Kumar Sarkar, Basheer V S

{"title":"Understanding early development: a detailed study of Clarias dussumieri (Valenciennes, 1840), a near-threatened catfish of the Western Ghats.","authors":"Sarath Varghese, Charan Ravi, Neethu Z, Abhilash C P, Saikrishnan K R, Chandana B L, Ajith Kumar T T, Uttam Kumar Sarkar, Basheer V S","doi":"10.1017/S0967199426100288","DOIUrl":"10.1017/S0967199426100288","url":null,"abstract":"The study documents the embryonic and larval development of Clarias dussumieri, a Near-Threatened, cultivable, and highly valued food fish endemic to the Western Ghats. Induced breeding facilitated detailed observation of developmental stages using light microscopy. Unfertilized eggs measured 1.5 ± 0.02 mm in diameter and enlarged to 1.7 ± 0.10 mm after fertilization (∼13% increase). The first cleavage occurred at 00:36 ± 00:02 h, reaching 64 cells by 01:35 ± 00:06 h. Epiboly progressed from 30% at 03:20 ± 00:10 h to 50% at 04:30 ± 00:05 h and 90% at 05:50 ± 00:10 h; neurulation was evident by 07:40 ± 01:10 h and somites by 11:08 ± 01:26 h. The first heartbeat appeared during the pharyngula period (17:25 ± 01:30 h), and hatching occurred at 25:30 ± 01:30 h at 26-27°C. Hatched larvae were 4.2 ± 0.02 mm total length, observed few melanophores by 12 h, conspicuous eye pigmentation by 24 h, and body pigmentation spreading by day 2 (5.90 ± 0.04 mm).The yolk sac was fully absorbed by 72 ± 2.50 h post-hatching, marking the onset of exogenous feeding. By day 4 (pre-flexion), larvae reached 7.1 ± 0.02 mm; initial notochord flexion began around day 7 and post-flexion from day 10, with juvenile-like morphology evident by day 25 (15.27-17.80 mm). The standardized timelines and measurements provide a baseline for hatchery practice and conservation aquaculture of C. dussumieri, supporting protocol refinement for improving survival and growth under controlled conditions.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"323-336"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the impacts of COVID-19 infection and vaccination on the outcomes of assisted reproductive technology (ART) cycles. 评估COVID-19感染和疫苗接种对辅助生殖技术（ART）周期结果的影响

IF 1.4 4区生物学

Zygote Pub Date : 2025-12-01 Epub Date: 2025-12-22 DOI: 10.1017/S0967199425100245

Farzaneh Shamlou Ahmadi, Ashraf Moini, Arezoo Arabipoor, Zahra Zolfaghari, Bita Ebrahimi, Firouzeh Ghaffari

{"title":"Evaluation of the impacts of COVID-19 infection and vaccination on the outcomes of assisted reproductive technology (ART) cycles.","authors":"Farzaneh Shamlou Ahmadi, Ashraf Moini, Arezoo Arabipoor, Zahra Zolfaghari, Bita Ebrahimi, Firouzeh Ghaffari","doi":"10.1017/S0967199425100245","DOIUrl":"10.1017/S0967199425100245","url":null,"abstract":"This study aimed to evaluate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and inactivated virus vaccination on intracytoplasmic sperm injection (ICSI) outcomes in infertile couples. A retrospective case-control study was conducted at the Royan Institute from August 2020 to March 2022. The study included 90 couples in the COVID-19 infection phase and 31 in the vaccination phase. A total of 30 infected but unvaccinated couples were compared to a control group of 60 couples with no COVID-19 infection or vaccination history. Additionally, 31 couples underwent treatment before and after receiving the Sinopharm inactivated vaccine. Key variables analysed included sperm parameters (concentration, motility, progressive motility and morphology), ovarian parameters (antral follicle count, oocyte retrieval), embryological outcomes and pregnancy outcomes. SARS-CoV-2 infection significantly reduced sperm motility (P = 0.02) and progressive motility (P = 0.01) compared to controls. Sperm concentration and morphology showed non-significant declines. Post-vaccination analysis revealed similar but statistically insignificant changes in sperm parameters. Ovarian stimulation parameters and embryological outcomes remained unaffected by both infection and vaccination. Although biochemical, clinical pregnancy and live birth rates were lower among the infected group, these differences did not reach statistical significance (p = 0.16, 0.08 and 0.09). SARS-CoV-2 infection has been associated with impaired sperm progressive motility, which may negatively influence ICSI outcomes. In contrast, vaccination with an inactivated virus does not appear to impact fertility outcomes. These findings provide crucial guidance for physicians and infertile couples managing treatments during and after the pandemic, suggesting the need for extended recovery periods before ART procedures following COVID-19 infection.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"285-294"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between follicle size, oocyte chromatin compaction, and acquisition of meiotic and developmental competences in Nellore (Bos indicus) cattle. 内洛牛卵泡大小、卵母细胞染色质压实与获得减数分裂和发育能力的关系。

IF 1.7 4区生物学

Zygote Pub Date : 2025-12-01 Epub Date: 2026-02-04 DOI: 10.1017/S0967199425100269

Gisele Zoccal Mingoti, Maria Isabela Azeredo Silva, Giovana Nunes, Priscila Chediek Dall'Acqua, Cíntia Rodrigues da Silva, Nathalia Rocha-Frigoni, Beatriz Caetano da Silva Leão

{"title":"Relationship between follicle size, oocyte chromatin compaction, and acquisition of meiotic and developmental competences in Nellore (Bos indicus) cattle.","authors":"Gisele Zoccal Mingoti, Maria Isabela Azeredo Silva, Giovana Nunes, Priscila Chediek Dall'Acqua, Cíntia Rodrigues da Silva, Nathalia Rocha-Frigoni, Beatriz Caetano da Silva Leão","doi":"10.1017/S0967199425100269","DOIUrl":"10.1017/S0967199425100269","url":null,"abstract":"This study aimed to investigate the relationship between oocyte meiotic and developmental competences and antral follicle diameter on random days of estrous in naturally cycling zebu females (Nellore - a tropical Bos indicus breed). Immature oocytes recovered from early antral follicles (diameter of 0.5 to 2 mm) exhibited a higher percentage of intact transzonal projections, but lower viability, smaller diameter and a higher proportion of chromatin decondensation when compared to those recovered from mid- (diameter > 2 to 6 mm) and late antral follicles (diameter > 6 mm), demonstrating that oocytes recovered from early antral follicles lack meiotic and developmental competence. Immature oocytes recovered from mid- or late antral follicles were homogeneous in terms of morphology and size, in addition to exhibiting a high proportion of a pattern of chromatin configuration compatible with high developmental competence, which may help explain the better oocyte quality and improved performance of zebu donors in IVP programs. At the end of the in vitro maturation culture, the percentage of oocytes that completed meiotic maturation was higher when they were recovered from late antral follicles compared to mid antral follicles, although the rate of embryonic development to the blastocyst stage was similar. Our results demonstrated a relationship between the acquisition of competences during the final stages of oocyte growth and morphofunctional events, including the chromatin structure remodeling, but further research is needed to better characterize the functional differences in ovarian physiology between bovine breeds that may impact the oocyte developmental potential.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"308-315"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First reproductive record of Dekeyseria picta (Siluriformes: Loricariidae): insights into embryonic development plasticity. 图片Dekeyseria picta （siluriforma: loricariides）的第一个生殖记录：对胚胎发育可塑性的见解。

IF 1.7 4区生物学

Zygote Pub Date : 2025-12-01 Epub Date: 2026-02-10 DOI: 10.1017/S096719942610029X

Ruben Dario Morales-Gamba, Armando Ortega-Lara

{"title":"First reproductive record of Dekeyseria picta (Siluriformes: Loricariidae): insights into embryonic development plasticity.","authors":"Ruben Dario Morales-Gamba, Armando Ortega-Lara","doi":"10.1017/S096719942610029X","DOIUrl":"10.1017/S096719942610029X","url":null,"abstract":"This study describes the embryonic and larval development of the Atabapo butterfly pleco Dekeyseria picta under captive conditions. A total of 19 wild-caught adults (male-to-female ratio of 9:10) were maintained together in a single 1000-L tank operated with a recirculating aquaculture system (RAS), at approximately 26°C, under a controlled 12:12 h light-dark cycle. A total of 21 natural spawning events produced an average of 66.5 ± 2.43 spherical eggs with a mean diameter of 3.896 ± 0.022 mm, characterized by a yellow yolk and a strongly adhesive chorion. Embryonic development lasted between three and seven days, and hatched larvae were classified into five developmental phases. Early phases exhibited limited differentiation and weak pigmentation, whereas advanced phases showed visible eyes, increased pigmentation, and progressive yolk absorption. Heartbeat activity and tail movements were observed throughout all phases. The hatching rate was below 40%, likely influenced by differences in chorion rupture efficiency among embryos at distinct developmental stages. Two developmental strategies potentially contributing to embryonic plasticity were identified: (i) a diapause-like state in which embryos temporarily arrested development at early phases without yolk utilization while remaining responsive to stimuli, and (ii) delayed hatching, in which embryos remained within the chorion for up to seven days, allowing further larval development in a protected environment. These strategies may represent adaptive responses to rapidly fluctuating hydrological and environmental conditions characteristic of the natural habitat of the species and emphasize the role of aquaculture in advancing reproductive knowledge and conservation.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"316-322"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of laser-assisted thinning and laser-assisted drilling techniques on assisted reproductive outcomes. 激光辅助减薄和激光辅助钻孔技术对辅助生殖结果的影响。

IF 1.4 4区生物学

Zygote Pub Date : 2025-10-01 Epub Date: 2025-12-02 DOI: 10.1017/S0967199425100208

İbrahim Pala, Funda Gode

{"title":"The effect of laser-assisted thinning and laser-assisted drilling techniques on assisted reproductive outcomes.","authors":"İbrahim Pala, Funda Gode","doi":"10.1017/S0967199425100208","DOIUrl":"10.1017/S0967199425100208","url":null,"abstract":"Purpose: To compare the effect of two different assisted hatching laser protocols thinning assisted hatching laser (TAH) vs drilling of assisted hatching laser (DAH) and non-assisted hatching control group (NAC) on clinical pregnancy and live birth rates in frozen thawed cleavage stage embryo transfer cycles.Patients and methods: This study included 310 infertile patients who underwent frozen embryo transfer (FET) cycles from 2021 to 2022 at the ART Unit of the Medical Point Hospital of Izmir University of Economics, Izmir. Patients included in the study were those between 20 and 40 years of age, who had undergone frozen-thawed embryo transfer after 'freeze-all' protocols. The exclusion criteria were azoospermia and degenerated embryos. In TAH, laser thinning was performed by making 4-5 shots at a depth of 50% of the thickness of the zona pellucida (ZP). In DAH, the laser opening was made from the outer part of the ZP to the inner part. In the last group in NAC, assisted hatching was not performed. Clinical pregnancy and ongoing pregnancy rates were compared between the TAH, DAH and NAC cycles.Results: There was no difference in terms of the age of the woman, the BMI and the sperm parameters in the three groups. There were no statistical differences between the groups in terms of the number of oocytes, embryos and the quality of the transferred embryos. Clinical pregnancy in thinning assisted hatching laser (TAH), drilling of assisted hatching laser (DAH), non-assisted hatching control group (NAC) cycles (38% vs 39% vs 45% p = 0.842, respectively.), ongoing pregnancy (34% vs 32% vs 39%; p = 0.670, respectively.) and live birth rates (34% vs 29% vs 35,4%; p = 0.586, respectively) were similar in three groups.Conclusion: In conclusion, no significant differences were found between the TAH, DAH and NAC groups in terms of ART outcomes.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"251-256"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles revolutionizing animal reproductive biotechnology: a review. 细胞外囊泡革新动物生殖生物技术：综述。

IF 1.4 4区生物学

Zygote Pub Date : 2025-10-01 Epub Date: 2025-12-15 DOI: 10.1017/S0967199425100233

Roberto Mendes Júnior, Agostinho Soares de Alcântara Neto, Lucy Vanessa Sulca Ñaupas, Deborah de Melo Magalhães Padilha, Ana Paula Ribeiro Rodrigues

{"title":"Extracellular vesicles revolutionizing animal reproductive biotechnology: a review.","authors":"Roberto Mendes Júnior, Agostinho Soares de Alcântara Neto, Lucy Vanessa Sulca Ñaupas, Deborah de Melo Magalhães Padilha, Ana Paula Ribeiro Rodrigues","doi":"10.1017/S0967199425100233","DOIUrl":"10.1017/S0967199425100233","url":null,"abstract":"Extracellular vesicles (EVs) are implicated in various functions within the complex mechanisms of intercellular communication. There are several subpopulations of EVs, including apoptotic bodies, microvesicles and exosomes. These nanovesicles are capable of transferring functional proteins and genetic information to alter the phenotype and function of recipient cells. In animal reproduction, numerous studies have demonstrated that EVs are actively involved in the regulation of different physiological events, modulating a variety of processes such as follicular development, spermatogenesis, oocyte maturation, fertilization and embryo development, with results indicating improved gamete quality, embryo development and cryotolerance. Additionally, EVs show therapeutic potential in restoring reproductive function and supporting maternal-embryonic communication in both domestic and wild species. Therefore, the present review aimed to describe the main studies conducted using EVs in the field of animal reproduction, highlighting their biological relevance, experimental applications and future prospects for clinical implementation in assisted reproductive technologies.","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"237-250"},"PeriodicalIF":1.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145757777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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