Extracellular vesicles revolutionizing animal reproductive biotechnology: a review.

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Zygote Pub Date : 2025-10-01 Epub Date: 2025-12-15 DOI:10.1017/S0967199425100233

Roberto Mendes Júnior, Agostinho Soares de Alcântara Neto, Lucy Vanessa Sulca Ñaupas, Deborah de Melo Magalhães Padilha, Ana Paula Ribeiro Rodrigues

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are implicated in various functions within the complex mechanisms of intercellular communication. There are several subpopulations of EVs, including apoptotic bodies, microvesicles and exosomes. These nanovesicles are capable of transferring functional proteins and genetic information to alter the phenotype and function of recipient cells. In animal reproduction, numerous studies have demonstrated that EVs are actively involved in the regulation of different physiological events, modulating a variety of processes such as follicular development, spermatogenesis, oocyte maturation, fertilization and embryo development, with results indicating improved gamete quality, embryo development and cryotolerance. Additionally, EVs show therapeutic potential in restoring reproductive function and supporting maternal-embryonic communication in both domestic and wild species. Therefore, the present review aimed to describe the main studies conducted using EVs in the field of animal reproduction, highlighting their biological relevance, experimental applications and future prospects for clinical implementation in assisted reproductive technologies.

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细胞外囊泡革新动物生殖生物技术：综述。

细胞外囊泡（EVs）在细胞间通讯的复杂机制中具有多种功能。ev有几个亚群，包括凋亡小体、微囊泡和外泌体。这些纳米囊泡能够传递功能蛋白和遗传信息，从而改变受体细胞的表型和功能。在动物生殖中，大量研究表明，EVs积极参与调节不同的生理事件，调节卵泡发育、精子发生、卵母细胞成熟、受精和胚胎发育等多种过程，结果表明配子质量、胚胎发育和低温耐受性得到改善。此外，在家养和野生物种中，ev在恢复生殖功能和支持母胚交流方面显示出治疗潜力。因此，本文综述了ev在动物生殖领域的主要研究，重点介绍了ev在辅助生殖技术中的生物学意义、实验应用和临床应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zygote 生物-发育生物学

CiteScore

1.70

自引率

5.90%

发文量

117

审稿时长

6-12 weeks

期刊介绍： An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies on gametogenesis through fertilization to gastrulation in animals and humans. The scope has been expanded to include clinical papers, molecular and developmental genetics. The editors will favour work describing fundamental processes in the cellular and molecular mechanisms of animal development, and, in particular, the identification of unifying principles in biology. Nonetheless, new technologies, review articles, debates and letters will become a prominent feature.