中华预防医学杂志最新文献

{"title":"[Parent-of-origin effect and its research progress in cardio-metabolic diseases].","authors":"H X Peng, M Y Wang, S Y Wang, H D Guo, T J Hou, Y X Li, H Y Zhang, Y Q Wu, X Y Qin, J Li, D F Chen, Y H Hu, T Wu","doi":"10.3760/cma.j.cn112150-20240922-00763","DOIUrl":"10.3760/cma.j.cn112150-20240922-00763","url":null,"abstract":"<p><p>Genomic imprinting refers to the phenomenon of differential expression of two alleles due to their different parental origins. Genes that produce genomic imprinting are usually called imprinted genes. The genetic effect caused by the presence of imprinted genes is called parent-of-origin effect. Parent-of-origin effect and genomic imprinting play important roles in the pathophysiological mechanism and occurrence and development of cardio-metabolic diseases. In-depth exploration of the law and potential roles of imprinted genes and parent-of-origin effects will help to better understand the mechanism of cardio-metabolic diseases, and also provide important theoretical basis for the precise treatment of diseases related to imprinted genes.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1552-1558"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Practices and considerations on the free HPV vaccination program for eligible girls in Zhejiang Province under the global initiative to accelerate cervical cancer elimination].","authors":"Y P Chen, X Deng, Y Wang, Y W Zhu, Y X Liang, H Q He, S Y Wang","doi":"10.3760/cma.j.cn112150-20250417-00326","DOIUrl":"10.3760/cma.j.cn112150-20250417-00326","url":null,"abstract":"<p><p>Against the backdrop of the global acceleration of cervical cancer elimination, China has been promoting pilot programs offering free or subsidized HPV vaccination for eligible girls. In 2022, Zhejiang Province initiated a free bivalent HPV vaccination program for eligible girls, expanding from pilot areas to the whole province. Through key measures such as effective multi-sectoral collaboration, full financial support, comprehensive health education and high-quality vaccination services, the program was successfully implemented. However, challenges were encountered during the implementation of the program, including difficulties in target population definition and HPV vaccine selection, as well as significant gap between vaccination intention and behavior. This article systematically analyzes the practices and challenges faced by Zhejiang Province, and proposes corresponding strategies and suggestions based on the best practices both domestically and internationally. It aims to provide references for the implementation of similar programs in other regions or even integrating HPV vaccine into the immunization program.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1495-1502"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparative analysis of free HPV vaccination programs across countries with different income levels worldwide: from implementation to evaluation].","authors":"Y W Zhu, Y P Chen, Y X Liang, S Y Wang","doi":"10.3760/cma.j.cn112150-20250508-00403","DOIUrl":"10.3760/cma.j.cn112150-20250508-00403","url":null,"abstract":"<p><p>Since the introduction of human papillomavirus (HPV) vaccines, countries around the world have actively promoted large-scale vaccination with HPV vaccines to improve their coverage for target populations. This study conducts a multidimensional analysis to quantify the policies, implementation models and evaluation outcomes of the free HPV vaccination program across countries at high, upper-middle and lower-middle income levels. The results reveal distinct patterns in implementation and evaluation among these countries. The results also suggest that China can learn from successful international experiences to explore more effective vaccination strategies to increase coverage. In parallel, it is essential to develop a scientifically grounded evaluation framework and conduct systematic evaluations to effectively support the continuous implementation of the free HPV vaccination program for target populations in China. Furthermore, China may consider incorporating appropriate HPV vaccines into the National Immunization Program and dynamically adjusting vaccine types as needed to accelerate the elimination of cervical cancer.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 ","pages":"1503-1511"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Performance validation and clinical application evaluation of fluorescent magnetic particle chemiluminescence method for the determination of sIgE].","authors":"W Q Shao, M Zhou, J Zhu, B S Pan, B L Wang, W Guo","doi":"10.3760/cma.j.cn112150-20250417-00322","DOIUrl":"10.3760/cma.j.cn112150-20250417-00322","url":null,"abstract":"<p><p>To evaluate the analytical performance of a specific IgE (sIgE) quantitative detection system and explore the clinical application effect of dust mite extract and component detection. The fluorescent magnetic particle chemiluminescence method was used to verify the analytical performance of sIgE for house dust mite (D1), dust mite (D2) extracts, and their components (Der p 1, Der p 2, Der p 10, and Der p 23), including precision, limit of blank (LoB), limit of detection (LoD), linear range, and interfering factors. This is a retrospective cohort study. A total of 50 patients with allergic rhinitis and 50 patients with allergic asthma diagnosed at Zhongshan Hospital Affiliated to Fudan University from January 2022 to August 2023 were selected, along with 70 apparently healthy individuals who underwent physical examinations in the hospital as the healthy control group. The positive rates of each sIgE component in the three groups were compared, and the receiver operating characteristic (ROC) curve for diagnosing dust mite allergy was plotted. The results showed that the fluorescent magnetic particle chemiluminescence method for detecting sIgE demonstrated good repeatability and intermediate precision within the range of 0.1-100 kU/L. The LoB, LoD, and linear range all met the specified requirements. Except for Der p 10, which was interfered by the presence of conjugated bilirubin and free bilirubin (exceeding 40 mg/dl), the detection of other allergens was not significantly affected by common endogenous substances. In healthy individuals, 10% had positive sIgE for dustmite extract; in asthmatic and allergic rhinitis patients, the positive rates were 70% and 82%, respectively. The double positive rate of D1 and D2 in the healthy group was 8.6%, while in asthmatic and allergic rhinitis patients, it was 66% and 70%, respectively. When 0.35 kU/L was used as the threshold, the sensitivity of sIgE for dust mite extract to predict component positivity was 100%, specificity was 61.5%, positive predictive value (PPV) was 80.2%, and negative predictive value (NPV) was 100%. When the threshold was optimized to 0.78 kU/L, the sensitivity was 96.8%, specificity was 92.1%, PPV was 95.2%, and NPV was 94.6%. In conclusion, the repeatability, intermediate precision, LoB, LoD, linear range, and anti-interference ability of the fluorescent magnetic particle chemiluminescence method for detecting sIgE meet the requirements of laboratory quality management. This ensures detection quality, meets clinical needs, and can be used for the auxiliary diagnosis of allergic diseases.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1427-1433"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Practice, effectiveness and prospects of standardized management of vaccination clinics in China].","authors":"Q S Yu, L Li, L Cao, J K Ye, Y F Song, Z N Zhang, X Y Wang, J Y He, R N Huang, L Wang, W Z Yu, Z D Yin","doi":"10.3760/cma.j.cn112150-20250327-00250","DOIUrl":"10.3760/cma.j.cn112150-20250327-00250","url":null,"abstract":"<p><p>As an important setting for the administration of vaccinations, the reasonable setting up and standardized management of vaccination clinics will enhance immunization service quality, public satisfaction, and improve the vaccination rate to protect people's health. In recent years, various provinces in China are continuously promoting the standardized construction and management of vaccination clinics. However, the level of standardization management remains unbalanced, and the capacity of vaccination services needs to be further improved. This paper reviews the standardized management process of vaccination clinics, summarizes the practice and achievements in various regions, and analyzes the challenges and issues during these processes, to provide reference for improving the standardized management level of vaccination clinics in the future.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1454-1461"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of epidemic characteristics and vaccination status of hemorrhagic fever with renal syndrome in Baoji City of Shaanxi Province from 2008 to 2023].","authors":"X D Li, H L Fu, H B Li, P Li","doi":"10.3760/cma.j.cn112150-20241203-00969","DOIUrl":"10.3760/cma.j.cn112150-20241203-00969","url":null,"abstract":"<p><p>To analyze the epidemic characteristics and vaccination status of hemorrhagic fever with renal syndrome (HFRS) in Baoji City from 2008 to 2023. The descriptive epidemiological method was used to collect the incidence data of HFRS cases in Baoji City from 2008 to 2003 in the Infectious Disease Reporting Information Management System. The epidemic characteristics of HFRS cases were summarized and analyzed. The data on HFRS vaccination from 2008 to 2023 were consulted through the Baoji Hemorrhagic Fever Vaccination Report, and the relationship between vaccination status and reported incidence was analyzed. The results showed that a total of 2 690 cases of HFRS were reported in Baoji City, with an annual average reported incidence rate of 6.94/100 000, 15 cases died and a case fatality rate of 0.41%. The number of reported HFRS cases showed a fluctuating trend, with a peak in 2011-2013. Since 2016, it entered a low-level stable fluctuation period, and the annual mortality rate dropped to below 1% after 2011. From 2008 to 2023, Fufeng County, Meixian County and Chencang District reported a large number of cases, but Linyou County and other counties in the north showed an upward trend in incidence, with obvious seasonal characteristics. Cases were mainly concentrated from October to January of the following year, accounting for 75.91% of the total number of cases. Farmers were the main reported occupations, accounting for 80.19% of the total number of cases. The ratio of male to female reported cases was 3.30∶1. The age group of 35-59 years old accounted for 51.08% of the cases, and the proportion of the age group of 60 years and above showed an upward trend (<i>χ</i>²=331.44, <i>P</i><0.001). From 2008 to 2023, a total of 1 559 619 people were vaccinated, and the vaccination rate of the target population aged 16-60 years reached 72.23%. With the increase in the vaccination rate, the incidence of HFRS continued to decrease. In summary, with the development of HFRS vaccination work, the epidemic characteristics of HFRS in Baoji City have changed, and the peak incidence has been controlled. The proportion of cases in the age group of 60 years and above continues to increase. HFRS vaccination is still an effective way of prevention and control, and vaccination strategies should be continuously optimized according to the characteristics of HFRS.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1528-1532"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Minutes of the 9th academic conference on vaccination challenge, countermeasures and prospect].","authors":"W Xu, Z W Zhang, K Han","doi":"10.3760/cma.j.cn112150-20250617-00557","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20250617-00557","url":null,"abstract":"","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1597"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current status of vaccination among the elderly in China and improvement strategies to increase vaccination rates].","authors":"X Liu, L J Liu, R Y Hu, L Cao, J K Ye, S Zhang, L Li, Y F Song, Z N Zhang, W Z Yu","doi":"10.3760/cma.j.cn112150-20250311-00193","DOIUrl":"10.3760/cma.j.cn112150-20250311-00193","url":null,"abstract":"<p><p>The health and well-being of the elderly have become a focal point for all sectors of society. As an effective means of preventing and controlling infectious diseases, vaccination plays a critical role in safeguarding human health. For older adults, timely and scientifically guided vaccination can significantly reduce the risk of serious illnesses while alleviating the associated economic burdens and pressure imposed on society. However, in practice, deficiencies in policy support, accessibility of vaccination services, and public awareness hinder some elderly individuals from fully benefiting from the protective effects of vaccines. This paper analyzes current vaccination practices for the elderly globally and proposes strategies to improve vaccination coverage, providing a scientific basis for advancing effective vaccination initiatives for this demographic in China.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1466-1470"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of serum allergen specific IgE detection results in children with allergic diseases in Hangzhou area].","authors":"F F Zhu, J Chen, H J Jia, H S Xu, T Jiang, L L Yang","doi":"10.3760/cma.j.cn112150-20250626-00589","DOIUrl":"10.3760/cma.j.cn112150-20250626-00589","url":null,"abstract":"<p><p>To investigate the distribution and development of common allergens in children in Hangzhou area, and to provide an epidemiological basis for the prevention, diagnosis, and treatment of allergic diseases in this area. This study is a retrospective study, selecting 3 524 children who underwent allergen screening at DiAn Medical Laboratory Center (Hangzhou) Co., Ltd. from January 2022 to January 2024 as the research subjects, including 2 012 males and 1 512 females. Among them, there were 1 098 infants (0-1 year olds), 1 673 toddlers (1-3 year olds), and 753 children (3-14 year olds). Immunoblotting was used to detect 21 allergen-specific immunoglobulin E (sIgE) antibodies. The positive rates of various allergens were calculated according to gender, age, and other factors, and the epidemiological characteristics and trends were analyzed. The results showed that the overall positive rate of sIgE was 60.33% (2 126/3 524). The main inhaled allergens were <i>Dermatophagoides pteronyssinus/Dermatophagoides farinae</i> (992, 28.15%), dog dander (295, 8.37%) and cat dander (181, 5.13%). The main food allergens were milk (696, 19.75%), egg white (541, 15.36%) and shrimp (205, 5.83%). Boys had significantly higher sIgE positivity rates than girls for <i>Dermatophagoides pteronyssinus/Dermatophagoides farinae</i>(642, 31.90%, <i>χ</i>²=10.10, <i>P</i>=0.001), house dust(61, 3.02%, <i>χ</i>²=5.12, <i>P</i>=0.024), cat dander(124, 6.16%, <i>χ</i>²=4.06, <i>P</i>=0.044), mold combinations(103, 5.14%, <i>χ</i>²=7.51, <i>P</i>=0.006), and tree pollen combinations(42, 2.07%, <i>χ</i>²=5.44, <i>P</i>=0.020) (all <i>P</i><0.05); With age, there was a significant increase in positivity rates for house dust mite/dust mite, house dust, mold combinations, milk, and beef (all <i>P</i><0.05), and a significant decrease in positivity rates for cockroach consumption, egg whites, shrimp, crab, cod, lobster/scallop, and soybeans (all <i>P</i><0.05), the positive rates of only ingestive allergens decreased significantly (<i>P</i><0.001), and the positive rates of only inhalant and mixed allergens increased significantly (<i>P</i><0.001). In conclusion,in the Hangzhou area, dust mites are the most common inhalant allergens among children with allergic diseases, while milk is the most common food allergen. Boys are more sensitive to inhalant allergens, and as children grow older, the positive rates for different allergens undergo significant changes. Dynamic monitoring of changes in specific IgE antibodies to various allergens can assist in the diagnosis, prevention, and treatment of allergic diseases.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1422-1426"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current status, challenges, and prospects of simultaneous vaccine administration in China's childhood immunization strategy].","authors":"X Liu, R Y Hu, J K Ye, L Cao, S Zhang, Y F Song, Z N Zhang, L Li, W Z Yu","doi":"10.3760/cma.j.cn112150-20250512-00415","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20250512-00415","url":null,"abstract":"<p><p>Vaccination has become one of the key public health interventions for reducing child mortality. With the implementation of the expanded programme on immunization, the number of vaccine types children need to receive is increasing, necessitating further optimization of childhood immunization strategies. The World Health Organization recommends simultaneous vaccination as one of the core strategies for optimizing childhood immunization schedules. This article analyzes the current status, challenges, and prospects of simultaneous vaccination strategies for children in China, aiming to provide a scientific basis for promoting and implementing strategies for the simultaneous administration of multiple vaccines to children.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 9","pages":"1462-1465"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}