中华预防医学杂志最新文献

{"title":"[Analysis of non-national immunization program vaccines inoculated in Shaanxi Province from 2019 to 2023].","authors":"C Zhang, T T Zhou, Y J Li, W J Tang, W J Hu","doi":"10.3760/cma.j.cn112150-20240604-00447","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240604-00447","url":null,"abstract":"<p><p>From 2019 to 2023, a total of 30.8602 million doses of non-National Immunization Program (non-NIP) vaccines were administered in Shaanxi Province, averaging 1 561 doses per 10 000 population. The annual administration of non-NIP vaccines increased from 4.359 1 million doses in 2019 to 7.858 2 million doses in 2023, with their proportional representation among all vaccines rising from 30.82% to 55.15%(<i>χ²_trend</i>=2 440 581.54, <i>P</i><0.001). The administration rate per 10 000 population increased from 1 105 doses to 1 986 doses during this period(<i>χ²_trend</i>=373.10, <i>P</i><0.001). Concurrently, the substitution rate of non-NIP vaccines for National Immunization Program vaccines rose from 4.94% in 2019 to 16.11% in 2023.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"697-701"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction of a diagnostic prediction model for childhood allergic asthma based on the detection results of specific IgE for airborne allergens].","authors":"C Y Yue, L Xiang, X L Hou, H J Huang","doi":"10.3760/cma.j.cn112150-20250210-00098","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20250210-00098","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To construct a diagnostic prediction model for childhood asthma and conduct a preliminary evaluation based on the test results of specific IgE (sIgE) for airborne allergens and in combination with clinical data. &lt;b&gt;Methods:&lt;/b&gt; This study is a case-control study. A total of 4 338 cases that completed the sIgE test for airborne allergens in the Allergy Department of Beijing Children's Hospital Affiliated to Capital Medical University from January to December 2023 were selected as the research subjects. They were divided into the asthma group and the non-asthma group based on the diagnostic information. Age, gender, cough and wheezing symptoms, and the classification results of sIgE concentrations of 15 airborne allergens were collected as the predictor variables of the asthma diagnostic prediction model. Differential analysis and LASSO regression were employed for the screening of predictor variables. The multivariate logistic regression method was applied to construct the nomogram prediction model. The data set was randomly split at a ratio of 7∶3 into a training set (3 036 cases) for constructing the prediction model and a validation set (1 302 cases) for testing the predictive efficacy of the model. The area under the receiver operating characteristic (ROC) curve (AUC), the Hosmer-Lemeshow calibration curve were utilized to assess the discrimination and goodness of fit of the model, and the clinical decision curve (DCA) was adopted to evaluate the clinical application value of the model. &lt;b&gt;Results:&lt;/b&gt; Among 4 338 pediatric cases, children aged 0 to &lt;3 years accounted for 10.17% (441 cases), those aged 3 to &lt;6 years accounted for 36.49% (1 583 cases), those aged 6 to &lt;12 years accounted for 46.98% (2 038 cases), and those aged 12 to 18 years accounted for 6.36% (276 cases). Males constituted 65.17% (2 827 cases), and females 34.83% (1 511 cases). The proportion of children without wheezing symptoms was 41.47% (1 799 cases), while those with wheezing symptoms was 58.53% (2 539 cases). The asthma group accounted for 41.77% (1 812 cases), and the non-asthma group for 58.23% (2 526 cases). Statistically significant differences were observed between the asthma group and the non-asthma group in 18 predictive variables including age, gender, wheezing symptoms, d1, d2, e1, e5, g2, g6, m6, t11, t3, t6, w1, w22, w6, wx5, and m3 (&lt;i&gt;P&lt;/i&gt;&lt;0.05). LASSO regression analysis identified six predictor variables: age (calculated in months), cough and wheezing symptoms, and sIgE of four airborne allergens, namely, Dermatophagoides pteronyssinus (d1), Canis familiaris dander (e5), Aspergillus fumigatus (m3), and Artemisia vulgaris pollen (w6).Multifactorial regression analysis revealed that the contribution degrees of the above-mentioned predictor variables to the asthma diagnosis prediction model were ranked as follows: cough and wheezing symptoms (&lt;i&gt;OR&lt;/i&gt;=24.37, &lt;i&gt;P&lt;&lt;/i&gt;0.001), m3 (&lt;i&gt;OR=&lt;/i&gt;1.34, &lt;i&gt;P&lt;/i&gt;&lt;0.001), d1 (&lt;i&gt;OR&lt;/i&gt;=1.22, ","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"658-666"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The reform path of China's health management system from Singapore's \"Health SG\" program: based on the practice and inspiration of prevention].","authors":"P Chen, K Huang","doi":"10.3760/cma.j.cn112150-20241215-01007","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20241215-01007","url":null,"abstract":"<p><p>Singapore's \"Health SG\" program takes \"prevention first\" personalized health management as the core, and successfully realizes the transformation of medical focus from \"disease treatment\" to \"active health management\" through measures such as family doctor contract system, community health ecosystem construction, digital empowerment and health points incentive. The program has significantly improved the screening rate and control rate of chronic diseases, and effectively alleviated the pressure of medical resource allocation. Based on the successful experience of Singapore and the current situation of China's health management system, this paper puts forward specific suggestions on optimizing the primary health service system, promoting the contract system of family doctors, accelerating digital health management and promoting urban and rural health equity, so as to provide reference for China to cope with the challenges of population aging and high incidence of chronic diseases.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"728-733"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of tobacco use situation and related factors among occupational population in Beijing in 2018].","authors":"J H Huang, R Zheng, L Qi, G Wang, Y Sun, J L Duan","doi":"10.3760/cma.j.cn112150-20240725-00597","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240725-00597","url":null,"abstract":"<p><p><b>Objective:</b> To understand the tobacco use situation and related factors among the occupational population in Beijing in 2018. <b>Methods:</b> The data were obtained from a special survey on \"Healthy Beijing People-Ten-year Action Plan for Health Promotion (2009-2018)\". From June to September 2018, 12 908 participants were recruited from 16 districts of Beijing using the stratified sampling method combined with the typical sampling method. Questionnaires were conducted to collect basic information, work situations, tobacco exposure in public places, and smoking cessation. The Chi-square test was used to compare the differences in current smoking rates, smoking cessation rates and second-hand smoke exposure rates among participants with different characteristics. Multivariate logistic regression analysis was used to analyze the related factors of tobacco use. <b>Results:</b> The present smoking rate of the occupational population in Beijing was 18.0% (95%<i>CI</i>: 17.3%-18.7%), and the passive smoking exposure rate of non-smokers was 61.0% (95%<i>CI:</i> 60.1%-61.9%). The smoking cessation rate among the working population was 22.2% (95%<i>CI</i>: 20.7%-23.7%), and the proportion of current smokers with the intention to quit was 63.9% (1 485/2 325). The present smoking rate of employees of different genders, ages, education levels and occupational nature showed statistically significant differences (<i>P</i><0.05). The results of multivariate logistic regression analysis showed that in males, compared with the age group of 16-29 years old, the risk of smoking increased in the age groups of 30-39 years old, 40-49 years old and over 50 years old [<i>OR</i> (95%<i>CI</i>) values were 1.49 (1.27-1.74), 1.34 (1.13-1.59) and 1.30 (1.06-1.59)]. Compared with those with junior high school or lower education, participants with high school/vocational/college education group had a higher risk of smoking (<i>OR</i>=1.38, 95%<i>CI</i>: 1.13-1.69), while those with master's degree or above had a lower risk of smoking (<i>OR</i>=0.30, 95%<i>CI</i>: 0.22-0.42). The physical workers (<i>OR</i>=1.28, 95%<i>CI</i>: 1.11-1.47) had a higher risk of smoking than the mental workers. <b>Conclusion:</b> The current smoking rate among the occupational population in Beijing is lower than the national level during the same period, but the exposure rate to second-hand smoke is relatively high. Age, educational level, job nature and gender are related factors of smoking.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"634-639"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association and mechanism between genetic variants in binding region of pancreatic and duodenum homeobox-1 and susceptibility to pancreatic cancer].","authors":"W Tian, Y Z Liu, B Li, J B Tian, X P Miao, Y Zhu","doi":"10.3760/cma.j.cn112150-20250113-00031","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20250113-00031","url":null,"abstract":"<p><p><b>Objective:</b> To systematically investigate the association and regulatory mechanism between genetic variants in the binding region of pancreatic and duodenal homeobox 1 (PDX1) and pancreatic cancer susceptibility in the Chinese population. <b>Methods:</b> Chromatin immunoprecipitation sequencing (ChIP-seq) was performed using the human pancreatic cancer cell line BxPC-3 to identify and annotate genetic variants within the PDX1 binding region. A two-center case-control study was conducted, and logistic regression models were employed to analyze the association between PDX1-related variants and pancreatic cancer susceptibility. Functional experiments were performed to elucidate the molecular mechanisms of these genetic variants. <b>Results:</b> ChIP-seq analysis identified 1 608 PDX1 binding regions. SNPs within these regions were significantly enriched in susceptible areas of pancreatic cancer (<i>P</i><0.001). The common variant rs154659, located within the most significant PDX1 binding peak, was further investigated. The multivariate logistic regression model showed that compared with individuals with TT genotype, individuals with CC genotype had a reduced risk of pancreatic cancer by 29.2% (<i>OR</i>=0.708, 95%<i>CI</i>: 0.589-0.850). Functional studies demonstrated that the rs154659[C] allele displayed higher relative luciferase activity than the rs154659[T] allele. Knockdown of PDX1 significantly attenuated the relative luciferase differences between the two alleles. <b>Conclusion:</b> Genetic variants in the PDX1 binding region are associated with pancreatic cancer risk. The rs154659 modulates pancreatic cancer susceptibility by specifically altering PDX1 binding activity.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"581-587"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genomic characterization of group A <i>Streptococcus</i> of different <i>emm</i>-type in Tianjin City from 2011 to 2024].","authors":"X H Lu, W Zhang, W Li, A P Yu, G W Liu, B L Zheng, X Chen, X Gao, X Y Li","doi":"10.3760/cma.j.cn112150-20240911-00725","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240911-00725","url":null,"abstract":"<p><p>To characterize the genomes of different <i>emm</i>-type group A <i>Streptococcus</i> (GAS), their virulence genes and drug resistance profiles in Tianjin City from 2011 to 2024. After PCR, a total of 42 strains with different years and <i>emm</i> types were selected for whole genome sequencing and multi-locus sequence typing (MLST), and the core genomes were used to generate a phylogenetic tree, after which the virulence genes and resistance genes were identified and analyzed, followed by the drug susceptibility test. In this study, the GAS strains were dominated by <i>emm</i>1 (50.0%) and <i>emm</i>12 (40.4%), and the MLST phenotypes were categorized into six types: ST36 (40.4%), ST1274 (26.1%), ST28 (23.8%), ST921 (4.7%), ST46 (2.3%), and ST403 (2.3%). There was a high consistency between their <i>emm</i>-types and ST types. A total of 68 virulence genes were detected in the genomes of 42 GAS strains, involving functional genes encoding exotoxin, bacterial adhesion, extracellular enzymes, etc. The virulence genes they carried were significantly different between <i>emm</i>1-type and <i>emm</i>12-type strains, such as <i>speA</i>. At the same time, the carrying rates of some virulence genes in the same <i>emm</i>-type strains changed with time, such as <i>hyl</i>. The resistance genes were basically the same among different <i>emm-</i>type strains except for the <i>vanSE</i> gene detected in all <i>emm</i>12 strains. The results of drug sensitivity showed that the GAS strains isolated in Tianjin City from 2011 to 2024 were sensitive to penicillin, cefazolin, chloramphenicol, vancomycin, and levofloxacin, while the resistance rates to erythromycin, azithromycin, clarithromycin, and clindamycin ranged from 88.5% to 100.0%, and there was a certain degree of consistency between the resistance phenotypes and the detected resistance genes. Overall, the main <i>emm</i> types and evolutionary features of GAS in Tianjin City from 2011 to 2024 were consistent with the dominant types in China, and the carrying rate of virulence genes and drug resistance genes differed significantly among different <i>emm</i>-type strains, and there were continuous evolution and variation in the prevalence of virulence genes in GAS.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"702-709"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The China-Thailand-South Korea Medical Laboratory and Preventive Medicine Seminar held in Shanghai City].","authors":"","doi":"10.3760/cma.j.cn112150-20250325-00241","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20250325-00241","url":null,"abstract":"","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"748"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nutrition intervention in the management of attention deficit hyperactivity disorder in children].","authors":"M C Wang, C L Pan, W L Yang, Y D Xi, H M Huang","doi":"10.3760/cma.j.cn112150-20240807-00635","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240807-00635","url":null,"abstract":"<p><p>Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental disorder with an estimated prevalence of approximately 6.4% among children and adolescents aged 6 to 16 in China. The etiology and pathogenesis of ADHD remain incompletely understood, and conventional treatment methods often have limited effectiveness. With advances in research into the etiology of ADHD, nutritional intervention has emerged as a potential adjunctive treatment and has garnered widespread attention. Multiple studies have demonstrated the potential effectiveness of nutritional interventions for ADHD. This review aims to summarize the progress in nutritional interventions for pediatric ADHD, particularly focusing on nutrient-level interventions (including polyunsaturated fatty acids, minerals, and vitamins), nutrition-related factors (such as probiotics), as well as the combined use of multiple nutrients and dietary nutrition (including dietary patterns). We will analyze and discuss the effectiveness of different nutritional interventions to provide a valuable reference for clinical nutritional diagnosis and treatment of the disease.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"710-715"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Meta-analysis of serum selenium and cancer risk].","authors":"X L Wen, J Y Li, L Li, W W Wei, S M Wang","doi":"10.3760/cma.j.cn112150-20241202-00964","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20241202-00964","url":null,"abstract":"<p><p><b>Objective:</b> To explore the association between serum selenium levels and total cancer risk in humans. <b>Methods:</b> A systematic search was conducted for Chinese and English literature on the association between selenium and cancer risk published up to December 2023 in the Chinese National Knowledge Infrastructure (CNKI), Wanfang, PubMed, EMbase, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) databases by using \"neoplasms\" \"selenium\" \"prospective-studies\" (both in English and Chinese) as keywords. The meta-analysis was performed using a random-effect model. The linear dose-response relationship was analyzed using a generalized least squares regression model, and the non-linear dose-response relationship was analyzed using a restricted cubic spline regression model. Publication bias was assessed by funnel plots and Egger's regression asymmetry test. <b>Results:</b> A total of 12 prospective studies were included from 16 408 articles retrieved, including seven studies from Europe, four from America, and one from Asia, with a total of 4 586 cancer cases reported. Meta-analysis revealed an inverse association between baseline serum selenium levels and total cancer risk (<i>RR</i>=0.68, 95%<i>CI</i>: 0.57-0.82, <i>P</i>=0.000). Furthermore, serum selenium was found to have a protective effect on both the incidence (<i>RR</i>=0.66, 95%<i>CI</i>: 0.53-0.84, <i>P</i>=0.001) and mortality (<i>RR</i>=0.70, 95%<i>CI</i>: 0.50-0.98, <i>P</i>=0.035) of total cancer. The inverse association between serum selenium and the incidence of total cancer was more pronounced in populations with low baseline serum selenium levels (<i>RR</i>=0.65, 95%<i>CI</i>: 0.48-0.89, <i>P</i>=0.007). Additionally, dose-response meta-analysis showed that for every 10 μg/L increase in baseline serum selenium concentration, there was a 26% reduction in incidence of total cancer (<i>RR</i>=0.74, 95%<i>CI</i>: 0.46-0.83, <i>P</i>=0.229) and a 6% reduction in mortality of total cancer (<i>RR</i>=0.94, 95%<i>CI</i>: 0.86-0.96, <i>P</i>=0.229). <b>Conclusion:</b> Serum selenium is negatively associated with the incidence and mortality of total cancer.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"561-571"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of serine protease inhibitors family in diseases].","authors":"Y Jiang, M Jiang, Y Long","doi":"10.3760/cma.j.cn112150-20241114-00907","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20241114-00907","url":null,"abstract":"<p><p>This article discusses the structure, function, signaling pathways, and disease associations of the serine protease inhibitors(SERPINS)family. The SERPINS family antagonizes the activity of serine proteases and plays critical roles in various biological processes, including coagulation, fibrinolysis, inflammatory responses, and immune modulation. SERPINS possess a conserved secondary structure and function through an irreversible suicide inhibition mechanism. Their dysfunction is associated with a multitude of clinical diseases, such as deep vein thrombosis, emphysema, dementia, and neurodegenerative disorders. Reviewing several key members of the SERPINS family, such as SERPINA1,SERPINA5,SERPINB2,SERPINC1 and SERPINE1, their physiological roles and functions, and their roles in related diseases, is of significant importance for further research into these conditions.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 5","pages":"734-746"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}