中华预防医学杂志最新文献

{"title":"[The investigation and spatio-temporal analysis of first importation associated D8 genotype measles case in a child, Shandong Province, 2023].","authors":"S T Wang, Y Liu, Q Xu, S Z Guo, D C Liu, A Q Xu, Z X Tao, L Zhang","doi":"10.3760/cma.j.cn112150-20240513-00383","DOIUrl":"10.3760/cma.j.cn112150-20240513-00383","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the epidemiological, etiological characteristics and transmission of an imported D8 genotype measles case in a child in Shandong Province, August 2023. <b>Methods:</b> A study was conducted on a measles case and 16 contacts in Shandong Province in August 2023. Field epidemiological surveys, including recent exposure and immunization history, were conducted. Serum and throat swab samples were collected from all 16 subjects. Measles IgM and IgG antibody levels and avidity were measured by ELISA, while virus detection and genotyping were performed using fluorescence quantitative PCR and RT-PCR. Genetic evolutionary analysis of the obtained sequences was conducted using MEGA and Beast software. <b>Results:</b> The case was an 11-year-old boy, a fifth-grade student, who developed symptoms on August 28, 2023. A total of five close contacts were investigated, including three family members (grandfather, father and sister) and two playmates. Additionally, 11 classmates who had close contact with the case's sister during the infectious period (within five days after the rash onset) were also investigated. Among the 16 serum samples tested, only one case was positive for IgM, while the other 15 samples were negative for IgM. The results of the serum antibody avidity test showed that among the 16 serum samples, 14 were positive for IgG. Of these, eight had a relative avidity index >55%, indicating high-avidity antibodies; one had a relative avidity index <45%, indicating low-avidity antibodies; and five had an avidity index between 45% and 55%. The IgG detection OD values for the case's sister and grandfather were higher than those of the other contacts. Based on the vaccination history of the subjects and the results of IgM and IgG tests, it was preliminarily determined that the case had a recent wild-type measles virus infection. The case's sister and grandfather had a history of measles wild-type virus infection, while the high-avidity antibodies in the other contacts were likely induced by the measles vaccine. The results of the pharyngeal swab tests showed that only the case was positive for measles virus nucleic acid, while the remaining 15 samples were negative for measles virus. The genetic evolutionary analysis revealed that the viral sequence of this case (Mvs/Shandong.CHN/38.23) had a 100% homology with the Hong Kong strain sequence from August 2023. It belonged to a different transmission chain from the D8 genotype strains that appeared in Shandong Province between 2018 and 2019, with sequence homology ranging from 98.0% to 98.8%. The sequence homology within the transmission chain of this case was between 99.1% and 100%. The evolutionary rate of this transmission chain was approximately 8.38×10<sup>-3</sup> sub/site/year, and the most recent common ancestor was estimated to have emerged around the year 2011. <b>Conclusion:</b> This case is the first imported D8 genotype measles case in Shandong Province. There","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"451-457"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on exposure and health risks of perchlorate in the environment].","authors":"R T Hao, L Zhang","doi":"10.3760/cma.j.cn112150-20241024-00844","DOIUrl":"10.3760/cma.j.cn112150-20241024-00844","url":null,"abstract":"<p><p>Perchlorate is a persistent inorganic pollutant, which has high stability, high water solubility, and strong oxidizing properties. It has been widely detected in various environmental media, including air, water and soil. Perchlorate primarily enters human body through diet and drinking water. As an inhibitor of iodine uptake, perchlorate mainly affects thyroid gland function after entering the human body, thereby influencing metabolism, neurodevelopment and other physiological functions. This poses a significant risk to human health. This paper summarizes epidemiological studies on the nature and source of perchlorate, its exposure in different environmental media, and its relationship with thyroid function, growth and development, and glucose and lipid metabolism. Additionally, it briefly discusses the related mechanisms of action, aiming to provide a reference for the prevention of perchlorate pollution in the environment and the assessment of health risks.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"509-515"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of the influence of dietary and nutritional factors on systemic lupus erythematosus].","authors":"Y F Deng, Q Wang","doi":"10.3760/cma.j.cn112150-20241210-00991","DOIUrl":"10.3760/cma.j.cn112150-20241210-00991","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by abnormal activation of the immune system, leading to damage of the body's own tissues and organs. The exact mechanisms underlying the pathogenesis of SLE remain incompletely understood. Increasing evidence underscores the significant role of dietary and nutritional factors in the onset, progression, and management of SLE. Modifications in dietary patterns and nutritional interventions offer a promising strategy for improving clinical outcomes and enhancing the quality of life in patients with SLE. This article synthesizes recent basic and clinical research on the impact of various nutritional elements and dietary approaches on the development, progression, and treatment of SLE. It also explores the mechanisms at different levels, aiming to provide valuable insights for future research in this area.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"526-534"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of burden in children under 10 years old of dietary iron deficiency among some countries in the world from 1990 to 2019].","authors":"K B Chen, T T Wang, M T Sun, M J Luo, X R Ruan, J B Qin","doi":"10.3760/cma.j.cn112150-20240514-00387","DOIUrl":"10.3760/cma.j.cn112150-20240514-00387","url":null,"abstract":"<p><p>Based on the Global Burden of Disease (GBD) 2019, this study characterized the burden of dietary iron deficiency across 154 countries participating in the Belt and Road Initiative (BRI). A joinpoint regression model was employed to assess temporal trends in disease burden. Pearson correlation analysis and locally weighted regression were utilized to investigate the relationship between burden and the socio-demographic index (SDI). Slope indices and concentration indices were calculated to evaluate health inequalities, while frontier analysis explored disease burden benchmarks. Key metrics included prevalence and disability-adjusted life years (DALYs). Results revealed downward trends in age-standardized prevalence rates and age-standardized DALYs rates of dietary iron deficiency among children under 10 years old in 117 and 125 BRI countries, respectively, from 1990 to 2019. A significant negative correlation was observed between disease burden and SDI in 2019 (<i>R</i>=-0.80, <i>P</i><0.001). The slope indices decreased from -936 (95%<i>CI</i>:-1 006, -806) in 1990 to -1 128 (95%<i>CI</i>:-1 256, -999) in 2019, while the concentration indices declined from -0.24 (95%<i>CI</i>:-0.28, -0.20) to -0.35 (95%<i>CI</i>:-0.39, -0.30) during the same period. Frontier analysis further identified substantial gaps between observed outcomes and optimal performance thresholds in several countries.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"468-473"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Liquid chip technology and its application in clinical laboratory diagnosis].","authors":"H D Gao, X Y Tang, X Y Hu, W Z Zhao, W Sun, X M Yu, M S Zhao","doi":"10.3760/cma.j.cn112150-20240708-00540","DOIUrl":"10.3760/cma.j.cn112150-20240708-00540","url":null,"abstract":"<p><p>Liquid chip technology is based on liquid carrier. Comparing to the traditional detection methods, it has unique characteristics such as multiple detection ability, high throughput, high sensitivity, good repeatability, less sample and fast analysis. It can analyse proteins, nucleic acids and other biological molecules in liquid. At present, it has been widely used in the laboratory diagnosis of tumors, autoimmune diseases, allergic diseases, cytokines related diseases, as well as infectious diseases. This article discussed the principles, detection performances, clinical applications and future prospects of liquid chip technology.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"542-548"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The epidemic trend and spatiotemporal distribution characteristics of congenital heart disease in Chinese perinatal infants].","authors":"Y Y Xue, J N Wang, Q Wang","doi":"10.3760/cma.j.cn112150-20241022-00838","DOIUrl":"10.3760/cma.j.cn112150-20241022-00838","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the prevalence trend and spatiotemporal distribution characteristics of congenital heart disease in China. <b>Methods:</b> Data on the incidence of congenital heart disease in China and provinces from 2002 to 2021 were collected through publicly available literature and reports. Joinpoint regression was used to assess the temporal trend of the incidence of congenital heart disease. Spatial autocorrelation analysis and spatiotemporal scanning statistics were used to analyze the spatial aggregation of hotspots and clustering areas of congenital heart disease occurrence. <b>Results:</b> The incidence of congenital heart disease in China showed a continuously increasing trend from 2002 to 2021, with an average annual increase of 15.33% (AAPC=15.33%, <i>P</i><0.001). Except for areas with missing data, 25 provinces showed an increasing trend (all AAPC>0, all <i>P</i><0.05), while there was no significant change in Guangdong and Guangxi (<i>P</i>=0.397 and 0.081). The results of global autocorrelation analysis showed that the occurrence of congenital heart disease had a certain clustering distribution, with the Global Moran's I>0 in 2005, 2006 and 2016, which were 0.23, 0.26 and 0.23 (<i>P</i>=0.027, 0.017 and 0.022). The results of local spatial autocorrelation showed that Hunan, Jiangxi and Fujian were high-high clustering areas, while the central and southwestern regions were low-low clustering areas. The results of segmental spatiotemporal scanning showed that eight clustering areas were found in four time periods (<i>P</i>≤0.001), and the clustering areas showed a trend of gradually expanding from none to certain coverage. <b>Conclusion:</b> From 2002 to 2021, the overall trend of congenital heart disease in China has been on the rise, with a certain degree of spatial aggregation. The clustering areas of spatiotemporal scanning have gradually increased, and the scope has gradually expanded.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"433-442"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Identification of endothelial cell key genes associated with pathogenesis and invasion of human venous malformations using single-nucleus RNA sequencing-based co-expression network analysis].","authors":"W B Liu, J J Lin, M J Zhang, C J Yuan, X J Feng, W T Jiao, J B Qiao, W Q Wang, B Fang, C K Chen","doi":"10.3760/cma.j.cn112150-20241230-01059","DOIUrl":"10.3760/cma.j.cn112150-20241230-01059","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to identify key genes in endothelial cell (EC) associated with the pathogenesis and progression of human venous malformations (VMs) through bioinformatics analysis, providing potential biomarkers for early screening and targeted therapy of VMs. <b>Methods:</b> A case-control study was conducted using surgically resected tissue specimens from VMs patients at the Third Affiliated Hospital of Zhengzhou University (from September 2021 to September 2023), with malformed venous tissues as the experimental group and distal normal venous tissues as controls. Single-nucleus RNA sequencing (snRNA-seq) was performed on paired experimental and control samples from four VM patients. High-dimensional weighted gene co-expression network analysis (hdWGCNA), combined with gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG), and protein-protein interaction (PPI) network analysis, identified critical genes. Validation experiments included 15 additional VM cases and controls using reverse transcription quantitative polymerase chain reaction (RT-qPCR), immunohistochemistry (IHC), and Western blot. <b>Results:</b> A total of 55 430 nuclei were captured using snRNA-seq, with 30 391 nuclei from the experimental group and 25 039 nuclei from the control group. Cluster analysis identified 22 distinct cell populations, which were annotated into 8 cell types. hdWGCNA revealed four modules associated with invasion, which were enriched in angiogenesis, integrin signaling, and cell adhesion according to GO analysis. KEGG pathway analysis indicated that the PI3K-AKT signaling pathway and focal adhesion are key regulatory mechanisms. PPI network analysis combined with cytoscape identified <i>EGFL7</i>, <i>TEK</i>, and <i>FLT1</i> as key genes. RT-qPCR results demonstrated that the relative mRNA expression levels of these three genes in the experimental group (6.66±2.31, 1.86±0.62, 3.49±0.58) were significantly higher than those in the control group (1.05±0.14, 1.00±0.14, 1.06±0.25), with statistically significant differences (<i>t</i>=9.37, 4.27, 11.20, <i>P</i><0.05). Immunohistochemical analysis showed that the relative protein expression levels of these three genes in the cytoplasm of the experimental group (0.84±0.15, 0.68±0.14, 0.85±0.12) were also significantly higher than those in the control group (0.19±0.05, 0.23±0.06, 0.30±0.05), with statistically significant differences (<i>t</i>=16.62, 5.93, 11.68, <i>P</i><0.05). Western blot analysis confirmed that the relative protein expression levels of these three genes in the experimental group (0.35±0.04, 0.36±0.09, 0.31±0.04) were significantly higher than those in the control group (0.19±0.01, 0.13±0.02, 0.14±0.04), with statistically significant differences (<i>t</i>=7.05, 4.61, 5.93, <i>P</i><0.05). <b>Conclusion:</b> <i>EGFL7, FLT1,</i> and <i>TEK</i> in EC may play crucial roles in the occurrence and invasion of VMs.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"458-467"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of the \"Technical Guidelines for Disinfection in Epidemic Prevention and Control of Large-Scale Events\"].","authors":"B Lu, Y Sun, L L Yang, H H Sun, W J Yang, X J Dong, Z Z Liu, Z K Sun, W Zhang, L Wang","doi":"10.3760/cma.j.cn112150-20240820-00674","DOIUrl":"10.3760/cma.j.cn112150-20240820-00674","url":null,"abstract":"<p><p>The \"Technical Guideline for Epidemic Prevention and Control Disinfection in Large-Scale Events\"(hereinafter referred to as \"the Guideline\"), organized and compiled by the National Disease Control and Prevention Administration, was officially released in April 2024. This guideline aims to ensure the effective implementation of large-scale group activities, mitigate the impact of infectious disease outbreaks on such events, and maintain hygiene and safety standards at event venues. During the compilation process, data were systematically collected in alignment with epidemic prevention requirements and disinfection principles, incorporating research findings from domestic and international disinfection practices. Information was gathered through field investigations, expert consultations in epidemiology and disinfection, and roundtable discussions with representatives from organizations responsible for disinfection operations at large-scale events, thereby ensuring the scientific rigor and practical applicability of the content. The Guideline provides comprehensive technical disinfection guidance for relevant authorities and event organizers, addressing critical aspects such as disinfection protocols, operational principles, emergency response strategies, and technical specifications. By standardizing hygiene assurance measures for large-scale events, including considerations of participant demographics, venue characteristics, and event scale, the guideline establishes a framework to proactively minimize the risk of infectious disease transmission.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"411-415"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Health economics evaluation of vaccination strategies for different human papillomavirus vaccines for 12-year-old female adolescents in China].","authors":"J H Li, X X Liu, L Tang, F Z Wang, Z D Yin","doi":"10.3760/cma.j.cn112150-20241120-00925","DOIUrl":"10.3760/cma.j.cn112150-20241120-00925","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the cost-effectiveness of administering two doses of different types of human papillomavirus (HPV) vaccines to 12-year-old female adolescents. <b>Methods:</b> A decision tree Markov model with genital warts and cervical cancer as target diseases was established to analyze the effects, costs, and Quality Adjusted Life Years (QALY) of strategies such as no vaccination, two doses of bivalent HPV (HPV-2), two doses of quadrivalent HPV (HPV-4), and two doses of nine-valent HPV (HPV-9) in a 12-year-old female adolescent cohort in 2023 using 50% of the procurement price or self-funded vaccination price in pilot provinces. The number of avoided cases of cervical cancer and genital warts and the incremental cost-utility ratio (ICUR) were compared between different strategies. <b>Results:</b> Compared with non-vaccination, female adolescents who received two doses of HPV-2, HPV-4 and HPV-9 were able to avoid 55.2% of cervical cancer cases with HPV-2, 77.11% and 78.68% of genital warts with HPV-4, and 54.99% and 73.46% of cervical cancer with HPV-9, respectively. The ICUR of strategies HPV-2, HPV-4, and HPV-9 was -28 470.44 yuan/QALY, 29 328.26 yuan/QALY and 48 106.85 yuan/QALY, respectively. HPV-2 was the most economical strategy and could achieve net cost savings. Single-factor sensitivity analysis showed that the results were robust, and the most influential factors were discount rate, vaccine prices and direct medical costs for low-grade precancerous lesions. The probability sensitivity analysis showed that compared with the national gross domestic product (GDP) per capita in 2023, the probability of cost-utility of HPV-2, HPV-4 and HPV-9 compared with non-vaccination was 99.51%, 89.03% and 67.81%, respectively. Only when the price of a single dose of HPV-4 and HPV-9 vaccines was lower than 26.12% and 20.68% of the current self-funded vaccination price, respectively, could there be a net cost saving. <b>Conclusion:</b> In the case where HPV-2 adopts the pilot province procurement price and the multivalent vaccine adopts a 50% self-funded vaccination price, the vaccination of 12-year-old female adolescents with HPV-2, HPV-4 and HPV-9 has cost-effectiveness, and HPV-2 is the most economical strategy.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"425-432"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of 12 Pathogens in surveillance cases of febrile respiratory syndrome in Daxing district of Beijing City from 2018 to 2023].","authors":"J F Tang, H Lei, M C Liu, Q L Li, T Li, X F Wang, Y D Gan, D T Zhang","doi":"10.3760/cma.j.cn112150-20240909-00716","DOIUrl":"10.3760/cma.j.cn112150-20240909-00716","url":null,"abstract":"<p><p>A total of 1 557 cases were included in the Febrile Respiratory Syndrome (FRS) surveillance conducted in Daxing District between 2018 and 2023. Twelve respiratory pathogens were investigated: human influenza virus (HIFV), human respiratory syncytial virus (HRSV), human parainfluenza virus (HPIV), human rhinovirus (HRV), human enterovirus (HEV), human adenovirus (HadV), human metapneumovirus (HMPV), human bocavirus (HBoV), Mycoplasma pneumoniae (MP), Chlamydia pneumoniae (CP), human coronavirus (HCoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results demonstrated an overall pathogen detection rate of 25.31% (394/1 557), with descending prevalence as follows: HIFV, SARS-CoV-2, HRV, HPIV, MP, HCoV, HRSV, HEV, HMPV, HadV, HBoV, and CP. Temporal analysis revealed detection rates of 26.98% (150/556) for 2018-2019, 15.81% (95/601) for 2020-2022, and 37.25% (149/400) for 2023, showing statistically significant interannual variation (χ²=59.703, <i>P</i><0.001). Compared with 2018-2019, 2023 exhibited significantly elevated detection rates for HIFV and HMPV (<i>P</i><0.05), while HRV, MP, HEV, and HBoV demonstrated significantly reduced rates (<i>P</i><0.05). Age-stratified analysis identified HIFV, HRSV, and HadV as the predominant pathogens in individuals aged <15 years, whereas SARS-CoV-2, HIFV, and HRV predominated in those aged ≥60 years.</p>","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"59 4","pages":"478-483"},"PeriodicalIF":0.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}