【心代谢性疾病的亲本效应及其研究进展】。

Q3 Medicine

中华预防医学杂志 Pub Date : 2025-09-06 DOI:10.3760/cma.j.cn112150-20240922-00763

H X Peng, M Y Wang, S Y Wang, H D Guo, T J Hou, Y X Li, H Y Zhang, Y Q Wu, X Y Qin, J Li, D F Chen, Y H Hu, T Wu

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引用次数: 0

摘要

基因组印迹是指两个等位基因由于亲本来源不同而产生的差异表达现象。产生基因组印记的基因通常被称为印记基因。由印迹基因的存在所引起的遗传效应称为亲本效应。亲本效应和基因组印迹在心脏代谢性疾病的病理生理机制和发生发展中起着重要作用。深入探索印迹基因和起源父母效应的规律和潜在作用，有助于更好地理解心代谢性疾病的发病机制，也为精准治疗与印迹基因相关的疾病提供重要的理论依据。

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[Parent-of-origin effect and its research progress in cardio-metabolic diseases].

Genomic imprinting refers to the phenomenon of differential expression of two alleles due to their different parental origins. Genes that produce genomic imprinting are usually called imprinted genes. The genetic effect caused by the presence of imprinted genes is called parent-of-origin effect. Parent-of-origin effect and genomic imprinting play important roles in the pathophysiological mechanism and occurrence and development of cardio-metabolic diseases. In-depth exploration of the law and potential roles of imprinted genes and parent-of-origin effects will help to better understand the mechanism of cardio-metabolic diseases, and also provide important theoretical basis for the precise treatment of diseases related to imprinted genes.

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来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.