Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Assessment of patient and neurosurgeon radiation exposure using a direct-reading dosimeter during transpedicular fixation for thoracic and lumbar spine injuries].","authors":"A Yu Kordonskiy, P B Popov, L I Beskin, A V Tupikin, V A Karanadze, E M Ivanov, R I Abdrafiev, A N Borodin, R S Saidov, A A Grin","doi":"10.17116/neiro20269003149","DOIUrl":"10.17116/neiro20269003149","url":null,"abstract":"<p><strong>Introduction: </strong>Individual dosimetry is routinely performed using thermoluminescent dosimeters (TLDs). Total dose is accumulated in these devices and periodically recorded by an accredited laboratory. This method does not provide real-time information on intraoperative radiation exposure.</p><p><strong>Objective: </strong>To compare X-ray doses received by patients with traumatic thoracic and/or lumbar spine injury during open and minimally invasive interventions.</p><p><strong>Material and methods: </strong>Ninety-two patients underwent surgery for thoracic and/or lumbar spine injury. Intraoperative analysis included dose-area products (DAP, cGy×cm²), individual TLD dosimeter readings of surgeons. Individual radiation dose equivalent was determined using four direct-reading dosimeters positioned on the operating table at distances of 0, 40, 80, and 120 cm from direct beam of radiation source.</p><p><strong>Results: </strong>Fifty-four patients underwent open surgery, 38 - transcutaneous procedure. Mean DAP was 2171 cGy×cm², mean radiation dose equivalent - 1.6 mSv. Minimally invasive procedures were associated with significantly higher radiation exposure: median DAP 3408.8 cGy×cm² and dose equivalent 2.3 mSv compared to 327.8 cGy×cm² and 0.2 mSv for open surgeries. Neurosurgeon radiation exposure did not exceed standards.</p><p><strong>Conclusion: </strong>Patient radiation exposure is significantly higher during minimally invasive procedures compared to open surgeries (mean dose equivalent 3 mSv versus 0.6 mSv). Understanding the patterns of radiation field is necessary for informed and safe use of X-rays.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prognostic modeling of long-term outcomes after minimally invasive lumbar fusion based on complex clinical, radiological and neuroimaging analysis in employees of JSC «Russian Railways»].","authors":"V A Byvaltsev, A A Kalinin, Yu Ya Pestryakov, E E Satardinova, S I Noskov","doi":"10.17116/neiro20269002144","DOIUrl":"10.17116/neiro20269002144","url":null,"abstract":"<p><p>The incidence of unsatisfactory postoperative outcomes after treatment of degenerative lumbosacral spine diseases depends on surgical method. Their prediction is difficult due to heterogeneity of clinical and instrumental characteristics of patient groups. Development of predictive models of clinical outcomes may be useful for decision making and favorable postoperative outcomes.</p><p><strong>Objective: </strong>To develop and validate the effectiveness of multivariate predictive model for assessing the risks and benefits of minimally invasive lumbar fusion in railway workers with degenerative lumbar spine diseases.</p><p><strong>Material and methods: </strong>We retrospectively analyzed prospective database consisting of 457 patients. They underwent minimally invasive lumbar fusion between 2020 and 2023. Comprehensive clinical, radiological and neuroimaging assessments were performed before surgery and 24 months later. Regression analysis was used to create prognostic models of long-term clinical outcomes (y0 - ODI; y1 - SF-36 PCS (physical component score); y2 - SF-36 MCS (mental component score); y3 - Macnab scale).</p><p><strong>Results: </strong>All clinical parameters (ODI, VAS, SF-36) significantly improved after surgery compared to preoperative values (<i>p</i><0.01). Within 90 days after surgery, redo surgery rate was 5.7%, and the number of readmissions throughout the entire follow-up period - 8.3%. About 87.3% of railway workers returned to previous work. Clinical deterioration was observed in 51 (11.2%) patients. Preoperative variables predict long-term clinical outcomes. Their role and dominance depend on prognostic model.</p><p><strong>Conclusion: </strong>Predictive models may be valuable to improve long-term outcomes when planning minimally invasive lumbar spine fusion.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Microsurgical treatment of cerebral arteriovenous malformations: a 20-year experience of the Burdenko Neurosurgical Center].","authors":"Sh Sh Eliava, An N Konovalov, Yu V Pilipenko, D N Okishev, F V Grebenev, A S Kheyreddin, O B Belousova, E Ch Alieva Isazade, A A Artemyev, T Yu Abzalov, I A Erokhin, S S Sergeeva, D A Starostenko","doi":"10.17116/neiro2026900216","DOIUrl":"10.17116/neiro2026900216","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the results of microsurgical treatment of cerebral arteriovenous malformations (AVMs) over a 20-year period and their dynamics taking into account clinical and morphological characteristics of malformations, baseline functional status of patients and clinically relevant outcome measures.</p><p><strong>Material and methods: </strong>A single-center retrospective cohort study included 1.273 cases of microsurgical treatment of cerebral AVMs between 2006 and 2025. Demographic data, AVM morphology, Spetzler-Martin grading, hemorrhage and seizures before surgery, preoperative embolization, early postoperative complications, and mRS scores before surgery and at discharge were assessed. A favorable outcome implied improvement or no deterioration compared to preoperative status. Clinically significant deterioration («new disability») was defined as deterioration compared to baseline status with mRS ≥3. Visual field defects were analyzed separately and not included in morbidity.</p><p><strong>Results: </strong>In-hospital mortality was 0.6%. Favorable outcomes were observed in 1.165 out of 1.271 patients (91.7%). Clinically significant deterioration («new disability») was observed in 8.3% of patients. The incidence of complications and adverse outcomes increased along with higher Spetzler-Martin grades. Patients with previous hemorrhage were more likely to have baseline neurological deficit, but the incidence of «new disability» in this group was no different from that in patients without hemorrhage. Preoperative embolization was more common in patients with more difficult AVMs.</p><p><strong>Conclusion: </strong>Microsurgical treatment of cerebral AVMs at a specialized center is characterized by low in-hospital mortality and high proportion of favorable functional outcomes.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"6-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Overall survival prediction scale for patients with grade 4 brain astrocytoma].","authors":"P V Datsenko, A S Chuguev, V A Gerasimov, A D Kaprin","doi":"10.17116/neiro20269001165","DOIUrl":"10.17116/neiro20269001165","url":null,"abstract":"<p><strong>Objective: </strong>To create a prognostic scale for overall survival in grade 4 astrocytomas based on molecular biological data.</p><p><strong>Material and methods: </strong>After morphological confirmation of WHO grade 4 astrocytoma (2021 WHO classification criteria), 175 patients were classified as GBM (grade 4) without <i>IDH1</i> mutations; <i>IDH1</i> mutation was detected in 25 patients (12.5%; G4 astrocytoma). Molecular biological analysis of <i>IDH1</i> gene mutations and MGMT promoter methylation was performed in 194 (97%) patients.</p><p><strong>Results: </strong>To study concomitant significance of <i>IDH1</i> mutation and MGMT promoter methylation in grade 4 gliomas, we created the <i>IDH1</i>/MGMT index(0 - <i>IDH1</i>+/MGMT+; 1 - <i>IDH1</i>/MGMT (+/-); 2 - <i>IDH1</i>-/MGMT-). This predictor was digitized in 194 patients who underwent molecular analysis. The most informative classification matrix according to overall survival was as follows: <i>IDH1</i>/MGMT index (OR=1.712; <i>p</i>=0.0004), REP (OR=1.971; <i>p</i>=0.0001), functional status before microsurgery at the lowest possible level (OR=1.797; <i>p</i>=0.001). Simple summation of numerical indicators for factors 1-3 in each patient allowed us to identify 5 prognostic classes: class 1 (0-1 points), class 2 (2 points), class 3 (3 points), class 4 (4 points), class 5 (5 points). Log-rank criterion for Kaplan-Meier survival curves revealed significant differences between classes (<i>χ</i>²=55.780; <i>p</i><0.001). The median survival rates were 71.5, 42.3, 23.6, 17.4 and 8.1 months, respectively. Significant differences in survival were noted between almost all neighboring classes: classes 1-2 (<i>χ</i>²=3.21; <i>p</i>=0.073), classes 2-3 (<i>χ</i>²=5.77; <i>p</i>=0.016), classes 3-4 (<i>χ</i>²=6.03; <i>p</i>=0.014), classes 4-5 (<i>χ</i>²=11.97; <i>p</i>=0.0005). In \"classes 1-3\" in prognostic scale, median overall survival was 44.98 months (<i>n</i>=53; 95% CI: 20.5-69.4) for 3 Gy fractionation regimen and only 23.23 months (<i>n</i>=78; 95% CI: 17.3-29.1; <i>χ</i>²=9.28; <i>p</i>=0.002) for 2 Gy regimen. There were other results for classes 4-5. Median overall survival for 3 and 2 Gy fractionation regimens was low: 17.41 (<i>n</i>=28; 95% Cl: 13.8-21.0) and 15.83 months (<i>n</i>=41; 95% Cl: 11.7-20.0; -2=0.59; <i>p</i>=0.442), respectively.</p><p><strong>Conclusion: </strong>The new prognostic scale for overall survival, based on molecular data, allows not only to predict further course of disease, but also to recommend irradiation 3 Gy for patients in classes 1-3 as an alternative to radiotherapy.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The FOUR scale in assessing patients with acute cerebral insufficiency].","authors":"O Z Arslanov, A A Belkin, A V Kulikov, N S Nagaev","doi":"10.17116/neiro20269001157","DOIUrl":"10.17116/neiro20269001157","url":null,"abstract":"<p><p>Treatment and rehabilitation of patients with acute cerebral insufficiency necessitate critical objectives (assessment of brain damage severity and prediction of potential outcomes). Despite the role of this stage, current consciousness assessment methods often lack sufficient accuracy and objectivity. A promising approach is the Full Outline of UnResponsiveness scale (FOUR) providing objective patient evaluation compared to traditional Glasgow Coma scale.</p><p><strong>Objective: </strong>To evaluate clinical significance of the FOUR scale for patients with cerebral insufficiency.</p><p><strong>Material and methods: </strong>A prospective single-center study included 200 patients with acute cerebral insufficiency. Analysis employed ROC curves, logistic regression and correlation methods.</p><p><strong>Results: </strong>The FOUR scale demonstrated high prognostic accuracy in comatose patients (AUC=0.944 vs. 0.742 for GCS, <i>p<</i> 0.001). Strong correlations were found between FOUR scores and GOS grades (rs=0.7546, <i>p<</i>0.0001), as well as prediction of mortality (OR=3.4, 95% CI 2.1-5.6). For patients with chronic consciousness disorders, the FOUR scale showed benefits (AUC=0.936 vs. 0.745 for GCS).</p><p><strong>Conclusion: </strong>The FOUR scale represents an optimal monitoring tool for patients with cerebral insufficiency.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evolution of methodological standards for systematic reviews and meta-analysis protocol on the influence of molecular genetic profile of meningioma on tumor recurrence].","authors":"G S Sergeev, M V Nesterchuk, V S Klimov, A S Gaytan, V V Kuftov, G V Danilov, N A Konovalov, D Yu Usachev, A L Krivoshapkin","doi":"10.17116/neiro202690041114","DOIUrl":"10.17116/neiro202690041114","url":null,"abstract":"<p><strong>Background: </strong>Traditional histological classification of meningiomas has low prognostic accuracy and necessitates integration of molecular biomarkers. However, current data are fragmented and require rigorous synthesis.</p><p><strong>Objective: </strong>To develop a meta-analysis protocol for quantitative assessment of the influence of molecular profile of meningiomas on long-term outcomes (overall survival and recurrence-free period) after surgical or combined treatment.</p><p><strong>Material and methods: </strong>The article provides historical analysis of transformation of evidence-based medicine standards from narrative reviews to algorithmic guidelines (QUOROM, MOOSE, PRISMA). The choice of the PRISMA-P 2020 protocol and Cochrane methodology as the standard for this study is justified.</p><p><strong>Results: </strong>A meta-analysis design was developed to assess the impact of genetic profile (<i>TERT, CDKN2A/B, NF2</i> status, DNA methylation) on the risk of recurrence. Inclusion criteria (PICOTS) cover all types of meningiomas. The protocol regulates searching strategy, independent screening (Rayyan) and risk of bias assessment using the QUIPS tool. Statistical synthesis of data is planned to identify the hierarchy of risk factors.</p><p><strong>Conclusion: </strong>Implementation of this protocol will ensure creation of a valid evidence base for stratification of risk of meningioma recurrence based on molecular genetic profile.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"114-121"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Midline approach through atlantooccipital membrane for removal of foreign bodies from the fourth ventricle].","authors":"K N Babichev, D V Svistov, V K Kuular, A Yu Boiarko","doi":"10.17116/neiro20269002121","DOIUrl":"10.17116/neiro20269002121","url":null,"abstract":"<p><p>The authors present 3 cases of removal of foreign bodies from the fourth ventricle after penetrating craniocerebral wounds. They used a midline approach through atlantooccipital membrane. Appropriate technique, clinical data and indications for this surgical procedure are presented.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Phosphorus MR spectroscopy: energetic metabolism and Warburg effect].","authors":"N E Elagina, A N Tyurina, L M Fadeeva, G V Pavlova, A V Kosyrkova, I N Pronin","doi":"10.17116/neiro2026900417","DOIUrl":"https://doi.org/10.17116/neiro2026900417","url":null,"abstract":"<p><p>Magnetic resonance spectroscopy (MRS) is a complementary imaging technique enabling non-invasive metabolic characterization of tissues in clinical practice. Proton MRS is more common for analysis of metabolites such as lactate and choline. This is valuable for preoperative assessment of glioma grade. However, it does not directly reflect phosphate energy metabolism. Phosphorus MRS enables assessment of phosphorus-containing compounds involved in tumor energy metabolism and membrane turnover.</p><p><strong>Objective: </strong>To assess the role of phosphorus MRS in metabolic characterization of low-grade and high-grade gliomas.</p><p><strong>Material and methods: </strong>The study included 46 patients with gliomas: 31 patients with high-grade gliomas and 15 patients with low-grade gliomas. The control group comprised 15 healthy volunteers. All participants underwent phosphorus MRS with assessment of spectral parameters of phosphorus-containing metabolites, metabolic ratios and intracellular pH.</p><p><strong>Results: </strong>Phosphorus MRS revealed differences in metabolic profile of tumor tissue between high-grade and low-grade gliomas. High-grade gliomas were characterized by signs of impaired energy and membrane metabolism, including changes in phosphorus-containing metabolite ratios and shift in intracellular pH. Low-grade gliomas demonstrated less severe metabolic alterations.</p><p><strong>Conclusion: </strong>Phosphorus MRS is a promising complementary imaging modality for non-invasive assessment of metabolic features of gliomas. This method may be used to refine their biological characteristics at the preoperative stage.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Postoperative anosmia after microsurgery for anterior circulation aneurysms].","authors":"M E Margulis, Yu V Pilipenko, E V Shelesko, Yu V Strunina, N A Azarova, M B Kholmatov, An N Konovalov","doi":"10.17116/neiro20269004130","DOIUrl":"https://doi.org/10.17116/neiro20269004130","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the factors contributing to postoperative anosmia and to evaluate the effectiveness of preventive strategies in microsurgery for cerebral aneurysms.</p><p><strong>Material and methods: </strong>The study included 117 patients with unruptured anterior circulation aneurysms who underwent surgery at the Burdenko Neurosurgery Center in 2024-2025. All patients underwent olfactometric assessment preoperatively, after 5-7 postoperative days and 6 months after surgery. Clinical, anatomical (CT angiography) and intraoperative factors were analyzed.</p><p><strong>Results: </strong>Postoperative anosmia occurred in 55 (47%) patients with bilateral involvement in 11 (20%) cases. Anosmia developed in 70.2% of patients with anterior communicating artery (ACoA) aneurysms. Significant anatomical predictors were superior (<i>p</i>=0.01) and anterior (<i>p</i>=0.01) ACoA aneurysm dome orientation. Intraoperative risk factors included nerve compression by brain spatula (<i>p</i><0.001) and arachnoid dissection of the nerve. In some cases, we noted a single-stage flow of blood along anterior cranial fossa base from olfactory tract during frontal lobe traction and arterial dissection. This «red drop» sign was an intraoperative marker of nerve injury (<i>p</i>=0.04). Transsylvian approach for middle cerebral artery aneurysms ensured 100% preservation of olfactory function (<i>p</i><0.001). After 6 months, olfactory function recovered in 33.3% of patients. Previous COVID-19 was associated with worse recovery (<i>p</i>=0.05).</p><p><strong>Conclusion: </strong>Postoperative anosmia is a frequent complication in aneurysm surgery. The main predictors are ACoA aneurysm and intraoperative traction-induced avulsion of the nerve. Preventive strategies include selection of less traumatic approach and minimized pressure on olfactory nerve. Arachnoid dissection of the nerve is not recommended.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Causes and microbiological spectrum of brain abscesses: modern data].","authors":"A I Baranich, A A Sychev, I A Savin, N V Kurdyumova, M V Sukhorukova, Z Sh Veliev, D S Korotkov, K O Kakurin, V G Kudrina","doi":"10.17116/neiro20269003137","DOIUrl":"10.17116/neiro20269003137","url":null,"abstract":"<p><p>Brain abscesses are relatively rare, yet they are life-threatening infections with high risk of persistent neurological impairment in survivors. Effectiveness of therapy depends on understanding the range of probable pathogens. This enables optimal empirical therapy avoiding broad-spectrum combinations and associated risks of drug-drug interactions. Available Russian literature predominantly contains case reports and reviews resulting in a lack of up-to-date epidemiological data on brain abscesses.</p><p><strong>Objective: </strong>To analyze current etiological and epidemiological data in a cohort of patients with verified brain abscesses.</p><p><strong>Material and methods: </strong>A single-center retrospective study enrolled 41 patients with primary brain abscesses between 2022 and 2025. The diagnosis was confirmed by contrast-enhanced MRI and/or intraoperative findings. Exclusion criteria: extracranial abscess, concomitant intracranial or head soft tissue infection and recurrent abscesses.</p><p><strong>Results: </strong>Abscesses occurred as complications of neurosurgery in 16 (39%) out of 41 patients, ENT diseases - in 4 (9.8%) cases. Odontogenic route of infection was established in 4 (9.8%) cases, and 2 (4.9%) patients had previous traumatic brain injury. Etiology was unknown in 36.6% of cases. Gram-positive cocci prevailed: Staphylococcus spp. (26.8%) and Streptococcus spp. (19.5%).</p><p><strong>Conclusion: </strong>These data highlight the need for regular updating of local epidemiological data on brain abscesses. A thorough analysis of anamnestic data in these patients can enable informed and timely prescription of appropriate empirical antimicrobial therapy. Choice of this therapy depends crucially on spectrum of probable pathogens, especially in the absence of microbiological verification.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}