Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Antidepressants as additional drugs for human brain gliomas].","authors":"A V Revishchin, G V Pavlova","doi":"10.17116/neiro20248806197","DOIUrl":"https://doi.org/10.17116/neiro20248806197","url":null,"abstract":"<p><p>Glioblastoma (GB) is the most aggressive malignant brain tumor. To date, there is no optimal treatment approach for this disease. Antidepressants with antitumor effects are one of the new therapeutic directions. A distinctive feature of these drugs is their approval for clinical practice in the treatment of depressive disorders.</p><p><strong>Objective: </strong>To analyze available literature data on mechanisms of antitumor action and advisability of antidepressants for GB.</p><p><strong>Material and methods: </strong>We reviewed the databases using the keywords «glioma», «antidepressants», «drug repurposing».</p><p><strong>Results: </strong>According to numerous preclinical studies, activity of antidepressants at the cellular level is aimed at enhancing apoptosis and autophagy, inhibiting the cell cycle, differentiating and/or maintaining the stem cell status, as well as migrating tumor cells.</p><p><strong>Conclusion: </strong>Available data can substantiate further experimental and clinical studies, as well as searching for therapeutic combinations using antidepressants for the treatment of human gliomas.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Optic canal stenosis in Crouzon syndrome: a case report and literature review].","authors":"I V Bolotnikova, A S Shapovalov, T B Bazarkhandaeva, V P Ivanov, V A Khachatryan, D A Gulyaev, V V Brzhesky, A V Kim","doi":"10.17116/neiro202488041100","DOIUrl":"10.17116/neiro202488041100","url":null,"abstract":"<p><strong>Background: </strong>Incidence of Crouzon syndrome is 1 per 25.000-31.000 newborns. This syndrome is extremely rarely accompanied by optic canal stenosis.</p><p><strong>Objective: </strong>To present a patient with Crouzon syndrome and optic canal stenosis, to discuss the management of such patients considering own and literature data.</p><p><strong>Material and methods: </strong>A 6-year-old boy presented with Crouzon syndrome (verified by molecular genetic research, i.e. FGFR2 gene mutation). The patient underwent 3 surgeries for craniosynostosis and hydrocephalus. Nevertheless, visual acuity progressively decreased despite patent ventriculoperitoneal shunt. Examination revealed severe decrease in visual functions with optic disc congestion under secondary atrophy. MRI data on subarachnoid CSF accumulation over both optic nerves potentially indicated optic canal stenosis. This assumption was confirmed by 3D CT.</p><p><strong>Results: </strong>The patient underwent decompression of both optic canals with subsequent improvement of visual functions.</p><p><strong>Conclusion: </strong>Vision decrease following Crouzon syndrome may be due to optic canal stenosis. Decompression may be effective, even in long-term course of disease, and improve visual functions.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Minimally invasive surgical treatment of extramedullary tumors at the level of craniovertebral junction: experience of the Burdenko Neurosurgical Center].","authors":"S V Kaprovoy, N A Konovalov, R A Onoprienko, Yu V Strunina, N D Shmelev","doi":"10.17116/neiro20248802139","DOIUrl":"10.17116/neiro20248802139","url":null,"abstract":"<p><strong>Objective: </strong>To describe own experience of treating patients with extramedullary tumors at the level of craniovertebral junction using minimally invasive surgical approaches.</p><p><strong>Material and methods: </strong>The study included 29 patients who underwent minimally invasive microsurgical resection of extramedullary tumors at the level of craniovertebral junction. We analyzed the main clinical and surgical parameters.</p><p><strong>Results: </strong>Gross total resection was achieved in most patients with high degree of safety. Two patients required redo surgery due to CSF leakage and soft tissue cyst. Mean length of hospital-stay was 7 days. VAS score of pain syndrome at discharge was 2 points and 0 points after 3 months. No significant differences in neurophysiological monitoring indicators were observed (<i>p</i>=0.76).</p><p><strong>Conclusion: </strong>Minimally invasive posterior approaches to extramedullary tumors at the level of craniovertebral junction can significantly reduce surgical trauma with equal extent of resection.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Growing skull fracture of the orbital roof: case report and literature review].","authors":"S A Eolchiyan, D M Chelushkin, N K Serova, L A Sergeeva, A I Batalov, S A Cherebylo","doi":"10.17116/neiro20248805177","DOIUrl":"10.17116/neiro20248805177","url":null,"abstract":"<p><strong>Background: </strong>Growing skull fracture (GSF) of the orbital roof is a rare complication of head injury in infancy and early childhood. Analysis of the Medline database between 1983 and 2023 identified 17 articles describing 63 children after surgical treatment of GSF of the orbital roof.</p><p><strong>Material and methods: </strong>We present a 2-year-old child with moderate traumatic brain injury (TBI) complicated by GSF of the orbital roof. Neuroimaging and literature data are described.</p><p><strong>Results: </strong>Severe ophthalmological symptoms in acute period of TBI subsequently partially regressed with persistent swelling of the upper eyelid and hypophthalmos. CT and MRI revealed a linear fracture of the frontal bone extending to superior orbital wall and intraorbital collection of cerebrospinal fluid (pseudomeningocele) mixed with blood. MR signs of GSF of the orbital roof with pseudomeningocele shrinkage were found in 5 weeks after injury. After 6 months, CT and MRI revealed signs of more severe GSF. Surgical treatment implied craniotomy, excision of scars, arachnoid membrane and abnormal brain matter, resection of deformed fracture edges, dura mater sealing and orbital roof reconstruction with bone autograft. Ophthalmological symptoms regressed after 6 months. The follow-up period was 6 years. There were no signs of fracture recurrence.</p><p><strong>Conclusion: </strong>In this case, acute intraorbital pseudomeningocele led to GSF of the orbital roof in 5 weeks after injury. Incomplete regression of ophthalmological symptoms, their aggravation or delayed appearance in children with orbital roof fracture requires a thorough examination including high-resolution CT and MRI, and orbital roof GSF should be considered in the differential diagnosis.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Melanoma metastasis to the brachial plexus and median nerve. A rare clinical case].","authors":"A V Gorodnina, A Yu Orlov, A S Nazarov, D A Sitovskaya","doi":"10.17116/neiro20248805193","DOIUrl":"10.17116/neiro20248805193","url":null,"abstract":"<p><p>Melanoma is a malignant neuroectodermal tumor arising from skin pigment cells (melanocytes). Distant metastases and damage to the nervous system occur mainly at the later stages of disease. However, primary tumor may not be verified despite distant metastases in some cases. We present a patient with metastatic melanoma to the left median nerve and brachial plexus without clear primary lesion. This case describes surgical treatment of melanoma metastasis followed by median neuropathy.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Short-lasting tentorial herniation may cause cortical blindness. A case report and systematic literature review].","authors":"Sh Sh Davlyatova, A B Kadasheva, T A Abramov, O Yu Titov, N N Isakov, A V Kozlov","doi":"10.17116/neiro20248805169","DOIUrl":"10.17116/neiro20248805169","url":null,"abstract":"<p><strong>Introduction: </strong>Cortical blindness occurs with bilateral damage to the visual cortex. It can be caused by various reasons, including the posterior cerebral arteries stroke due to the tentorial herniation.</p><p><strong>Material and methods: </strong>A case of a 40-year-old patient with a large right-sided sphenoidal meningioma. A systematic review on the problem of cortical blindness after tentorial herniation according to the PRISMA guideline.</p><p><strong>Results: </strong>Subtotal removal of dense meningioma. At night after the operation, there was an acute headache, then a coma. Immediately dehydration therapy, tracheal intubation, mechanical ventilation. CT scan showed a small hemorrhage in the tumor bed and subarachnoid space, brain edema and dislocation. After 53 minutes, ventricular drainage was installed, intracranial pressure was normal and ranged from 6 to 14 mmHg. After sedation withdrawal, cortical blindness was detected, which did not regress for 1.5 years. There are no other neurological symptoms, the patient walks, serves herself. Radiation therapy in a total of 54 Gy for the remainder of the grade 1 meningioma ensured tumor control.</p><p><strong>Discussion: </strong>The time window for restoration of the cerebral blood flow, according to the European Stroke Organization guidelines, is 4.5 hours. In this case, compression of the posterior cerebral arteries lasted less than 53 minutes, however, irreversible ischemia developed in their territory; the outcome on the modified Rankine scale was 4 points. Similar cases are not described in the literature.</p><p><strong>Conclusion: </strong>Patients should be warned about even the non-obvious risks of neurosurgical intervention, since even timely measures taken do not always avoid complications.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Magnetic resonance imaging and PET/CT with 11C-methionine for primary central nervous system vasculitis].","authors":"T Yu Skvortsova, Zh I Savintseva, A I Kholyavin, A F Gurchin, Yu M Zabrodskaya","doi":"10.17116/neiro20248806171","DOIUrl":"10.17116/neiro20248806171","url":null,"abstract":"<p><p>Primary central nervous system vasculitis is still a challenge due to rarity of disease, unspecific clinical and neurological presentation, as well as low specificity of MRI and laboratory tests.</p><p><strong>Objective: </strong>To present the potential of hybrid neuroimaging in diagnosis of primary central nervous system vasculitis.</p><p><strong>Material and methods: </strong>The results of MRI, PET/CT with 11C-methionine, histological and immunochemical data in a 23-year-old patient with first-time epileptic seizure are demonstrated.</p><p><strong>Results: </strong>MRI revealed multifocal lesion of the left frontal lobe with contrast accumulation, edema and mass effect. The largest lesion demonstrated high 11C-methionine uptake that was typical for tumor. Stereotactic biopsy of this lesion was performed. Morphological examination revealed lymphocytic vasculitis.</p><p><strong>Conclusion: </strong>Radiological and metabolic semiotics of primary central nervous system vasculitis can mimic cerebral tumor. High ¹¹C-methionine uptake in active inflammation focus is valuable to choose the target for biopsy.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Postoperative outcomes after simultaneous surgery for cervical radiculopathy combined with distal peripheral nerve compression].","authors":"V A Byvaltsev, A A Kalinin, A V Kukharev, A A Burnashev","doi":"10.17116/neiro20248806139","DOIUrl":"https://doi.org/10.17116/neiro20248806139","url":null,"abstract":"<p><p>To date, the optimal therapeutic and diagnostic strategy in patients with simultaneous clinical manifestations of degenerative cervical spine disease and upper-extremity nerve compression is still unclear.</p><p><strong>Objective: </strong>To analyze the results of simultaneous surgical interventions in patients with cervical radiculopathy combined with distal peripheral compression-induced ischemic neuropathy.</p><p><strong>Material and methods: </strong>We retrospectively studied postoperative outcomes in 23 patients with two-level degenerative cervical spine disease with radiculopathy and peripheral nerve compression (cubital canal, Guyon's canal or carpal tunnel syndromes). Two surgical teams performed interventions. Technical features of interventions, postoperative characteristics, clinical parameters (VAS scores of pain, NDI, SF-36 and DASH scores) and complications according to the Dindo-Clavien classification were studied.</p><p><strong>Results: </strong>Mean surgery time was 104 min, blood loss - 75 ml, length of hospital-stay - 4 days. In long-term period, cervical pain score decreased from 73 (57;88) to 6 (3;11) mm (<i>p</i>=0.006), pain in upper extremities from 85 (74;95) to 3 (2; 5) mm (<i>p</i>=0.001), NDI from 74 (60; 86) to 6 (6;10) (<i>p</i>=0.001) points. Physical component of health increased from 26.12 (19.37; 35.51) to 52.26 (50.68; 56.42) (<i>p</i>=0.007) scores, psychological component - from 32.68 (18.57;40.52) to 54.92 (50.73;56.92) scores (<i>p</i> =0.003). DASH score of upper limb function improved from 74 (62;80) to 8 (6;10) points. There were 3 (13%) minor complications Dindo-Clavien grade I, II and IIIA after cervical spine surgery and 2 (8.7%) events after peripheral nerve repair. Only 1 (4.3%) serious complication (Grade IIIB, IV and V) was identified after cervical spine surgery.</p><p><strong>Conclusion: </strong>Simultaneous surgery for cervical radiculopathy combined with peripheral nerve compression is safe and effective for appropriate patients.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Our approach to the treatment of vestibular schwannomas with arachnoid dissection of the facial nerve].","authors":"I M Alekseev, V A Ovchinnikov, S M Chupalenkov, A A Zuev","doi":"10.17116/neiro20248804138","DOIUrl":"10.17116/neiro20248804138","url":null,"abstract":"<p><p>Preserving the function of the facial nerve is extremely important in surgery for vestibular schwannomas. Two methods of arachnoid dissection are described for resection of vestibular schwannoma via retrosigmoid approach (from the brain stem and internal auditory canal).</p><p><strong>Objective: </strong>To evaluate the results of arachnoid dissection of the facial nerve from internal auditory canal when resecting the vestibular schwannoma.</p><p><strong>Material and methods: </strong>We analyzed 61 patients with vestibular schwannomas. Patients were divided into 2 groups depending on surgical technique. We estimated facial nerve function before and after surgery, preoperative dimension of vestibular schwannoma and extent of resection. The influence of various factors on extent of resection and postoperative facial nerve function was studied.</p><p><strong>Results: </strong>Vestibular schwannoma resection from the brain stem was performed in 30 patients, arachnoid dissection - in 31 patients. There was no significant between-group difference. Gross total resection was performed in 78.7% of cases. Both techniques demonstrated similar results regarding extent of resection. Arachnoid dissection showed the advantage regarding facial nerve function immediately after surgery (<i>p</i>=0.012) and 6 months later (<i>p</i><0.001). Normal facial nerve function in 6 months after arachnoid dissection was observed in 80.7% of patients. Preoperative dimension of tumor influenced facial nerve function in addition to technique of resection (<i>p</i>=0.001).</p><p><strong>Conclusion: </strong>We identified the factors influencing facial nerve function after resection of vestibular schwannoma. Surgical technique was the most significant factor. These data expand and popularize arachnoid dissection in surgery of vestibular schwannomas.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"38-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cerebral persistent primitive arteries. Clinical case of combination with intracranial aneurysm and review of the literature].","authors":"D I Shtadler, V D Shtadler, M S Staroverov, G A Fukalov, O G Karakulov, M A Lebedev, D V Kurnikov, S N Goryunov, A A Gagai, A S Yakunina, V A Lukyanchikov","doi":"10.17116/neiro20248802177","DOIUrl":"10.17116/neiro20248802177","url":null,"abstract":"<p><p>Cerebral persistent primitive arteries are uncommon and associated with cerebrovascular diseases, like cerebral aneurysms. They can cause vertebrobasilar ischemia and neuropathy of the cranial nerves. The authors present a patient with trigeminal artery associated with giant partially thrombosed cavernous internal cerebral artery aneurysm.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}