Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Neuroimaging predictors of favorable outcomes after shunting procedures in patients with Hakim-Adams syndrome: a pilot prospective randomized trial].","authors":"A V Stanishevskiy, G V Gavrilov, B G Adleyba, M N Radkov, D V Svistov, I D Sukhinov","doi":"10.17116/neiro20258901168","DOIUrl":"10.17116/neiro20258901168","url":null,"abstract":"<p><p>Higher effectiveness of cerebrospinal fluid shunting procedures is still an unresolved issue in the treatment of idiopathic normal pressure hydrocephalus. Thus, over 15% of patients do not experience symptom regression in postoperative period. In recent years, several MRI predictors have been actively investigated to forecast the outcomes of cerebrospinal fluid shunting procedures. We have previously introduced a prognostic model for comprehensive evaluation of MRI data facilitating identification of patients likely to benefit from surgical intervention.</p><p><strong>Objective: </strong>To evaluate diagnostic properties of MRI data comprehensive assessment model compared to traditional invasive diagnostic method (spinal tap test) in prospective randomized trial.</p><p><strong>Material and methods: </strong>MRI data and postoperative outcomes in patients diagnosed with idiopathic normal pressure hydrocephalus who underwent ventriculoperitoneal shunting between September 2022 and April 2024 were analyzed in prospective randomized study. In the study group, surgical decisions were based on MRI data, while the control group followed an algorithm incorporating invasive diagnostic method (spinal tap-test). Ventriculoperitoneal shunting with constant-pressure valve implantation was performed in all patients selected for surgery.</p><p><strong>Results: </strong>The study included 54 patients (25 ones in the study group and 29 ones in the control group). Surgery was performed in 21 and 20 patients, respectively. We found no advantages of invasive diagnostic methods over comprehensive assessment of MRI data in predicting the effectiveness of surgical treatment.</p><p><strong>Conclusion: </strong>Comprehensive assessment of MRI findings allows for avoiding invasive diagnostic procedures in decision-making on cerebrospinal fluid shunting surgery in some patients with idiopathic normal pressure hydrocephalus.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 1","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparative analysis of combined treatment methods for patients with single brain lesions].","authors":"M Yu Ostapenko, V A Lukshin, D Yu Usachev, A V Golanov, E R Vetlova, A A Durgaryan, N G Kobyakov","doi":"10.17116/neiro20248804113","DOIUrl":"10.17116/neiro20248804113","url":null,"abstract":"<p><p>Primary brain metastases are common in oncology. Preoperative stereotactic radiosurgery followed by surgical resection is a perspective approach.</p><p><strong>Objective: </strong>To evaluate own experience of preoperative radiosurgery followed by surgical resection (RS+S) of metastasis regarding local control, leptomeningeal progression, surgical and radiation-induced complications; to compare treatment outcomes with surgical resection and subsequent radiotherapy (S+SRT).</p><p><strong>Material and methods. a: </strong>Retrospective study included 66 patients with solitary brain metastasis. Two groups of patients were distinguished: group 1 (<i>n</i>=34) - postoperative irradiation, group 2 (<i>n</i>=32) - preoperative irradiation. The median age was 49.5 years (range 36-75).</p><p><strong>Results: </strong>Local 3-, 6- and 12-month control among patients with postoperative irradiation was 88.2%, 79.4% and 42.9%, in the group of preoperative irradiation - 100%, 93.3% and 66.7%, respectively (<i>p</i>=0.021). Leptomeningeal progression developed in 11 patients (8 and 3 ones, respectively). The one-year survival rate was 73.5% and 84.4%, respectively (<i>p</i>=0.33). Long-term surgical and radiation-induced complications occurred in 12 (18.2%) patients.</p><p><strong>Conclusion: </strong>Preoperative radiosurgery with subsequent resection provides higher local control and lower incidence of leptomeningeal progression in patients with single brain metastases.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Choice of fractionation regimen for Grade IV gliomas depending on rapid early progression].","authors":"A S Chuguev, T M Kobyletskaya, V A Gerasimov, A A Belikova, A D Kaprin, P V Datsenko","doi":"10.17116/neiro20248805123","DOIUrl":"https://doi.org/10.17116/neiro20248805123","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of two fractionation regimens on survival in patients with Grade IV gliomas depending on rapid early progression (REP).</p><p><strong>Material and methods: </strong>Fractionation with prescribed doses of 2 and 3 Gy was alternately used in 140 patients with morphologically confirmed Grade IV glioma using a pairwise modeling strategy.</p><p><strong>Results: </strong>REP was diagnosed in 60 (42.9%) out of 140 patients with Grade IV gliomas and 55 (45.5%) out of 121 patients with glioblastomas. Fatal outcome was observed in 111 (79.3%) patients, 99 (70.7%) ones died from progression of glioma. In case of no REP, the median overall survival as of December 2023 was 32.20 (95% CI 25.7-38.7) months, with REP - only 16.03 (95% CI 13.5-18.6) months (<i>p</i><0.0001). Median survival was slightly lower in patients with glioblastoma - 28.2 and 16.5 months, respectively (<i>p</i><0.0001).</p><p><p>In patients with Grade IV gliomas and no REP, 3 Gy (<i>n</i>=40) fractionation regimen was followed by median overall survival 44.98 (95% Cl 15.3-74.6) months, 2 Gy (<i>n</i>=40) - 20.99 (95% CI 9.2-32.7) months (<i>p</i>=0.027). In case of glioblastoma, differences between fractionation regimes lose significance - medians 33.7 and 19.7 months, respectively (<i>p</i>=0.081). According to multivariate analysis, 3 Gy fractionation regimen is more effective than standard radiotherapy (<i>p</i>=0.009) in patients without REP, while significance of isoeffective doses <59.5Gy≥ is slightly lower (<i>p</i>=0.020). Radiotherapy on the background of temozolomide is equally important (<i>p</i>=0.007).</p><p><p>In patients with grade 4 gliomas and REP, 3 Gy (<i>n</i>=30) fractionation regimen was followed by median overall survival 17.18 (95% CI 14.2-20.2) months, 2 Gy (<i>n</i>=30) - 12.88 (95% CI 5.4-20.3) months (<i>p</i>=0.849). In case of glioblastoma, Cox model classification matrix looks as follows: fractionation variant (<i>p</i>=0.423), isoeffective dose <59.5Gy≥ (<i>p</i><0.0001), temozolomide during radiotherapy (<i>p</i>=0.701), functional status (<i>p</i>=0.485).</p><p><strong>Conclusion: </strong>In patients with Grade IV gliomas and no REP, 3 Gy fractionation regimen has significant advantages over standard radiotherapy regarding overall survival. In case of more aggressive course of tumor (REP), higher single dose does not improve treatment outcomes. Isoeffective dose ≥59.5Gy is of great importance.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Focal cortical dysplasia: visual assessment of MRI and MR morphometry data].","authors":"A M Shevchenko, E L Pogosbekyan, A I Batalov, A N Tyurina, L M Fadeeva, S B Agrba, I N Pronin","doi":"10.17116/neiro20248803145","DOIUrl":"https://doi.org/10.17116/neiro20248803145","url":null,"abstract":"<p><strong>Objective: </strong>Assessing the diagnostic significance of MR morphometry in determining the localization of focal cortical dysplasias (FCD).</p><p><strong>Material and methods: </strong>The study included 13 children after surgery for drug-resistant epilepsy caused by FCD type II and stable postoperative remission of seizures (Engel class IA, median follow-up 56 months). We analyzed the results of independent expert assessment of native MR data by three radiologists (HARNESS protocol) and MR morphometry data regarding accuracy of FCD localization. We considered 2 indicators, i.e. local cortical thickening and gray-white matter blurring.</p><p><strong>Results: </strong>FCD detection rate was higher after MR morphometry compared to visual analysis of native MR data using the HARNESS protocol. MR morphometry also makes it possible to more often identify gray-white matter blurring as a sign often missed by radiologists (<i>p</i><0.05).</p><p><strong>Conclusion: </strong>MR morphometry is an additional non-invasive method for assessing the localization of FCD.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 3","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Giant pericranial sinus with extensive occipital calvarium defect].","authors":"A V Semenov, A A Semenov, A E Makarova","doi":"10.17116/neiro20248806177","DOIUrl":"10.17116/neiro20248806177","url":null,"abstract":"<p><strong>Background: </strong>Giant non-traumatic and non-iatrogenic cranial vault defects are poorly studied due to their rarity. Therefore, diagnosis and analysis of their causes are difficult. In available literature, we found only 4 cases of giant pericranial sinus accompanied by extensive cranial vault defects.</p><p><strong>Objective: </strong>To present a rare and difficult diagnostic case of cranial vault lesion with non-traumatic and non-iatrogenic extensive bone defect, as well as to propose treatment of this pathology.</p><p><p>The patient presented with complaints of a «growing» parietal-occipital cranial vault defect in November 2022. This defect occurred in childhood. A comprehensive examination including CT angiography of cerebral vessels was followed by surgical treatment (bone resection along skull defect edge with biopsy (aponeurosis, periosteum, bone) and subsequent closure with titanium plate). Postoperative period was uneventful. CT of the skull and brain, including angiography and sinusography, were performed. The follow-up period was more than 10 months with favorable outcome.</p><p><p>Considering anamnesis, clinical and additional diagnostic data, we established giant dominant-type true pericranial sinus.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"77-87"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intrascopic predictors of favorable outcomes after ventriculoperitoneal shunting in Hakim-Adams syndrome: a single-center retrospective non-randomized study].","authors":"A V Stanishevskiy, G V Gavrilov, A V Lebedenko, B G Adleyba, M N Radkov, D V Svistov, V Yu Cherebillo","doi":"10.17116/neiro20248805160","DOIUrl":"https://doi.org/10.17116/neiro20248805160","url":null,"abstract":"<p><p>The main feature of idiopathic normal pressure hydrocephalus is reversible clinical manifestations after timely ventriculoperitoneal shunting. However, the effectiveness of such interventions does not exceed 85%. Invasive diagnostic methods are used to select candidates for surgery. At the same time, literature data indicate neuroimaging symptoms predicting postoperative outcomes without invasive examination.</p><p><strong>Objective: </strong>To identify intrascopic predictors of favorable outcomes after ventriculoperitoneal shunting in Hakim-Adams syndrome; to present a model for evaluating MRI data and selecting candidates for surgery.</p><p><strong>Material and methods: </strong>A single-center retrospective non-randomized study enrolled head MRI data in patients with idiopathic normal-pressure hydrocephalus who underwent ventriculoperitoneal shunting between September 2020 and March 2022. There were 34 patients including 15 ones in the main group (significant improvement after surgery) and 19 ones in the control group. We analyzed quantitative neuroimaging features: ventriculocranial indices, DESH syndrome (DESH score), angle of corpus callosum at the level of anterior and posterior commissures, dimensions of temporal horns of lateral ventricles, the number of lacunar infarcts in basal ganglia and white matter of hemispheres.</p><p><strong>Results: </strong>We identified the most significant predictors of favorable outcomes after ventriculoperitoneal shunting: Evans index, indexed longitudinal size of lateral ventricles, angle of corpus callosum (at the level of anterior and posterior commissures) and DESH score. We created a classification model using discriminant analysis. This model allows us to predict the outcomes after ventriculoperitoneal shunting.</p><p><strong>Conclusion: </strong>A comprehensive assessment of intrascopic symptoms allows us to predict the outcomes after ventriculoperitoneal shunting in patients with Hakim-Adams syndrome. In the future, we can avoid invasive diagnostic manipulations in some patients.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Problems of monitoring malignant neoplasms of the central nervous system in the Siberian Federal District and ways to solve them].","authors":"L D Zhuikova, E L Choynzonov, O A Ananina, G A Kononova, L V Pikalova, A I Ryabova, A S Zhuikova","doi":"10.17116/neiro20248805114","DOIUrl":"https://doi.org/10.17116/neiro20248805114","url":null,"abstract":"<p><strong>Background: </strong>Incidence and recording of neuro-oncological tumors comprise an important problem in the world and In Russia including the Siberian federal district.</p><p><strong>Objective: </strong>To analyze the incidence of malignant tumors of the central nervous system (CNS) (C70-72) in the Siberian federal district and appropriate constituent territories.</p><p><strong>Material and methods: </strong>Analysis of standardized indicators was based on form No. 7 \"Information on malignant neoplasms\" for the period 2013-2022, population and male-to-female ratio in the Siberian federal district.</p><p><strong>Results: </strong>The number of patients with CNS tumors increases in the Siberian federal district while relative rates of CNS cancer incidence are stable (men 5.2±0.2%, women 3.8±0.2%). The peak incidence has shifted from the age of 65-69 years to older category (75-79 years). Mean age of patients increased by 4.6 years (53.8±1.9 years in 2022) for men and 5.5 years (58.3±1.7 years in 2022) for women (<i>p</i><0.001). We developed the algorithm for therapeutic and diagnostic care in patients with CNS tumors to solve permanent organizational problems in the Tomsk region. A specialized neuro-oncological registry based on territorial cancer registry was used.</p><p><strong>Conclusion: </strong>Development and implementation of neuro-oncological registry programs for all tumors of the central nervous system will be valuable to assess oncological epidemiological situation. Moreover, we can expect earlier diagnosis and timely specialized treatment of such patients.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Posterior petrous meningioma with secondary trigeminal neuralgia: microsurgical resection after stereotactic radiosurgery (case report and literature review)].","authors":"K S Gordienko, A V Trashin, V V Stepanenko, Yu A Shulev","doi":"10.17116/neiro20248804185","DOIUrl":"10.17116/neiro20248804185","url":null,"abstract":"<p><p>According to the literature, cerebellopontine angle tumors cause secondary trigeminal neuralgia and other symptoms of neurovascular compression in 1-9.9% of cases. We present a 58-year-old patient with left-sided secondary trigeminal neuralgia caused by ipsilateral posterior petrous meningioma. Stereotactic irradiation was followed by effective tumor growth control. However, residual trigeminal pain paroxysms significantly reduced the quality of life and required subsequent microsurgery. Trigeminal facial pain regressed after total resection of tumor. Considering this clinical case, we would like to discuss several issues: follow-up of meningioma requiring radiosurgery, course of secondary trigeminal neuralgia in a patient with apical petrous meningioma, characteristics of pain before and after radiosurgery, the best treatment option for these patients. Stereotactic radiosurgery seems unreasonable for CPA tumors with secondary trigeminal neuralgia. Indeed, persistent pain is possible even after tumor shrinkage. Moreover, primary stereotactic irradiation significantly complicates subsequent resection of tumor.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endoscopic transnasal resection of clival meningiomas].","authors":"A N Shkarubo, I V Chernov, A A Veselkov, D N Andreev, Z F Yakupova, P P Kalinin","doi":"10.17116/neiro202488021105","DOIUrl":"10.17116/neiro202488021105","url":null,"abstract":"<p><strong>Background: </strong>Surgical treatment of ventral and ventrolateral meningiomas of posterior cranial fossa is difficult in modern neurosurgery. This is due to peculiarities of approach to these areas and concentration of critical structures (cranial nerves and great vessels). Currently, endoscopic transnasal approach to these meningiomas allows partial, and in some cases, total resection. However, this technique is not widespread.</p><p><strong>Objective: </strong>To analyze the world literature data on postoperative outcomes in patients with clival and petroclival meningiomas after endoscopic transnasal resection.</p><p><strong>Material and methods: </strong>We analyzed 22 articles representing treatment of 61 patients with clival and petroclival meningiomas.</p><p><strong>Results: </strong>Total or near-total resection was achieved in 22.9% of cases, subtotal resection - 40.9%, partial resection - 26.2% (data were not provided in other cases). Even partial and subtotal resection leads to significant regression of symptoms.</p><p><strong>Conclusion: </strong>Endoscopic transnasal surgery is a full-fledged alternative to transcranial approaches in surgical treatment of clival meningiomas. It is also an additional option for patients with petroclival meningiomas after ineffective transcranial approaches. Transnasal tumor shrinkage and devascularization lead to brainstem decompression, regression of hydrocephalus and baseline clinical symptoms.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic factors in degenerative disc disease].","authors":"V A Chekhonatsky, K B Mirzaev, G V Pavlova, D Yu Usachev, N B Zakharova, A A Chekhonatsky, A V Kuznetsov, A V Gorozhanin, O N Dreval","doi":"10.17116/neiro202488021112","DOIUrl":"10.17116/neiro202488021112","url":null,"abstract":"<p><strong>Objective: </strong>To analyze available literature data on the role of genetic factors in degenerative disc disease.</p><p><strong>Methodology: </strong>We reviewed the PubMed, MEDLINE, Cohrane Library, e-Library databases using the following keywords: degenerative spine lesions, intervertebral disc herniation, pathogenesis, genetic regulation.</p><p><strong>Results: </strong>Searching depth was 2002-2022. We reviewed 84 references. Exclusion criteria: duplicate publications, reviews without detailed description of results, opinions. Finally, we included 43 the most significant studies.</p><p><strong>Conclusion: </strong>There are literature data on proinflammatory cytokines, growth factors and osteodestructive processes in pathogenesis of degenerative disc disease. However, there is only fragmentary information about the role of genetic regulation of these processes. Some factors, such as microRNA, TGF-b, VEGF, MMP are still poorly understood.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}