Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献_第5页

[Impact of TERT and CDKN2A/B driver mutations on meningioma recurrence: a systematic review and meta-analysis]. [TERT和CDKN2A/B驱动突变对脑膜瘤复发的影响：系统回顾和荟萃分析]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269005176

G S Sergeev, M V Nesterchuk, V S Klimov, A S Gaytan, V V Kuftov, G V Danilov, N A Konovalov, D Yu Usachev, A L Krivoshapkin

{"title":"[Impact of TERT and CDKN2A/B driver mutations on meningioma recurrence: a systematic review and meta-analysis].","authors":"G S Sergeev, M V Nesterchuk, V S Klimov, A S Gaytan, V V Kuftov, G V Danilov, N A Konovalov, D Yu Usachev, A L Krivoshapkin","doi":"10.17116/neiro20269005176","DOIUrl":"10.17116/neiro20269005176","url":null,"abstract":"Background: Evolution of the WHO classification for meningiomas demonstrates a shift towards integrative approach, where molecular markers are essential for risk stratification. However, their prognostic significance depending on histological grade requires further clarification.Objective: To evaluate the impact of TERT promoter mutations and CDKN2A/B deletions on meningioma recurrence, stratified by tumor grade.Material and methods: A systematic review and meta-analysis (PRISMA-P) of 17 cohort studies (n=5867) was conducted. Random-effect models and network meta-analysis were employed to assess overall survival (OS) and progression-free survival (PFS).Results: The TERT mutation significantly worsens prognosis (OS HR=2.78; PFS HR=2.63), but the effect is context-dependent. In WHO Grade 1-2 tumors, it acts as a potent driver of aggression (HR~5.00, \"initiation effect\"), whereas in Grade 3 its contribution diminishes (HR~1.5) amidst general genomic instability. Homozygous deletion of CDKN2A/B is confirmed as a universal marker of early recurrence (HR=3.72) with up to 5-fold risk increment. Sensitivity analysis revealed that clonal mutations (detected by Sanger sequencing) hold greater prognostic value than subclonal ones (detected by NGS).Conclusion: TERT screening is essential for WHO Grade 1 and 2 meningiomas to identify occult aggression, while CDKN2A/B assessment is a priority for Grade 3 tumors.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 5","pages":"76-89"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sensations and satisfaction of patients undergoing awake craniotomy]. [清醒开颅术患者的感觉和满意度]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269001139

E V Sinbukhova, A Yu Lubnin, A S Kulikov

{"title":"[Sensations and satisfaction of patients undergoing awake craniotomy].","authors":"E V Sinbukhova, A Yu Lubnin, A S Kulikov","doi":"10.17116/neiro20269001139","DOIUrl":"10.17116/neiro20269001139","url":null,"abstract":"Modern anesthetic methods can provide successful brain mapping in almost any patient. Despite integration of awake craniotomy in the world's leading neurosurgical clinics, some anesthesiologists and neurosurgeons still believe that awake craniotomy for resection of brain tumors is difficult for patients.Objective: To analyze patient satisfaction and subjective feelings after awake craniotomy.Material and methods: There were 30 participants after awake craniotomy. Mean age of patients was 43.2 years. Original checklist for assessment of patient satisfaction after awake craniotomy was developed by Sinbukhova E.V. and Lubnin A.Yu. Pain was assessed using visual analogue scale. We estimated anxiety using Hanin-Spielberger and HADS scales.Results: About 86% of patients had high satisfaction scores for \"memories before surgery\", 56.7% of patient - for \"memories during surgery\", 33.7% of patients - for \"memories after surgery\".Conclusion: When evaluating awake craniotomy according to 10-point scale (10 points - very comfortable anesthesia), only one patient chose 9 points, and all other ones chose the highest score.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Impact of cabergoline on fibrosis in prolactinoma]. 卡麦角林对催乳素瘤纤维化的影响。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269002185

I A Matsueva, A A Paltsev, K A Guseva, U A Tsoy, E N Grineva

{"title":"[Impact of cabergoline on fibrosis in prolactinoma].","authors":"I A Matsueva, A A Paltsev, K A Guseva, U A Tsoy, E N Grineva","doi":"10.17116/neiro20269002185","DOIUrl":"10.17116/neiro20269002185","url":null,"abstract":"Dopamine agonists are an effective and safe treatment for prolactinomas. However, analysis of recent data has shown that dopamine agonists, including cabergoline, can cause tumor fibrosis and complicate subsequent surgery.Objective: To determine the presence or absence of prolactinoma fibrosis in patients receiving cabergoline before surgery and to evaluate its impact on postoperative outcomes.Material and methods: The study included 58 patients with prolactinoma and preoperative cabergoline therapy who underwent transsphenoidal adenomectomy between January 2018 and March 2025. To identify fibrosis, we analyzed prolactinoma tissue samples regarding connective tissue using Masson's trichrome staining.Results: Fibrosis in prolactinoma was detected in 18 (31%) patients who received cabergoline. Comparison of patients with prolactinoma fibrosis (group 1, 18 patients) with patients whose prolactinomas did not show fibrosis (group 2, 40 patients) revealed significant differences regarding treatment duration and cabergoline dose (76 vs. 17 months, p<0.001; 3.25 mg/week vs. 2 mg/week, respectively, p=0.049). Resection of fibrous prolactinoma required more time (median 30 min) than non-fibrous prolactinoma (20 min) (p=0.04). The total number of complications was higher in patients with prolactinoma fibrosis (p=0.041).Conclusion: Treatment of prolactinoma with cabergoline can lead to fibrosis, and appropriate probability is associated with duration of preoperative therapy. Cabergoline-induced fibrosis increased duration of resection and number of complications.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anatomical basis for a new method of atlas osteosynthesis in unstable C1 vertebra fractures]. [不稳定C1椎体骨折寰椎植骨新方法的解剖学基础]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269002137

V N Rashidov, I Yu Lisitskii, A V Lychagin, R L Kambiev, K M Kulakov, A Yu Zarov, A L Korkunov, V G Cherepanov, I A Vyazankin, E Yu Tselischeva

{"title":"[Anatomical basis for a new method of atlas osteosynthesis in unstable C1 vertebra fractures].","authors":"V N Rashidov, I Yu Lisitskii, A V Lychagin, R L Kambiev, K M Kulakov, A Yu Zarov, A L Korkunov, V G Cherepanov, I A Vyazankin, E Yu Tselischeva","doi":"10.17116/neiro20269002137","DOIUrl":"10.17116/neiro20269002137","url":null,"abstract":"Background: Surgical treatment for unstable atlas fractures is still controversial. Harm's atlantoaxial fusion or more extensive occipitospondylodesis reduces quality of life and functional status. Biomechanical rationales for anterior and posterior C1 osteosynthesis are based on small sample, and the role of ligamentous complex in C1-C2 segment remains understudied.Objective: To evaluate the effectiveness of a new method of surgical treatment for unstable fractures of the first cervical vertebra.Material and methods: Biomechanical analysis enrolled 10 anatomical specimens. Various injuries of the atlas ring and ligament complex were simulated. The role of apical and cruciate ligaments as additional stabilizers of craniovertebral junction was assessed. Morphometric parameters and anatomical relationships were presented using new surgical method for unstable C1 vertebral fractures and Harm's atlantoaxial fusion as a comparative treatment model.Results: Instability was observed in all cases of ligamentous complex injury. Rotation angle in atlantoaxial segment remained stable. New surgical method for C1 vertebral injury reduces anterior atlantodental interval to 2.37±0.27 mm, distance between articular surfaces of C1-C2 vertebrae to 3.51±0.46 mm and Redlund-Johnell index to 36.61±1.22 mm without block rotation in atlantoaxial joint.Conclusion: Original surgical method for unstable C1 fractures is effective when patient selection principles are followed. Preoperative planning and assessment of integrity of craniovertebral ligaments are essential to avoid tactical errors when choosing surgical intervention.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Tentorial meningiomas extending along transverse and sigmoid sinuses to jugular vein bulb]. [幕脑膜瘤沿横窦和乙状窦延伸至颈静脉球]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269001173

S A Melchenko, M A Brehuncov, I V Senko, I V Grigoriev, I S Gumin, M B Dolgushin, G E Golodnev

{"title":"[Tentorial meningiomas extending along transverse and sigmoid sinuses to jugular vein bulb].","authors":"S A Melchenko, M A Brehuncov, I V Senko, I V Grigoriev, I S Gumin, M B Dolgushin, G E Golodnev","doi":"10.17116/neiro20269001173","DOIUrl":"10.17116/neiro20269001173","url":null,"abstract":"The authors describe 3 patients with tentorial meningiomas (type T6-T7 according to classification by M.G. Yasargil) extending into transverse and sigmoid sinuses towards jugular vein. The authors also analyze foreign experience in the treatment of similar meningiomas and difficulties accompanying choice of treatment strategy for such patients. To preserve functionally significant brain structures and functional status, the authors performed subtotal resection and decompression of caudal nerves within jugular foramen in each case. Neurological symptoms partially regressed in postoperative period in all patients. In long-term follow-up, continued tumor growth in 2 out of 3 patients required redo surgery. Further research of multimodal treatment approach to such patients, including combination of surgery with stereotactic radiotherapy, seems perspective considering close relationship of such meningiomas with functionally significant brain structures, impossibility of safe simultaneous total resection and high probability of continued tumor growth after subtotal resection.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Scoring system for unstable gunshot and blast-fragmentation wounds to the thoracolumbar spine]. [不稳定胸腰椎枪伤和爆炸碎片伤的评分系统]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro2026900515

V A Manukovsky, A O Kelin, M N Kravtsov, G I Antonov, V I Badalov, I V Basankin, Z Sh Aliev

{"title":"[Scoring system for unstable gunshot and blast-fragmentation wounds to the thoracolumbar spine].","authors":"V A Manukovsky, A O Kelin, M N Kravtsov, G I Antonov, V I Badalov, I V Basankin, Z Sh Aliev","doi":"10.17116/neiro2026900515","DOIUrl":"https://doi.org/10.17116/neiro2026900515","url":null,"abstract":"Background: According to the authors, up to 9.8% of gunshot wounds to the spine are unstable. The lack of tactical classification complicates decision-making regarding the need for fusion surgery. Thus, a scoring protocol was developed for assessing unstable gunshot wounds to the thoracolumbar spine.Material and methods: The second phase of the study involved survey of 19 expert surgeons. Participants completed the questionnaires twice with a 2-month interval. The Kappa coefficient was used to determine inter- and intra-expert agreement regarding applicability of classifications, presence of injury and contribution of injury of specific anatomical structure to destabilization. The third stage involves statistical analysis and development of a scoring tactical classification.Results: Traditional assessment systems for closed spinal injuries have extremely low reproducibility when applied to gunshot wounds. Experts demonstrated the greatest consensus when assessing bilateral fractures of the facet joints (κ=0.553-0.614) or roots of arches (κ=0.683-0.713) and vertebral body destruction involving both endplates (κ=0.556-0.570 - moderate agreement). A scoring tactical surgical classification of unstable gunshot wounds to the thoracolumbar spine was developed.Conclusion: AUC (0.866 for unstable and 0.888 for stable cases) allows the developed classification to be characterized as an \"excellent classifier\". Considering 87.9% sensitivity and 72.3% specificity (for unstable cases), we can recommend this method for neurosurgeons and traumatologists to optimize treatment strategies for the wounded.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 5","pages":"5-15"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prognostic factors of GMFCS class improvement after selective dorsal rhizotomy in children with cerebral palsy]. [脑瘫患儿选择性背根切断术后GMFCS分级改善的预后因素]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269002154

K V Sysoev, A A Kulaeva, A Yu Smirnova, A V Kim

{"title":"[Prognostic factors of GMFCS class improvement after selective dorsal rhizotomy in children with cerebral palsy].","authors":"K V Sysoev, A A Kulaeva, A Yu Smirnova, A V Kim","doi":"10.17116/neiro20269002154","DOIUrl":"10.17116/neiro20269002154","url":null,"abstract":"Selective dorsal rhizotomy (SDR) is a surgical method for children with spastic cerebral palsy (CP). In addition to reducing spasticity, some patients experience significant improvement of functional status after surgery (GMFCS class).Objective: To identify additional prognostic factors of GMFCS functional class improvement following SDR in children with spastic CP.Material and methods: A retrospective analysis of treatment outcomes included 71 patients aged 2-16 years who underwent SDR between 2022 and 2024. As a part of pre- and postoperative in-hospital examination, we analyzed muscle tone using the modified Ashworth scale (MAS) and GMFCS functional class. Preoperative brain MRI data were also taken into account. Telephone survey was conducted to assess long-term outcomes in follow-up period from 2 months to 2 years 11 months (mean 1 year 1 month 10 days).Results: When evaluating significance of various prognostic factors, such as age, baseline GMFCS class, patient socialization before surgery, botulinum toxin therapy, motor rehabilitation, and orthopedic interventions before and after surgery, as well as severity of structural brain changes according to MRI data, we found no significant association with more favorable functional outcomes.Conclusion: Our data may substantiate intermediate functional classes, detailed functional status assessment scales, and monitoring of systemic rehabilitation according to individual characteristics with subsequent analysis of treatment outcomes in these groups.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Microsurgical treatment of tentorial meningiomas: a systematic review]. [显微外科治疗幕脑膜瘤：系统回顾]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro202690041106

R A Sultanov, R S Dzhindzhikhadze, A V Polyakov, V S Gadzhiagaev, A N Abdullaev, A D Zaitsev, E I Salyamova

引用次数: 0

[Rapid ventricular pacing for induced hypotension in clipping of a large aneurysm of vertebrobasilar confluence]. [快速心室起搏治疗椎基底动脉汇合处大动脉瘤致低血压]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269004175

R S Dzhindzhikhadze, V S Gadzhiagaev, A V Polyakov, A I Gvelesiani, S N Kavadin

{"title":"[Rapid ventricular pacing for induced hypotension in clipping of a large aneurysm of vertebrobasilar confluence].","authors":"R S Dzhindzhikhadze, V S Gadzhiagaev, A V Polyakov, A I Gvelesiani, S N Kavadin","doi":"10.17116/neiro20269004175","DOIUrl":"10.17116/neiro20269004175","url":null,"abstract":"Background: Despite advances in endovascular technologies, microsurgical clipping is still a relevant treatment for cerebral aneurysms. Blood flow reduction techniques become necessary in some cases (no adequate proximal and distal blood flow control). Rapid ventricular pacing is a new effective technique for controllable hypotension and aneurysm sac relaxation.Objective: To demonstrate successful rapid ventricular pacing in microsurgical clipping of a large aneurysm of vertebrobasilar confluence in acute period of SAH.Material and methods: A 64-year-old patient with SAH from vertebrobasilar confluence aneurysm underwent successful microsurgical treatment.The patient underwent surgery on the second day after hemorrhage. Surgery was performed through a right-sided retrosigmoid approach. Two episodes of rapid ventricular pacing were used to relax the aneurysm and reduce the risk of intraoperative rupture. The effect was achieved almost immediately after initiation with episodes lasting no more than 50 seconds. Controllable hypotension minimized bleeding. There were no postoperative neurological complications. CT angiography showed complete exclusion of aneurysm. The patient was discharged after 10 postoperative days.Conclusion: Rapid ventricular pacing may be justified in the treatment of complex cerebral aneurysms when surgical blood flow control is difficult. Large-scale studies are needed to develop patient selection algorithms for this surgery.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"75-86"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[IDH-mutant gliomas. State of the art]. [IDH-mutant神经胶质瘤。最先进的技术]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269005170

M V Ryzhova

引用次数: 0