Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献_第10页

[Dysphagia as the main symptom in anterior cervical spine osteophytes (Forestier disease and cervical spondylosis deformans). Case reports and literature review]. [吞咽困难是颈椎前部骨质增生（Forestier 病和颈椎变形症）的主要症状。病例报告和文献综述]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248802169

A V Trashin, N V Vikherev, E M Belov, V A Shamanin, V V Stepanenko

引用次数: 0

[Primary tumors of the brain stem. State of the problem]. [脑干原发性肿瘤：问题现状]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248802198

A V Gavryushin, E A Khukhlaeva, A A Veselkov, I N Pronin, A N Konovalov

引用次数: 0

[Intrathecal baclofen therapy: a 30-year experience]. [鞘内巴氯芬疗法：30 年的经验]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248803196

I N Morozov, K V Nesterin

{"title":"[Intrathecal baclofen therapy: a 30-year experience].","authors":"I N Morozov, K V Nesterin","doi":"10.17116/neiro20248803196","DOIUrl":"https://doi.org/10.17116/neiro20248803196","url":null,"abstract":"Background: The first pump for intrathecal administration of baclofen was implanted in 1984. Over thirty years, intrathecal prolonged infusion of muscle relaxants has occupied a worthy niche among all methods for correction of non-focal drug-resistant disabling muscle spasticity. However, this method has not become routine despite high awareness of specialists in Russia and abroad, as well as undeniable advantages for restoring the daily activity, improving the walking pattern and providing care and quality of life in people with limited mobility. This is due to scrupulous analysis of adverse events and accurate attitude towards its use.The purpose of this review was to systematize data on indications, selection criteria, pump implantation technique, subsequent patient management and treatment outcomes over a 30-year history.Method: A review of national and foreign literature was performed.Results and conclusion: Prolonged intrathecal baclofen therapy is perspective for long-term treatment of severe spasticity interfering with quality of life and self-care if oral muscle relaxants are contraindicated or ineffective. This procedure is effective for impaired articulation, chewing and spastic pain syndrome. One can reduce the incidence of side effects via correct dosage of the drug, and tolerance to therapy can be reduced by timely elimination of problems with catheter.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 3","pages":"96-102"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Human glioma malignancy grade and migratory capacity depending on expression of GDNF isoforms in vitro]. [人胶质瘤恶性程度和迁移能力取决于体外GDNF异构体的表达]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248806131

D V Shamadykova, L G Zakharova, S A Pavlova, G V Pavlova

{"title":"[Human glioma malignancy grade and migratory capacity depending on expression of GDNF isoforms in vitro].","authors":"D V Shamadykova, L G Zakharova, S A Pavlova, G V Pavlova","doi":"10.17116/neiro20248806131","DOIUrl":"https://doi.org/10.17116/neiro20248806131","url":null,"abstract":"Glial cell line-derived neurotrophic factor (GDNF) is essential in maintaining the viability, function and differentiation of neuronal cells. In addition to its function in healthy nervous tissue, GDNF is involved in pathological processes, such as glioma growth. GDNF is represented by 2 main isoforms: pre-α-pro-GDNF (αGDNF) and pre-β-pro-GDNF (βGDNF). αGDNF maintains cell viability, and βGDNF has neurotrophic properties. The relationship between GDNF expression and human glioma malignancy grade, as well as migratory properties of tumor cells remains poorly understood.Objective: To assess the expression of mRNA splice variants of GDNF in glioma cell cultures with various malignancy grades (I-IV) and degrees of migration.Material and methods: In this study, αGDNF and βGDNF expression was analyzed in 15 human glioma cell cultures using Southern blot hybridization of GDNF cDNA and reverse transcription with PCR to amplify splice variants of GDNF mRNA.Results: The highest expression of αGDNF and βGDNF isoforms was observed in cell cultures of human gliomas with extensive migratory activity. Low βGDNF expression without αGDNF expression is typical only for gliomas with low migratory activity. In addition, we found additional patterns of mRNA expression that have not been previously described.Conclusion: The relationship between GDNF and malignancy grade is unclear. Nevertheless, GDNF expression is higher in glioblastomas. Overall GDNF expression is increased in glioma cells with high migration activity. At the same time, αGDNF and βGDNF isoforms demonstrate higher expression in actively migrating cells that can indicate their participation in regulation of tumor migration properties. No αGDNF expression with simultaneous low βGDNF expression may be a prognostic sign of low migration activity of human glioma cells.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neuromodulatory pharmacotherapy individualization in prolonged and chronic consciousness disorders after severe traumatic brain injury]. [严重脑外伤后长期和慢性意识障碍的神经调节药物治疗个体化]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248803174

E V Aleksandrova, O S Zaitsev, A A Potapov

引用次数: 0

[Diagnostic criteria for prolonged and chronic disturbances of consciousness after aneurysmal subarachnoid hemorrhages]. [动脉瘤性蛛网膜下腔出血后长期和慢性意识障碍的诊断标准]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro202488041117

E V Sergeenko, O B Belousova, Yu V Pilipenko

{"title":"[Diagnostic criteria for prolonged and chronic disturbances of consciousness after aneurysmal subarachnoid hemorrhages].","authors":"E V Sergeenko, O B Belousova, Yu V Pilipenko","doi":"10.17116/neiro202488041117","DOIUrl":"10.17116/neiro202488041117","url":null,"abstract":"Background: In recent years, prolonged states of impaired consciousness became widespread among patients with aneurysmal subarachnoid hemorrhage. Treatment and maintenance of vital functions in such patients represent a complex medical, economic and social problem. In this regard, searching for the causes of prolonged states of impaired consciousness and predicting the outcomes are important.Objective: To analyze available literature data on prevention and treatment of prolonged states of impaired consciousness after aneurysmal subarachnoid hemorrhage.Results: We reviewed the PubMed database using the keywords «unresponsive wakefulness syndrome», «persistent vegetative state2, «minimal consciousness state» and «outcome of subarachnoid hemorrhage». Only 4 reports devoted to the causes and treatment outcomes in patients with prolonged impairment of consciousness after aneurysmal subarachnoid hemorrhage were found. At the same time, patients with aneurysmal subarachnoid hemorrhage comprise up to 11% among all cases of prolonged states of impaired consciousness. Examination, management and treatment of patients with prolonged impairment of consciousness after aneurysmal subarachnoid hemorrhage are carried out according to general principles without taking into account specific etiological and pathogenetic factors.Conclusion: Increased number of patients with prolonged impairment of consciousness after aneurysmal subarachnoid hemorrhage necessitates analysis of etiopathogenesis and outcomes of these disorders based on modern clinical, instrumental and laboratory assessment of the brain.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Radiosurgery for cerebral cavernous malformations: a systematic review]. [放射外科治疗脑海绵畸形：系统性综述]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro202488041107

D E Semenov, O B Belousova, V V Kostyuchenko, A V Golanov

{"title":"[Radiosurgery for cerebral cavernous malformations: a systematic review].","authors":"D E Semenov, O B Belousova, V V Kostyuchenko, A V Golanov","doi":"10.17116/neiro202488041107","DOIUrl":"10.17116/neiro202488041107","url":null,"abstract":"Background: Stereotactic radiosurgery (SRS) for cerebral cavernous malformations has been used for more than 30 years. However, indications for this method and outcomes are still discussable.Objective: To analyze available literature data on SRS for cerebral cavernous malformations with assessment of indications for treatment, radiation parameters, radiological and clinical complications and outcomes.Results: The final analysis included 20 reports describing post-SRS outcomes in 1834 patients with cerebral cavernous malformations. The main radiation parameter was mean radiation dose to the edge of cavernous malformation (prescribed dose, 13.25±2.16 Gy). In natural course of malformation, mean incidence of hemorrhages from cavernous malformation when counted after the second hemorrhage was 25.9±14.6%, after the patient's birth - 2.59±0.44%. Mean follow-up period after SRS was 66.7±24.1 months. Incidence of hemorrhages from cavernous malformation after SRS for the first 2 years of follow-up was assessed in 14 studies (4.67±3.51%). Incidence of hemorrhages ≥2 years after SRS was analyzed in 12 studies (1.55±0.8%).Conclusion: Despite significant global experience in SRS for cerebral cavernous malformations and many studies devoted to this problem, clear patient selection criteria have not yet been formulated. Modern selection principles have insufficient evidence base.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"107-116"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Analysis of intracranial saccular aneurysm wall: neuroimaging and histopathological correlates]. [颅内囊状动脉瘤壁分析：神经影像学和组织病理学相关性]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248803152

K S Semin, G A Demyashkin, N E Zakharova, Sh Sh Eliava, A S Kheireddin, A N Konovalov, D B Kalaeva, A I Batalov, I N Pronin

{"title":"[Analysis of intracranial saccular aneurysm wall: neuroimaging and histopathological correlates].","authors":"K S Semin, G A Demyashkin, N E Zakharova, Sh Sh Eliava, A S Kheireddin, A N Konovalov, D B Kalaeva, A I Batalov, I N Pronin","doi":"10.17116/neiro20248803152","DOIUrl":"https://doi.org/10.17116/neiro20248803152","url":null,"abstract":"Background: Contrast enhancement of intracranial aneurysm wall during MRI with targeted visualization of vascular wall correlates with previous aneurysm rupture and, according to some data, may be a predictor of further rupture of unruptured aneurysms.Objective: To analyze possible causes of aneurysm contrast enhancement considering morphological data of aneurysm walls.Material and methods: The study included 44 patients with intracranial aneurysms who underwent preoperative MRI between November 2020 and September 2022. Each aneurysm was assessed regarding contrast enhancement pattern. Microsurgical treatment of aneurysm was accompanied by resection of its wall for subsequent histological and immunohistochemical analysis regarding thrombosis, inflammation and neovascularization. Specimens were subjected to histological and immunochemical analysis. Immunohistochemical analysis was valuable to estimate inflammatory markers CD68 and CD3, as well as neurovascularization marker SD31.Results: Aneurysms with contrast-enhanced walls were characterized by higher number of CD3+, CD68+, CD31+ cells and parietal clots. Intensity of contrast enhancement correlated with aneurysm wall abnormalities.Conclusion: Contrast enhancement of aneurysm wall can characterize various morphological abnormalities.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 3","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prospective analysis of inflammatory markers and perioperative clinical data in children with craniosynostosis undergoing reconstructive surgery]. [前瞻性分析接受整形手术的颅骨发育不良患儿的炎症标志物和围手术期临床数据]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248801170

B A Bashiryan, O A Gadzhieva, L A Satanin, E A Lavrenyuk, V A Tere, N A Mazerkina, A V Sakharov, I V Getmanova, V V Roginsky

{"title":"[Prospective analysis of inflammatory markers and perioperative clinical data in children with craniosynostosis undergoing reconstructive surgery].","authors":"B A Bashiryan, O A Gadzhieva, L A Satanin, E A Lavrenyuk, V A Tere, N A Mazerkina, A V Sakharov, I V Getmanova, V V Roginsky","doi":"10.17116/neiro20248801170","DOIUrl":"10.17116/neiro20248801170","url":null,"abstract":"Background: Craniosynostosis (CS) is a group of skull malformations manifested by congenital absence or premature closure of cranial sutures. Reconstructive surgery in the second half of life is traditional approach for CS. The issues of surgical stress response after reconstructive surgery for CS in children are still unclear.Objective: To evaluate clinical and laboratory parameters in children undergoing traumatic reconstructive surgery for CS.Material and methods: Inclusion criteria were CS, reconstructive surgery, age <24 months, no comorbidities and available laboratory diagnostic protocol including complete blood count, biochemical blood test with analysis of C-reactive protein, procalcitonin, ferritin and presepsin. The study included 32 patients (24 (75%) boys and 8 (25%) girls) aged 10.29±4.99 months after surgery between October 2021 and June 2022. Non-syndromic and syndromic forms of CS were observed in 25 (78.1%) and 7 (21.9%) cases, respectively.Results: There were no infectious complications. We analyzed postoperative clinical data, fever, clinical and biochemical markers of inflammation.Conclusion: Early postoperative period after reconstructive surgery for CS in children is accompanied by significant increase of inflammatory markers (C-reactive protein, procalcitonin, ferritin). However, these findings do not indicate infectious complications. This is a manifestation of nonspecific systemic reaction. Severity of systemic inflammatory response syndrome with increase in acute phase proteins indicates highly traumatic reconstructive surgery for CS in children. Analysis of serum presepsin allows for differential diagnosis between infectious complication and uncomplicated course of early postoperative period.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 1","pages":"70-78"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Is it possible to detect surface antigen CD133 on patient-derived glioblastoma continuous cell cultures using fluorescent aptamers?] [利用荧光适配体检测源自患者的胶质母细胞瘤连续细胞培养物上的表面抗原CD133是否可行？］

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2024-01-01 DOI: 10.17116/neiro20248801156

V L Moiseenko, O M Antipova, S A Pavlova, I N Pronin, G V Pavlova, A M Kopylov

{"title":"[Is it possible to detect surface antigen CD133 on patient-derived glioblastoma continuous cell cultures using fluorescent aptamers?]","authors":"V L Moiseenko, O M Antipova, S A Pavlova, I N Pronin, G V Pavlova, A M Kopylov","doi":"10.17116/neiro20248801156","DOIUrl":"10.17116/neiro20248801156","url":null,"abstract":"Theranostics combines diagnostics and therapeutic exposure. Regarding glioblastomas, theranostics solves the problem of detecting and destroying tumor stem cells resistant to irradiation and chemotherapy and causing tumor recurrence. Transmembrane surface antigen CD133 is considered as a potential marker of tumor stem cells.Objective: To detect CD133 in patient-derived glioblastoma continuous cell cultures using fluorescence microscopy and modified aptamers (molecular recognition elements) anti-CD133.Material and methods: To detect CD133, we used mousey fluorescence monoclonal antibodies anti-CD133 MA1-219, FAM-modified DNA aptamers anti-CD133 AP-1-M and Cs5. Non-aptamer DNA oligonucleotide NADO was used as a negative control. Detection was performed for three samples of patient-derived glioblastoma continuous cell cultures coded as 1548, 1721 and 1793.Results: MA1-219 antibodies brightly stained cell culture 1548, to a lesser extent - 1721. There was diffuse staining of cell culture 1793. Cs5-FAM aptamer stained cells in a similar way, but much weaker. AP-1-M-FAM aptamer interacted with cells even weaker and diffusely stained only cell culture 1793. Non-aptamer NADO did not stain cell culture 1548 and very weakly diffusely stained cell culture 1793.Conclusion: For both molecular recognition elements (MA1-219 antibody and Cs5 aptamer), 3 cell culture samples can be arranged in the following order possibly reflecting CD133 status decrease: strong signal for cell culture 1548, much weaker for 1721, even weaker for 1793. Only cell culture 1548 can be considered CD133 positive with combination of Cs5+ and NADO signals. Cell culture 1793 is CD133 false positive with combination of Cs5+ and NADO+ signals.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 1","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0