Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Research of interaction of fluorescent anti-CD133 DNA aptamers with glioblastoma cell cultures using flow cytometry].","authors":"V L Ivko, V E Makeeva, O M Antipova, E A Savchenko, I N Pronin, G V Pavlova, A M Kopylov","doi":"10.17116/neiro20269002115","DOIUrl":"https://doi.org/10.17116/neiro20269002115","url":null,"abstract":"<p><p>Glioblastoma or grade IV glioma is characterized by extremely poor prognosis. Resistance to radio- / chemotherapy and recurrences are associated with tumor stem cells. Transmembrane protein CD133 is considered a potential marker of tumor stem cells. To overcome the limitations of detecting cellular CD133 by antibodies, potential of aptamers (nucleic acid-based molecular recognition elements) is being explored. To obtain reproducible results, it is necessary to study the interaction of fluorescent aptamers to CD133 with standard cell lines and cell cultures derived from patient tumors using various methods.</p><p><strong>Objective: </strong>To detect the CD133 marker in continuous cell cultures of patient-derived GB cells using fluorescent DNA aptamers by flow cytometry.</p><p><strong>Material and methods: </strong>Fluorescein (FAM)-labeled DNA aptamers of the Cs and Ap series were used to detect the CD133 marker. Three continuous cell cultures from the Burdenko Neurosurgical Center Biobank were tested using flow cytometry. Burdenko: BU881 (107), G01, and Sus (harvested from postoperative GB tissues).</p><p><strong>Results: </strong>CD133 DNA aptamers at a concentration of 1 <i>μ</i>M yield positive signals for GB cell cultures. Their magnitude correlates with CD133 gene transcription. Fluorescence signal shift (∆MFI) for FAM DNA aptamers of the Cs and Ap series is greater for BU881 cells (1942 and 5449 c.u., respectively) than for G01 cells (1469 and 1817 c.u., respectively). This is consistent with CD133 gene transcription. There is no fluorescence signal shift for Sus cells with minimal CD133 gene transcription.</p><p><strong>Conclusion: </strong>Fluorescein-labeled DNA aptamers of the Cs and Ap series at a concentration of 1 <i>μ</i>M enable detection of the CD133 marker in continuous cell cultures of GB through flow cytometry.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Surgical treatment of hemifacial spasm: a systematic review].","authors":"V N Shimansky, L A Sidneva, S V Tanyashin, A A Ogurtsova, V K Poshataev, M V Kolycheva, I O Kugushev, R A Sadykov, V A Gorbulev","doi":"10.17116/neiro202690021112","DOIUrl":"https://doi.org/10.17116/neiro202690021112","url":null,"abstract":"<p><p>The annual incidence of hemifacial spasm is 8-15 cases per 100.000. This disease is not life-threatening, but it significantly impacts the quality of life. Primary treatment is vascular decompression of the facial nerve. Thus, improvement of appropriate technique is crucial for higher efficacy and safety.</p><p><strong>Objective: </strong>To determine the optimal algorithm for vascular decompression according to available international experience in surgical treatment of hemifacial spasm.</p><p><strong>Material and methods: </strong>A systematic review was conducted in accordance with the PRISMA guidelines. To identify relevant publications, we screened the PubMed, Google Scholar, and eLibrary databases through October 2024 using the keywords «microvascular decompression» and «hemifacial spasm». Only full-text articles in Russian, English, or French were included in the study.</p><p><strong>Results: </strong>Among 364 manuscripts, 24 met the inclusion criteria. The majority of studies demonstrated available experience and effectiveness of vascular decompression without description of surgical approach.</p><p><strong>Conclusion: </strong>Considering global experience, we proposed an optimal surgical algorithm, including initial dissection of bulbar nerves and facial nerve decompression, if possible, along its entire length.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Gunshot craniocerebral wound complicated by anaerobic brain abscess. Case report and literature review].","authors":"N R Saburov, I N Isengaliev, D E Alekseev, D V Svistov, Sh Kh Gizatullin, I I Ivanov, I N Chirko, E A Kim","doi":"10.17116/neiro20269002192","DOIUrl":"https://doi.org/10.17116/neiro20269002192","url":null,"abstract":"<p><p>Brain abscess is a focal infectious inflammatory lesion characterized by collection of pus in brain tissue surrounded by a vascularized capsule. The most common cause is spread of microorganisms from distant foci of infection (e.g., odontogenic infection or sinusitis). The risk of intracranial infectious complications and mortality increases significantly in penetrating gunshot wounds to the skull and brain.</p><p><strong>Material and methods: </strong>Available literature contains a few studies on infectious complications following combat traumatic brain injury. This article presents treatment of anaerobic brain abscess in a patient with previous penetrating gunshot skull wound.</p><p><strong>Results: </strong>A 24-year-old patient admitted for specialized medical care with penetrating blind radial shrapnel skull and brain wound in the left occipital region complicated by intracerebral anaerobic abscess. The patient underwent secondary surgical debridement of craniocerebral wound, removal of abscess, and drainage system placement. On the fourth postoperative day, sedation was discontinued. There was moderate impairment of consciousness. By the ninth day, consciousness became normal. After primary treatment, the patient was transferred for rehabilitation.</p><p><strong>Conclusion: </strong>This case highlights the role of strict adherence to the principles of emergency neurosurgical care when treating wounds complicated by intracranial infection.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"92-97"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lost anatomical structure - pharyngeal pituitary gland (Hypophysis pharyngealis or Erdheim pituitary gland): a review and case report].","authors":"L A Satanin, V V Kulikov, S E Shemyakov, N A Chernikova, A N Shkarubo, L V Shishkina, I N Pronin, E V Shelesko, L I Astafyeva, N A Mazerkina, M L Satanina, D Sh Adueva","doi":"10.17116/neiro20269001183","DOIUrl":"https://doi.org/10.17116/neiro20269001183","url":null,"abstract":"<p><p>Pharyngeal pituitary gland is a glandular structure located along the path of Rathke's pouch (along the midline under mucous membrane of the nasopharynx near the lower wall of sphenoid bone). The purpose of this study was to examine literature data on anatomy and physiology of pharyngeal pituitary gland, its possible relationship with extracranial ectopic pituitary adenomas, as well as to describe appropriate patient. Literary data confirm pharyngeal pituitary gland as a permanent human anatomical structure capable of release of all hormones similar to those of anterior pituitary gland. Functional significance of pharyngeal pituitary gland is unknown. However, it may be a source of ectopic adenomas in nasopharynx and skull base. These data are important for diagnosis in patients with endocrine disorders associated with malformations and ectopic pituitary adenomas.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hypothalamic obesity in adults with craniopharyngiomas: prevalence and risk factors before and after neurosurgical treatment].","authors":"I S Klochkova, L I Astafyeva, M A Kutin, A N Konovalov, Yu G Sidneva, A N Shkarubo, P L Kalinin","doi":"10.17116/neiro20269002177","DOIUrl":"https://doi.org/10.17116/neiro20269002177","url":null,"abstract":"<p><p>Hypothalamic obesity (weight gain due to hypothalamic damage) is a common complication of surgical treatment of craniopharyngiomas. Data on the prevalence and clinical features of hypothalamic obesity in adults with craniopharyngiomas are scarce, and reports on prognostic factors are contradictory.</p><p><strong>Objective: </strong>To assess the prevalence and risk factors of hypothalamic obesity before and after neurosurgical treatment of craniopharyngiomas in adults.</p><p><strong>Material and methods: </strong>This prospective study included 99 adults with craniopharyngioma. A comprehensive examination was performed. Damage to hypothalamic-pituitary structures was assessed using preoperative MRI, clinical, laboratory and intraoperative data.</p><p><strong>Results: </strong>Pre- and postoperative hypothalamic obesity was detected in 32 (32%) and 47 (57.3%) patients, respectively. Hypothalamic obesity was significantly more common in pituitary stalk and ventricular craniopharyngiomas compared to endosuprasellar craniopharyngiomas (<i>p</i><0.05). Fifty-nine (71%) patients experienced significant (≥5%) body weight gain after surgery (median 15% [8.8; 24.0] or 11 kg [7; 17]). Analysis of groups with and without hypothalamic obesity after surgery revealed significant differences in baseline body mass index (30.8 kg/m² [27.0; 35.9] and 22.1 kg/m² [19.4; 25.2], respectively, <i>p</i><0.001), incidence of mental disorders (36.2% and 14.3%, respectively, <i>p</i>=0.027) and preoperative hypogonadism (93.5% and 71.4%, respectively, <i>p</i>=0.013). In multivariate analysis, independent risk factors of hypothalamic obesity were preoperative body mass index with a cutoff value of 27 kg/m² and third ventricular bottom lesions due to tumor infiltration. No effect of histological type of craniopharyngioma, surgical approach or extent of surgery on the incidence of hypothalamic obesity was found.</p><p><strong>Conclusion: </strong>There was high incidence of hypothalamic obesity due to tumor growth and surgical treatment in adults with craniopharyngioma. Predictors of hypothalamic obesity after surgery for craniopharyngioma were baseline body mass index and damage to third ventricle bottom.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Principles of systematization and formation of surgical strategies for craniovertebral region lesions].","authors":"V V Stepanenko, A V Trashin, V A Shamanin, K S Gordienko, Yu A Shulev, R V Khalepa, M A Kosimshoev, Yu E Kubetsky, D A Rzayev","doi":"10.17116/neiro20269001121","DOIUrl":"https://doi.org/10.17116/neiro20269001121","url":null,"abstract":"<p><p>Surgical treatment of craniovertebral junction (CVJ) lesions is a complex multidisciplinary problem. Despite diverse diseases and traumatic injuries of CVJ, many authors note universality of clinical manifestations. This allows for their systematization and formation of homogeneous groups based on dominant clinical syndrome.</p><p><strong>Objective: </strong>To apply dominant clinical syndrome for systematizing CVJ lesions and formation of surgical strategies.</p><p><strong>Material and methods: </strong>A retrospective analysis and systematization of patient groups with surgical CVJ lesions were conducted in 2 neurosurgical hospitals. The study included 181 patients with one of the five main CVJ lesions. Inclusion criteria were CVJ diseases and lesions: trauma - 76 (42%), developmental anomalies - 19 (10%), inflammatory and genetic diseases - 9 (5%), extradural tumors - 27 (15%), intradural tumors - 50 (28%). Systematization of material was based on the principle of dominant clinical syndrome. Two types of dominant clinical syndrome were distinguished: compression and instability. The specialized scales were used: the White & Panjabi criteria for trauma and anomalies, the Spinal Instability Neoplastic Score (SINS) for CVJ tumors, the Ranawat scale for rheumatoid arthritis, and the Kang scale for assessing compression of medulla oblongata and spinal cord.</p><p><strong>Results: </strong>We distinguished 2 groups depending on dominant clinical syndrome: group 1 with compression (97 (54%) patients) and group 2 with instability (84 (46%) patients). Group I included 97 patients with trauma (<i>n</i>= 10, 10.3%), anomalies (<i>n</i>=16, 16.5%), inflammatory and genetic storage diseases (<i>n</i>=8, 8.2%), extradural tumors (<i>n</i>=13, 13.4%), intradural tumors (<i>n</i>=50, 51.6%). In this group, decompression was performed at the first stage. After eliminating compression of medulla oblongata and upper spinal cord, bone fixation was performed in 26 (34%) patients. Group II included 84 patients with trauma (<i>n</i>=66, 78.5%), anomalies (<i>n</i>=3, 3.5%), inflammatory and genetic storage diseases (<i>n</i>=1, 1.2%), extradural tumors (<i>n</i>=14, 16.8%). All patients underwent various fusion procedures. Of these, 17 (20.2%) patients underwent concomitant fusion and resection for extradural tumors, rheumatoid arthritis, and late sequelae of trauma.</p><p><strong>Conclusion: </strong>Anatomical, biomechanical, and clinical similarities allow for classification of surgical CVJ lesions based on dominant clinical syndrome. Identification of dominant clinical syndrome allows for appropriate surgical strategies, sequence of surgical stages and their timing.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endocrine inactive pituitary microadenomas: current data on natural history and follow-up approaches].","authors":"D N Dzhatieva, E A Pigarova, L K Dzeranova","doi":"10.17116/neiro20269002198","DOIUrl":"https://doi.org/10.17116/neiro20269002198","url":null,"abstract":"<p><p>Endocrine inactive pituitary microadenomas are ones of the most common incidental findings in neuroimaging. Their prevalence is up to tens of cases per 100.000. According to current data, the vast majority of microadenomas remain stable over long-term follow-up, and the risk of progression, hypopituitarism, or the need for surgical intervention is extremely low. Clinical factors such as baseline adenoma size, gender and age have not proven predictive value for the risk of microadenoma growth. Current recommendations for follow-up vary significantly. There is evidence of safety of less aggressive strategies (delaying the first MRI for up to 3 years without clinical manifestations and no routine hormonal screening in patients with stable course). This approach combines clinical effectiveness and cost-effectiveness. Thus, current data allow us to consider endocrine inactive pituitary microadenomas as lesions with favorable prognosis. Revising international guidelines in favor of more rational and personalized surveillance strategies appears to be a justified and necessary step to optimize clinical practice.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"98-102"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[First clinical application of autologous fibrin sealant Vivostat for neurosurgery in Kazakhstan and Central Asia].","authors":"E N Kuanyshev, B S Syzdykova, D K Teltayev, K H Mustafin","doi":"10.17116/neiro20269002170","DOIUrl":"https://doi.org/10.17116/neiro20269002170","url":null,"abstract":"<p><strong>Background: </strong>Watertight dural closure and skull base reconstruction remain key challenges in neurosurgery. Autologous fibrin sealant Vivostat, produced from the patient's own blood, provides high biocompatibility, elasticity, and reliable adhesion. The absence of clinical data on its use in Central Asian countries highlights the relevance of the present study.</p><p><strong>Objective: </strong>To evaluate the clinical efficacy and safety of autologous fibrin sealant Vivostat for dural sealing and skull base reconstruction.</p><p><strong>Material and methods: </strong>This retrospective-prospective study included 110 patients operated on at the National Center of Neurosurgery (Astana, Kazakhstan) between August 2024 and September 2025. The sealant, derived from autologous blood using the Vivostat system, was applied for dural defect sealing and fixation of reconstructive grafts. The primary outcomes were the incidence of postoperative cerebrospinal fluid (CSF) leakage, infectious complications, and the need for reoperation.</p><p><strong>Results: </strong>The mean patient age was 48.9±14.7 years; 60% were women. An endoscopic transnasal approach was used in 65 patients, craniotomy in 35, and other approaches in 10. Polymerization occurred almost instantly, reaching maximal strength within 1-2 minutes. Successful sealing was achieved in 109 (99.1%) patients, while 1 (0.9%) patient required reoperation due to nasal CSF leakage and epistaxis. No infectious, allergic, or thromboembolic complications were observed.</p><p><strong>Conclusion: </strong>The use of autologous fibrin sealant Vivostat demonstrated high efficacy and safety for dural sealing and skull base reconstruction. The method reduced the risk of postoperative CSF leakage and reoperation. This study presents the first clinical experience with Vivostat in Central Asia.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"70-76"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Composition and toxicity of shrapnel in mine-explosive and fragmentation craniocerebral wounds compared to titanium implants: a pilot study].","authors":"V P Orlov, Yu A Nashchekina, P O Nikonov, A V Nashchekin, S D Mirzametov, B V Martynov, E M Ivankova, N K Vasileva, D V Svistov","doi":"10.17116/neiro2026900116","DOIUrl":"https://doi.org/10.17116/neiro2026900116","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate elemental composition and cytotoxicity of metal fragments of wounding projectiles based on modern alloys from mine blast and shrapnel craniocerebral wounds in comparison with titanium plates (control) in relation to human cell line T98G (human, glioblastoma, epithelial-like environment EMEM).</p><p><strong>Material and methods: </strong>We studied 12 wounding projectiles removed from the brain. Three ferromagnetic samples were selected to determine composition and cytotoxicity. Composition of fragments was studied using spectral analysis. Surface of samples and their elemental composition were examined using electron microscope (SEM) JSM-7001F (JEOL, Japan) equipped with X-ray spectral microanalysis attachment INCA x-sight (Oxford Instruments, England). Cytotoxicity of medium with wounding projectiles was determined in comparison with control medium using methyl tetrazolium test. Human cell line T98G (human, glioblastoma) (Institute of Cytology, St. Petersburg) was used to study cytotoxicity of fragments and titanium plates (control). Cell morphology was assessed using optical light microscopy.</p><p><strong>Results: </strong>According to elemental analysis, all fragments were represented by alloys of various metals and other chemical elements. Methyl-tetrazolium test revealed high cytotoxicity of all fragments. Titanium VT6 plates were biocompatible with cultured cells.</p><p><strong>Conclusion: </strong>All fragments of modern projectiles release toxic metal oxides in nutrient medium significantly reducing viability of cells regardless of elemental composition of fragments. VT6 titanium plates are biocompatible with cultured cells and can be used as implants during surgical interventions.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidural spinal cord stimulation in hereditary spastic paraplegia: preliminary results].","authors":"V M Akinfiev, A S Simonyan, A O Gushcha, V V Krylov","doi":"10.17116/neiro20269002162","DOIUrl":"https://doi.org/10.17116/neiro20269002162","url":null,"abstract":"<p><p>Hereditary spastic paraplegia is a diverse group of inherited neurodegenerative diseases characterized by spasticity and weakness in the lower extremities. Treatment is comprehensive and includes pharmacotherapy and physical therapy. If these approaches are ineffective, neurosurgical methods such as rhizotomy or intrathecal baclofen therapy are applied. Epidural spinal cord stimulation is still poorly studied.</p><p><strong>Objective: </strong>To evaluate safety and efficacy of epidural spinal cord stimulation in patients with hereditary spastic paraplegia.</p><p><strong>Material and methods: </strong>The study (2015-2024) included patients with hereditary spastic paraplegia refractory to conservative treatment. After test stimulation, permanent spinal stimulation systems (classic generator-based and wireless external) were implanted in 18 patients. The modified Ashworth scale, the Spastic Paraplegia Rating Scale (SPRS), the Timed Up and Go Test (TUG), the Ten-Meters Walk Test (10MWT), and the SF-36 questionnaire were used to assess neurological status preoperatively and six months after surgery. The study was approved by local ethics committee.</p><p><strong>Results: </strong>Implantation of permanent stimulation system (electrodes at the level of Th10-Th12) was performed in 18 patients (13 men, 5 women). Of these, 7 patients received wireless systems with external energy source, while 11 ones received classic generator systems. Six months after the intervention, we observed improvements in the following parameters compared to pre-implantation state: MAS score from 3 to 1.5-1 (18 patients); TUG test by 11.2-19.7% (17 patients); 10MWT test by 12.6-20.5% (17 patients); SPRS score by 27.9% (17 patients); SF-36 score 30-66% (16 patients).</p><p><strong>Conclusion: </strong>Epidural spinal cord stimulation may be considered for hereditary spastic paraplegia, but further research is needed to clarify its role in symptomatic treatment of spastic paraplegia.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}