Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Surgical treatment of hemifacial spasm: a systematic review].","authors":"V N Shimansky, L A Sidneva, S V Tanyashin, A A Ogurtsova, V K Poshataev, M V Kolycheva, I O Kugushev, R A Sadykov, V A Gorbulev","doi":"10.17116/neiro202690021112","DOIUrl":"10.17116/neiro202690021112","url":null,"abstract":"<p><p>The annual incidence of hemifacial spasm is 8-15 cases per 100.000. This disease is not life-threatening, but it significantly impacts the quality of life. Primary treatment is vascular decompression of the facial nerve. Thus, improvement of appropriate technique is crucial for higher efficacy and safety.</p><p><strong>Objective: </strong>To determine the optimal algorithm for vascular decompression according to available international experience in surgical treatment of hemifacial spasm.</p><p><strong>Material and methods: </strong>A systematic review was conducted in accordance with the PRISMA guidelines. To identify relevant publications, we screened the PubMed, Google Scholar, and eLibrary databases through October 2024 using the keywords «microvascular decompression» and «hemifacial spasm». Only full-text articles in Russian, English, or French were included in the study.</p><p><strong>Results: </strong>Among 364 manuscripts, 24 met the inclusion criteria. The majority of studies demonstrated available experience and effectiveness of vascular decompression without description of surgical approach.</p><p><strong>Conclusion: </strong>Considering global experience, we proposed an optimal surgical algorithm, including initial dissection of bulbar nerves and facial nerve decompression, if possible, along its entire length.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research of interaction of fluorescent anti-CD133 DNA aptamers with glioblastoma cell cultures using flow cytometry].","authors":"V L Ivko, V E Makeeva, O M Antipova, E A Savchenko, I N Pronin, G V Pavlova, A M Kopylov","doi":"10.17116/neiro20269002115","DOIUrl":"10.17116/neiro20269002115","url":null,"abstract":"<p><p>Glioblastoma or grade IV glioma is characterized by extremely poor prognosis. Resistance to radio- / chemotherapy and recurrences are associated with tumor stem cells. Transmembrane protein CD133 is considered a potential marker of tumor stem cells. To overcome the limitations of detecting cellular CD133 by antibodies, potential of aptamers (nucleic acid-based molecular recognition elements) is being explored. To obtain reproducible results, it is necessary to study the interaction of fluorescent aptamers to CD133 with standard cell lines and cell cultures derived from patient tumors using various methods.</p><p><strong>Objective: </strong>To detect the CD133 marker in continuous cell cultures of patient-derived GB cells using fluorescent DNA aptamers by flow cytometry.</p><p><strong>Material and methods: </strong>Fluorescein (FAM)-labeled DNA aptamers of the Cs and Ap series were used to detect the CD133 marker. Three continuous cell cultures from the Burdenko Neurosurgical Center Biobank were tested using flow cytometry. Burdenko: BU881 (107), G01, and Sus (harvested from postoperative GB tissues).</p><p><strong>Results: </strong>CD133 DNA aptamers at a concentration of 1 <i>μ</i>M yield positive signals for GB cell cultures. Their magnitude correlates with CD133 gene transcription. Fluorescence signal shift (∆MFI) for FAM DNA aptamers of the Cs and Ap series is greater for BU881 cells (1942 and 5449 c.u., respectively) than for G01 cells (1469 and 1817 c.u., respectively). This is consistent with CD133 gene transcription. There is no fluorescence signal shift for Sus cells with minimal CD133 gene transcription.</p><p><strong>Conclusion: </strong>Fluorescein-labeled DNA aptamers of the Cs and Ap series at a concentration of 1 <i>μ</i>M enable detection of the CD133 marker in continuous cell cultures of GB through flow cytometry.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Augmented reality in surgery for craniosynostosis in children].","authors":"L A Satanin, A A Artemyev, A N Konovalov, A V Sakharov, D N Okishev, T Yu Abzalov, I A Erokhin, S S Sergeeva, V A Tere, N A Azarova, E S Burkhan, S K Gorelyshev","doi":"10.17116/neiro20269003128","DOIUrl":"10.17116/neiro20269003128","url":null,"abstract":"<p><p>Augmented reality (AR) is a new tool in surgical treatment of craniofacial deformities, in particular, craniosynostosis.</p><p><strong>Objective: </strong>To clarify the indications for AR navigation system, technical capabilities of system, its advantages and disadvantages in surgery for craniosynostosis in children, as well as to compare these findings with literature data.</p><p><strong>Material and methods: </strong>In 2025, nine consecutive surgical interventions were performed using this method in patients with craniosynostosis at the Burdenko Neurosurgery Center. There were 7 boys (78%) and 2 girls (22%) aged 38.8 ± 54.7 (7-156) months.</p><p><strong>Results: </strong>AR navigation allowed us to simulate results of preoperative virtual planning in reconstructive procedures. This ensured accuracy of interventions. AR navigation localized intracranial structures, such as endostoses and venous sinuses, whose visualization made surgery safer. This technique was valuable to mark craniotomy lines, control distraction device position and bone fragments, and assess conformity of final reconstruction with scheduled one. Preoperative modeling took 173.3±61.4 (90-240) min. Overall intraoperative time spent for AR navigation was 33.9±15.6 (15-60) min.</p><p><strong>Conclusion: </strong>The augmented reality system appears to be perspective in surgery for craniosynostosis enabling real time intraoperative neuronavigation. Further development of augmented reality techniques in craniosynostosis surgery will improve outcomes and make results more predictable and safe.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"28-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Laparoscopic assistance for peritoneal catheter positioning in adults scheduled for ventriculoperitoneal shunting at the Pavlov First Saint Petersburg State Medical University].","authors":"M D Burmakina, G V Gavrilov, S A Abytov, A A Trushin, A V Stanishevsky, V Y Cherebillo","doi":"10.17116/neiro20269004121","DOIUrl":"https://doi.org/10.17116/neiro20269004121","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of laparoscopic assistance for peritoneal catheter implantation in adults scheduled for ventriculoperitoneal shunting.</p><p><strong>Material and methods: </strong>A prospective study enrolled 38 patients divided into 2 groups: laparoscopic approach (<i>n</i>=18) and mini-laparotomy (<i>n</i>=20). Surgery time, incision length, pain syndrome and catheter position were assessed.</p><p><strong>Results: </strong>In the main group, surgery time was significantly shorter (40.0 [37.0; 44.0] versus 48.0 [46.0; 50.0] min, <i>p</i><0.001). The same was true for duration of abdominal stage (10.0 [9.0; 12.0] and 15.0 [14.0; 16.0] min, respectively, <i>p</i><0.001). The incision length was 15 [14; 16] versus 49 [47; 52] mm (<i>p</i><0.001). VAS score of pain were lower in the main group (4.5 [4.0; 5.0] versus 5.5 [5.0; 6.0] points; <i>p</i>=0.048). Pain regression was faster (4.0 [3.0; 5.0] versus 7.0 [6.0; 8.0] days; <i>p</i><0.001). Laparoscopy ensured accurate catheter positioning in all patients.</p><p><strong>Conclusion: </strong>Laparoscopic assistance in ventriculoperitoneal shunting reduces surgery time and invasiveness, ensures accurate catheter positioning and reduces pain. This method is effective in complicated and intact abdominal anamnesis, and improves immediate outcomes.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vascular decompression in the treatment of vagoglossopharyngeal neuralgia].","authors":"G Yu Grigoryan, D Yu Usachev, Yu A Grigoryan","doi":"10.17116/neiro20269004115","DOIUrl":"https://doi.org/10.17116/neiro20269004115","url":null,"abstract":"<p><strong>Background: </strong>Vagoglossopharyngeal neuralgia (VGFN) is an uncommon facial pain syndrome caused by neurovascular conflict.</p><p><strong>Objective: </strong>To evaluate anatomical relationships between cranial nerves IX-X and compressing arteries, as well as effectiveness of vascular decompression (VD) in these patients.</p><p><strong>Material and methods: </strong>VD via retrosigmoid approach was performed in 9 patients with VGFN. Age of patients was 33-72 years. There were 4 males and 5 females. Two ones had right-sided lesions, 7 - left-sided lesions. Mean follow-up period was 8.5 years (range 3-15).</p><p><strong>Results: </strong>Neurovascular conflict was caused by posterior inferior cerebellar artery (PICA) in 6 cases, anterior inferior cerebellar artery (AICA) and PICA in 2 cases, PICA and vertebral artery in 1 case. Interposition technique was used in 7 cases, transposition of vessels - in 2 cases. Complete relief of VGFN was achieved in all patients. Mild dysphonia without dysphagia was registered in 1 case and regressed throughout 1.5 months. There were no VGFN recurrences.</p><p><strong>Conclusion: </strong>VD is a highly effective surgical method for VGFN with low rate of complications and pain recurrences.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Gunshot craniocerebral wound complicated by anaerobic brain abscess. Case report and literature review].","authors":"N R Saburov, I N Isengaliev, D E Alekseev, D V Svistov, Sh Kh Gizatullin, I I Ivanov, I N Chirko, E A Kim","doi":"10.17116/neiro20269002192","DOIUrl":"10.17116/neiro20269002192","url":null,"abstract":"<p><p>Brain abscess is a focal infectious inflammatory lesion characterized by collection of pus in brain tissue surrounded by a vascularized capsule. The most common cause is spread of microorganisms from distant foci of infection (e.g., odontogenic infection or sinusitis). The risk of intracranial infectious complications and mortality increases significantly in penetrating gunshot wounds to the skull and brain.</p><p><strong>Material and methods: </strong>Available literature contains a few studies on infectious complications following combat traumatic brain injury. This article presents treatment of anaerobic brain abscess in a patient with previous penetrating gunshot skull wound.</p><p><strong>Results: </strong>A 24-year-old patient admitted for specialized medical care with penetrating blind radial shrapnel skull and brain wound in the left occipital region complicated by intracerebral anaerobic abscess. The patient underwent secondary surgical debridement of craniocerebral wound, removal of abscess, and drainage system placement. On the fourth postoperative day, sedation was discontinued. There was moderate impairment of consciousness. By the ninth day, consciousness became normal. After primary treatment, the patient was transferred for rehabilitation.</p><p><strong>Conclusion: </strong>This case highlights the role of strict adherence to the principles of emergency neurosurgical care when treating wounds complicated by intracranial infection.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"92-97"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and prognostic value of IL-6 and IL-2 monitoring in patients with severe traumatic brain injury].","authors":"A A Sychev, I A Savin, G V Danilov, A I Baranich, K O Kakurin, Yu V Strunina, A V Oshorov, A D Kravchuk","doi":"10.17116/neiro20269003112","DOIUrl":"10.17116/neiro20269003112","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is characterized by high mortality and severe disability worldwide representing a major social, economic, and medical problem. Pathogenesis of secondary brain damage is underpinned by a cascade of neuroinflammatory reactions triggered by cytokine release. Key mediators include interleukin-6 (IL-6) and interleukin-2 (sIL-2R) system. However, their daily dynamics in acute period of severe trauma and relationship with intracranial hypertension remain poorly understood.</p><p><strong>Material and methods: </strong>The study was conducted at the Burdenko Neurosurgical Center. Inclusion criteria: acute TBI, admission within 24 hours, age 18-75 years. Exclusion criteria: atonic coma, decompensation of chronic diseases. IL-6, sIL-2R, C-reactive protein, and procalcitonin were assessed.</p><p><strong>Results: </strong>There were 74 patients with severe TBI (19 women, mean age 34.0±12.5 years). The mortality rate was 14.9% (11 patients). Biphasic cytokine dynamics was revealed. Early increase in IL-6 on day 1 reflected extent of primary injury. On the 2^nd day, IL-6 levels remained significantly higher in patients with fatal outcome (median 40.2 vs. 22.4 pg/ml, <i>p</i><0.05). Secondary increase was recorded after 3 days and coincided with manifestation of infectious complications peaking on day 5. On day 5, sIL-2R levels were found to be more than 2.5-fold higher in patients with fatal outcome (1660.0 vs. 649.0 pg/ml, <i>p</i><0.05). In fatal patients, we found strong direct correlation between IL-6 and intracranial pressure (rho=0.71), as well as inverse correlation with cerebral perfusion pressure.</p><p><strong>Conclusion: </strong>Biphasic cytokine response develops in acute phase of severe traumatic brain injury. Early phase (2 days) is characterized by increased IL-6 according to extent of primary cerebral injury. The second phase (days 3-14) is associated with infectious complications and characterized by increased sIL-2R and IL-6. It is not their absolute value, but temporal dynamics is prognostically significant. No IL-6 reduction by 48 hours after injury indicates uncontrollable neuroinflammation and potentially unfavorable outcomes. Peak (more than 2.5 times) increase in sIL-2R on day 5 is a marker of transformation of protective inflammation into systemic hyperinflammatory syndrome. Direct correlation between IL-6 and intracranial hypertension in fatal patients confirms pathogenetic role of this cytokine in secondary brain injury. IL-6 and sIL-2R monitoring may enable timely identification of patients with high risk of fatal intracranial hypertension and ensure a personalized approach to intensive care.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Subdural hematoma without subarachnoid hemorrhage caused by ruptured traumatic distal aneurysm of anterior cerebral artery].","authors":"D N Kopachev, Zh B Semenova, S V Meshcheryakov, O V Karaseva, N A Knyazeva, A G Gagloev","doi":"10.17116/neiro20269004161","DOIUrl":"https://doi.org/10.17116/neiro20269004161","url":null,"abstract":"<p><strong>Objective: </strong>To describe a rare complication of non-penetrating traumatic brain injury.</p><p><strong>Material and methods: </strong>We present a 16-year-old patient with multiple skeletal lesions and mild traumatic brain injury (TBI). Two weeks after injury, clinical status suddenly worsened due to large subdural hematoma without signs of subarachnoid hemorrhage despite normal neuroimaging data at baseline.</p><p><strong>Results: </strong>Examination revealed pericallosal artery aneurysm. Microsurgical intervention with aneurysm excision was performed. Histological examination revealed thrombotic masses containing fibrin and no vascular walls of aneurysm. Therefore, the aneurysm was regarded as traumatic false aneurysm resulting from detachment of small artery. There were no neurological disorders at discharge.</p><p><strong>Conclusion: </strong>Acute subdural hematoma in delayed period after TBI requires CT angiography to rule out traumatic aneurysm.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"61-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lost anatomical structure - pharyngeal pituitary gland (Hypophysis pharyngealis or Erdheim pituitary gland): a review and case report].","authors":"L A Satanin, V V Kulikov, S E Shemyakov, N A Chernikova, A N Shkarubo, L V Shishkina, I N Pronin, E V Shelesko, L I Astafyeva, N A Mazerkina, M L Satanina, D Sh Adueva","doi":"10.17116/neiro20269001183","DOIUrl":"10.17116/neiro20269001183","url":null,"abstract":"<p><p>Pharyngeal pituitary gland is a glandular structure located along the path of Rathke's pouch (along the midline under mucous membrane of the nasopharynx near the lower wall of sphenoid bone). The purpose of this study was to examine literature data on anatomy and physiology of pharyngeal pituitary gland, its possible relationship with extracranial ectopic pituitary adenomas, as well as to describe appropriate patient. Literary data confirm pharyngeal pituitary gland as a permanent human anatomical structure capable of release of all hormones similar to those of anterior pituitary gland. Functional significance of pharyngeal pituitary gland is unknown. However, it may be a source of ectopic adenomas in nasopharynx and skull base. These data are important for diagnosis in patients with endocrine disorders associated with malformations and ectopic pituitary adenomas.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hypothalamic obesity in adults with craniopharyngiomas: prevalence and risk factors before and after neurosurgical treatment].","authors":"I S Klochkova, L I Astafyeva, M A Kutin, A N Konovalov, Yu G Sidneva, A N Shkarubo, P L Kalinin","doi":"10.17116/neiro20269002177","DOIUrl":"10.17116/neiro20269002177","url":null,"abstract":"<p><p>Hypothalamic obesity (weight gain due to hypothalamic damage) is a common complication of surgical treatment of craniopharyngiomas. Data on the prevalence and clinical features of hypothalamic obesity in adults with craniopharyngiomas are scarce, and reports on prognostic factors are contradictory.</p><p><strong>Objective: </strong>To assess the prevalence and risk factors of hypothalamic obesity before and after neurosurgical treatment of craniopharyngiomas in adults.</p><p><strong>Material and methods: </strong>This prospective study included 99 adults with craniopharyngioma. A comprehensive examination was performed. Damage to hypothalamic-pituitary structures was assessed using preoperative MRI, clinical, laboratory and intraoperative data.</p><p><strong>Results: </strong>Pre- and postoperative hypothalamic obesity was detected in 32 (32%) and 47 (57.3%) patients, respectively. Hypothalamic obesity was significantly more common in pituitary stalk and ventricular craniopharyngiomas compared to endosuprasellar craniopharyngiomas (<i>p</i><0.05). Fifty-nine (71%) patients experienced significant (≥5%) body weight gain after surgery (median 15% [8.8; 24.0] or 11 kg [7; 17]). Analysis of groups with and without hypothalamic obesity after surgery revealed significant differences in baseline body mass index (30.8 kg/m² [27.0; 35.9] and 22.1 kg/m² [19.4; 25.2], respectively, <i>p</i><0.001), incidence of mental disorders (36.2% and 14.3%, respectively, <i>p</i>=0.027) and preoperative hypogonadism (93.5% and 71.4%, respectively, <i>p</i>=0.013). In multivariate analysis, independent risk factors of hypothalamic obesity were preoperative body mass index with a cutoff value of 27 kg/m² and third ventricular bottom lesions due to tumor infiltration. No effect of histological type of craniopharyngioma, surgical approach or extent of surgery on the incidence of hypothalamic obesity was found.</p><p><strong>Conclusion: </strong>There was high incidence of hypothalamic obesity due to tumor growth and surgical treatment in adults with craniopharyngioma. Predictors of hypothalamic obesity after surgery for craniopharyngioma were baseline body mass index and damage to third ventricle bottom.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}