Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

[The use of radiosurgery in the treatment of patients with single brain metastasis]. 【放射外科在单发脑转移患者中的应用】。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro2025890216

M Yu Ostapenko, V A Lukshin, D Yu Usachev, A V Golanov, E R Vetlova, G L Kobyakov

{"title":"[The use of radiosurgery in the treatment of patients with single brain metastasis].","authors":"M Yu Ostapenko, V A Lukshin, D Yu Usachev, A V Golanov, E R Vetlova, G L Kobyakov","doi":"10.17116/neiro2025890216","DOIUrl":"10.17116/neiro2025890216","url":null,"abstract":"Brain metastases occur in approximately 20% of all cancer patients. Stereotactic radiosurgery alone and in combination with surgical resection is one of the approaches to treating patients with brain metastases.Objective: To evaluate the effectiveness of stereotactic radiosurgery regarding local control, overall survival and complications; to compare stereotactic radiosurgery alone and preoperative stereotactic radiotherapy.Material and methods: A retrospective study included 85 patients with single brain metastasis. The first group comprised 45 patients who underwent stereotactic radiosurgery, while the second group included 40 patients who underwent preoperative stereotactic radiotherapy and subsequent surgical treatment. Mean age was 59 and 56 years (p=0.2), radiation volume - 4.4 and 15.9 cm³, respectively (p<0.05).Results: Local growth control after preoperative stereotactic radiotherapy followed by resection was 100%, 97.5%, and 87.5% after 3, 6, and 12 months, respectively. After stereotactic radiotherapy alone, these values were 100%, 95.6% and 88.9%, respectively (p=0.4). One-year survival was 87.5% after preoperative radiotherapy and 64.4% after stereotactic radiosurgery alone (p<0.05). Among 85 patients, 16 (18.8%) ones had long-term surgical and post-radiation complications.Conclusion: Stereotactic radiotherapy alone is effective. However, there are limitations in tumor size (up to 2.5 cm) and volume (9.5 cm³). Preoperative stereotactic radiotherapy followed by surgical resection is advisable for larger tumors (up to 4.5 cm and 18.9 cm³) with high rates of overall survival and local growth control.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 2","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[High-grade astrocytoma with piloid features: case report and systematic review]. 【具有核样特征的高级别星形细胞瘤：病例报告及系统回顾】。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258902183

Yu M Poluektov, N A Konovalov, M V Ryzhova, N I Bychkovskii, N V Lasunin, B A Zakirov, D S Kim

{"title":"[High-grade astrocytoma with piloid features: case report and systematic review].","authors":"Yu M Poluektov, N A Konovalov, M V Ryzhova, N I Bychkovskii, N V Lasunin, B A Zakirov, D S Kim","doi":"10.17116/neiro20258902183","DOIUrl":"10.17116/neiro20258902183","url":null,"abstract":"In 2021, a new type of tumor was defined according to the new WHO classification (high-grade astrocytoma with piloid features, HGAP). Morphological and neuroimaging differences of HGAP from pilocytic astrocytoma complicate diagnosis. Now, significant detection of this tumor is possible only using molecular genetic testing, in particular, methylation profile analysis.Objective: To present a patient with HGAP and perform a systematic review of studies devoted to adults with HGAP regarding clinical course, diagnosis, protocols and treatment outcomes.Material and methods: Selection of studies was carried out in accordance with the PRISMA recommendations. The authors analyzed the studies independently of each other. All data were systematized. A case report was described jointly with attending physicians and pathologists.Results and discussion: HGAP is characterized by rapid progression and resistance to therapy. This case illustrates the importance of awareness of neurosurgeons and necessitates molecular genetic tests to identify this group of tumors.Conclusion: HGAP is a rare and aggressive tumor. Treatment algorithm for such patients has not yet been developed. The world experience of treatment is presented by individual series. Analysis of methylation profile is necessary for patients with atypical course of tumors similar to pilocytic astrocytoma.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 2","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[History of the Development of the Department of Neurosurgery of the Russian Medical Academy of Medical Sciences (to the 90th Anniversary of the Department of Neurosurgery)]. 【俄罗斯医学科学院神经外科发展历史（至神经外科成立90周年）】。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro202589011116

D Y Usachev, O N Dreval, V A Lazarev, A V Baskov, G G Shaginyan, I I Tsuladze, A V Kuznetsov, V L Puchkov, V A Chekhonatsky, O V Mukhina, K V Lyubimaya

引用次数: 0

[Liquid biopsy for detection of H3K27m and BRAF V600E mutations in patients with diffuse brainstem tumors]. 【液体活检检测弥漫性脑干肿瘤患者H3K27m和BRAF V600E突变】。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258901111

A V Gavryushin, L I Papusha, A A Veselkov, M A Zaitseva, E A Khukhlaeva, A N Konovalov, A E Druy

{"title":"[Liquid biopsy for detection of H3K27m and BRAF V600E mutations in patients with diffuse brainstem tumors].","authors":"A V Gavryushin, L I Papusha, A A Veselkov, M A Zaitseva, E A Khukhlaeva, A N Konovalov, A E Druy","doi":"10.17116/neiro20258901111","DOIUrl":"10.17116/neiro20258901111","url":null,"abstract":"Despite the progress in understanding the pathogenesis of diffuse brainstem tumors, treatment of these neoplasms is usually empirical and conducted without morphological and molecular verification. Liquid biopsy is a minimally invasive technique providing data on tumor biology without standard biopsy. This method is based on analysis of cell-free nucleic acids (predominantly, extracellular DNA) in biological fluids with detection of specific mutations. Despite wide implementation in diagnosis and disease monitoring in extracranial malignancies, it is infrequently applied in neuro-oncology.Objective: To estimate diagnostic value of liquid biopsy in detecting H3K27 and BRAF V600E mutations in patients with diffuse brainstem tumors.Material and methods: Lumbar puncture with cerebrospinal fluid sampling was performed in 16 patients (5 children and 11 adults) with diffuse brainstem tumors verified by neuroimaging data. Cell-free DNA (cfDNA) was used in digital droplet PCR for determination of H3F3A K28M and BRAF V600E oncogenic missense variants. In 14 patients, investigation of cfDNA was performed in parallel with analysis of correspondent mutations in DNA derived from tumor tissue.Results: None patient had BRAF V600E mutation. H3F3A K28M variant was detected in 5 CSF samples and 6 tumor specimens from patients who underwent surgical biopsy. Thus, overall sensitivity of the method in determination of H3F3A K28M variant was 92.9% (13/14).Conclusion: Liquid biopsy is highly informative for identifying the specific mutation H3F3A K28M and often verifies diffuse brainstem glioma without standard biopsy.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Laparoscopic resection of neurogenic presacral tumors]. 腹腔镜下神经源性骶前肿瘤切除术。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258901159

Y E Kubetsky, E E Labzina, M A Kosimshoev, D P Kholtobin, R V Khalepa, A O Nabiev, D A Rzaev

{"title":"[Laparoscopic resection of neurogenic presacral tumors].","authors":"Y E Kubetsky, E E Labzina, M A Kosimshoev, D P Kholtobin, R V Khalepa, A O Nabiev, D A Rzaev","doi":"10.17116/neiro20258901159","DOIUrl":"10.17116/neiro20258901159","url":null,"abstract":"Laparoscopic approach is common in pelvic tumor surgery. Several small samples of patients after laparoscopic resection of presacral neurogenic tumors were described. Safety and advantages of this intervention are interesting.Objective: To analyze clinical outcomes of laparoscopic resection of presacral neurogenic tumors.Material and methods: Eleven patients including 2 children aged 11 and 17 years underwent laparoscopic tumor resection between 2021 and 2024. We estimated tumor size and localization, surgery time, blood loss, complications, postoperative hospital-stay, histological diagnosis and continued growth or recurrence in the follow-up period. The median follow-up was 19.2 (3-36) months.Results: Tumor size ranged from 4 to 10 cm, mean surgery time - 153.6 min, blood loss - 356.4 ml. Postoperative complications developed in 7 patients, including acute urinary retention, neuropathic pain syndrome, hematomas and dynamic intestinal obstruction. Total resection was achieved in 8 (72.7%) patients, subtotal resection - 2 (18.2%), partial resection - 1 (9.1%) case. Tumors were predominantly neurogenic: 6 (54.5%) - sacral nerve schwannomas, 1 (9%) - NF1-related schwannomatosis, 1 (9%) - meningioma, 1 (9%) - ganglioneuroma, 1 (9%) - fibromyxoid sarcoma, 1 (9%) - solitary fibrous tumor. There were no recurrences, continued growth or recurrence of preoperative symptoms in the follow-up period.Conclusion: Laparoscopic resection of presacral neurogenic tumors is an effective surgical technique with good visualization of surgical field and possible gross total resection.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Percutaneous ultrasound-guided neurolysis with local administration of betamethasone in the treatment of Morton's neuroma]. [经皮超声引导下局部应用倍他米松治疗莫顿神经瘤]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258901152

Z Kh Plieva, M A Razin, A G Fedyakov, A V Baskov, A V Gorozhanin, A V Kuznetsov, O V Mukhina, E V Batalova

{"title":"[Percutaneous ultrasound-guided neurolysis with local administration of betamethasone in the treatment of Morton's neuroma].","authors":"Z Kh Plieva, M A Razin, A G Fedyakov, A V Baskov, A V Gorozhanin, A V Kuznetsov, O V Mukhina, E V Batalova","doi":"10.17116/neiro20258901152","DOIUrl":"10.17116/neiro20258901152","url":null,"abstract":"Morton's neuroma is one of the most common entrapment mononeuropathies of peripheral nerves. The main clinical manifestation is neuropathic pain syndrome in the foot. Currently, many methods of treatment are proposed. Despite the advantages of each method, the main disadvantages are low effectiveness, aggravation of symptoms due to scar-related complications, or relatively high incidence of complications following surgical invasion.Objective: To evaluate the effectiveness of percutaneous ultrasound-guided neurolysis with local administration of betamethasone in patients with Morton's neuroma.Material and methods: The study included 14 female patients aged 24-56 years (mean 44.7±6.4). We analyzed VAS scores of pain syndrome (mean 7.1±1.1) and DN4 scores of neuropathic pain (mean 4.9±0.9). Ultrasound imaging was performed to estimate localization and volume of neuroma. Mean volume of neuroma was 226±142 mm3.Results: Mean follow-up was 12 months. In 12 out of 14 patients, there was a significant decrease in pain intensity to VAS score 1.1±0.6 and regression of neuropathic pain to DN4 score 0.5±0.5. In 2 cases, neuropathic pain recurred after 6 months with enlargement of neuromas (to 429 and 452 mm3). There were no complications in any patient.Conclusion: Percutaneous ultrasound-guided neurolysis of Morton's neuroma with local administration of betamethasone is an effective and promising minimally invasive method. Selection criterion for this procedure may be small volume of neuroma. Further research is required to clarify the indications for this procedure.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Selective dorsal rhizotomy in children with hereditary spastic paraplegia]. [选择性背根切断术治疗遗传性痉挛性截瘫]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258901146

E I Smolyankina, D Yu Zinenko

引用次数: 0

[Microsurgical resection of dominant hemisphere gliomas with intraoperative speech mapping by a staff neurologist]. [工作神经科医师术中语言定位的优势半球胶质瘤显微外科切除术]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258902114

A V Semenov, K A Rumyantseva, M E Eroshenko, V V Egorenkov, V M Moiseenko, M V Sinkin

{"title":"[Microsurgical resection of dominant hemisphere gliomas with intraoperative speech mapping by a staff neurologist].","authors":"A V Semenov, K A Rumyantseva, M E Eroshenko, V V Egorenkov, V M Moiseenko, M V Sinkin","doi":"10.17116/neiro20258902114","DOIUrl":"10.17116/neiro20258902114","url":null,"abstract":"Intraoperative awakening with speech mapping is used to minimize the risk of irreparable neurological deficit in patients with tumors located near speech zones. However, the lack of staff neurolinguist or neuropsychologist in the majority of neurosurgical departments is one of the limiting factors.Objective: To analyze surgical treatment of patients with glial tumors near speech and motor centers using intraoperative awakening with speech mapping by staff neurologist.Material and methods: We analyzed postoperative outcomes in 15 patients with dominant hemisphere gliomas of functionally significant areas between 2020 and 2024. All surgeries were accompanied by multimodal neurophysiological monitoring including intraoperative awakening and mapping by staff neurologist without neuropsychologist or neurolinguist. Intraoperative contrast-enhanced MRI was performed in 3 (20.0%) patients (T2WI and T1WI). Postoperative MRI was performed on the first postoperative day in all patients for objective assessment of resection quality.Results: Total resection was achieved in 13 (86.7%) cases, subtotal - in 2 (13.3%) cases. In 11 (73.3%) patients, no postoperative neurological deficit was detected. Three (20.0%) patients had transient speech impairment with regression throughout a month. Persistent deficit developed in 1 (6.7%) patient.Conclusion: Standardized speech mapping methods and staff neurologist for cortical mapping during resection of gliomas near functionally significant speech zones maintain high extent of resection without higher risk of permanent speech disorders. Widespread speech mapping by staff neurologists of neurosurgical departments will increase the number of function-preserving surgeries in all regions of the Russian Federation.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 2","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Professional realization of female neurosurgeons in context of the main indicators of quality of life]. 【女性神经外科医生在生活质量主要指标背景下的职业实现】。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258902162

A E Bykanov, A D Gurkina, O A Rastvorova, E I Konovalova, I O Kurzakova, Yu V Strunina

{"title":"[Professional realization of female neurosurgeons in context of the main indicators of quality of life].","authors":"A E Bykanov, A D Gurkina, O A Rastvorova, E I Konovalova, I O Kurzakova, Yu V Strunina","doi":"10.17116/neiro20258902162","DOIUrl":"10.17116/neiro20258902162","url":null,"abstract":"Objective: To investigate realization of expectations of female neurosurgeons in professional and personal terms and influence of profession on the quality of life.Material and methods: We surveyed 44 female neurosurgeons from 17 hospitals of the Russian Federation and CIS between 2020 and 2023. Survey was voluntary and anonymous.Results: Mean age of women was 32 years (45% were younger than 30 years, 55% were older), more than half of them had more than 5-year experience. Almost half of female neurosurgeons were dissatisfied with results of their professional activity. Most of the women felt that they needed to work harder than their male colleagues to be recognized equally in professional environment. One third of respondents (32%) are considering quitting specialty completely and devoting themselves to their families in the future.Conclusion: Female neurosurgeons often have to sacrifice personal life and family to achieve the results similar to those in men. This can lead to emotional burnout.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 2","pages":"62-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Surgical treatment of orbitocranial and orbital cavernous venous malformations (ophthalmological aspects)]. [眶颅和眶海绵状静脉畸形的外科治疗（眼科方面）]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2025-01-01 DOI: 10.17116/neiro20258902148

A P Trunova, N K Serova, N V Lasunin, N N Grigorieva

{"title":"[Surgical treatment of orbitocranial and orbital cavernous venous malformations (ophthalmological aspects)].","authors":"A P Trunova, N K Serova, N V Lasunin, N N Grigorieva","doi":"10.17116/neiro20258902148","DOIUrl":"10.17116/neiro20258902148","url":null,"abstract":"Background: Orbital cavernous venous malformation is a vascular malformation with slow blood flow velocity and common orbital lesion in adults.Objective: To analyze surgical treatment of orbitocranial and orbital cavernous venous malformations and factors influencing the outcomes.Material and methods: The study included 54 patients with apical orbital cavernous venous malformation extending into the cranial cavity (group I) and 31 patients with cavernous venous malformation of anterior and/or middle third of the orbit (group II) between 2004 and 2024.Results: The following approaches were used for resection of malformations: osteoplastic lateral orbitotomy, supraorbital, orbitozygomatic, endoscopic transnasal, transconjunctival approach. In early postoperative period, 15 patients in the 1st group had deterioration of visual function. Of these, 8 ones developed blindness due to occlusion of central retinal artery. Most often, deterioration of visual functions was associated with extension of malformation into the optic canal, moderate-to-severe visual impairment and late preoperative stage of visual impairment (p<0.05). There was no deterioration of visual functions in the 2nd group. Deterioration of oculomotor function was noted in 70% and 24% of cases, respectively. Exophthalmos partially or completely regressed in both groups.Conclusion: Spread of cavernous venous malformation into the optic canal, preoperative state of visual functions and stage of visual impairment influence visual functions after surgery. Oculomotor function in delayed postoperative period is restored more often than visual functions.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 2","pages":"48-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0