D Y Usachev, O N Dreval, V A Lazarev, A V Baskov, G G Shaginyan, I I Tsuladze, A V Kuznetsov, V L Puchkov, V A Chekhonatsky, O V Mukhina, K V Lyubimaya
{"title":"[History of the Development of the Department of Neurosurgery of the Russian Medical Academy of Medical Sciences (to the 90th Anniversary of the Department of Neurosurgery)].","authors":"D Y Usachev, O N Dreval, V A Lazarev, A V Baskov, G G Shaginyan, I I Tsuladze, A V Kuznetsov, V L Puchkov, V A Chekhonatsky, O V Mukhina, K V Lyubimaya","doi":"10.17116/neiro202589011116","DOIUrl":"10.17116/neiro202589011116","url":null,"abstract":"<p><p>According to the order of April 15, 1935, the opening of the Department of Neurosurgery, the first head of which was Nikolai N. Burdenko, laid the foundation for the development of neurosurgical activity and training of neurosurgical personnel in the USSR within the walls of the Russian Medical Academy of Medical Sciences (TsIUV). N.N. Burdenko was an outstanding Soviet surgeon, one of the founders of neurosurgery, academician of the Academy of Sciences of the USSR (1939) and the Academy of Medical Sciences of the USSR (1944-1946), Hero of Socialist Labor, honorary member of the British Royal Society of Surgeons and the Paris Academy of Surgery, Colonel General of Medical Service.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 1","pages":"116-120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A V Gavryushin, L I Papusha, A A Veselkov, M A Zaitseva, E A Khukhlaeva, A N Konovalov, A E Druy
{"title":"[Liquid biopsy for detection of H3K27m and BRAF V600E mutations in patients with diffuse brainstem tumors].","authors":"A V Gavryushin, L I Papusha, A A Veselkov, M A Zaitseva, E A Khukhlaeva, A N Konovalov, A E Druy","doi":"10.17116/neiro20258901111","DOIUrl":"10.17116/neiro20258901111","url":null,"abstract":"<p><p>Despite the progress in understanding the pathogenesis of diffuse brainstem tumors, treatment of these neoplasms is usually empirical and conducted without morphological and molecular verification. Liquid biopsy is a minimally invasive technique providing data on tumor biology without standard biopsy. This method is based on analysis of cell-free nucleic acids (predominantly, extracellular DNA) in biological fluids with detection of specific mutations. Despite wide implementation in diagnosis and disease monitoring in extracranial malignancies, it is infrequently applied in neuro-oncology.</p><p><strong>Objective: </strong>To estimate diagnostic value of liquid biopsy in detecting H3K27 and BRAF V600E mutations in patients with diffuse brainstem tumors.</p><p><strong>Material and methods: </strong>Lumbar puncture with cerebrospinal fluid sampling was performed in 16 patients (5 children and 11 adults) with diffuse brainstem tumors verified by neuroimaging data. Cell-free DNA (cfDNA) was used in digital droplet PCR for determination of <i>H3F3A</i> K28M and <i>BRAF</i> V600E oncogenic missense variants. In 14 patients, investigation of cfDNA was performed in parallel with analysis of correspondent mutations in DNA derived from tumor tissue.</p><p><strong>Results: </strong>None patient had <i>BRAF</i> V600E mutation. <i>H3F3A</i> K28M variant was detected in 5 CSF samples and 6 tumor specimens from patients who underwent surgical biopsy. Thus, overall sensitivity of the method in determination of <i>H3F3A</i> K28M variant was 92.9% (13/14).</p><p><strong>Conclusion: </strong>Liquid biopsy is highly informative for identifying the specific mutation H3F3A K28M and often verifies diffuse brainstem glioma without standard biopsy.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Yu Kurnukhina, V Yu Cherebillo, G V Gavrilov, V A Grachev
{"title":"[Sellar collision tumors: difficulties of preoperative neuroimaging and selection of surgical approach. Case reports and literature review].","authors":"M Yu Kurnukhina, V Yu Cherebillo, G V Gavrilov, V A Grachev","doi":"10.17116/neiro20258903175","DOIUrl":"https://doi.org/10.17116/neiro20258903175","url":null,"abstract":"<p><p>Sellar tumors are predominantly benign neoplasms accounting for approximately 14-18% of all brain tumors. For many decades, there have been a few clinical cases confirming possible simultaneous coexistence of two nosological groups in one area. We present 2 rare cases of sellar collision tumors (a 61-year-old male with pituitary adenoma and craniopharyngioma; a 68-year-old female with pituitary adenoma and meningioma of tubercle), clinical features, anamnesis, preoperative neuroimaging, intraoperative picture and postoperative outcomes. Combination of pituitary adenoma and craniopharyngioma/ meningioma as a type of collision tumors requires caution at all stages of treatment due to impossible preoperative analysis of tumor density and, accordingly, correct choice of surgical access. Transsphenoidal endoscopic access reduces mortality rate according to literature data. Preoperative MR elastometry needs to be studied in depth including patients with sellar collision tumors.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 3","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A V Dimertsev, N V Pedyash, Kh O Shavkatbekov, N P Utyashev, E A Gordeeva, A A Zuev, Yu V Batmanova
{"title":"[Stereo-EEG-guided radiofrequency thermocoagulations in drug-resistant focal epilepsy].","authors":"A V Dimertsev, N V Pedyash, Kh O Shavkatbekov, N P Utyashev, E A Gordeeva, A A Zuev, Yu V Batmanova","doi":"10.17116/neiro2025890317","DOIUrl":"https://doi.org/10.17116/neiro2025890317","url":null,"abstract":"<p><strong>Background: </strong>Preoperative examination of patients with focal drug-resistant epilepsy requires invasive diagnostic methods in 30-40% of cases. Stereo-EEG is one of them and often the most significant for verification of epileptogenic zone and its subsequent resection. The desire to minimize surgical trauma led to idea of local radiofrequency thermocoagulation through SEEG electrodes [1]. This allows destruction of epileptogenic zones during examination. Despite the safety of this method, appropriate studies are contradictory and require further analysis [2].</p><p><strong>Objective: </strong>To clarify the role of radiofrequency thermocoagulation in diagnosis and treatment of patients with focal drug-resistant epilepsy.</p><p><strong>Material and methods: </strong>A single-center retrospective study included 75 patients with focal drug-resistant epilepsy who underwent radiofrequency thermocoagulation between 2020 and 2023. The results were assessed 6 and 12 months after thermocoagulation.</p><p><strong>Results: </strong>Six-month freedom from seizures was 35% (26 patients). Seizure rate decreased by more than 50% (McHugh I-II) in 39 (52%) patients. Most patients with the McHugh II outcome (10 out of 12) experienced less incidence and intensity of seizures. This made unnecessary subsequent surgery. MR-negative nature of epilepsy (<i>p</i>=0.015), right-sided localization of epileptogenic substrate (<i>p</i>=0.032) and bihemispheric distribution (<i>p</i>=0.05) were negative predictors of treatment outcomes. A relationship was found between localization of radiofrequency thermocoagulation in the frontal lobe and freedom from seizures. Mean volume of one thermocoagulation point was 0.98±0.3 cm<sup>3</sup>. The number of points did not significantly influence the outcomes either for the McHugh scale (<i>p</i>=0.654) or for the Engel scale (<i>p</i>=0.288). Total volume of thermocoagulation foci ranged from 0.52 to 13.5 cm<sup>3</sup> (mean 3.85±2.9). Twenty-six (35%) patients underwent surgery for persistent and/or recurrent seizures after radiofrequency thermocoagulation (SEEG-guided resection of epileptogenic zones). After 12 months, freedom from seizures was 28% (21 patients), seizure rate decrease by more than 50% (McHugh I-II) was observed in 33 (44%) patients. McHugh class III outcome was observed in 12 patients (16%). MR-negative nature of epilepsy (<i>p</i>=0.009) and right-sided localization of epileptogenic substrate (<i>p</i><0.001) were negative predictors regarding Engel I outcomes.</p><p><strong>Conclusion: </strong>Stereo-EEG-guided radiofrequency thermocoagulation is a unique and safe technique significantly reducing the incidence and intensity of epileptic seizures in patients with focal drug-resistant epilepsy with minimal iatrogenic risk.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 3","pages":"7-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E A Bogoslovskaya, S K Gorelyshev, U V Tomale, A Yu Akimov, A V Alekseev, K A Bardeeva, V V Demyanenko, S S Zolotarev, S A Kirsanov, K A Kovalkov, I I Larkin, S B Medoev, R M Pankratiev, D R Pogosova, A V Seliverstov, A S Sukharev, A G Timershin, O A Usatova, E F Fatykhova, A S Shapovalov
{"title":"[Surgical treatment of posthemorrhagic hydrocephalus in premature infants].","authors":"E A Bogoslovskaya, S K Gorelyshev, U V Tomale, A Yu Akimov, A V Alekseev, K A Bardeeva, V V Demyanenko, S S Zolotarev, S A Kirsanov, K A Kovalkov, I I Larkin, S B Medoev, R M Pankratiev, D R Pogosova, A V Seliverstov, A S Sukharev, A G Timershin, O A Usatova, E F Fatykhova, A S Shapovalov","doi":"10.17116/neiro2025890417","DOIUrl":"https://doi.org/10.17116/neiro2025890417","url":null,"abstract":"<p><strong>Rationale: </strong>Hydrocephalus as a consequence of intraventricular hemorrhage (IVH) in premature infants is a life-threatening complication of the neonatal period. The question remains as to which methods are best to be used for temporary drainage of cerebrospinal fluid until sufficient body mass for possible shunt implantation is achieved.</p><p><strong>Objective: </strong>Is to compare four methods of temporary treatment of posthemorrhagic hydrocephalus in terms of their safety and effectiveness.</p><p><strong>Material and methods: </strong>A multicenter (12 healthcare facilities of the Russian Federation) prospective study included 165 premature infants with IVH and signs of worsening enlargement of the ventricles. External ventricular drainage (EVD) was used in 43 observations, ventriculosubgaleal shunt (VSGS) in 93 observations, neuroendoscopic lavage (NEL) in 25 observations and Ommaya reservoir - in 4. Methods were compared by effectiveness and postoperative complications. The examination of patients in catamnesis was carried out at the age of 6, 12, 24 and 36 months.</p><p><strong>Results: </strong>Differences regarding brain tissue defect in the access zone (the highest in the NEL group and the lowest in EVD group, <i>p</i><0.001); multilocular hydrocephalus frequency (the highest in the EVD group - 33% and the lowest in the NEL group - 17%, <i>p</i><0.05); proportion of patients in need of permanent shunting (the highest indicator in the VSGS group - 88.1% and the lowest in the NEL group - 57%, <i>p</i><0.001); number of infectious complications (most of all in the EVD group - 12%, the lowest in the NEL group - 0%) have been revealed. The best indicators of children's motor development have been noted in the NEL group (2.25), the worst in the EVD group - 3.75. Long-term mortality in the distant period amounted to 7%.</p><p><strong>Conclusion: </strong>The most effective method of temporary arresting of hydrocephalus is neuroendoscopic lavage. It has a minimal number of infectious and other complications, the best hydrocephalus stabilization, low percentage of complicated hydrocephalus (multilocular) and the best motor development indicators and does not require reinterventions.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 4","pages":"7-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A R Grishina, O M Vorobyova, I A Danilova, L B Mitrofanova
{"title":"[Glymphatic system in health and disease: a narrative review].","authors":"A R Grishina, O M Vorobyova, I A Danilova, L B Mitrofanova","doi":"10.17116/neiro202589041112","DOIUrl":"https://doi.org/10.17116/neiro202589041112","url":null,"abstract":"<p><p>The main functional parts of the glymphatic system are perivascular spaces and surrounding astrocytes. Cerebrospinal fluid enters the brain parenchyma from subarachnoid cisterns through perivascular Virchow-Robin spaces and passes into the interstitium through aquaporin channels in astrocytes. Then, cerebrospinal fluid removes metabolic products and mixes with interstitial fluid. Outflow of cerebrospinal fluid with metabolic products from the brain parenchyma occurs in three ways. The first route is periarterial through intermuscular spaces in the middle layer of cerebral arteries. The second route is perivenous. The third route is lymphatic through meningeal or sinus-associated lymphatic vessels. They provide drainage of macromolecules and immunocompetent cells from the brain to the cervical lymph nodes. Gliomas are accompanied by inhibition of normal cerebrospinal fluid outflow pathways, mainly due to additional intracranial tissue, and compensatory cerebrospinal fluid outflow along the spinal cord. Reduced cerebrospinal fluid release with impaired outflow contribute to accumulation of toxic metabolic products, proinflammatory cytokines and chemokines. Transport of antigens to lymph nodes is inhibited that disrupts antitumor immunity. Impaired cerebrospinal fluid circulation also reduces the effectiveness of intracranial drug delivery. One of the mechanisms of pathogenesis of glioma metastasis is based on migration of tumor cells along classical and meningeal lymphatic pathways. Damage to the latter contributes to metastasis.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 4","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Review of the book by A.A. Skoromets, A.V. Amelin, E.R. Barantsevich, I.A. Voznyuk, A.P. Skoromets, T.A. Skoromets, V.A. Sorokoumov, N.V. Shuleshova Cerebral Angioneurology, ed. by Academician of the Russian Academy of Sciences Yu.A. Shcherbuk: in 2 vols. St. Petersburg: Polytechnic; 2024].","authors":"G E Chmutin","doi":"10.17116/neiro202589041127","DOIUrl":"https://doi.org/10.17116/neiro202589041127","url":null,"abstract":"<p><p>Review of the book by A.A. Skoromets, A.V. Amelin, E.R. Barantsevich, I.A. Voznyuk, A.P. Skoromets, T.A. Skoromets, V.A. Sorokoumov, N.V. Shuleshova Cerebral Angioneurology, ed. by Academician of the Russian Academy of Sciences Yu.A. Shcherbuk: in 2 vols. St. Petersburg: Polytechnic; 2024.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 4","pages":"127"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N I Mikhailov, A M Zaitsev, M A Kucheryavykh, P Yu Petrova, O N Kirsanova, Kh S Kosumova
{"title":"[Metastatic meningiomas: a case series and literature review].","authors":"N I Mikhailov, A M Zaitsev, M A Kucheryavykh, P Yu Petrova, O N Kirsanova, Kh S Kosumova","doi":"10.17116/neiro20258903183","DOIUrl":"10.17116/neiro20258903183","url":null,"abstract":"<p><strong>Background: </strong>The probability of meningiomas metastasizing is 0.18%, and the causes are unclear. The most common localizations of extracranial metastases are lung (37.2%), bones (16.5%) and liver (9.2%). There are no effective treatment algorithms for metastatic meningiomas. Treatment tactics consists of symptomatic surgery and radiotherapy.</p><p><strong>Material and methods: </strong>We present 3 patients including a 75-year-old woman with grade 1 meningioma and metastasis to occipital lymph node, a 59-year-old man with meningioma grade 2 and lung metastasis, a 45-year-old woman with grade 2 meningioma with extracranial component and lung metastasis.</p><p><strong>Results and discussion: </strong>A female patient with grade 1 meningioma and occipital lymph node metastasis showed clinical stabilization after surgical treatment. The follow-up was 14 months. Treatment with nitrosourea was ineffective for metastatic lung lesions in a patient with grade II meningioma. Combination of bevacizumab and everolimus in a patient with G2 meningioma within craniovertebral junction and metastatic lung lesion achieved stabilization in all foci. The follow-up was 6 months.</p><p><strong>Conclusion: </strong>It is necessary to continue accumulation of clinical experience due to rarity of meningioma metastasizing. Treatment of such patients remains individual.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 3","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A O Sosnov, A V Dubovoy, S Yu Yulusov, D M Galaktionov, A V Gogolev
{"title":"[Surgical treatment of eccentric-fusiform aneurysm of proximal basilar artery. Case report and literature review].","authors":"A O Sosnov, A V Dubovoy, S Yu Yulusov, D M Galaktionov, A V Gogolev","doi":"10.17116/neiro20258903192","DOIUrl":"10.17116/neiro20258903192","url":null,"abstract":"<p><p>Basilar artery aneurysm is a rare and difficult pathology that can require combination of various surgical methods. The authors present successful combined endovascular and microsurgical treatment of fusiform aneurysm of proximal basilar artery and confluence of vertebral arteries with high origin of the left posterior inferior cerebellar artery from aneurysm dome. The choice of preliminary revascularization of functionally significant artery involved in aneurysm and subsequent endovascular occlusion of aneurysm are considered.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 3","pages":"92-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O A Pavlov, A V Dubovoy, K N Babichev, M A Snegirev
{"title":"[Internal thoracic artery for high-flow extra-intracranial bypass graft. Case report and literature review].","authors":"O A Pavlov, A V Dubovoy, K N Babichev, M A Snegirev","doi":"10.17116/neiro202589031100","DOIUrl":"10.17116/neiro202589031100","url":null,"abstract":"<p><strong>Objective: </strong>To describe the first experience of internal thoracic artery for high-flow extra-intracranial bypass.</p><p><strong>Material and methods: </strong>Internal thoracic artery was used for high-flow extra-intracranial bypass in a patient with giant aneurysm of internal carotid artery. Internal thoracic artery harvesting technique is presented. A systematic review is devoted to the role of internal thoracic artery in neurosurgery. The main advantages and disadvantages of internal thoracic artery are described.</p><p><strong>Results: </strong>High-flow extra-intracranial bypass through internal thoracic artery allowed safe ICA occlusion. CT- angiography confirmed graft patency.</p><p><strong>Conclusion: </strong>We present the first experience of internal thoracic artery for high-flow bypass. The advantages and disadvantages are described. A final decision in favor of one or another graft requires further research.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"89 3","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}