Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献_第3页

[Composition and toxicity of shrapnel in mine-explosive and fragmentation craniocerebral wounds compared to titanium implants: a pilot study]. [与钛植入物相比，地雷爆炸和碎片性颅脑损伤中弹片的成分和毒性：一项初步研究]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro2026900116

V P Orlov, Yu A Nashchekina, P O Nikonov, A V Nashchekin, S D Mirzametov, B V Martynov, E M Ivankova, N K Vasileva, D V Svistov

{"title":"[Composition and toxicity of shrapnel in mine-explosive and fragmentation craniocerebral wounds compared to titanium implants: a pilot study].","authors":"V P Orlov, Yu A Nashchekina, P O Nikonov, A V Nashchekin, S D Mirzametov, B V Martynov, E M Ivankova, N K Vasileva, D V Svistov","doi":"10.17116/neiro2026900116","DOIUrl":"10.17116/neiro2026900116","url":null,"abstract":"Objective: To evaluate elemental composition and cytotoxicity of metal fragments of wounding projectiles based on modern alloys from mine blast and shrapnel craniocerebral wounds in comparison with titanium plates (control) in relation to human cell line T98G (human, glioblastoma, epithelial-like environment EMEM).Material and methods: We studied 12 wounding projectiles removed from the brain. Three ferromagnetic samples were selected to determine composition and cytotoxicity. Composition of fragments was studied using spectral analysis. Surface of samples and their elemental composition were examined using electron microscope (SEM) JSM-7001F (JEOL, Japan) equipped with X-ray spectral microanalysis attachment INCA x-sight (Oxford Instruments, England). Cytotoxicity of medium with wounding projectiles was determined in comparison with control medium using methyl tetrazolium test. Human cell line T98G (human, glioblastoma) (Institute of Cytology, St. Petersburg) was used to study cytotoxicity of fragments and titanium plates (control). Cell morphology was assessed using optical light microscopy.Results: According to elemental analysis, all fragments were represented by alloys of various metals and other chemical elements. Methyl-tetrazolium test revealed high cytotoxicity of all fragments. Titanium VT6 plates were biocompatible with cultured cells.Conclusion: All fragments of modern projectiles release toxic metal oxides in nutrient medium significantly reducing viability of cells regardless of elemental composition of fragments. VT6 titanium plates are biocompatible with cultured cells and can be used as implants during surgical interventions.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 1","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Breast cancer metastasis to parasagittal meningioma: a case report and literature review]. 【乳腺癌向矢状旁脑膜瘤转移1例并文献复习】。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269003180

V N Shimansky, I I Isazade, M V Kolycheva, G P Snigireva, M V Ryzhova, V V Karnaukhov

{"title":"[Breast cancer metastasis to parasagittal meningioma: a case report and literature review].","authors":"V N Shimansky, I I Isazade, M V Kolycheva, G P Snigireva, M V Ryzhova, V V Karnaukhov","doi":"10.17116/neiro20269003180","DOIUrl":"10.17116/neiro20269003180","url":null,"abstract":"Introduction: Tumor-to-tumor metastasis is a rare phenomenon, and meningiomas are the most frequent recipient in these cases. The most common donor tumors are breast and lung cancers.Objective: To describe a rare clinical case of breast adenocarcinoma metastasis to meningioma, problems of diagnosis and treatment.Material and methods: A 67-year-old patient presented with breast cancer. Neuroimaging revealed parasagittal intracranial tumor. Resection of tumor was followed by histological and immunohistochemical examination of specimens. There was postoperative radiotherapy (CyberKnife). The authors present a rare case of breast cancer metastasis to parasagittal meningioma and reviewed 152 available cases in the literature.Results: Histological examination revealed two components: benign transitional meningioma (Grade I) and invasive breast adenocarcinoma metastasis (positive expression of AE1/AE3 CK). Tumor stabilization was achieved after resection and subsequent radiotherapy.Conclusion: This rare case demonstrates the need for a more detailed neuroradiological examination in patients with previously diagnosed malignancies referred for surgical treatment of intracranial meningiomas.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prognostic value of miR-130, miR-148, miR-194 and miR-605 serum expression in glioblastoma patients]. [miR-130、miR-148、miR-194和miR-605血清表达在胶质母细胞瘤患者中的预后价值]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269003120

D V Mysik, A Yerokhina, L V Spirina, A I Ryabova

{"title":"[Prognostic value of miR-130, miR-148, miR-194 and miR-605 serum expression in glioblastoma patients].","authors":"D V Mysik, A Yerokhina, L V Spirina, A I Ryabova","doi":"10.17116/neiro20269003120","DOIUrl":"10.17116/neiro20269003120","url":null,"abstract":"Introduction: In modern neurooncology, molecular and clinical-morphological markers are used to assess prognosis and select treatment strategies for glioblastoma. Currently, researchers are focusing on microRNAs in biological fluids that can predict outcomes of disease.Objective: To analyze serum expression of miR-130, miR-148, miR-194, and miR-605 in patients with glioblastoma depending on clinical and molecular genetic parameters of tumor.Material and methods: The study included 39 patients with newly diagnosed glioblastoma (IDH-wildtype, WHO Grade 4) between 2021 and 2023 (median age 55 years; 95% CI 47-61). Expression of miR-130, miR-148, miR-194, and miR-605 was assessed in serum samples collected before chemoradiotherapy. Patients underwent combined therapy: maximal tumor resection, chemoradiotherapy (60 Gy) with temozolomide and adjuvant chemotherapy. MicroRNA levels were determined by real-time PCR. MGMT methylation, TP53 and Ki-67 expression, recurrence-free survival and tumor metabolic activity (SPECT) were analyzed.Results: There was a significant association between miR-148 expression and MGMT promoter methylation (increase by 1.6 times). MiR-194 expression decreased by 1.2 times. MiR-130 increased by 1.5 times with MGMT methylation and Ki-67 >25%. In patients with TP53 expression >10%, MiR-130 increased by 3 times. No association was found between expression of microRNAs and SPECT data.Conclusion: MiR-148 is associated with MGMT methylation and can have prognostic significance. Reduced miR-194 with MGMT methylation and increased miR-130 with high Ki-67 and TP53 indicate involvement of these microRNAs in formation of aggressive glioblastoma phenotype and their potential as prognostic biomarkers.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Epidural spinal cord stimulation in hereditary spastic paraplegia: preliminary results]. [硬膜外脊髓刺激治疗遗传性痉挛性截瘫：初步结果]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269002162

V M Akinfiev, A S Simonyan, A O Gushcha, V V Krylov

{"title":"[Epidural spinal cord stimulation in hereditary spastic paraplegia: preliminary results].","authors":"V M Akinfiev, A S Simonyan, A O Gushcha, V V Krylov","doi":"10.17116/neiro20269002162","DOIUrl":"10.17116/neiro20269002162","url":null,"abstract":"Hereditary spastic paraplegia is a diverse group of inherited neurodegenerative diseases characterized by spasticity and weakness in the lower extremities. Treatment is comprehensive and includes pharmacotherapy and physical therapy. If these approaches are ineffective, neurosurgical methods such as rhizotomy or intrathecal baclofen therapy are applied. Epidural spinal cord stimulation is still poorly studied.Objective: To evaluate safety and efficacy of epidural spinal cord stimulation in patients with hereditary spastic paraplegia.Material and methods: The study (2015-2024) included patients with hereditary spastic paraplegia refractory to conservative treatment. After test stimulation, permanent spinal stimulation systems (classic generator-based and wireless external) were implanted in 18 patients. The modified Ashworth scale, the Spastic Paraplegia Rating Scale (SPRS), the Timed Up and Go Test (TUG), the Ten-Meters Walk Test (10MWT), and the SF-36 questionnaire were used to assess neurological status preoperatively and six months after surgery. The study was approved by local ethics committee.Results: Implantation of permanent stimulation system (electrodes at the level of Th10-Th12) was performed in 18 patients (13 men, 5 women). Of these, 7 patients received wireless systems with external energy source, while 11 ones received classic generator systems. Six months after the intervention, we observed improvements in the following parameters compared to pre-implantation state: MAS score from 3 to 1.5-1 (18 patients); TUG test by 11.2-19.7% (17 patients); 10MWT test by 12.6-20.5% (17 patients); SPRS score by 27.9% (17 patients); SF-36 score 30-66% (16 patients).Conclusion: Epidural spinal cord stimulation may be considered for hereditary spastic paraplegia, but further research is needed to clarify its role in symptomatic treatment of spastic paraplegia.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 2","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Stereo-EEG-guided radiofrequency thermocoagulation in patients with drug-resistant epilepsy: a systematic review]. [立体脑电图引导射频热凝治疗耐药癫痫：一项系统综述]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269004195

Yu V Batmanova, I M Alekseev, A A Zuev

{"title":"[Stereo-EEG-guided radiofrequency thermocoagulation in patients with drug-resistant epilepsy: a systematic review].","authors":"Yu V Batmanova, I M Alekseev, A A Zuev","doi":"10.17116/neiro20269004195","DOIUrl":"10.17116/neiro20269004195","url":null,"abstract":"Background: Radiofrequency thermocoagulation (RFTC) allows for destruction of epileptogenic zone during stereo-electroencephalographic (stereo-EEG) monitoring. This technique can serve therapeutic and diagnostic purposes in the treatment of patients with drug-resistant epilepsy (DRE).Objective: A systematic review of literature data on RFTC, its technique, efficacy, and safety in patients with DRE.Material and methods: This review was conducted according to the PRISMA 2020 criteria and registered in the PROSPERO registry. Two researchers selected studies in three stages using appropriate keywords. Studies with sample size ≥ 5 patients devoted to RFTC in patients with DRE were included. Studies demonstrating the effectiveness of RFTC for seizures with a minimum follow-up of 6 months were eligible. Case reports, reviews, manuscripts without available full text and non-eligible studies were excluded.Results: The review included 41 articles and 1.417 patients. The main causes of RFTC during stereo-EEG were contraindications for resection, the need for additional information on location of ictal zone, coagulation as an additional method for epileptogenic zone destruction and treatment of seizures in patients with indications for resection. The overall complication rate ranged from 0% to 60% (in 5.3% of patients). Neurological deficit was transient in 64% of cases. Favorable outcomes (Engel I) after RFTC without additional treatment were achieved in 24.9% of patients with DRE.Conclusion: Stereo-EEG navigated RFTC is a promising technique for examination and treatment of patients with DRE. It is safe and effective. However, standardization of coagulation parameters and prospective multiple-center studies are needed to obtain more accurate data.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 4","pages":"95-105"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Dinamic of biochemical parameters in patients with vestibular schwannoma in perioperative period]. [前庭神经鞘瘤患者围手术期生化指标动态变化]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269005146

N A Lesteva, N V Dryagina, A N Kondratyev

{"title":"[Dinamic of biochemical parameters in patients with vestibular schwannoma in perioperative period].","authors":"N A Lesteva, N V Dryagina, A N Kondratyev","doi":"10.17116/neiro20269005146","DOIUrl":"https://doi.org/10.17116/neiro20269005146","url":null,"abstract":"The correlation of cardiovascular and humoral responses to neurosurgical trauma near the cranial nerves is interesting for predicting of the postoperative period.Objective: To study the correlation between cardiovascular and humoral responses to neurosurgical intervention for vestibular schwannoma (VS) by comparing changes in blood parameters during the intraoperative period.Material and methods: The study included data of 92 neurosurgical patients who underwent surgery for vestibular schwannoma. The patients were divided into two groups: 46 patients without vegetative reactions during tumor removal; 43 patients who had type 1 vegetative reactions; 3 patients had type 2 vegetative reactions, but the last group for the small number of patients was excluded from statistical analysis. Biochemical indicators were studied, including glucose, lactate, urea, uric acid, total protein, albumin, total bilirubin, cholesterol, creatinine, creatine kinase, myoglobin, lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), amylase, iron, C-reactive protein (CRP), sodium, and potassium at various stages of the perioperative period.Results: The level of uric acid in the plasma of patients in group 1 on the first postoperative day was higher than in patients in group 2. Creatine kinase levels increased in all groups. C-reactive protein exceeded the reference values 4-5 times on the first postoperative day.Conclusion: Dynamics of changes in uric acid, CRP, glucose, and lactate levels are the result of the body's humoral response to multifactorial influences during neurosurgical intervention, most pronounced in combination with type 2 vegetative reactions, which are a consequence of hypercatecholaminemia.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 5","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sex differences in neuroplasticity and functional recovery after neurosurgical interventions]. [神经外科干预后神经可塑性和功能恢复的性别差异]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro202690051113

F A Yusupov, M Sh Abdykadyrov

{"title":"[Sex differences in neuroplasticity and functional recovery after neurosurgical interventions].","authors":"F A Yusupov, M Sh Abdykadyrov","doi":"10.17116/neiro202690051113","DOIUrl":"10.17116/neiro202690051113","url":null,"abstract":"Objective: To analyze modern data on the influence of biological sex and gender factors on mechanisms of neuroplasticity and functional recovery after neurosurgical interventions.Material and methods: We reviewed the databases (PubMed, Scopus, Russian Science Citation Index (RSCI) and Google Scholar) over the past 10 years. The review covers clinical trials, prospective and retrospective cohort studies and animal models of traumatic brain injury, surgery for brain cancer, vascular accidents and spinal cord injury. The main parameters were diffusion tensor imaging data, functional MRI, hormonal profile and standardized clinical scales including the modified Rankin scale, Barthel index, ASIA and FIM scales.Results: Female brain has better interhemispheric connectivity that provides adaptive advantage in focal lesions of dominant hemisphere. Male brain is optimized for intrahemispheric signaling promoting faster motor coordination. Estrogens and progesterone have neuroprotective effect through modulation of inflammatory response and support of myelination, but this effect depends on age and phase of reproductive cycle. In clinical practice, women often demonstrate lower rates of functional independence at discharge after stroke due to comorbidity and social factors, despite equal or superior potential for neurological recovery compared to men.Conclusion: Biological sex is a critical determinant of neurosurgical outcomes. Discrepancy between biological recovery potential (higher in women) and actual functional outcomes (often better in men) highlights the need to develop personalized, gender-specific rehabilitation protocols taking into account specifics of connectome and hormonal backgrounds.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 5","pages":"113-119"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Sectoral schwannomatosis of the lower extremities]. [下肢局部神经鞘瘤病]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269003143

A V Gorodnina, D A Sitovskaya, A Yu Orlov

引用次数: 0

[Battery of tests for speech mapping in brain surgery «Linguistic intraoperative support»]. [脑外科中语音映射的一系列测试«术中语言支持»]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269004187

E P Dmitrova, S B Buklina, N E Gronskaya, A S Zyryanov, A V Chrabaszcz, E S Krasilova, I V Makarova, A Sh Minnigulova, E A Stupina, O A Tasenko, V A Tolkacheva, K V Untila, M I Hodzhametova, M V Khudyakova, O V Dragoy

引用次数: 0

[Multidisciplinary approach to the treatment of aggressive hormone releasing adenoma: a case report and literature review]. [多学科方法治疗侵袭性激素释放性腺瘤：1例报告及文献复习]。

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko Pub Date : 2026-01-01 DOI: 10.17116/neiro20269003186

G D Gabaidze, L G Ebanoidze, D V Lisina, L K Dzeranova, E A Pigarova, E G Przhiyalkovskaya, A Yu Grigoriev, M A Perepelova, A A Kolomeytseva, L I Astafyeva, T M Alexeeva, G L Kobyakov, M A Kutin, A P Kononykhina

{"title":"[Multidisciplinary approach to the treatment of aggressive hormone releasing adenoma: a case report and literature review].","authors":"G D Gabaidze, L G Ebanoidze, D V Lisina, L K Dzeranova, E A Pigarova, E G Przhiyalkovskaya, A Yu Grigoriev, M A Perepelova, A A Kolomeytseva, L I Astafyeva, T M Alexeeva, G L Kobyakov, M A Kutin, A P Kononykhina","doi":"10.17116/neiro20269003186","DOIUrl":"10.17116/neiro20269003186","url":null,"abstract":"Background: Despite available modern therapeutic options for acromegaly, resistant and aggressive forms of growth hormone releasing adenoma remain a significant clinical challenge with unsatisfactory outcomes.Material and methods: The authors present a young patient with invasive growth hormone releasing adenoma characterized by aggressive growth, high proliferation index and previously unreported TP53 gene mutation, PD-L1 and VEGF expression, resistance to somatostatin analogues and no disease control despite combined therapy including growth hormone receptor antagonist.Results: A patient with aggressive somatotropinoma experienced tumor growth despite previous neurosurgical interventions, radio- and chemotherapy, as well as targeted therapy. External beam radiation therapy is recommended as the only treatment option. The authors also examine aspects of multidisciplinary approach, results of antiangiogenic, chemo- and immunotherapy with immune checkpoint inhibitors when neurosurgery, traditional medications, and radiotherapy are ineffective.Conclusion: This case underscores the necessity of extended immunohistochemical profiling and molecular genetic sequencing of pituitary tumors to facilitate development of personalized therapeutic strategies for aggressive somatotropinomas refractory to standard treatment modalities.","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"90 3","pages":"86-93"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0