Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Human glioma malignancy grade and migratory capacity depending on expression of GDNF isoforms in vitro].","authors":"D V Shamadykova, L G Zakharova, S A Pavlova, G V Pavlova","doi":"10.17116/neiro20248806131","DOIUrl":"https://doi.org/10.17116/neiro20248806131","url":null,"abstract":"<p><p>Glial cell line-derived neurotrophic factor (GDNF) is essential in maintaining the viability, function and differentiation of neuronal cells. In addition to its function in healthy nervous tissue, GDNF is involved in pathological processes, such as glioma growth. GDNF is represented by 2 main isoforms: pre-α-pro-GDNF (αGDNF) and pre-β-pro-GDNF (βGDNF). αGDNF maintains cell viability, and βGDNF has neurotrophic properties. The relationship between GDNF expression and human glioma malignancy grade, as well as migratory properties of tumor cells remains poorly understood.</p><p><strong>Objective: </strong>To assess the expression of mRNA splice variants of GDNF in glioma cell cultures with various malignancy grades (I-IV) and degrees of migration.</p><p><strong>Material and methods: </strong>In this study, αGDNF and βGDNF expression was analyzed in 15 human glioma cell cultures using Southern blot hybridization of GDNF cDNA and reverse transcription with PCR to amplify splice variants of GDNF mRNA.</p><p><strong>Results: </strong>The highest expression of αGDNF and βGDNF isoforms was observed in cell cultures of human gliomas with extensive migratory activity. Low βGDNF expression without αGDNF expression is typical only for gliomas with low migratory activity. In addition, we found additional patterns of mRNA expression that have not been previously described.</p><p><strong>Conclusion: </strong>The relationship between GDNF and malignancy grade is unclear. Nevertheless, GDNF expression is higher in glioblastomas. Overall GDNF expression is increased in glioma cells with high migration activity. At the same time, αGDNF and βGDNF isoforms demonstrate higher expression in actively migrating cells that can indicate their participation in regulation of tumor migration properties. No αGDNF expression with simultaneous low βGDNF expression may be a prognostic sign of low migration activity of human glioma cells.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neuromodulatory pharmacotherapy individualization in prolonged and chronic consciousness disorders after severe traumatic brain injury].","authors":"E V Aleksandrova, O S Zaitsev, A A Potapov","doi":"10.17116/neiro20248803174","DOIUrl":"10.17116/neiro20248803174","url":null,"abstract":"<p><p>One of the most probable causes of effective therapy for post-comatose disorders of consciousness is the lack of individualization of drug prescriptions. In this observational study, we analyzed 48 courses of neuromodulatory therapy in 28 patients with prolonged and chronic disorders of consciousness following severe traumatic brain injury. Comparison of 24 effective and 24 ineffective courses demonstrated higher effectiveness of pharmacotherapy through its individualization, i.e. the choice of a drug whose neuromodulatory spectrum would correspond to neurological syndromes of neurotransmitter dysfunction. In this approach, 74% of therapy courses were effective while opposite management resulted only 34% of effective courses.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 3","pages":"74-80"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic criteria for prolonged and chronic disturbances of consciousness after aneurysmal subarachnoid hemorrhages].","authors":"E V Sergeenko, O B Belousova, Yu V Pilipenko","doi":"10.17116/neiro202488041117","DOIUrl":"10.17116/neiro202488041117","url":null,"abstract":"<p><strong>Background: </strong>In recent years, prolonged states of impaired consciousness became widespread among patients with aneurysmal subarachnoid hemorrhage. Treatment and maintenance of vital functions in such patients represent a complex medical, economic and social problem. In this regard, searching for the causes of prolonged states of impaired consciousness and predicting the outcomes are important.</p><p><strong>Objective: </strong>To analyze available literature data on prevention and treatment of prolonged states of impaired consciousness after aneurysmal subarachnoid hemorrhage.</p><p><strong>Results: </strong>We reviewed the PubMed database using the keywords «unresponsive wakefulness syndrome», «persistent vegetative state2, «minimal consciousness state» and «outcome of subarachnoid hemorrhage». Only 4 reports devoted to the causes and treatment outcomes in patients with prolonged impairment of consciousness after aneurysmal subarachnoid hemorrhage were found. At the same time, patients with aneurysmal subarachnoid hemorrhage comprise up to 11% among all cases of prolonged states of impaired consciousness. Examination, management and treatment of patients with prolonged impairment of consciousness after aneurysmal subarachnoid hemorrhage are carried out according to general principles without taking into account specific etiological and pathogenetic factors.</p><p><strong>Conclusion: </strong>Increased number of patients with prolonged impairment of consciousness after aneurysmal subarachnoid hemorrhage necessitates analysis of etiopathogenesis and outcomes of these disorders based on modern clinical, instrumental and laboratory assessment of the brain.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Radiosurgery for cerebral cavernous malformations: a systematic review].","authors":"D E Semenov, O B Belousova, V V Kostyuchenko, A V Golanov","doi":"10.17116/neiro202488041107","DOIUrl":"10.17116/neiro202488041107","url":null,"abstract":"<p><strong>Background: </strong>Stereotactic radiosurgery (SRS) for cerebral cavernous malformations has been used for more than 30 years. However, indications for this method and outcomes are still discussable.</p><p><strong>Objective: </strong>To analyze available literature data on SRS for cerebral cavernous malformations with assessment of indications for treatment, radiation parameters, radiological and clinical complications and outcomes.</p><p><strong>Results: </strong>The final analysis included 20 reports describing post-SRS outcomes in 1834 patients with cerebral cavernous malformations. The main radiation parameter was mean radiation dose to the edge of cavernous malformation (prescribed dose, 13.25±2.16 Gy). In natural course of malformation, mean incidence of hemorrhages from cavernous malformation when counted after the second hemorrhage was 25.9±14.6%, after the patient's birth - 2.59±0.44%. Mean follow-up period after SRS was 66.7±24.1 months. Incidence of hemorrhages from cavernous malformation after SRS for the first 2 years of follow-up was assessed in 14 studies (4.67±3.51%). Incidence of hemorrhages ≥2 years after SRS was analyzed in 12 studies (1.55±0.8%).</p><p><strong>Conclusion: </strong>Despite significant global experience in SRS for cerebral cavernous malformations and many studies devoted to this problem, clear patient selection criteria have not yet been formulated. Modern selection principles have insufficient evidence base.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"107-116"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of intracranial saccular aneurysm wall: neuroimaging and histopathological correlates].","authors":"K S Semin, G A Demyashkin, N E Zakharova, Sh Sh Eliava, A S Kheireddin, A N Konovalov, D B Kalaeva, A I Batalov, I N Pronin","doi":"10.17116/neiro20248803152","DOIUrl":"https://doi.org/10.17116/neiro20248803152","url":null,"abstract":"<p><strong>Background: </strong>Contrast enhancement of intracranial aneurysm wall during MRI with targeted visualization of vascular wall correlates with previous aneurysm rupture and, according to some data, may be a predictor of further rupture of unruptured aneurysms.</p><p><strong>Objective: </strong>To analyze possible causes of aneurysm contrast enhancement considering morphological data of aneurysm walls.</p><p><strong>Material and methods: </strong>The study included 44 patients with intracranial aneurysms who underwent preoperative MRI between November 2020 and September 2022. Each aneurysm was assessed regarding contrast enhancement pattern. Microsurgical treatment of aneurysm was accompanied by resection of its wall for subsequent histological and immunohistochemical analysis regarding thrombosis, inflammation and neovascularization. Specimens were subjected to histological and immunochemical analysis. Immunohistochemical analysis was valuable to estimate inflammatory markers CD68 and CD3, as well as neurovascularization marker SD31.</p><p><strong>Results: </strong>Aneurysms with contrast-enhanced walls were characterized by higher number of CD3+, CD68+, CD31+ cells and parietal clots. Intensity of contrast enhancement correlated with aneurysm wall abnormalities.</p><p><strong>Conclusion: </strong>Contrast enhancement of aneurysm wall can characterize various morphological abnormalities.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 3","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prospective analysis of inflammatory markers and perioperative clinical data in children with craniosynostosis undergoing reconstructive surgery].","authors":"B A Bashiryan, O A Gadzhieva, L A Satanin, E A Lavrenyuk, V A Tere, N A Mazerkina, A V Sakharov, I V Getmanova, V V Roginsky","doi":"10.17116/neiro20248801170","DOIUrl":"10.17116/neiro20248801170","url":null,"abstract":"<p><strong>Background: </strong>Craniosynostosis (CS) is a group of skull malformations manifested by congenital absence or premature closure of cranial sutures. Reconstructive surgery in the second half of life is traditional approach for CS. The issues of surgical stress response after reconstructive surgery for CS in children are still unclear.</p><p><strong>Objective: </strong>To evaluate clinical and laboratory parameters in children undergoing traumatic reconstructive surgery for CS.</p><p><strong>Material and methods: </strong>Inclusion criteria were CS, reconstructive surgery, age <24 months, no comorbidities and available laboratory diagnostic protocol including complete blood count, biochemical blood test with analysis of C-reactive protein, procalcitonin, ferritin and presepsin. The study included 32 patients (24 (75%) boys and 8 (25%) girls) aged 10.29±4.99 months after surgery between October 2021 and June 2022. Non-syndromic and syndromic forms of CS were observed in 25 (78.1%) and 7 (21.9%) cases, respectively.</p><p><strong>Results: </strong>There were no infectious complications. We analyzed postoperative clinical data, fever, clinical and biochemical markers of inflammation.</p><p><strong>Conclusion: </strong>Early postoperative period after reconstructive surgery for CS in children is accompanied by significant increase of inflammatory markers (C-reactive protein, procalcitonin, ferritin). However, these findings do not indicate infectious complications. This is a manifestation of nonspecific systemic reaction. Severity of systemic inflammatory response syndrome with increase in acute phase proteins indicates highly traumatic reconstructive surgery for CS in children. Analysis of serum presepsin allows for differential diagnosis between infectious complication and uncomplicated course of early postoperative period.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 1","pages":"70-78"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Is it possible to detect surface antigen CD133 on patient-derived glioblastoma continuous cell cultures using fluorescent aptamers?]","authors":"V L Moiseenko, O M Antipova, S A Pavlova, I N Pronin, G V Pavlova, A M Kopylov","doi":"10.17116/neiro20248801156","DOIUrl":"10.17116/neiro20248801156","url":null,"abstract":"<p><p>Theranostics combines diagnostics and therapeutic exposure. Regarding glioblastomas, theranostics solves the problem of detecting and destroying tumor stem cells resistant to irradiation and chemotherapy and causing tumor recurrence. Transmembrane surface antigen CD133 is considered as a potential marker of tumor stem cells.</p><p><strong>Objective: </strong>To detect CD133 in patient-derived glioblastoma continuous cell cultures using fluorescence microscopy and modified aptamers (molecular recognition elements) anti-CD133.</p><p><strong>Material and methods: </strong>To detect CD133, we used mousey fluorescence monoclonal antibodies anti-CD133 MA1-219, FAM-modified DNA aptamers anti-CD133 AP-1-M and Cs5. Non-aptamer DNA oligonucleotide NADO was used as a negative control. Detection was performed for three samples of patient-derived glioblastoma continuous cell cultures coded as 1548, 1721 and 1793.</p><p><strong>Results: </strong>MA1-219 antibodies brightly stained cell culture 1548, to a lesser extent - 1721. There was diffuse staining of cell culture 1793. Cs5-FAM aptamer stained cells in a similar way, but much weaker. AP-1-M-FAM aptamer interacted with cells even weaker and diffusely stained only cell culture 1793. Non-aptamer NADO did not stain cell culture 1548 and very weakly diffusely stained cell culture 1793.</p><p><strong>Conclusion: </strong>For both molecular recognition elements (MA1-219 antibody and Cs5 aptamer), 3 cell culture samples can be arranged in the following order possibly reflecting CD133 status decrease: strong signal for cell culture 1548, much weaker for 1721, even weaker for 1793. Only cell culture 1548 can be considered CD133 positive with combination of Cs5+ and NADO signals. Cell culture 1793 is CD133 false positive with combination of Cs5+ and NADO+ signals.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 1","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bacterial contamination of autologous blood in reinfusion in neurosurgery: a phenomenon or a problem?]","authors":"O K Kvan, N B Teryaeva, M V Sukhorukova, A Yu Lubnin","doi":"10.17116/neiro20248802154","DOIUrl":"10.17116/neiro20248802154","url":null,"abstract":"<p><p>There is a problem of bacterial contamination of autologous blood despite long-term experience of intraoperative blood salvage and reinfusion.</p><p><strong>Objective: </strong>To analyze safety of blood reinfusion with white blood cell filtration and X-ray irradiation for blood decontamination in neurosurgery.</p><p><strong>Material and methods: </strong>The study included 57 patients with various neurosurgical diseases. We used intraoperative blood reinfusion in all patients considering high predictable risk of major blood loss due to neurosurgical diseases, features of neoplasm topography, anamnesis and examination data. Microbiological examination of autologous blood was carried out at different stages before reinfusion.</p><p><strong>Results: </strong>Bacterial contamination of autologous blood samples was observed in 42% of patients. Enlargement of surgical access to paranasal sinuses in patients with craniofacial lesions poses a potential risk of bacterial contamination of autologous blood. Additional methods of decontamination including white blood cell filtration and X-ray irradiation reduced bacterial load. The above-mentioned methods were less effective for decontamination of microflora not typical for human skin compared to saprophytic ones. There were no postoperative infectious complications.</p><p><strong>Conclusion: </strong>Combination of white blood cell filtration and X-ray irradiation reduces bacterial contamination and increases safety of reinfusion although these methods do not completely free autologous blood from opportunistic microorganisms. Decontamination quality significantly depended on microflora and surgical approach.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Therapeutic and diagnostic classification of degenerative spondylolisthesis: validation and multiple-center inter-observer agreement].","authors":"E S Baykov, A G Nazarenko, N A Konovalov, A I Vasiliev, A V Evsyukov, D M Kozlov, A S Nikitin, R M Nanaev, A G Martikyan, Yu M Poluektov, E S Brinyuk, S N Makarov, A A Kuleshov, A I Kokorev, A V Krutko","doi":"10.17116/neiro20248806113","DOIUrl":"10.17116/neiro20248806113","url":null,"abstract":"<p><strong>Object: </strong>To evaluate inter- and intra-observer agreement of the proposed diagnostic and treatment classification of degenerative spondylolisthesis.</p><p><strong>Material and methods: </strong>The proposed diagnostic and treatment classification of degenerative spondylolisthesis was validated according to the GRRAS protocol. For this purpose, we retrospectively analyzed MRI, CT and spinal radiography data in 20 patients. Inter- and intra-observer agreement was carried out by 11 experts from 6 federal institutions of Russia. Fleiss and Cohen's kappas were calculated using the Statistical Package for the Social Sciences (SPSS), version 21.0 (SPSS Inc., Chicago, IL, USA).</p><p><strong>Results: </strong>Validation was carried out in two stages. The first stage (3 experts from one clinical unit): inter-observer agreement k (Fleiss)=0.863 [0.786; 0.939]; intra-observer agreement - Cohen's kappa >0.81 (expert 1 - k=0.931, expert 2 - k=0.908, expert 3 - k=0.862). The second stage was multiple-center and included 11 experts. Inter-observer agreement k(Fleiss) was 0.792 [0.767; 0.817]. We compared agreement among surgeons with comparable experience depending on specialty: orthopedic - k=0.799 [0.774; 0.814]; neurosurgeons - k=0.791[0.769; 0.817] (<i>p</i>=0.687). Surgeon's experience did not affect significance of classification: <10-year experience - k=0.781 [0.767; 0.798], >10-year experience - k=0.808 [0.789; 0.817] (<i>p</i>=0.287).</p><p><strong>Conclusion: </strong>The presented diagnostic and treatment classification of degenerative spondylolisthesis has significant inter- and intra-observer multiple-center and multidisciplinary agreement. Integration of classification into clinical practice will allow standardization of surgical tactics for degenerative spondylolisthesis.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[PET/CT with 11C-methionine as a predictor of disease-free survival in patients with IDH1 wild type diffuse glioma].","authors":"T Yu Skvortsova, Zh I Savintseva, A F Gurchin, R Yu Seliverstov","doi":"10.17116/neiro2024880516","DOIUrl":"https://doi.org/10.17116/neiro2024880516","url":null,"abstract":"<p><p>Prognosis of <i>IDH</i> (<i>IDHwt</i>) wild-type gliomas is worse compared to <i>IDH</i>-mutant tumors regardless of histological criteria for glioblastoma. However, there is still uncertainty regarding favorable course of disease and predictors of long-term survival in <i>IDHwt</i> gliomas.</p><p><strong>Objective: </strong>To study the metabolic characteristics of <i>IDH1wt</i> diffuse astrocytomas using ¹¹C-methionine PET/CT and prognostic significance of PET-associated parameters for disease-free survival.</p><p><strong>Material and methods: </strong>We analyzed 79 adults with <i>IDH1wt</i> diffuse gliomas. Quantitative analysis consisted of ¹¹C-methionine accumulation index and metabolic tumor volume. Kaplan-Meier and Cox analyses were used to determine prognostic significance of histological findings and PET parameters.</p><p><strong>Results: </strong>Glioblastoma and astrocytoma grade 2 or 3 were diagnosed in 41% and 59% of patients, respectively. Accumulation index significantly differed between astrocytomas grade 2 and 3 (<i>p</i>=0.03). Significant predictors of disease-free survival were age, histological type of astrocytoma and tumor grade, contrast enhancement, PET-associated biomarkers (accumulation index and metabolic tumor volume) and compliance of metabolic pattern with glioblastoma syndrome (<i>p</i><0.05). Disease-free survival >24 months was established for age <41 years, maximum accumulation index <1.64, tumor accumulation index <1.39 and metabolic tumor volume <13.44 cm³. In multivariate Cox analysis, independent predictors of disease-free survival were age and PET syndrome of glioblastoma.</p><p><strong>Conclusion: </strong>Diffuse <i>IDH1wt</i> gliomas are a heterogeneous group differing in metabolic characteristics and prognosis. PET/CT with ¹¹C-methionine may be effective for stratifying patients into groups with unfavorable and favorable prognosis, as well as assessment of advisability of in-depth searching for <i>IDH1</i>/<i>IDH2</i> mutation.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}