Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko最新文献

{"title":"[Surgical treatment of recurrent herniated discs of the lumbar spine depending on risk factors].","authors":"V A Chekhonatsky, A V Kuznetsov, D Yu Usachev, N B Zakharova, A A Chekhonatsky, A V Gorozhanin, O N Dreval","doi":"10.17116/neiro20248804131","DOIUrl":"10.17116/neiro20248804131","url":null,"abstract":"<p><p>According to the literature, recurrent disc herniation of the lumbar spine occurs in 5-10% of cases. Objective. To develop an algorithm for surgical treatment of recurrent lumbar spine disc herniation based on analysis of risk factors of relapse and assessment of intra- and postoperative period.</p><p><strong>Material and methods: </strong>The study included 61 patients with recurrent intervertebral disc herniation. Thirty patients underwent repeated microdiscectomy without transpedicular fixation, 31 patients - resection of recurrent disc herniation with transpedicular fixation (PLIF technique). The control group included 63 patients without recurrent disc herniation. Mean follow-up period was 3.5 years.</p><p><strong>Results: </strong>Discectomy with transpedicular fixation is characterized by larger extent, prolonged surgery time and rehabilitation period. However, there is lower risk of recurrent disc herniation and CSF leakage. Repeated microdisectomy without transpedicular fixation is characterized by smaller extent and shorter surgery time, as well as faster recovery period. Nevertheless, we have higher risk of recurrent disc herniation and CSF leakage. We developed a method for assessing the probability of recurrent intervertebral disc herniation. This algorithm allows us to predict the probability of recurrent disc herniation in a particular patient with 86.7% accuracy.</p><p><strong>Conclusion: </strong>We proposed an algorithm for choosing surgical treatment of recurrent disc herniation. Microdiscectomy without fixation is advisable for the risk of recurrent disc herniation <30%, discectomy with transpedicular fixation - for risk of disc herniation >30%.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 4","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intraoperative magnet in removal of intracerebral metallic foreign bodies].","authors":"R S Martynov, A V Stanishevskiy, A E Chistyakov, D E Alekseev, K N Babichev, N K Vasilyeva, D V Svistov","doi":"10.17116/neiro20248805146","DOIUrl":"https://doi.org/10.17116/neiro20248805146","url":null,"abstract":"<p><strong>Background: </strong>Advisability of magnets in neurotrauma is due to pattern of patients admitted to neurosurgical departments of military hospitals with wounds accompanied by intracranial fixation of foreign metallic ferromagnetic bodies.</p><p><strong>Objective: </strong>To study dimensions, mass and magnetic properties of fragments extracted from gunshot wounds inflicted by modern weapons; to assess the feasibility of devices and instruments for removing foreign bodies.</p><p><strong>Material and methods: </strong>We analyzed foreign bodies extracted after gunshot wounds. Shape, dimension, weight and magnetic properties were studied. We estimated 532 foreign bodies (497 surgeries) extracted at the Kirov Military Medical Academy and 83 foreign bodies (79 surgeries) extracted at the Burdenko Military Clinical Hospital. Distribution by anatomical regions was established for both groups. We intraoperatively used cylindrical neodymium magnets 3×20 and 5×20 mm to extract magnetic foreign bodies. These magnets were brought to the target using standard surgical tweezers or original devices.</p><p><strong>Results: </strong>The median mass of removed fragments was 0.385 (Q₁-Q₃=0.12-1.435; min-max≤0.01-30.5) g at the Kirov Military Medical Academy and 0.4 (Q₁-Q₃≤0.001-1.6; min-max≤0.01-11.4) g at the Burdenko Military Clinical Hospital. Magnetic foreign bodies were found in 501 (94.2%) and 74 (94.8%) cases, respectively. In 8.8% of cases, foreign bodies were not removed due to difficult-to-reach location accompanied by higher risk of adverse outcomes after extraction.</p><p><strong>Conclusion: </strong>Extracted foreign bodies after combat injuries have magnetic properties in 94% of cases. Intraoperative magnet allows for safe extraction of fragments in 91% of cases. Devices with adjustable magnetic field strength seem perspective. Further analysis of indications for removal of wounding projectiles in primary and, especially, repeated surgical treatment of craniocerebral wounds is needed.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nonspecific craniovertebral spondylitis].","authors":"I Yu Lisitsky, A V Lychagin, A Yu Zarov, A L Korkunov, V G Cherepanov, I A Vyzankin, E Yu Tselishcheva","doi":"10.17116/neiro20248803121","DOIUrl":"https://doi.org/10.17116/neiro20248803121","url":null,"abstract":"<p><strong>Objective: </strong>To analyze surgical strategy for nonspecific spondylitis of the craniovertebral region (CVR) taking into account clinical features and morphological signs of disease.</p><p><strong>Material and methods: </strong>Eight patients with nonspecific spondylitis of CVR underwent surgery (4 women and 4 men aged 31-75 years). Three patients had pain syndrome, 5 ones - conduction disorders. Combined interventions were performed in 5 patients with neurological disorders. Of these, 3 patients underwent transoral decompression with subsequent occipitospondylodesis. In other cases, stages of surgical treatment were reverse. Four patients underwent simultaneous interventions, 1 patient - with 7-day interval. Patients with pain syndrome underwent occipitospondylodesis.</p><p><strong>Results: </strong>In all patients, postoperative VAS score of pain syndrome decreased by 5-7 points (mean 5.5). Among 5 patients with conduction symptoms, regression of neurological disorders 1 year after surgery was achieved in 2 cases, and complete recovery was observed in 3 patients (Frankel E). In all cases, examination confirmed relief of inflammatory process and no compression of the spinal cord and medulla oblongata. One patient had a dehiscence of the wound edges of posterior pharyngeal wall, and another one had implant fracture in 3 years after surgery.</p><p><strong>Conclusion: </strong>Active surgical approach is reasonable for nonspecific spondylitis of CVR. Craniocervical fixation eliminates pain and risk of neurological complications following atlantoaxial instability. Conduction disorders require simultaneous transoral decompression and occipitospondylodesis in patients with nonspecific purulent craniovertebral lesions. Impaired head tilt complicates transoral stage. In this regard, it is more rational to carry out craniocervical fixation at the last stage.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 3","pages":"21-30"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prolonged spinal and sacral neurostimulation in children with pelvic organ dysfunction: preliminary analysis].","authors":"A G Timershin, D V Kreshchenok, S A Konovalov, P I Mironov","doi":"10.17116/neiro20248802131","DOIUrl":"10.17116/neiro20248802131","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of long-term spinal and sacral programmable neurostimulation for pelvic organ dysfunction in patients with myelodysplasia and chronic dysfunction of the bladder and rectum.</p><p><strong>Material and methods: </strong>A retrospective study included 32 children aged 1-17 years (mean 10.7) with myelodysplasia, pelvic organ dysfunction and ineffective therapy including botulinum therapy and exclusion of tethered spinal cord syndrome. All children underwent comprehensive urodynamic examination with analysis of bladder and residual urine volume, mean flow rate, intravesical pressure and total urine volume, as well as electromyographic examination. Examination was carried out before surgery, after 6, 12 and 36 months. We applied urinary diary, NBSS questionnaire and urodynamic examination data. All patients underwent neurological examinations (neurological status, magnetic resonance imaging of the spinal cord, computed tomography and radiography of the spine, electroneuromyography). The study was conducted at the neurosurgical department of the Republican Children's Clinical Hospital in Ufa between 2014 and 2022. There were 32 implantations of epidural neurostimulators for pelvic organ dysfunctions.</p><p><strong>Results: </strong><i>P</i>atients used epidural spinal and sacral stimulation up to 6 times a day for 10-15 min turning on the pulse generator. This method significantly increased urinary volume, decreased episodes of urinary leakage and fecal incontinence, residual volume after urination and number of periodic catheterizations compared to baseline data. Sixteen patients were very satisfied, 10 ones were moderately satisfied, and 2 patients were not satisfied with therapy. The number of bladder catheterizations per day decreased by 51.1%. Urine volume significantly increased from 131.5±16.1 to 236±16.7 ml, intravesical pressure decreased from 23.5±4.2 to 18.5±2.1 cm H₂O (by 20.3%).</p><p><strong>Conclusion: </strong>Chronic epidural spinal and sacral stimulation can improve the quality of life in patients with pelvic organ dysfunction. This technique may be effective for pelvic organ dysfunction caused by myelodysplasia.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[To the origins of surgery for acoustic neuromas].","authors":"V N Shimansky, I O Kugushev, A B Kadasheva, V K Poshataev, K V Shevchenko, S V Tanyashin","doi":"10.17116/neiro20248802187","DOIUrl":"10.17116/neiro20248802187","url":null,"abstract":"<p><p>Acoustic neuroma is one of the most common tumors of the posterior cranial fossa. Its removal is always a challenge for the neurosurgeon and the patient. The history of surgery for acoustic neuromas is inextricably linked with the history of neurosurgery in general. The modern surgical community must know history and be able to use it. Only then will the development of surgery lead to the preservation of the quality of life of patients. In the history of surgery for acoustic neuromas, the stages of its development are clearly visible from the description of the clinical picture through the study of the anatomy of the cerebellopontine angle to modern microsurgical removal.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 2","pages":"87-97"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Novel Rat Glioblastoma 101/8 Model: A Comparative PET-CT Study with C6 Rat model].","authors":"I N Pronin, A A Postnov, A A Lipengolts, G V Pavlova, A V Revishchin, V A Skribitsky, Yu A Finogenova, A V Smirnova, K E Shpakova, E Yu Grigorieva, Yu A Kozlova, A I Alekseeva","doi":"10.17116/neiro20248806154","DOIUrl":"10.17116/neiro20248806154","url":null,"abstract":"<p><p>The development of new drugs in nuclear medicine for diagnosis or treatment (chemotherapy) of brain tumors, in particular gliomas, is inextricably linked with the use of tumor models in animals (usually rats).</p><p><strong>Objective: </strong>To compare the widely used glioma cell model C6 and the new experimental tissue model of glioblastoma 101.8.</p><p><strong>Material and methods: </strong>A comparison was made of the diagnostic and morphological characteristics of the presented glioma models in two groups of animals with intracranially implanted tissue strain of experimental glioblastoma 101.8 (<i>n</i>=4) and the C6 glioma cell line (<i>n</i>=4) throughout the tumor development cycle within the rat brain. To monitor the progress of tumor growth and development, each animal underwent repeated diagnostic studies using PET-CT with ¹⁸F-FDG and ¹⁸F-FET to assess the metabolic activity and volume of the tumor. Also MRI images were collected. After the end of data acquisition, a histological examination of the tumor was carried out.</p><p><strong>Results: </strong>The tissue model of glioblastoma 101.8 demonstrated rapid growth and pronounced accumulation of the tracers in all animals during the tumor observation cycle. Formation of intratumoral necrosis and signs of disruption of the blood-brain barrier (BBB) were detected. In PET-CT studies of animals with a transplanted C6 tumor, no visible necrosis in the tumor structure was observed. Tumor growth was less rapid than in the case of model 101.8. The obtained morphological characteristics of 101.8 tumors transplanted into the rat brain demonstrated similar properties observed in real clinical conditions in patients with glioblastoma of the brain (necrosis, neovascularization, multiple pseudopalisade structures).</p><p><strong>Conclusions: </strong>Tumor model 101.8 can be recommended for scientific research as it most closely reproduces the diagnostic and morphological features of a human glioblastoma.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Decolonization of autologous blood with cefuroxime during hardware reinfusion in neurosurgical patients].","authors":"O K Kvan, N B Teryaeva, M V Sukhorukova, A V Kozlov, A Yu Lubnin","doi":"10.17116/neiro20248806147","DOIUrl":"https://doi.org/10.17116/neiro20248806147","url":null,"abstract":"<p><p>Autologous blood obtained during hardware reinfusion can be bacterially contaminated with skin microflora in most cases (up to 90%) regardless of the area of surgical intervention. Increased volume of washing solution for red blood cell management, white blood cell filtration and X-ray irradiation do not always provide complete decontamination.</p><p><strong>Objective: </strong>To analyze the effectiveness of adding cefuroxime to extracorporeal circuit during hardware blood reinfusion.</p><p><strong>Material and methods: </strong>The study included 50 patients with intracranial tumors. Hardware blood reinfusion was used due to baseline disease, blood supply to the neoplasm and high risk of intraoperative blood loss. All patients received perioperative antibiotic prophylaxis. We assessed the effectiveness of decontamination using microbiological control at all stages of the procedure. We used the XTRA Liva Nova complex autologous blood recovery system (Popt protocol), PALL Purecell RC2VAE leukocyte filters, BacT/ALERT 3D automatic microbiological analyzer and vials with FA Plus and FN Plus medium and adsorbent. X-ray irradiation of autologous erythrocytes was performed at a dose of 25 Gy (ARDOK-1 device).</p><p><strong>Results: </strong>Addition of cefuroxime 1.5 g to blood collection reservoir excluded bacterial growth in autologous blood samples from this reservoir in 100% of cases. At subsequent stages of blood processing, we isolated <i>S. epidermidis</i>, <i>S. aureus</i>, <i>S. hominis</i>, <i>S. capitis</i>, as well as Acinetobacter ursingii, Morganella morganii and Klebsiella aerogenes from some samples. Maximum bacterial contamination was observed at the stage of erythrocyte washing (34% of samples). After leukocyte filtration and blood irradiation, this value was 8%.</p><p><strong>Conclusion: </strong>Combination of all decontamination methods (erythrocyte washing in large volume of solution, leukocyte filtration and irradiation) together with adding cefuroxime into extracorporeal circuit excluded bacterial growth in 92% of samples of autologous erythrocytes.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Long-term postoperative outcomes in patients with lumbosacral spine synovial cysts].","authors":"N A Konovalov, E S Brinyuk, Yu M Poluektov, S V Kaprovoy, R A Onoprienko, B A Zakirov, D S Kim, V A Beloborodov, I A Stepanov, N I Bychkovskii","doi":"10.17116/neiro20248805138","DOIUrl":"10.17116/neiro20248805138","url":null,"abstract":"<p><p>Searching of literature data revealed only a few reports devoted to long-term postoperative outcomes in patients with lumbosacral spine synovial cysts. These results are ambiguous and largely contradictory.</p><p><strong>Objective: </strong>To analyze the long-term postoperative outcomes in patients with lumbosacral spine synovial cysts.</p><p><strong>Material and methods: </strong>A retrospective observational cohort study was performed between January 2015 ando September 2022. The study included patients who underwent surgical treatment for lumbosacral spine synovial cysts with clinical and neurological manifestations. There were 94 medical records of respondents (36 (38.3%) men and 58 (61.7%) women aged 18-82 years). Mean postoperative follow-up period was 24.6±7.5 months.</p><p><strong>Results: </strong>Patients underwent various surgical interventions for synovial cysts. VAS scores of pain syndrome after 3, 6, 9, 12 and 24 postoperative months revealed significant pain relief in the lower back and extremities (<i>p</i><0.01). In long-term follow-up period, we observed significantly lower disability (Oswestry Disability Index) (<i>p</i><0.001). Adverse postoperative events occurred in 9 (9.6%) cases.</p><p><strong>Conclusion: </strong>Interlaminectomy with cyst wall resection and preservation or partial resection (no more than 1/3) of facet joint without segmental fusion is an effective and preferable surgical method with minimal incidence of adverse clinical events.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Congenital basal encephaloceles involving functionally important structures].","authors":"N A Chernikova, L A Satanin, E V Shelesko, G V Danilov, S B Agrba, A N Shkarubo, N A Mazerkina, M L Satanina","doi":"10.17116/neiro202488051102","DOIUrl":"10.17116/neiro202488051102","url":null,"abstract":"<p><p>In rare cases, basal encephaloceles can include important brain structures (pituitary gland, chiasm, third ventricle walls, cerebral vessels).</p><p><strong>Material and methods: </strong>We reviewed 43 articles (78 cases) devoted to basal encephaloceles involving functionally important structures. Analysis included transsphenoidal and sphenoethmoidal hernias.</p><p><strong>Results: </strong>Nasal breathing disorders were found in 76.9% of cases, decreased visual acuity - 53.8%, endocrine disorders - 44.9%, nasal CSF leakage - 14.1%, meningitis - 10.3%. Concomitant malformations occurred in 85.9%. Severe respiratory disorders (52.6%, <i>p</i><0.05) and multiple concomitant malformations (71.7%, <i>p</i><0.05) were more common among patients with sphenoethmoidal encephalocele. Among 78 patients, 73.1% underwent surgery while follow-up was preferable in 26.9% of cases. There was progression of endocrine disorders (9.5%), visual impairment (4.8%) and nasal breathing disorders (4.8%) in follow-up period. Surgical treatment also has many risks. Transcranial, transnasal, transoral and combined approaches are currently used. It was not possible to establish the most effective surgical approach due to heterogeneous clinical data. Postoperative complications occurred in 47.4% of cases (endocrine disorders - 33.3%, CSF leakage - 8.8%, visual impairment - 1.8%, infectious complications - 14%). Mortality rate was 3.5%.</p><p><strong>Conclusion: </strong>Congenital basal encephalocele involving functionally important structures is an extremely rare developmental defect. Such patients often have concomitant anomalies. Comprehensive examination is necessary to estimate the structures included in hernial sac and concomitant diseases. Treatment strategy should be determined individually after thorough examination and comparison of all risks. Surgical treatment is associated with high risk of complications due to damage to the structures comprising encephalocele.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 5","pages":"102-109"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[PET/CT with 11C-methionine in assessment of brain glioma metabolism].","authors":"N B Vikhrova, D B Kalaeva, A N Tyurina, A Yu Belyaev, G V Danilov, I N Pronin","doi":"10.17116/neiro20248801163","DOIUrl":"10.17116/neiro20248801163","url":null,"abstract":"<p><strong>Objective: </strong>To study 11C-methionine (MET) metabolism in gliomas using CNS tumor biobank imaging data.</p><p><strong>Material and methods: </strong>MRI and 11C-MET PET/CT were performed in 225 patients (49±14 years, M/F=84/101) according to standard protocols with analysis of 11C-MET accumulation index and volumetric parameters (V_FLAIR, V_PET and V_PET/FLAIR). These results were compared with molecular genetic testing and 2-year overall survival.</p><p><strong>Results: </strong>We examined 225 patients with gliomas (97 glioblastomas, 70 astrocytomas, 58 oligodendrogliomas). Accumulation index and volume of 11C-MET in glioblastomas were significantly higher in the general group (AI=2.90, Se 69%, Sp 76%, AUC 0.76; V_PET=24.3 cm³, Se 67%, Sp 60%, AUC 0.65; V_PET/FLAIR 0.46, Se 60%, Sp 69%, AUC 0.67) and within the group of astrocytomas (AI=2.93, Se 68%, Sp 89%, AUC 0.84; V_PET=8.06 cm³, Se 91%, Sp 35%, AUC 0.66; V_PET/FLAIR 0.27, Se 77%, Sp 60%, AUC 0.71). The median 2-year overall survival in patients with glioblastomas was 13 months that was significantly lower compared to IDH «+» gliomas (<i>p</i><0.0001). There was a relationship between high accumulation index of 11C-MET and shorter overall survival in patients with glioblastomas. Significantly higher AI >3.59 (Se 89%, Sp 67%, AUC 0.79) was additionally obtained in subgroup of patients with glioblastomas >50 years (<i>n</i>=34) for EGFR «+» tumors.</p><p><strong>Conclusion: </strong>We found variable 11C-MET metabolism in WHO 2021 gliomas and confirmed significant difference in metabolic activity and volume of 11C-MET accumulation in glioblastomas compared to IDH «+» gliomas. Moreover, we revealed the relationship between high accumulation index and shorter survival. Analysis of 11C-MET metabolism in patients over 50 years old revealed higher accumulation index in the EGFR «+» group. Further comparison of these imaging methods and assessment of other significant mutations are necessary to identify the anatomical and metabolic patterns of IDH «+» gliomas.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 1","pages":"63-69"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}