Zhonghua yi xue za zhi最新文献

{"title":"[Causes and management strategies for unplanned reoperation after endoscopic middle ear surgery].","authors":"F Zhou, Z L Wang, Y M Li, X Chen","doi":"10.3760/cma.j.cn112137-20250914-02389","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250914-02389","url":null,"abstract":"<p><p>The clinical data of 24 patients (25 ears) aged (42.4±13.5) years who underwent unplanned reoperation in the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine between January 2018 and May 2025 were retrospectively analyzed, including 12 males and 12 females. The main reasons for the reoperation were tympanic adhesion/granulation hyperplasia (68.0%, 17/25), displacement/dislocation of artificial ossicles (32.0%, 8/25), reperforation of tympanic membrane (32.0%, 8/25), and recurrence of cholesteatoma (28.0%, 7/25). The air-bone conductance differences at each frequency were significantly reduced after the reoperation (<i>P</i><0.001). The reoperation rate can be reduced by preserving the normal tympanic membrane mucosa, using anti-adhesion materials, repairing the tympanic membrane with the sandwich method, implanting the complete type artificial ossicle with the Ω-shaped base plate, and thoroughly removing the cholesteatoma epithelium, and other preventive and therapeutic strategies.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 16","pages":"1639-1643"},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of perioperative transcutaneous auricular vagus nerve stimulation on pain and sleep quality after glaucoma surgery].","authors":"Y Wang, W J Shen, Y J Du, J B Xue, C H Xi, H Li, G Y Wang","doi":"10.3760/cma.j.cn112137-20251027-02774","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251027-02774","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effects of perioperative transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain and early sleep quality in patients undergoing glaucoma surgery under general anesthesia. <b>Methods:</b> A total of 94 hospitalized patients scheduled for elective glaucoma surgery under general anesthesia at Beijing Tongren Hospital, Capital Medical University, from April to August 2024 were prospectively enrolled and randomly assigned using a random number table to either the taVNS group (<i>n</i>=47) or the sham stimulation group (s-taVNS group) (<i>n</i>=47). In the taVNS group, active electrical stimulation was applied to the left auricular concha area starting from 2 days before surgery, while the s-taVNS group received electrode placement without current output. Stimulation was performed twice daily for 30 min each session until the first postoperative day. The primary outcome was the incidence of moderate to severe pain within 24 hours after surgery, defined as a Numeric Rating Scale (NRS) score≥4 score. Secondary outcomes included NRS scores at different time points, use of rescue analgesics, insomnia severity index (ISI) scores. Comparisons were made between the two groups regarding the primary and secondary outcome measures. <b>Results:</b> The taVNS group included 27 males and 20 females, aged (56.5±11.3) years; the s-taVNS group included 26 males and 21 females, aged (58.4±9.7) years, with no significant differences in age or gender between the two groups (all <i>P</i>>0.05). The incidence of moderate to severe pain within 24 hours after surgery was lower in the taVNS group than in the s-taVNS group [14.9% (7/47) v. 38.3% (18/47), <i>P</i>=0.010]. The proportion of patients requiring acetaminophen for rescue analgesia within 24 hours postoperatively was lower in the taVNS group than in the s-taVNS group [8.5% (4/47) vs 23.4% (11/47), <i>P</i>=0.049]. The ISI score on the first postoperative night was lower in the taVNS group than in the s-taVNS group [(3.1±2.7) score vs (5.7±4.3) score, <i>P</i>=0.018]. <b>Conclusion:</b> Perioperative taVNS can effectively reduce the incidence of moderate to severe postoperative pain and improve early postoperative sleep quality in patients undergoing glaucoma surgery under general anesthesia.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 16","pages":"1624-1629"},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current status of artificial intelligence applications in cervical cancer screening: a systematic review].","authors":"Z Y Zhao, Q J Zheng, X L Zhao, F H Zhao, Y Zhang","doi":"10.3760/cma.j.cn112137-20251226-03434","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251226-03434","url":null,"abstract":"<p><p><b>Objective:</b> To systematically summarize and evaluate the current application status and research progress of artificial intelligence (AI) in cervical cancer screening in China. <b>Methods:</b> Literature related to the application of AI in cervical cancer screening in China was searched in PubMed, Embase, Cochrane Library, IEEE, China National Knowledge Infrastructure (CNKI), and Wanfang Database using the keywords\"cervical cancer\",\"artificial intelligence\",\"screening\",\"machine learning\",\"deep learning\",\"neural network\",\"uterine cervical neoplasms,\"uterine cervical tumor\",\"diagnosis\", and\"China\". The search was limited to studies published in Chinese and English. As of July 2025, a total of 35 eligible articles were included. Basic information from the included studies was extracted and summarized. In addition, the National Medical Products Administration (NMPA) official website was searched using the term\"cervix\"to identify approved AI-assisted cervical cancer screening products. <b>Results:</b> A total of 21 AI-assisted cervical cancer screening technologies were identified, including 17 technologies for primary screening, mainly AI-assisted cytology, and 4 technologies for colposcopic diagnosis. For AI-assisted cytology, the sensitivity ranged from 67.5% to 100.0% and the specificity ranged from 9.9% to 99.8% in hospital-based populations, with the overall accuracy of some technologies exceeding 90%. In community-based screening populations, the sensitivity ranged from 83.0% to 100.0% and the specificity ranged from 74.2% to 99.9%. Most studies suggested that AI could improve the diagnostic performance of pathologists to some extent, shorten the average slide-reading time, and enhance overall screening efficiency. A total of 24 AI-assisted cervical cancer screening products have been approved by the NMPA, all of which are AI-assisted cytology technologies, and corresponding studies were identified for 8 of these products. For AI-assisted colposcopic diagnosis used as a standalone screening modality, the sensitivity and specificity for identifying cervical intraepithelial neoplasia grade 2 (CIN2) or worse ranged from 43.6% to 95.5% and from 51.8% to 93.9%, respectively; for cervical intraepithelial neoplasia grade 3 (CIN3) or worse, the sensitivity ranged from 35.1% to 97.5% and the specificity ranged from 56.6% to 87.2%. In the physician-assisting mode, the sensitivity increased to 95.1%-97.5%, with improvements in interobserver consistency and diagnostic accuracy among less experienced colposcopists. <b>Conclusions:</b> AI has shown promising potential in cervical cancer screening in China. However, more scientific evidence is needed to determine whether it can be effectively integrated into the existing cervical cancer prevention and control system in China.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 16","pages":"1630-1638"},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical features of 13 children with neuronal ceroid lipofuscinosis type 2].","authors":"K Liu, H Q Zhao, Q Zhang, C Chen, J Chen, Y Huang, L P Zou","doi":"10.3760/cma.j.cn112137-20260129-00328","DOIUrl":"10.3760/cma.j.cn112137-20260129-00328","url":null,"abstract":"<p><p>Clinical data were retrospectively collected from 13 children with type 2 neuronal ceroid lipofuscinosis (CLN2) who underwent genetic testing for definitive diagnosis and were followed up at the Chinese PLA General Hospital from January 2018 to December 2023. The clinical features, disease progression, and prognosis were analyzed. The age at onset was [<i>M</i>(<i>Q</i>₁<i>, Q</i>₃)] 3.7 (3.2, 4.5) years, including 7 males and 6 females. The follow-up was conducted once every 3 months during the first 2 years after diagnosis, and once every 6 months starting from the 3rd year, with the last follow-up until December 2025. All patients presented with epilepsy as the initial manifestation, of whom 8 patients had myoclonic seizures. Psychomotor regression occurred in 10 patients shortly after seizure onset. Tripeptidyl peptidase 1 (TPP1) activity was below the normal reference range in all patients, and all harbored biallelic pathogenic or likely pathogenic variants in the TPP1 gene. Brain magnetic resonance imaging revealed cerebellar atrophy in all cases, and electroencephalography demonstrated generalized abnormalities in all patients. Disease progression exhibited relatively distinct stage-wise features. Within>1-2 years of onset, eleven patients developed ataxia and 10 experienced language regression. Within>2-3 years, ten patients had lost independent ambulation and 9 had lost language function. Within>3-5 years, all patients lost motor and language abilities, and 10 developed severe dysphagia. Five patients died during follow-up. In conclusion, CLN2 typically presents in early childhood with epilepsy as the predominant initial manifestation, followed by progressive neurofunctional decline and cerebellar atrophy. Markedly reduced TPP1 activity together with pathogenic TPP1 variants supports the diagnosis.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 15","pages":"1493-1496"},"PeriodicalIF":0.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the standardized construction and management of biobanks for allergic diseases (2026 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20251110-02926","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251110-02926","url":null,"abstract":"<p><p>To standardize the construction and management of biobanks for allergic diseases in China and promote the deep integration of clinical resources with research needs, the Allergy Prevention and Control Committee of the Chinese Preventive Medicine Association, the Chinese Society of Allergy of the Chinese Medical Association, and the National Clinical Research Center for Respiratory Diseases, among other institutions, jointly led the development of the \"Expert consensus on the standardized construction and management of biobanks for allergic diseases (2026 edition)\". This consensus was formulated based on the \"Guidelines for the Development/Revision of Clinical Practice Guidelines in China (2022 edition)\" and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system, through multidisciplinary expert discussions and Delphi voting. The content covers strategic positioning, standardized collection and processing, ethical and privacy protection, information management and data governance, full-process quality control, biosafety risk prevention, and personnel development. The consensus puts forward 10 recommendations, emphasizes a collaborative mechanism of \"co-construction, co-management, and sharing\", and provides scientific and actionable practical guidance tailored to China's regional characteristics. It aims to advance the development of precision medicine for allergic diseases and contribute China's expertise to global allergy research.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 ","pages":"1578-1589"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the efficacy of an endotherapy rob-assistant system in the treatment of gastrointestinal polyps in beagle dogs].","authors":"Z X Wang, L H Peng, B Yan, J Yang, Z K Wang, H B Wang, J Chen, Y S Yang","doi":"10.3760/cma.j.cn112137-20251119-03014","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251119-03014","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the efficacy of the endotherapy rob-assistant (ERA) system in treating gastrointestinal polyps in beagle dogs. <b>Methods:</b> Sixteen beagle dogs, aged 10-20 months and weighing 8-15 kg, were enrolled. They were randomly divided into an experimental group (ERA-assisted, <i>n</i>=8) and a control group (assisted by an instrument nurse, <i>n</i>=8) using a random number table. Artificial polyps were created in the gastric antrum, gastric body, gastric fundus, and colon using high-frequency electrocoagulation marking. Endoscopic mucosal biopsy and endoscopic mucosal resection were then performed. Procedural success rate, operation time, and complications were compared between the groups. Wound healing was assessed two weeks postoperatively. <b>Results:</b> All the artificial polyp models were successfully established, success rate: 100% (16/16). All procedures were completed without intraoperative complications, and postoperative wound healing was favorable. Compared with the control group, the experimental group showed no statistically significant difference in EMR operation time[<i>M</i> (<i>Q</i>₁, <i>Q</i>₃)] [344 (330, 388) vs 372 (330, 422) s, <i>P</i>>0.05]. Both the instrument transfer time [upper endoscopy: 9 (8, 9) vs 10 (8, 13) s; colonoscopy: 8 (8, 9) vs 11 (10, 13) s, all <i>P<</i>0.05] and the biopsy operation time [upper endoscopy: 67 (53, 79) vs 79 (73, 87) s; colonoscopy: 64 (51, 72) vs 77 (71, 81) s, all <i>P<</i>0.05] were significantly shorter in the experimental group, compared to the control group. Furthermore, the incidence of risky maneuvers was significantly lower than that of the control group [43% (100/233) vs 0, <i>P<</i>0.05]. <b>Conclusion:</b> The ERA system is safe and effective for treating gastrointestinal polyps in beagle dogs.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 13","pages":"1242-1247"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the use of interleukin-1 inhibitors for autoimmune inflammatory diseases (2026 edition)​].","authors":"","doi":"10.3760/cma.j.cn112137-20251122-03058","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251122-03058","url":null,"abstract":"<p><p>Interleukin-1 (IL-1) plays a core role in the pathogenesis of autoimmune inflammatory diseases (AIID). Blocking the inflammatory cascade driven by IL-1 has become a critical strategy for the treatment of various AIID. Since IL-1 inhibitors were approved on the market in China on October 2023, they have attracted great attention in clinical practice and have been increasingly used in clinical settings. In order to reduce the clinical uncertainties and potential risks that may be brought about by off-label drug use, the Rheumatology and Immunology Professional Committee of the China Primary Health Care Foundation organized experts from multiple disciplines to focus on 12 clinical issues regarding the treatment of AIID with IL-1 inhibitors. Based on the latest evidence-based medical evidence and China's national conditions, fourteen recommendations on crystal-induced arthropathies, autoinflammatory syndrome and periodic fever syndrome have been formulated, aiming to standardize the clinical application and pharmaceutical management of IL-1 inhibitors in China.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 13","pages":"1191-1207"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and genetic characteristics of pseudohypoparathyroidism type 1].","authors":"F Y Tian, J Qing, C F Zhu, Y N Li, X Y He, C Wang, Y Y Lyu, X D Kong","doi":"10.3760/cma.j.cn112137-20251103-02854","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251103-02854","url":null,"abstract":"<p><p>A retrospective study was conducted to include patients with genetically confirmed pseudohypoparathyroidism (PHP) type 1 at the First Affiliated Hospital of Zhengzhou University from August 2016 to April 2025, aiming to analyze their clinical and genetic characteristics. A total of 15 patients with PHP type 1 were enrolled, including 7 males and 8 females, with a median age of onset at 12.0 years (range: 3.5-40.0 years). Among them, 4 cases were PHP 1A and 11 cases were PHP 1B. All patients exhibited elevated parathyroid hormone levels, and 14 had hypocalcemia. Hyperphosphatemia was observed in all pediatric patients, while serum phosphate levels were normal in adult patients. Six patients had hypokalemia. Two patients had hypertension (including one with idiopathic hyperaldosteronism). Three patients had concurrent autoimmune thyroid diseases. There was significant clinical phenotypic overlap between PHP 1A and PHP 1B. In addition to the typical features of parathyroid hormone resistance and hypocalcemia, patients with PHP type 1 could also present with age-related serum phosphate abnormalities, hypokalemia, hypertension, autoimmune thyroid diseases, and other atypical phenotypes. Regarding genetic characteristics, 4 cases of PHP 1A exhibited maternally inherited inactivating variants in the GNAS gene. Among the 11 PHP 1B cases, 10 had methylation defects in the GNAS gene imprinting control region (including 3 familial cases and 7 sporadic cases), while the remaining 1 case had a copy number variation [20(chr20:?_44996182-62737512_?)*2 ROH], representing paternal uniparental disomy of chromosome 20q, consistent with sporadic PHP1B. In clinical practice, precise classification requires the integration of clinical phenotypes with molecular genetic findings, along with systematic evaluation and long-term follow-up.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 13","pages":"1248-1252"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on techniques and material selection for dural closure in neurosurgery (2026 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20251114-02973","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251114-02973","url":null,"abstract":"<p><p>To standardize dural closure techniques and material selection in neurosurgery and reduce the incidence of postoperative complications such as cerebrospinal fluid leakage, led by the Neurosurgery Branch of the Chinese Medical Association, domestic experts in neurosurgery and related fields were organized to follow the principles of evidence-based medicine and grading of recommendations assessment, development and evaluation (GRADE) system. The consensus was formulated based on a systematic review of high-quality international evidence combined with clinical practice in China. The consensus underscores the pivotal role of achieving \"Watertight Dural Closure (WTDC)\" and establishes a stepwise material selection strategy: prioritizing autologous tissue as the primary choice, supplemented by dural patches, and reinforced by dural sealants. For the first time, this consensus introduces a four-type morphological classification for dural incisions (Types Ⅰ-Ⅳ) and a five-grade classification for dural closure integrity (Grades A-E), upon which a quantitative risk assessment system has been established. Addressing key clinical issues, including repair material characteristics, technique application based on incision types and closure grades, site-specific repair strategies for different anatomical locations, management of special populations, and postoperative outcome evaluation, the Consensus formulates a total of 19 recommendations, aiming to provide a systematic and standardized clinical decision-making framework and operational guidance for dural repair in neurosurgery.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 13","pages":"1208-1220"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Radiographic characteristics of sciatic scoliosis secondary to lumbar disc herniation].","authors":"Z M Xu, Q H Zhao, B Wang, Z Z Zhu, Y Qiu, X Sun","doi":"10.3760/cma.j.cn112137-20250908-02330","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250908-02330","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the radiographic characteristics of lumbar disc herniation (LDH) associated with sciatic scoliosis and to compare coronal and sagittal alignment parameters between adolescent and adult patients. <b>Methods:</b> A retrospective analysis was conducted on patients with LDH who underwent unilateral endoscopic discectomy or unilateral laminotomy with discectomy at Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, between January 2017 and July 2025. A total of 86 adolescents with LDH complicated by sciatic scoliosis were included as the adolescent group. Using a random number table, 172 adult patients who met the identical diagnostic and treatment criteria during the same period were selected and matched in a 1∶2 ratio to form the adult group. Based on sagittal balance status, patients were further classified into a balanced group [sagittal vertical axis (SVA)≤40 mm] and an imbalanced group (SVA>40 mm). Spinopelvic sagittal parameters were evaluated. Differences in sagittal and coronal alignment between groups were compared. Furthermore, the associations among the side of disc herniation, the direction of scoliotic curvature, and trunk shift were analyzed. <b>Results:</b> In patients with LDH complicated by sciatic scoliosis, the mean lumbosacral curve was 15.3°±5.8°, the thoracic/thoracolumbar curve was 16.9°±5.4°, apical vertebral translation was (2.9±1.6) cm, and trunk shift was (3.0±1.5) cm. Overall, 79.8% (206/258) of the patients exhibited lumbosacral curve convexity on the same side as the disc herniation, while 81.0% (209/258) demonstrated trunk shift toward the side contralateral to the herniation (both <i>P</i><0.01). Compared with the imbalanced group, the balanced group showed smaller trunk shift and apical vertebral translation [(2.8±1.2) vs (3.3±1.7) cm and (2.7±1.4) vs (3.1±1.7) cm, respectively, both <i>P</i><0.05]. Further analysis revealed that adolescents had lower thoracic kyphosis (TK), lumbar lordosis (LL), lower lumbar lordosis, and sacral slope (SS) than adults (13.2°±9.8° vs 17.4°±11.0°, 19.5°±14.2° vs 30.3°±15.6°, 16.7°±11.9° vs 23.8°±11.6°, and 23.4°±6.4° vs 26.7°±8.3°, respectively); while, the SVA and pelvic tilt (PT) were significantly greater than those in adults [(70.5±58.4) vs (41.8±52.6) mm, and 25.7°±10.5° vs 20.8°±9.3°, respectively] (all <i>P</i><0.05). <b>Conclusions:</b> Patients with LDH complicated by sciatic scoliosis typically exhibit characteristic imaging features, including trunk tilt toward the side contralateral to the herniation, herniation predominantly on the convex side of the lumbosacral curve, and sagittal imbalance. Sagittal imbalance is coupled with coronal deformity and more pronounced in adolescent patients.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 13","pages":"1234-1241"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}