Zhonghua yi xue za zhi最新文献

{"title":"[Establishment of an in vitro fibrotic endometrial organoid model and investigation of the early intervention effects of placenta-derived mesenchymal stem cell-derived extracellular vesicles (Pd-MSC-EV) on endometrial fibrosis].","authors":"T Y Zhang, H D Liu, Y Yu, S W Wang","doi":"10.3760/cma.j.cn112137-20260116-00190","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260116-00190","url":null,"abstract":"<p><p><b>Objective:</b> To establish an in vitro fibrotic endometrial organoid model and investigate the early intervention effects of placenta-derived mesenchymal stem cell extracellular vesicles (Pd-MSC-EV) on fibrotic injury in endometrial organoids. <b>Methods:</b> Cell clusters were isolated from the endometrial tissues of healthy female mice and used to establish a three-dimensional endometrial organoid culture system. The structure and cellular composition of the organoids were characterized by histological staining and immunofluorescence staining. To construct an in vitro fibrosis model, the organoids were treated with different concentrations of transforming growth factor-β1 (TGF-β1), and model establishment was evaluated based on organoid morphological changes and the mRNA expression of fibrosis-related genes, including collagen type Ⅰ alpha 1 chain (COL1A1), α-smooth muscle actin (α-SMA), and fibronectin (FN). Pd-MSC-EVs were isolated and characterized by transmission electron microscopy, nanoparticle tracking analysis, and western blotting. The effects of Pd-MSC-EVs on TGF-β1-induced fibrotic changes in endometrial organoids were then assessed by morphological observation, real-time quantitative PCR (RT-qPCR) analysis of COL1A1, α-SMA, and FN mRNA expression, and immunofluorescence detection of COL1A1 and α-SMA protein expression. All experiments were repeated three times. <b>Results:</b> Mouse endometrial organoids with lumen-like structures were successfully established and expressed the epithelial markers E-cadherin and CK8 as well as the stromal marker Vimentin. Compared with the control group, TGF-β1 treatment disrupted organoid architecture and increased the mRNA expression levels of fibrosis-related genes, including COL1A1, α-SMA and FN, in a dose-dependent manner (all <i>P</i><0.001). The isolated Pd-MSC-EV showed typical cup-shaped or disk-like vesicular morphology, with an average particle size of (163.8±50.0) nm, and expressed the exosomal markers CD63, CD81 and TSG101. Compared with the TGF-β1 group, co-treatment with Pd-MSC-EV alleviated organoid structural damage and reduced the mRNA expression levels of COL1A1, α-SMA and FN (all <i>P</i><0.001). Immunofluorescence showed that COL1A1 protein expression was lower in the Pd-MSC-EV group than in the TGF-β1 group (<i>P</i><0.005), while α-SMA protein expression showed a decreasing trend. <b>Conclusion:</b> Pd-MSC-EV attenuate TGF-β1-induced fibrotic changes in endometrial organoids in vitro and reduce organoid structural injury, providing experimental evidence for mechanistic studies and potential intervention strategies for endometrial fibrosis-related diseases such as intrauterine adhesions.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3155-3163"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between progesterone levels on the day of ovulation and pregnancy outcomes in patients with normal ovarian response undergoing natural cycle frozen embryo transfer].","authors":"L L Lei, Y L Lan, Y Liang, L Y Zhou, R Song, Y Li","doi":"10.3760/cma.j.cn112137-20251125-03081","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251125-03081","url":null,"abstract":"<p><p>This study explored the influence of progesterone (P) levels on the day of ovulation on pregnancy outcomes in patients with normal ovarian response undergoing natural-cycle frozen-thawed embryo transfer. A total of 384 natural-cycle frozen-thawed embryo transfer cycles of patients with normal ovarian response treated at the Reproductive Medicine Center of Beijing Obstetrics and Gynecology Hospital, Capital Medical University, from August 2022 to December 2024 were retrospectively enrolled in the study. Subjects were divided into Group A (P≤1 μg/L), Group B (1 μg/L<P≤3 μg/L), and Group C (P>3 μg/L) based on serum progesterone concentrations on the ovulation day. Baseline clinical data and pregnancy outcomes were compared across the three groups, and the effects of ovulation-day progesterone levels and other clinical indicators on pregnancy outcomes were statistically analyzed. Group A consisted of 94 patients with a mean age of (31.2±5.4) years; group B included 173 patients with a mean age of (30.4±5.9) years; group C comprised 117 patients with a mean age of (30.8±5.2) years. The results showed that Group B had a clinical pregnancy rate of 55.5%(96/173)and an embryo implantation rate of 46.1%(118/256), which were significantly higher than those of Group A [39.4%(37/94)and 31.5%(45/143)] and Group C [46.2%(54/117)and 37.1%(63/170)], with statistically significant intergroup differences (<i>P</i><0.05). Multivariate logistic regression after adjustment for confounding variables verified that ovulation-day progesterone level was an independent risk factor for clinical pregnancy (<i>OR</i>=1.27, 95%<i>CI</i>: 1.10-1.45, <i>P</i>=0.001), while BMI acted as a protective factor for clinical pregnancy (<i>OR</i>=0.93, 95%<i>CI</i>: 0.87-1.00, <i>P</i>=0.037). In conclusion, progesterone level on the day of ovulation serves as a crucial indicator affecting clinical pregnancy outcomes of natural-cycle frozen-thawed embryo transfer, and routine monitoring of this parameter in clinical practice is conducive to optimizing transplantation protocols and improving the overall clinical pregnancy rate.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3174-3177"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the construction and management of cancer pain clinics (2026 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20260329-00838","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260329-00838","url":null,"abstract":"<p><p>Cancer pain is one of the most common symptoms in patients with malignancies and significantly impairs quality of life. Inadequate pain control may reduce treatment adherence and adversely affect overall prognosis. Cancer pain clinics are specialized outpatient services dedicated to standardized assessment, diagnosis, treatment, and longitudinal management of cancer pain. To standardize the establishment and operational management of cancer pain clinics in China, the Chinese Association for the Study of Pain convened experts in relevant fields. Grounded in evidence-based principles and informed by national and international guidelines and policy documents, this consensus was developed using the RAND/UCLA Appropriateness Method and a modified Delphi process to generate recommendations. This consensus provides standardized recommendations on the functional positioning of cancer pain clinics, tiered construction models, personnel qualifications and training, medication and facility requirements, standardized clinical pathways, multidisciplinary collaboration, and quality management. It aims to provide scientific and practical guidance for healthcare institutions to establish standardized cancer pain outpatient clinics, promote the standardization, homogenization, and sustainable development of outpatient cancer pain management.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3118-3129"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characteristics and individual mortality burden of functional dependency, cognitive impairment, and depressive symptoms among older adults in China].","authors":"Y T Wang, S J Li, Z H Li, Y Hu, J Wu, Y F Wu, Y L Jiang, W J Zhou, Y Zeng, Y Tang, Y Yao","doi":"10.3760/cma.j.cn112137-20260123-00271","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260123-00271","url":null,"abstract":"<p><p><b>Objective:</b> To describe the epidemiological characteristics of functional dependency, cognitive impairment, and depressive symptoms (the \"3Ds\": Dependency, Dementia, and Depression) among older adults in China, and to evaluate the association of \"3Ds\" co-occurrence and index with the risk of all-cause mortality. <b>Methods:</b> Based on the 2018 and 2021 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), adults aged≥65 years were included. To characterize prevalence, the baseline sample was classified into five groups: no \"3Ds\"(intact physical function, cognition, and mental health), dependency only (functional dependency alone), cognitive impairment only, depressive symptoms only, and co-occurrence of all three. To evaluate the association with mortality, participants were grouped by cumulative \"3Ds index\" score as 0 (no deficit, reference), 1, 2, or 3 (presence of any one, any two, or all three deficits, respectively). Cox proportional hazards models assessed the effects of the \"3Ds\" and cardiometabolic multimorbidity (CMM) on all-cause mortality; a Random Survival Forest (RSF) model validated variable importance (VIMP); and causal mediation analysis examined the mediating role of self-rated health. <b>Results:</b> Among 13 682 participants at baseline in 2018 [mean age (84.74±11.39) years], the prevalence of functional dependency, cognitive impairment, and depressive symptoms was 22.96% (3 142/13 682), 16.04% (2 194/13 682), and 41.70% (5 705/13 682), respectively, and the co-occurrence rate of all three was 4.03% (552/13 682). In the mortality analysis of 11 909 participants [(median follow-up 28 (1-40) months, 2 872 deaths], multivariable Cox regression showed that, compared with participants scoring 0 on the \"3Ds index\", the risk of all-cause mortality rose significantly across scores of 1 to 3: <i>HR</i>=1.31 (95%<i>CI</i>: 1.19-1.44) for a score of 1, <i>HR</i>=1.86 (95%<i>CI</i>: 1.66-2.09) for 2, and <i>HR</i>=2.16 (95%<i>CI</i>: 1.83-2.55) for 3, indicating a significant linear dose-response relationship (<i>P</i> for trend<0.001); by contrast, CMM was not significantly associated with all-cause mortality (<i>HR</i>=1.02, 95%<i>CI</i>: 0.91-1.13). The RSF model identified the \"3Ds index\" as a leading predictor of all-cause mortality (VIMP=0.104), second only to age. Self-rated health significantly and partially mediated the \"3Ds\"-mortality association, accounting for 9.77%-12.37% of the total effect. <b>Conclusions:</b> Co-occurrence of the \"3Ds\" is prevalent among Chinese older adults, particularly the oldest-old, and shows significant demographic heterogeneity. The \"3Ds index\"-reflecting impairment in physical function, cognition, and mental health-shows a significant dose-response association with all-cause mortality that is partially mediated by self-rated health, and may serve as a simple composite indicator for early identification of mortality risk in the oldest-old.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3164-3173"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy of rescue extracorporeal membrane oxygenation combined with delayed left ventricular assist device implantation for in-hospital sudden cardiac arrest in end-stage heart failure patients].","authors":"Y Shen, Y Dong, Q S Wu, X F Dai, G C Zhang, L W Chen","doi":"10.3760/cma.j.cn112137-20260202-00364","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260202-00364","url":null,"abstract":"<p><p>The data of eight patients with end-stage heart failure who experienced in-hospital sudden cardiac arrest and received cardiopulmonary resuscitation (CPR), followed by extracorporeal membrane oxygenation (ECMO) combined with delayed left ventricular assist device (LVAD) implantation in Fujian Medical University Union Hospital from January 2022 to June 2025 were retrospectively reviewed. Among them, there were seven males and one female, with a median age of 56 (50, 63) years. The etiologies included ischemic cardiomyopathy (five cases), dilated cardiomyopathy (two cases) and low cardiac output syndrome after severe valvular heart disease surgery (one case). All patients were stabilized by ECMO rescue before LVAD implantation, with an ECMO support time of 9.5 (6.5, 12.0) days. All surgeries were performed under general anesthesia with cardiopulmonary bypass. Postoperatively, six cases discharged smoothly, two cases died in hospital, and one case developed cerebral infarction which recovered after interventional thrombectomy. For discharged patients, follow-up was conducted at 1, 3, 6 and 12 months, the mechanical pump functioned normally, and cardiac function was significantly improved. The study suggests that ECMO can stabilize the condition of these high-risk patients, and bridging to LVAD can relieve the pressure on the donor heart and improve prognosis.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3178-3182"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Precision pain management in pancreatic ductal adenocarcinoma: therapeutic progress and mechanism-based approaches targeting tumor-nerve-immune crosstalk].","authors":"H L Gao, J X Yang, W W Cheng","doi":"10.3760/cma.j.cn112137-20260114-00173","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260114-00173","url":null,"abstract":"<p><p>Cancer pain in pancreatic ductal adenocarcinoma (PDAC) is characterized by complex mechanisms, severe, and often difficult-to-control. Pain not only represents a major source of suffering for PDAC patients but can also promote tumor progression through intricate neuro-immune crosstalk networks. The traditional three-step analgesic ladder is often insufficient for managing PDAC pain. In recent years, the earlier application of minimally invasive interventional techniques, the adoption of multi-disciplinary team, and the integration of smart healthcare tools are driving PDAC pain management toward more precise approaches. Exploration of the tumor-neuro-immune interaction network offers novel insights for driving personalized analgesia. This article systematically reviews the latest advances in analgesic approaches for PDAC, with an emphasis on optimizing existing therapies, defining the role of minimally invasive interventions, and outlining future research directions for precision analgesia.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3106-3111"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role and status of standardized cancer pain management in comprehensive cancer care].","authors":"G L Xie","doi":"10.3760/cma.j.cn112137-20260701-01663","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260701-01663","url":null,"abstract":"<p><p>Standardized cancer pain management is an essential component of comprehensive cancer care. Pain is one of the most common and distressing symptoms in palliative care for patients with advanced cancer. Persistent pain severely impairs daily function and quality of life. The implementation of standardized cancer pain management, including standardized assessment, analgesic treatment, adverse effect management, follow-up, and end-of-life care, has significantly improved pain control and quality of life, with the goal of achieving optimal pain relief and preserving dignity throughout the disease course. However, several challenges remain, including inadequate attention, non-standardized assessment, uneven access to analgesics, and limited application of minimally invasive interventions. This review summarizes the current status, role, and key strategies of standardized cancer pain management, aiming to provide evidence for establishing standardized pain management systems and improving comprehensive cancer care.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3083-3089"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical features of high-frequency sudden sensorineural hearing loss and factors influencing its therapeutic efficacy].","authors":"J Y Guo, H Wang, F F Guo, Q X Cui, X H Zhao, G H Chen, J Li, J Guan, D Y Wang, Q J Wang","doi":"10.3760/cma.j.cn112137-20251125-03087","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20251125-03087","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the clinical characteristics of patients with high-frequency sudden sensorineural hearing loss and the factors affecting therapeutic efficacy. <b>Methods:</b> The clinical data of patients with high-frequency sudden sensorineural hearing loss who were treated in the Department of Otology, Chinese PLA General Hospital, from January 2009 to April 2025 were retrospectively reviewed. Demographic characteristics, precipitating factors, accompanying symptoms, comorbidities, and audiological features were collected and analyzed. Multivariate logistic regression analysis was further performed to identify factors affecting treatment efficacy. <b>Results:</b> A total of 90 patients aged (41.1±14.1) years were included, with 57 males and 33 females. Definite precipitating factors were identified in 38.9% (35/90) of patients, and excessive fatigue was the most common factor (14.4%, 13/90). Hypertension was the most frequent comorbidity (20.0%, 18/90). Tinnitus was the most common accompanying symptom (94.4%, 85/90), followed by aural fullness (66.7%, 60/90) and vertigo (20.0%, 18/90). Compared with patients with involvement at 4 and 8 kHz, those with involvement at 2, 4, and 8 kHz were older, had lower phonetically balanced maximum scores, and showed lower otoacoustic emission response rates, with statistically significant differences (all <i>P</i><0.05). The overall treatment effectiveness rate was only 20.0% (18/90). Multivariate logistic regression analysis demonstrated that delayed presentation after onset (<i>OR</i>=1.07, 95%<i>CI</i>: 1.02-1.12, <i>P</i>=0.005), aural fullness (<i>OR</i>=3.68, 95%<i>CI</i>: 1.05-12.86, <i>P</i>=0.042), and female sex (<i>OR</i>=7.73, 95%<i>CI</i>: 1.70-35.14, <i>P</i>=0.008) were associated with poor prognosis. <b>Conclusions:</b> Patients with high-frequency sudden sensorineural hearing loss frequently present with high-pitched tinnitus and aural fullness. Compared with patients without 2 kHz involvement, those with 2 kHz impairment are older and have poorer speech recognition ability. Overall treatment outcomes are unsatisfactory, and delayed presentation after onset, ear fullness, and female sex are associated with poor prognosis.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3142-3147"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on vaccination for herpes zoster (2026 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20260513-01282","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20260513-01282","url":null,"abstract":"<p><p>Herpes zoster (HZ) is a skin disease caused by the reactivation of latent varicella-zoster virus (VZV) in the body, clinically characterized by a unilateral vesicular rash distributed along the affected dermatomes. It commonly occurs in older adults and immunocompromised individuals. With the acceleration of global population aging, the incidence of HZ has significantly increased, showing a trend toward younger age groups and a high risk of complications, such as postherpetic neuralgia (PHN), which imposes a heavy health and economic burden on patients and society. In recent years, China has made remarkable progress in the development and application of HZ vaccines, particularly with the approval and use of the recombinant zoster vaccine (RZV) and the zoster vaccine live (ZVL), which are of great significance for the prevention of HZ and its complications. To further standardize HZ vaccination strategies, the Varicella and Herpes Zoster Prevention and Control Branch of the China Association for Vaccines organized national experts in virology, immunology, infectious diseases, geriatrics, and preventive medicine to formulate this consensus based on evidence-based medical evidence and clinical practice experience. This consensus systematically elaborates on the disease burden of HZ, vaccine efficacy and safety, vaccination strategies, recommendations for special populations, and other aspects, aiming to provide scientific and standardized guidance for clinicians and public health workers, and to promote widespread vaccination against HZ in adults and the prevention and control of the disease.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 30","pages":"3130-3141"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the management of obesity in the elderly(2026 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20260403-00919","DOIUrl":"10.3760/cma.j.cn112137-20260403-00919","url":null,"abstract":"<p><p>Obesity in the elderly has become a prominent public health issue. Due to physiological changes and multimorbidity in the elderly population, obesity presents complex clinical manifestations with markedly increased management difficulties. Based on this, National Center for Gerontology, Obesity and Diabetes Group, Chinese Diabetes Society, Chinese Medical Association organized a multidisciplinary panel of experts in obesity and formulated this consensus after multiple rounds of rigorous evaluation and iterative revisions. The consensus emphasizes that the management of geriatric obesity requires a comprehensive assessment tailored to age and overall health status, employing a patient-centered, individualized and stratified management strategy. Following the principle of \"safety first, functional improvement, and steady progress\", the goal is to reduce visceral fat accumulation, maintain or increase muscle mass, protect bone health, and improve physical function and health status. Special attention should be paid to sarcopenia in the elderly. Adequate intake of high-quality protein foods, combined with a comprehensive resistance exercise program tailored to individual limitations, could effectively improve muscle mass. Furthermore, weight loss medications should be selected based on the evidence of benefit for obesity-related complications or comorbidities, with close monitoring of adverse reactions.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"106 29","pages":"3007-3019"},"PeriodicalIF":0.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}