Zhonghua yi xue za zhi最新文献

{"title":"[The correlation of lipid profile and serum osmolality with kidney progression in patients with type 2 diabetes mellitus].","authors":"J J Da, R Dong, Q Li, Y Q Yang, J Yuan, J H Luo, Y Zha","doi":"10.3760/cma.j.cn112137-20241111-02522","DOIUrl":"10.3760/cma.j.cn112137-20241111-02522","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the correlation of lipid profile and serum osmolality (OsP) with kidney progression in patients with type 2 diabetes mellitus (T2DM). <b>Methods:</b> A nested case-control study was conducted. Inpatients with T2DM who visited Guizhou Provincial People's Hospital in 2019 were included. Demographic characteristics, laboratory indices, and kidney progression events were collected. The correlation of lipid profile and OsP with kidney progression in T2DM were analyzed using multivariable Cox proportional hazards regression models and causal mediation analysis. <b>Results:</b> A total of 1 219 patients (714 males and 505 females) were included, aged (59.7±14.6) years. The median (<i>Q</i>₁, <i>Q</i>₃) follow-up duration was 54 (51, 58) months, with a loss to follow-up rate of 11.9% (145/1 219). Kidney progression occurred in 21.3% (260/1 219) of the patients. Cox proportional hazards regression analysis revealed that elevated OsP (<i>HR</i>=1.02, 95%<i>CI</i>: 1.01-1.02, <i>P</i><0.001), remnant cholesterol (RC) (<i>HR</i>=1.12, 95%<i>CI</i>: 1.02-1.23, <i>P</i>=0.023), apolipoprotein B (ApoB) (<i>HR</i>=1.59, 95%<i>CI</i>: 1.02-2.46, <i>P</i>=0.040), and age (<i>HR</i>=1.02, 95%<i>CI</i>: 1.01-1.03, <i>P</i><0.001) were identified as risk factors for kidney progression in T2DM. Compared with OsP<310 mmol/L, patients with OsP≥310 mmol/L had a significantly increased risk of kidney progression (<i>HR</i>=1.94, 95%<i>CI</i>: 1.50-2.51, <i>P</i><0.001). Causal mediation analysis using bootstrap resampling (N=5 000) indicated that RC and ApoB mediated 3.39% (95%<i>CI</i>: 0.98%-5.00%, <i>P</i>=0.020) and 9.54% (95%<i>CI</i>: 8.28%-17.00%, <i>P</i>=0.048) of the effect of OsP on kidney progression, respectively. <b>Conclusion:</b> Elevated OsP level in T2DM patients is a risk factor for kidney progression, with RC and ApoB mediating the effect of OsP on kidney progression in T2DM.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"888-893"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Predictive value of ventricular repolarization heterogeneity parameters for malignant arrhythmias in children with viral myocarditis].","authors":"X L Lian, T Sun, H X Wang, J Y Xu, Y M Wang, J P Yang","doi":"10.3760/cma.j.cn112137-20241115-02564","DOIUrl":"10.3760/cma.j.cn112137-20241115-02564","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the construction and clinical value of a predictive model for malignant ventricular arrhythmias (MVA) in children with viral myocarditis (VMC) based on parameters of ventricular repolarization heterogeneity. &lt;b&gt;Methods:&lt;/b&gt; We retrospectively analyzed 99 children with VMC admitted to Henan Provincial People's Hospital from January 2019 to February 2023 as the training set, and 38 children with VMC admitted from March 2023 to May 2024 as the external validation set in a cross-sectional study. Patients were divided into MVA and non-MVA groups based on the occurrence of MVA. We measured QT interval (QT), corrected QT interval (QTc), T-wave peak-end interval (TpTe), and heart rate-corrected TpTe (TpTec) in all children using conventional electrocardiography and Holter monitoring. Multi-variate logistic regression analysis was used to identify factors influencing the occurrence of MVA in children with VMC and the efficacy of models predicting MVA with cardiac troponin I (cTnI) and different electrocardiographic parameters was evaluated using the receiver operating characteristic (ROC) curve. The predictive power of the models was internally and externally validated through C-index, Hosmer-Lemeshow goodness-of-fit test, ROC curves, and decision curve analysis. &lt;b&gt;Results:&lt;/b&gt; There were 99 children in the training set and 38 in the external validation set, with no significant differences in age [(6.9±3.7) vs (6.9±3.4) years] and gender (boys: 46.5% vs 50.0%) between the two groups (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). In the training set, there were 47 cases (47.5%) in the MVA group, and there were 20 cases (52.6%) in the MVA group in the external validation set. In both the training and external validation sets, there were statistically significant differences in cTnI, QTc, TpTec, and TpTe/QT between the MVA and non-MVA groups (&lt;i&gt;P&lt;/i&gt;&lt;0.01). TpTec [&lt;i&gt;OR&lt;/i&gt; (95%&lt;i&gt;CI&lt;/i&gt;): 1.123 (1.067-1.183)] and TpTe/QT [&lt;i&gt;OR&lt;/i&gt; (95%&lt;i&gt;CI&lt;/i&gt;): 1.026 (1.008-1.045)] were both associated with the occurrence of MVA in children with VMC. The Hosmer-Lemeshow goodness-of-fit test showed that there was no statistically significant difference between the predicted and observed values (&lt;i&gt;P&lt;/i&gt;=0.294). The area under the ROC curve (AUC) (95%&lt;i&gt;CI&lt;/i&gt;) for cTnI to predict MVA in VMC children was 0.651 (0.540-0.763), with a sensitivity of 0.617 and a specificity of 0.865 when the Youden's index was maximized (2 475.000). For TpTec, the AUC (95%&lt;i&gt;CI&lt;/i&gt;) was 0.917 (0.859-0.975), with a sensitivity of 0.723 and a specificity of 0.981 when the Youden's index was maximized (110.500). For TpTe/QT, the AUC (95%&lt;i&gt;CI&lt;/i&gt;) was 0.825 (0.746-0.905), with a sensitivity of 0.745 and a specificity of 0.750 when the Youden's index was maximized (0.265). The AUC (95%&lt;i&gt;CI&lt;/i&gt;) for the combination of TpTec and TpTe/QT was 0.939 (0.892-0.987), with a sensitivity of 0.894 and a specificity of 0.865 when the Youden's index was maximized (0.472), which was higher than that","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"912-918"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress and prospects of finerenone in the treatment of type 2 diabetes mellitus related chronic kidney disease].","authors":"X P Zhang, S K Pan, K Chen, D W Liu, M Chen, Z S Liu","doi":"10.3760/cma.j.cn112137-20241122-02617","DOIUrl":"10.3760/cma.j.cn112137-20241122-02617","url":null,"abstract":"<p><p>The number of patients with type 2 diabetes mellitus (T2DM)-related chronic kidney disease (CKD) is substantial, and the disease burden is severe. Despite current treatment options, even with standard therapy, patients still face a high risk of kidney disease progression and cardiovascular events. Finerenone, a novel, highly selective, non-steroidal mineralocorticoid receptor antagonist (nsMRA), can directly and effectively block kidney and cardiovascular damage caused by excessive activation of mineralocorticoid receptors, while maintaining good safety. This article provides a review of the mechanism of action, clinical application value, guideline recommendations, and future prospects of finerenone.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"872-877"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the application of high-flow nasal oxygen therapy in eye and ear-nose-throat anesthesia airway management (2025 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20241015-02337","DOIUrl":"10.3760/cma.j.cn112137-20241015-02337","url":null,"abstract":"<p><p>In recent years, the application of high-flow nasal cannula (HFNC) in clinical anesthesia has become increasingly widespread. Its feasibility, effectiveness, and safety in perioperative oxygen therapy have been progressively confirmed and recognized. This technology has demonstrated significant advancements and innovations in airway management within anesthesia, particularly in addressing difficult airways. Patients undergoing eye and ear-nose-throat (ENT) surgeries frequently present with difficult airways, imposing higher demands on airway management techniques. However, there remains a lack of clear evidence-based guidelines and structured recommendations regarding the application of HFNC in ENT anesthesia airway management. Based on relevant research progress both domestically and internationally, as well as Chinese clinical practice, the Otorhinolaryngology Anesthesiology Group of the Chinese Society of Anesthesiology organized an expert team to formulate this consensus. The consensus systematically elaborates on the physiological mechanisms, applicable scenarios, and specific operational methods of HFNC, from theory to practice. It covers multiple aspects, including the induction phase, intraoperative non-intubated anesthesia management, postoperative extubation oxygen therapy, and applications in special populations. Addressing different clinical needs, the consensus clearly outlines the recommendations, contraindications, and precautions for HFNC, further standardizing its application in ENT anesthesia airway management and providing an evidence-based framework for optimizing perioperative airway management. This consensus aims to promote the standardized application of HFNC technology in ENT anesthesia, improve patient safety, and provide theoretical support and practical guidance for future clinical research and technological advancements.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"878-887"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The correlation between inflammatory factors and renal function impairment in patients with proliferative diabetic retinopathy undergoing vitrectomy].","authors":"X Y Wang, J Bai, C Z Liu, X S Cao","doi":"10.3760/cma.j.cn112137-20240925-02177","DOIUrl":"10.3760/cma.j.cn112137-20240925-02177","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the correlation between inflammatory factors and renal function impairment in patients with proliferative diabetic retinopathy (PDR) undergoing pars plana vitrectomy. <b>Methods:</b> The clinical data of patients with PDR who underwent vitreoretinal surgery at Beijing Tongren Hospital, Capital Medical University, from July 2019 to January 2021 were retrospectively analyzed. Using a estimated glomerular filtration rate (eGFR) cut-off value of<60 ml·min^-1· (1.73 m²)^-1, the cohort was stratified into two groups: renal impairment group and non-renal impairment group. The differences between the two groups were compared, and a multivariate logistic regression model was used to examine the factors associated with renal function injury. <b>Results:</b> A total of 923 patients aged (51.5±11.6) years were enrolled in the study, including 537 males and 386 females. There were 151 patients (16.4%) and 772 patients (83.6%) in renal impairment group and non-renal impairment group, respectively. Compared with the non-renal impairment group, the renal impairment group had higher systolic blood pressure (SBP), neutrophil count, high-sensitivity C-reactive protein (hs-CRP), homocysteine, triglycerides, total cholesterol, and complement C4 levels (all <i>P</i><0.05). However, glycated hemoglobin (HbA1c), lymphocyte count, serum albumin, high-density lipoprotein cholesterol (HDL-C), and complement C3 levels were lower in the renal impairment group (all <i>P</i><0.05). Multivariate logistic regression analysis demonstrated that elevated hs-CRP (<i>OR</i>=1.041, 95%<i>CI</i>: 1.002-1.082), reduced complement C3 (<i>OR</i>=0.996, 95%<i>CI</i>: 0.995-0.998), and elevated complement C4 (<i>OR</i>=1.007, 95%<i>CI</i>: 1.005-1.010) were inflammatory-related factors associated with renal impairment in patients with PDR. Other related factors included SBP (<i>OR</i>=1.015, 95%<i>CI</i>: 1.002-1.028), serum albumin (<i>OR</i>=0.842, 95%<i>CI</i>: 0.806-0.879), and homocysteine (<i>OR</i>=1.098, 95%<i>CI</i>: 1.064-1.132). <b>Conclusion:</b> There is a correlation between inflammatory factors (such as hs-CRP, complement C3, and complement C4) and the occurrence of renal function impairment in PDR patients undergoing vitrectomy.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"894-899"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The mechanism of β-hydroxybutyrylation in G6PDX regulated by β-hydroxybutyric acid on alleviating podocyte injury induced by high glucose].","authors":"L X Lyu, M Y Hu, Y Q Lei, S K Pan, D W Liu, S J Zhou, Z S Liu","doi":"10.3760/cma.j.cn112137-20241028-02421","DOIUrl":"10.3760/cma.j.cn112137-20241028-02421","url":null,"abstract":"<p><p><b>Objective:</b> To explore the mechanism of β-hydroxybutyric acid (β-HB) mediated β-hydroxybutyrylation in glucose-6-phosphate dehydrogenation (G6PDX) on reducing the damage of podocyte induced by high glucose. <b>Methods:</b> Mouse podocytes (MPC-5) were stimulated with high glucose to establish a podocyte injury model of diabetic nephropathy. The cells were divided into three groups: the control group, the high glucose group (stimulated with 30 mmol/L glucose for 48 hours), and the high glucose+β-HB group (stimulated with 30 mmol/L glucose plus 20 mmol/L β-HB for 48 hours). The content of β-HB, cell viability, and the expressions of podocin, Wilms tumor protein 1 (WT-1), and synaptopodin in MPC-5 cells of each group were measured. Liquid chromatography-tandem mass spectrometry was employed to screen for potential protein sites undergoing β-hydroxybutyrylation, and the expression of G6PDX was detected. A mutant vector was transfected to mutate the lysine at position 432 of G6PDX to arginine. The cells were then divided into three groups: the high glucose group (stimulated with 30 mmol/L glucose for 48 hours), the high glucose+β-HB group (stimulated with high glucose and 20 mmol/L β-HB for 48 hours), and the high glucose+β-HB+site mutation group (subjected to high glucose, β-HB, and transfection of a plasmid for lysine site mutation). The cell viability and G6PDX expression in each subgroup were determined. <b>Results:</b> Compared with the control group, the cell viability in the high glucose group was significantly decreased (34.8%±2.8% vs 100.0%±8.5%, <i>P</i><0.001). In contrast, the cell viability in the high glucose+β-HB group was significantly higher than that in the high glucose group (72.7%±1.9% vs 34.8%±2.8%, <i>P</i><0.001). Moreover, β-HB could ameliorate podocyte injury induced by high glucose, as evidenced by the increased expressions of podocin (0.63±0.02 vs 0.39±0.03, <i>P</i><0.001), WT-1 (0.75±0.04 vs 0.50±0.03, <i>P</i><0.001), and synaptopodin (0.74±0.02 vs 0.56±0.02, <i>P</i><0.001). Liquid chromatography-tandem mass spectrometry analysis revealed an increased β-hydroxybutyrylation modification of the lysine at position 432 of G6PDX after β-HB treatment (fold change>1.5). The results of Western blotting (0.68±0.05 vs 0.38±0.01, <i>P</i><0.001), PCR (0.70±0.10 vs 0.15±0.03, <i>P</i><0.001), and immunofluorescence all indicated an upregulation of G6PDX expression. After the site mutation, the restoration of cell viability under β-HB treatment was restricted (171.7%±7.1% vs 259.7%±14.6%, <i>P<</i>0.001). Additionally, the results of Western blotting (1.43±0.04 vs 2.22±0.09, <i>P</i><0.001) and PCR (2.33±0.16 vs 3.60±0.34, <i>P</i><0.001) showed a decrease in G6PDX expression compared with that with simple β-HB treatment. <b>Conclusion:</b> β-HB mediated β-hydroxybutyrylation of G6PDX can alleviate podocyte injury induced by high glucose.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"900-906"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the respiratory pathogen test during the winter and spring of 2023-2024 in multiple locations of China with direct-to-consumer testing and the epidemiological characteristics of respiratory syncytial virus].","authors":"H L Jiang, Y P Duan, M Y Jiang, Y X Sun, L Z Feng","doi":"10.3760/cma.j.cn112137-20240712-01590","DOIUrl":"10.3760/cma.j.cn112137-20240712-01590","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the detection status of respiratory pathogens with direct-to-consumer testing and the characteristics of the population with human respiratory syncytial virus (HRSV) detection in the winter and spring of 2023-2024. <b>Methods:</b> From October 2023 to April 2024, polymerase chain reaction (PCR) detection of 12 respiratory pathogens was conducted among the general population willing to be tested in the cross-sectional study of 7 cities across the country. Age, gender, and symptom data of the tested population were collected. Chi-square test was used to analyze the differences in HRSV detection rates among different genders, ages, and regions. The temporal distribution of HRSV detection and the situation of co-infection were also analyzed. <b>Results:</b> A total of 459 972 test samples were included, and the age [<i>M</i> (<i>Q₁</i>, <i>Q₃</i>)] was 30 (9,38) with an age range of 0 to 90 years. The total number of HRSV detections was 17 387, with a total detection rate of 3.78%. The HRSV detection rates in the 0-1 year old (11.56%, 1 669/14 440), 2-5 years old (8.09%, 3 746/46 300), 60-74 years old (3.60%, 807/22 386), and≥75 years old (4.31%, 169/3 921) were higher than those in the 6-17 years old (2.93%, 3 238/110 502) and 18-59 years old (2.96%, 7 758/262 423) (<i>P</i><0.003 3). The HRSV detection rate in North China (5.51%, 11 648/211 450) was higher than that in East China (2.41%, 3 964/164 806), South China (2.14%, 1 722/80 579), and Southwest China (1.69%, 53/3 137) (<i>P</i><0.008 3). HRSV in North China showed a single peak epidemic pattern, with an epidemic peak from November 2023 to January 2024; compared with North China, the epidemic period of HRSV in South China started earlier, with epidemic peaks in October 2023 and March-April 2024; in East China, HRSV showed epidemic peaks in early January 2024 and March 2024. Among the HRSV-detected population, the proportion of HRSV co-detected with one pathogen was the highest (46.62%, 8, 106/17, 387), with the highest proportion being HRSV co-detected with one bacterium (43.42%, 7, 549/17, 387). <b>Conclusions:</b> The findings from the direct-to-consumer testing of respiratory pathogens during the winter and spring of 2023-2024 reveals that HRSV is predominantly detected in children aged 0-5 years old and elderly individuals≥60 years old. The epidemic period for HRSV in South China precedes that in North China. Furthermore, HRSV is frequently associated with a specific type of bacteria.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"924-930"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application study on single-channel contrast agent/tracer injection mode of positron emission tomography/magnetic resonance imaging examination].","authors":"Y Q Chen, Y T Ding, T T Chu, J Sun, Y Y Xie, L Dong, L L Gao, L J Zhang","doi":"10.3760/cma.j.cn112137-20240825-01959","DOIUrl":"10.3760/cma.j.cn112137-20240825-01959","url":null,"abstract":"<p><p><b>Objective:</b> To explore the application value of the single-channel contrast agent/tracer injection mode in positron emission tomography/magnetic resonance imaging (PET/MRI) examination. <b>Methods:</b> A total of 65 patients who underwent PET/MRI examination in the Department of Radiology of General Hospital of Eastern Theater from June 2021 to March 2022 were prospectively enrolled as the control group (double-channel contrast/tracer injection mode), and 78 patients examined from April to May 2022 as the test group (single-channel contrast/tracer injection mode).The nursing operation time, the puncture success rate of indwelling needle, the incidence of blood extravasation, and the image quality were analyzed and compared between two groups. <b>Results:</b> The age of 143 patients was (53.7±16.3) years, and 90 (63.0%) were male. The control group was (54.7±17.0) years, with 43 males (66.2%). The test group was (50.8±18.5) years, with 47 males (60.3%). The nursing operation time of patients in the test group was shorter than that in the control group [3.2 (3.0, 3.3) vs 6.2 (5.4, 6.5) min]. The success rate of indwelling needle puncture in the test group was higher than that in the control group [100.0 (78/78) vs 92.3% (60/65)], and the rate of blood extravasation was lower than that in the control group [0 (0/78) vs 6.2% (4/65)] (all <i>P</i><0.05). There was no statistically difference in the pass rate of PET/MRI images between two groups [94.9% (74/78) vs 98.5% (64/65), <i>P</i>=0.374]. <b>Conclusion:</b> Compared with the traditional double-channel contrast agent/tracer injection mode, the single-channel contrast agent/tracer injection mode reduces the nursing operation time and the incidence of blood extravasation, increases the success rate of indwelling needle puncture, and does not affect the image quality of PET/MRI.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 12","pages":"907-911"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Practice guidelines for diagnosis, treatment, and prevention of tuberculosis in patients with rheumatic disease].","authors":"","doi":"10.3760/cma.j.cn112137-20250208-00281","DOIUrl":"10.3760/cma.j.cn112137-20250208-00281","url":null,"abstract":"<p><p>China is a high-burden country for tuberculosis (TB), and patients with rheumatic diseases (RD) are at significantly increased risk of TB infection and progression. Currently, there are no comprehensive clinical practice guidelines providing recommendations for the screening, diagnosis, treatment, and prevention of TB in RD patients. To address this issue, the Collaborative Group for TB Prevention and Control in Patients with RD in China, in collaboration with the Chinese Society of Clinical Epidemiology and Evidence-Based Medicine, Chinese Society of Rheumatology, Chinese Society of Tuberculosis and Chinese Society of Infectious Diseases, developed evidence-based recommendations. These were formulated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology and the Reporting Items for Practice Guidelines in Healthcare (RIGHT) standards. Based on the 14 clinical questions formed from the preliminary research, including: (1) which RD patients need to be screened for TB, (2) how to select the screening methods for TB, (3) whether to conduct re-screening for latent tuberculosis infection (LTBI) after the initial screening is negative, (4) how to diagnose and differentiate RD patients with active tuberculosis (ATB), (5) the indications and courses of empirical anti-TB treatment for RD patients suspected of ATB, (6) how to diagnose drug-resistant TB in RD patients with ATB, (7) the characteristics and management of subclinical TB in RD patients with ATB, (8) the recommended treatment regimens and courses for TB in RD patients, (9) the interaction between anti-TB drugs and RD treatment drugs and how to choose alternative regimens, (10) how to handle adverse drug reactions during anti-TB treatment in RD patients, (11) how to evaluate the effectiveness of anti-TB treatment in RD patients, (12) the indications for initiating tuberculosis preventive treatment (TPT) in RD patients, (13) the recommended regimens and courses for TPT in RD patients, (14) the protection period of TPT and whether to repeat it, detailed evidence-based recommendations were provided, aiming to offer decision support for clinical practice.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 ","pages":"1303-1321"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy and safety of stereoelectroencephalography-guided 3D radiofrequency thermocoagulation for the treatment of drug-resistant medial temporal lobe epilepsy with hippocampal sclerosis].","authors":"L Jin, D X Zhi, Y F Yang, S C Chen, T R Wang, D Lu, Y Z Shan","doi":"10.3760/cma.j.cn112137-20240925-02179","DOIUrl":"10.3760/cma.j.cn112137-20240925-02179","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the efficacy and safety of stereotactic electroencephalography (SEEG)-guided 3D radiofrequency thermocoagulation (RF-TC) in the treatment of drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS). <b>Methods:</b> This study was a randomized controlled trial. The patients with drug-resistant mTLE-HS recruited from Xuanwu Hospital, Capital Medical University between August 2019 and October 2022 were prospectively enrolled. The patients were randomly assigned to receive either anterior temporal lobectomy (ATL) or RF-TC treatment using a variable block randomization method. All patients were assessed both preoperatively and 1 year postoperatively. The postoperative outcomes in terms of epileptic seizure results, visual field defects, and surgery-related complications were compared between the two groups. <b>Results:</b> A total of 38 patients were included, 19 males and 19 females, with an average age of (28.3±6.9) years. There were 20 cases in the ATL group and 18 cases in the RF-TC group. There was no statistically significant difference in age [(28.5±5.7) vs (28.2±8.1), <i>P</i>=0.848] or gender distribution (7/20 vs 12/18, <i>P</i>=0.103) between the both groups. At the 1-year follow-up post-surgery, there was no statistically significant difference in the proportion of patients achieving Engel Class Ⅰfor epileptic seizure results between the ATL group and the RF-TC group (17/20 vs 13/18, <i>P</i>=0.438). The proportion of patients in the ATL group who developed visual field defects was higher than that in the RF-TC group (15/20 vs 3/18, <i>P</i><0.010). No severe adverse events were observed in both groups. <b>Conclusion:</b> The epilepsy control efficacy of SEEG-guided 3D RF-TC is comparable to that of traditional surgery, while offering superior outcomes in visual field preservation.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 11","pages":"827-833"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}