{"title":"[Expert consensus on multidisciplinary diagnosis and treatment of gastroparesis (2025 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20241119-02588","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241119-02588","url":null,"abstract":"<p><p>Gastroparesis is a gastric motility disorder characterized by delayed gastric emptying in the absence of mechanical obstruction. Gastroparesis significantly impacts patients' psychological well-being and quality of life, potentially leading to psychological disorders such as anxiety and depression, and also imposes a heavy economic burden on patients and society. This expert consensus covers relevant views on its etiology (diabetes, surgery, drug-induced, idiopathic, scleroderma, etc.), symptomatology, diagnosis (scintigraphic imaging, ultrasound contrast meal assessment, and radiopaque marker gastric motility testing), and treatment (pharmacological therapy, nutritional support, traditional Chinese medicine, and interventions targeting the pylorus, such as endoscopic surgery and surgical procedures). Therefore, this expert consensus advocates the establishment of a multidisciplinary team diagnosis and treatment model, which will further standardize and optimize the diagnosis and treatment process of Gastroparesis in China.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 21","pages":"1700-1714"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Tian, J Li, X Liu, T L Mei, M X Wang, J Wu, Q Sun
{"title":"[Analysis of therapeutic effect of non-bioartificial liver on cholestatic liver disease in children].","authors":"N Tian, J Li, X Liu, T L Mei, M X Wang, J Wu, Q Sun","doi":"10.3760/cma.j.cn112137-20241227-02943","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241227-02943","url":null,"abstract":"<p><p>The patients diagnosed with cholestatic liver disease at Beijing Children's Hospital, Capital Medical University from April 2022 to April 2024 were retrospectively collected and divided into non-biological artificial liver (NBAL) group and standard medical therapy (SMT) group according to treatment methods. The decline of liver function indexes 3, 7 and 14 days after treatment was compared until Auaust 2024. The NBAL group was divided into plasma exchange (PE) group, plasma adsorption group and combined treatment group according to the treatment mode. The decline of liver function indicators before and after different treatment modes was compared. A total of 16 patients were included. There were 8 patients in the SMT group, including 5 males and 3 females, aged (7.5±3.3) years. There were 8 patients in the NBAL group, including 2 males and 6 females, aged (6.9±4.6) years. The patients were followed up for 28 months. On the 3rd day of treatment, the decrease of total bilirubin (TBIL) [(118.8±95.3) vs (18.2±45.7) μmol/L] and direct bilirubin (DBIL) [(96.2±81.5) vs (18.2±45.7) μmol/L] in NBAL group was higher than that in SMT group; On the 7th and 14th day of treatment, the decrease of TBIL and DBIL in NBAL group was higher than that in SMT group (all P<0.05). The 8 children in the NBAL group received artificial liver treatment for 23 times, including 8 in the PE group, 9 in the plasma adsorption group, and 6 in the combined treatment group. The decrease of alanine aminotransferase (ALT) in PE group was higher than that in plasma adsorption group and combined treatment group [(175.5±79.4) vs (107.9±70.5) and (60.3±87.2) U/L, respectively, both <i>P</i><0.05]. The therapeutic effect of NBAL on cholestatic liver disease in children is better than that of medical treatment. The effect of plasma adsorption and combined therapy is equivalent to that of PE in reducing liver function indexes.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 21","pages":"1741-1745"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J R Zhao, X Y Pang, J M Bai, J H Zhang, H F Wang, M Li, Z H Chen, H M Cheng, L Ling, X S Huang
{"title":"[Progression patterns of lower motor neuron involvement in the lower medulla oblongata and cervical spinal cord of amyotrophic lateral sclerosis patients].","authors":"J R Zhao, X Y Pang, J M Bai, J H Zhang, H F Wang, M Li, Z H Chen, H M Cheng, L Ling, X S Huang","doi":"10.3760/cma.j.cn112137-20241229-02957","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241229-02957","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the lower motor neuron (LMN) involvement patterns in the lower medulla oblongata and cervical spinal cord in amyotrophic lateral sclerosis (ALS) patients. <b>Methods:</b> The needle electromyography (EMG) data of 200 patients with non-thoracic onset sporadic ALS, hospitalized in the Neurology Department of the First Medical Center of the Chinese PLA General Hospital from September 2022 to December 2023, were retropectively analyzed. All participants met the EI Escorial-Revised diagnostic criteria. According to the onset site, the patients were divided into the lower medulla oblongata onset group(34 cases), the spinal cord onset group(166 cases) [including the lower cervical spinal cord onset group (92 cases) and the lumbosacral spinal cord onset group (74 cases)]. Electromyography (EMG) abnormalities in the muscles innervated by the lower medulla oblongata and cervical cord were counted, and the characteristics of LMN involvement were analyzed. The binomial distribution test was used to determine whether the progression of LMN involvement to the second central nervous system segment was random. <b>Results:</b> Among 200 ALS patients, there were 111 males (55.5%) and 89 females (44.5%), with an age onset of 28-86 (56±11) years. 20 (10.0%) cases with normal sternocleidomastoid (SCM)-EMG or trapezius (TRA)-EMG results, and 7 (3.5%) cases with normal SCM-EMG and TRA-EMG results were observed in patients with LMN involvement in both the lower medulla oblongata and lower cervical spinal cord. The abnormal rates of EMG at the onset of lower cervical spinal cord were tongue muscle (GEN)-EMG (88.2%, 30/34), TRA-EMG (70.6%, 24/34) and SCM-EMG (67.6%, 23/34), respectively. The abnormal rates of EMG at the onset of lower cervical spinal cord were TRA-EMG (72.8%, 67/92), SCM-EMG (38.0%, 35/92) and GEN-EMG (32.6%, 30/92), respectively. The binomial distribution test showed that the progression of LMN involvement to the second segment of the central nervous system was not random (all <i>P</i><0.05). In low bulbar onset patients, the abnormal rate of LMN involvement was higher in the lower cervical spinal cord segment [100.0% (34/34)], and lower in the lumbosacral spinal cord segment[91.2% (31/34)]. In the lower cervical spinal cord onset group, the abnormal rate of LMN involvement was lower in the the low medulla obliterum[32.6% (30/92)] and high in the lumbosacral spinal cord [96.7% (89/92)].In the lumbosacral spinal cord onset group, the abnormal rate of LMN involvement was low in the low medulla oblata [27.0% (20/74)] and high in the lower cervical spinal cord [94.6% (70/74)]. <b>Conclusions:</b> The progression of LMN involvement in the lower medulla oblongata and cervical spinal cord is primarily continuous, while a discontinuous progression pattern was also observed. The lower medulla oblongata of ALS patients with spinal onset is relatively less involved in disease progression.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 21","pages":"1721-1727"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y X Xiong, Z Cai, J Liao, Y J Zhao, Y Li, Y He, H Q Niu, K Zhao
{"title":"[Clinical analysis of vancomycin continuous intravenous infusion in the treatment of patients with central nervous system infections].","authors":"Y X Xiong, Z Cai, J Liao, Y J Zhao, Y Li, Y He, H Q Niu, K Zhao","doi":"10.3760/cma.j.cn112137-20241010-02282","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241010-02282","url":null,"abstract":"<p><p>This study retrospectively analyzed the clinical data of patients with central nervous system infections (CNSI) after neurosurgery in the Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, from September 2010 to September 2022. Based on vancomycin administration regimens, the patients were divided into the intermittent intravenous infusion (IIV) group and the continuous intravenous infusion (CIV) group. Hematological indices were evaluated before and after vancomycin therapy to compare short-term efficacy and safety between the two regimens.A total of 90 patients were included, including 50 patients in the IIV group [28 males and 22 females, aged (50.9±12.6) years] and 40 patients in the CIV group [29 males and 11 females, aged (54.5±13.3) years].The CIV group demonstrated significantly lower post-treatment neutrophil-to-lymphocyte ratio (NLR: 7.0±4.4 vs 9.2±4.8), systemic inflammatory response index (SIRI) (6.1±6.0 vs 9.9±8.2), and incidence of augmented renal clearance (ARC) [10.0% (4/40) vs 42.0% (21/50)] compared to the IIV group. Additionally, the CIV group achieved higher trough concentration target attainment rates [85.0% (34/40) vs 56.0% (28/50)] and superior short-term clinical efficacy [72.5% (29/40) vs 52.0% (26/50)]than those in the IIV group (<i>P</i><0.05). No significant difference in nephrotoxicity was observed between the two groups after the treatment (<i>P</i>>0.05).Compared to IIV, CIV can improve trough concentration target attainment, reduced ARC incidence, and enhance therapeutic efficacy in CNSI patients, suggesting that CIV may be a more optimized administration strategy for CNSI management.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 21","pages":"1746-1750"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Chen, H Li, F Gao, W Q Wang, Y Liu, Y Liu, Y N Wang, X B Xu
{"title":"[Genomic characteristics of sequence type 80 of <i>Campylobacter fetus</i> subsp. <i>testudinum</i> from bacteremia].","authors":"F Chen, H Li, F Gao, W Q Wang, Y Liu, Y Liu, Y N Wang, X B Xu","doi":"10.3760/cma.j.cn112137-20241225-02932","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241225-02932","url":null,"abstract":"<p><p>To analyze the genomic characteristics of <i>Campylobacter fetus</i> subsp. <i>testudinum</i> (Cft) sequence type (ST) 80 from bacteremia patient. The clinical data of a male patient admitted to Shanghai Xinhua Hospital on October 16, 2023 were retrospectively analyzed. The clinical diagnoses were type B aortic dissection, thoracic and abdominal aortic infection, and bacteremia. The isolated was resistant to nalidixic acid, ciprofloxacin and tetracycline. The whole genome sequencing revealed a novel sequence type ST80 and resistance genes are predicted: Aminoglycosides aph(3')-Ⅱa, tetracyclines tet(O), glycopeptides (blmt) and a single amino acid mutation gyrA (T86I) in the Quinolone resistance determining region. Nine heterologous genes were predicted in the 19 genes, and 41 of the 79 genes were flagella genes. The virulence genes included ciaB and cell lethal expansion toxins (typhoid toxin) cdtA, cdtB, cdtC. Type Ⅳ secretion system and S-layer surface protein colonization gene (sapA) coexist. The patient was treated with piperacillin/tazobactam sodium combined with doxycycline and azithromycin for 20 d and discharged after thoracoabdominal aortic replacement and branch artery reconstruction. Soft-shelled turtles may be a potential new host of Cft infection or a vector of foodborne invasive cases due to their biological characteristics of fusion recombinant.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 21","pages":"1737-1740"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Current status and future directions of the diagnosis and treatment for head and neck tumor in China].","authors":"C Li, D R Wang, R H Sun, Z Y Zhang","doi":"10.3760/cma.j.cn112137-20250120-00169","DOIUrl":"10.3760/cma.j.cn112137-20250120-00169","url":null,"abstract":"<p><p>Head and neck tumor is one of the diseases that seriously endanger human health, with complicated pathological mechanisms and diverse clinical manifestations, posing great challenges on the clinical diagnosis and treatment. Domestic experts actively explore new methods of screening and diagnosis, aiming to enhance the level of early detection, early diagnosis and treatment, and improve the prognosis of patients. In terms of treatment strategy, the treatment of head and neck tumors is gradually transforming to the direction of integration and individualization. Surgery, radiotherapy, chemotherapy and immunotargeted therapy work together to provide patients with a more accurate and individualized treatment plan. This review deeply analyzes the epidemiological characteristics, diagnostic methods and treatment strategies of head and neck tumors, and offers the future development direction, aiming to provide valuable references for researchers and clinical practitioners and improve the diagnosis and treatment of head and neck tumors in China.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 20","pages":"1567-1571"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Centrally mediated abdominal pain syndrome: how should we understand it?]","authors":"X Q Li","doi":"10.3760/cma.j.cn112137-20250128-00229","DOIUrl":"10.3760/cma.j.cn112137-20250128-00229","url":null,"abstract":"<p><p>Centrally mediated abdominal pain syndrome (CAPS) is a functional gastrointestinal disorder newly proposed in the Rome Ⅳ diagnostic criteria, highlighting the important role of abnormal gut-brain interaction in pathogenesis. Careful and detailed inquiry of the characteristics of abdominal pain, accompanying behaviors, and psychosocial background can help to establish the diagnosis of CAPS and reduce unnecessary examinations and interventions. The good and effective doctor-patient relationship, combined with medications such as neuromodulators and non-drug treatments such as psychotherapy can maximize the efficiency. This article addresses the challenges in the diagnosis and treatment of CAPS by elaborating on the diagnostic criteria, pathogenesis, clinical features, and therapeutic strategies, aiming to enhance the understanding of CAPS.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 19","pages":"1481-1484"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Reflux hypersensitivity: from pathogenesis to diagnosis and treatment].","authors":"Y L Xiao","doi":"10.3760/cma.j.cn112137-20250205-00249","DOIUrl":"10.3760/cma.j.cn112137-20250205-00249","url":null,"abstract":"<p><p>Reflux hypersensitive (RH) is a type of functional esophageal disorders that can cause gastroesophageal reflux symptoms. Its pathogenesis is not completely clear, but it is generally believed to be related to the abnormal interaction of brain-gut axis, including increased peripheral nerve sensitivity, damaged mucosal integrity, increased central nervous sensitivity and psychological factors. Currently, there is no standardized treatment for RH. The commonly used treatment methods include acid suppression therapy, pain modulators, anti-reflux surgery, psychotherapy, etc. However, these treatments, can only benefit some patients. This article will focus on the above pathogenesis, diagnosis and treatment, and further explore the causes of RH symptoms.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 19","pages":"1485-1491"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F F Zhang, X Y Yang, X L Shao, J F Wang, Y J Chen, B Liu, Y M Shi, W J Yu, Y T Wang
{"title":"[Comparison of the diagnostic value of rest <sup>18</sup>F-FDG PET myocardial ischemic memory imaging and rest <sup>99</sup>Tc<sup>m</sup>-MIBI SPECT myocardial perfusion imaging for obstructive coronary artery disease in patients with suspected unstable angina].","authors":"F F Zhang, X Y Yang, X L Shao, J F Wang, Y J Chen, B Liu, Y M Shi, W J Yu, Y T Wang","doi":"10.3760/cma.j.cn112137-20250304-00508","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250304-00508","url":null,"abstract":"<p><p><b>Objective:</b> To compare the diagnostic value of rest <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography (PET) myocardial ischemic memory imaging and rest <sup>99</sup>Tc<sup>m</sup>-methoxyisobutylisonitrile (MIBI) single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for obstructive coronary artery disease (CAD) in patients with suspected unstable angina (UA). <b>Methods:</b> This prospective study included low-and medium-risk patients who presented with chest pain or discomfort at the Chest Pain Center or Cardiovascular Department of the Third Affiliated Hospital of Soochow University from September 2020 to June 2024. These patients, whose initial clinical assessments were negative but still suspected of UA, all underwent rest <sup>99</sup>Tc<sup>m</sup>-MIBI SPECT MPI, rest <sup>18</sup>F-FDG PET myocardial ischemic memory imaging, and invasive coronary angiography (ICA). Using ICA as the diagnostic gold standard, the diagnostic value of rest <sup>99</sup>Tc<sup>m</sup>-MIBI SPECT MPI and rest <sup>18</sup>F-FDG PET myocardial ischemic memory imaging were compared for obstructive CAD in suspected UA patients. The diagnostic performance was assessed using receiver operating characteristic curves. <b>Results:</b> A total of 274 patients with suspected UA were included, of whom 158 (57.7%) had ICA confirmed obstructive CAD [112 males(70.9%), aged (64.3±10.3) years], and 116 (42.3%) had no obstructive CAD [61 males(52.6%), aged (65.4±8.4) years].Rest <sup>18</sup>F-FDG PET myocardial ischemic memory imaging demonstrated significantly higher sensitivity (67.7% vs 52.5%), specificity (90.5% vs 78.4%), positive predictive value (90.7% vs 76.9%), negative predictive value (67.3% vs 54.8%), accuracy (77.4% vs 63.5%), and the area under the curve [0.79 (95%<i>CI:</i> 0.74-0.84) vs 0.66 (95%<i>CI:</i> 0.60-0.71)] compared to rest <sup>99</sup>Tc<sup>m</sup>-MIBI SPECT MPI (all <i>P</i><0.05). The net reclassification improvement (NRI) index for the diagnosis of obstructive CAD using rest <sup>18</sup>F-FDG PET myocardial ischemic memory imaging over <sup>99</sup>Tc<sup>m</sup>-MIBI SPECT MPI was 0.27 (95%<i>CI</i>: 0.14-0.41), and the difference was statistically significant (<i>P</i><0.05). <b>Conclusion:</b> Rest <sup>18</sup>F-FDG PET myocardial ischemic memory imaging demonstrates superior diagnostic performance compared to <sup>99</sup>Tc<sup>m</sup>-MIBI SPECT MPI for obstructive CAD in patients with suspected UA.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 18","pages":"1392-1399"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Wang, X F Liu, Y L Chen, Y L Li, J L Xu, Y F Lyu, X F Li, D G Zhang
{"title":"[Characterization of balance function during the interictal period of vertigo attacks in patients with Ménière's disease].","authors":"C Wang, X F Liu, Y L Chen, Y L Li, J L Xu, Y F Lyu, X F Li, D G Zhang","doi":"10.3760/cma.j.cn112137-20241120-02596","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20241120-02596","url":null,"abstract":"<p><p>This study aimed to investigate the characteristics of balance function during the interictal period in patients with Ménière's disease (MD) and analyze related influencing factors. A retrospective analysis was conducted on the clinical data of 183 MD patients admitted to the Vertigo Department of Shandong ENT Hospital between July 2021 and December 2023. Balance function was assessed using the sensory organization test (SOT), along with evaluations of mean hearing threshold, semicircular canal function, otolith organ function, and endolymphatic hydrops status. The cohort comprised 89 male and 94 female patients, aged (46.3±9.1) years. SOT results revealed balance dysfunction in 87 cases (47.5%), categorized into vestibular dysfunction type (58 cases), visual dependence type (13 cases), and visual-vestibular dysfunction type (16 cases). Multivariate logistic regression analysis identified abnormal ocular vestibular evoked myogenic potentials (<i>OR</i>=1.977, 95%<i>CI</i>: 1.023-3.819) and abnormal caloric test results (<i>OR</i>=2.310, 95%<i>CI</i>: 1.153-4.630) as significant influencing factors for balance dysfunction. This study suggests a high prevalence of balance dysfunction during the interictal period in MD patients, with utricular function and low-frequency horizontal semicircular canal function being key determinants of balance performance.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 18","pages":"1426-1430"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}