Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology最新文献

{"title":"Natural Flavonoids as Anticancer Agents: Targeting the HIF-1α Signaling Pathway.","authors":"Nirmala Shinde, Ashwini Satalkar, Sachin Bhosale, Vrushali Patole, Shubhangi Agale","doi":"10.62958/j.cjap.2025.008","DOIUrl":"https://doi.org/10.62958/j.cjap.2025.008","url":null,"abstract":"<p><strong>Background: </strong>The clinical effectiveness of wide range of currently available anticancer drugs is being reduced .HIF-1 alpha is essential for the reprogramming of cancer cells' metabolism,so cancer treatments include inhibiting the HIF-1α signaling pathway and The evidence underscores the potential of natural flavonoids as HIF-1α inhibitors in cancer therapy.</p><p><strong>Objective: </strong>To provide more comprehensive overview of inhibition of flavonoids on HIF-1 which may be useful for developing new compounds with enhanced anticancer properties and also to provide reasearchers with a thought to design potent and low toxic anticancer candidates.</p><p><strong>Material and methods: </strong>A comprehensive review of recent literature was conducted to identify studies investigating the effects of natural flavonoids and their derivatives on HIF-1α activity. Emphasis was placed on mechanisms of action, efficacy, and toxicity profiles, as well as their impact on tumor hypoxia and associated pathways such as vascularization and glycolysis.</p><p><strong>Result: </strong>Recent findings demonstrate that various natural flavonoids effectively downregulate HIF-1α through distinct mechanisms. These compounds exhibit significant anti-cancer properties while maintaining low toxicity, making them viable candidates for further development. Several studies have also highlighted the ability of flavonoids to influence tumor vascularization and glycolytic pathways, thereby enhancing their therapeutic potential.</p><p><strong>Conclusion: </strong>In this review in order to increase bioavailability , solubility and to better understand the impact of anticancer flavonoids on HIF-1 alpha, amino acids or amino groups were added to the flavonoid structure. understanding the effect of anticancer flavonoids on HIF-1 α may be relevant in the development of novel compounds with increased anticancer activity.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250008"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting FLT3 Mutations in Acute Myeloid Leukemia: The Role of Quizartinib in Precision Medicine.","authors":"Manoj Kumbhare, Siddhi Chandak, Bhagwan Ide, Aishwarya Dukare, Sakshi Velhal, Harshali Gode, Nishant Pagere, Arshad Shaikh","doi":"10.62958/j.cjap.2025.007","DOIUrl":"https://doi.org/10.62958/j.cjap.2025.007","url":null,"abstract":"<p><p>Acute Myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy that disproportionately affects older individuals. Among the various genetic alterations, FLT3 internal tendem duplication (FLT3-ITD) mutations are present in approximately 20-30% of patients and are linked to rapid disease progression and frequent relapses. This review evaluates the role of quizartinib, a second-generation, highly selective FLT3 inhibitor, as a targeted therapeutic option for relapsed or refractory AML. Preclinical studies have demonstrated that quizartinib offers potent inhibition of FLT3 signaling, favorable pharmacokinetic properties, and high bioavailability. Early-phase clinical trials reported promising remission rates in patients harboring FLT3-ITD mutations, while phase III studies further substantiated its efficacy by showing improved overall survival when used alone or alongside standard chemotherapy. Despite these advances, quizartinib's clinical use is limited by challenges such as acquired resistance, off-target effects-including QT interval prolongation-and complex drug-drug interactions. Ongoing research is focused on elucidating resistance mechanisms and developing effective combination regimens to optimize its therapeutic potential. Overall, quizartinib represents a significant breakthrough in precision medicine for AML, offering a promising avenue to improve patient outcomes in this challenging disease.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250007"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Insights and Emerging Applications of Nanogel-Based Topical Drug Delivery Systems.","authors":"Manoj Kumbhare, Prajakta Shinde, Dhanashree Mohite, Vaishnavi Rokade, Siddhi Chandak, Aishwarya Dukare","doi":"10.62958/j.cjap.2025.006","DOIUrl":"https://doi.org/10.62958/j.cjap.2025.006","url":null,"abstract":"<p><strong>Purpose: </strong>Nanogels (NGs) represent a new generation of nanoscale hydrogel particles with immense biomedical applications, especially drug delivery System (DDS). Nanogels (NGs) are soft and water-retentive materials that deliver drugs in controlled and sustained release while maintaining high biocompatibility and biodegradability.</p><p><strong>Method: </strong>This review paper primarily focuses on the applications, mechanism, therapies. The capability to react with environmental signals, such as pH, temperature, or enzymatic activity, makes nanogels a promising platform for targeted therapy. Polysaccharide-based nanogels increase biocompatibility and reduce toxicity, allowing for extended therapeutic applications.</p><p><strong>Result: </strong>This reviews the structural properties, drug release mechanisms, and newer developments in nanogel formulations. It also presents the future outlook for nanogels in precision medicine, highlighting their potential in transcending pharmacological obstacles towards enhancing drug delivery and therapeutic efficacies in various branches of medicine.</p><p><strong>Conclusion: </strong>By overcoming existing drawbacks, nanogels have the potential to revolutionize drug delivery and therapeutic interventions in diverse clinical settings.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250006"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the Potential of Alpelisib in Breast Cancer: A Comprehensive Review.","authors":"Siddhi M Chandak, Manoj R Kumbhare, Vrushali P Patole","doi":"10.62958/j.cjap.2025.005","DOIUrl":"https://doi.org/10.62958/j.cjap.2025.005","url":null,"abstract":"<p><p>Alpelisib is a cancer therapy drug that has shown significant promise in the treatment of certain types of cancer. Its pharmacokinetics and pharmacodynamics indicate that it is absorbed better orally and has a prolong half-life, allowing for once-every day dosing. Currently, its mechanism of action is established to be the suppression of phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), which is the pivotal enzyme of PI3K pathway, which is abnomal in most cancers. The chemistry of alpelisib involves its selective inhibition of PI3K, targeting specifically HR-positive, HER2-negative breast cancer with PIK3CA mutations. The common side effects associated with alpelisib include fever, peripheral edema, fatigue, headache, skin rash, alopecia, pruritis, hyperglycemia, increased gamma-glutamyl transferase, decreased serum calcium, weight loss, diarrhea, nausea, increased serum lipase, decreased appetite, stomatitis, vomiting, dysgeusia, lymphocytopenia, prolonged PTT, and increased serum creatinine. The use of alpelisib in cancer therapy is being extensively studied through various clinical trials, aiming to determine the optimal patient populations for treatment and explore alternative tumor indications and drug combine regimens.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250005"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mini-review on Immunoblotting Technique in Vaccine Development: Current Innovations.","authors":"Roshan Kumar Dubey","doi":"10.62958/j.cjap.2025.004","DOIUrl":"https://doi.org/10.62958/j.cjap.2025.004","url":null,"abstract":"<p><p>Immunoblotting, commonly known as Western blotting, remains a pivotal technique in the identification and quantification of specific proteins, offering critical insights into antigen-antibody interactions essential for vaccine development. This mini-review highlights the evolving role of immunoblotting in modern vaccinology, focusing on its application in evaluating immune responses, verifying antigen expression, and screening candidate vaccine components. Current innovations, including enhanced detection systems, high-throughput formats, and integration with proteomics, have significantly improved the sensitivity and specificity of this method. Moreover, advancements in automation and data analysis are streamlining workflows, enabling faster and more reliable vaccine research. This review underscores the continued relevance of immunoblotting in the post-genomic era, particularly as new vaccine platforms, such as mRNA and vector-based vaccines, demand precise immunological validation.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250004"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evaluation on Rabbit of Lakshadi Anjana Drops: Physico-Chemical, Histopathological, and Anti-Inflammatory Insights for Ocular Therapeutic Applications.","authors":"Praveena P Nair, Manjiri Pritam Keskar","doi":"10.62958/j.cjap.2025.002","DOIUrl":"10.62958/j.cjap.2025.002","url":null,"abstract":"<p><strong>Introduction: </strong>Lakshadi Anjana Drops, a traditional Ayurvedic ocular formulation, is designed to alleviate eye-related conditions. Composed of herbal ingredients with therapeutic properties, this study aimed to evaluate the formulation's quality, safety, and efficacy through physico-chemical, microbiological, and preclinical analysis.</p><p><strong>Methods: </strong>Formulation was analyzed for physico-chemical parameters such as pH, refractive index, peroxide value, saponification value, and iodine value. Preclinical testing was conducted using New Zealand white rabbits, where the Draize test was used to evaluate ocular safety and carrageenan-induced ocular inflammation model was employed to assess anti-inflammatory efficacy. Histopathological analysis of ocular tissues was performed to assess potential tissue damage.</p><p><strong>Results: </strong>pH of Lakshadi Anjana Drops was found to be 7.82, confirming its suitability for ocular use. Physico-chemical parameters, including refractive index (1.4542), peroxide value (2.18 meq/kg), saponification value (210), and iodine value (38.49), were within acceptable limits, ensuring stability. Preclinical results indicated minimal ocular irritation and significant anti-inflammatory activity, comparable to a marketed formulation. Histopathological analysis showed minimal epithelial thickening, with no significant tissue damage.</p><p><strong>Conclusion: </strong>Lakshadi Anjana Drops exhibited strong physico-chemical stability, and biocompatibility, supporting its therapeutic potential for ocular applications. The combination of traditional Ayurvedic ingredients with modern scientific validation highlights its promise for clinical use in ocular therapeutics.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in Drug Delivery Systems for Biologics: Enhancing Stability and Targeted Delivery for Next-Generation Therapeutics.","authors":"Pushpendra Kumar, Ankit Goel, Biswajit Dash, Poonam Rishishwar, Jailani S, Meghraj Vivekanand Suryawanshi, Sanjay Rishishwar, Neethu Asokan","doi":"10.62958/j.cjap.2025.001","DOIUrl":"10.62958/j.cjap.2025.001","url":null,"abstract":"<p><p>The aim of this study is to explore and evaluate recent innovations in drug delivery systems (DDS) for biologics, focusing on enhancing stability and targeted delivery to improve the efficacy and safety of next-generation therapeutics. The most recent developments in a variety of DDS, such as nanoparticles, microneedles, hydrogels, and biodegradable polymers, were examined in depth. Information from peer-audited diaries, clinical preliminaries, and mechanical reports were blended to survey the presentation of these frameworks concerning dependability, designated conveyance, patient consistence, and controlled discharge. A radar chart was used in a comparative analysis to show the advantages and disadvantages of each DDS. Utilizing cutting-edge DDS, our analysis revealed significant improvements in the stability and targeted delivery of biologics. Nanoparticles exhibited the most elevated precision in designated conveyance at 92% and showed a 85% improvement in soundness. With an 88% satisfaction rate and moderate improvements in other criteria, microneedles achieved the highest level of patient compliance. Biodegradable polymers provided a balanced enhancement across all criteria, with 88% improvements in stability, 87% improvements in targeted delivery, and 89% improvements in controlled release for hydrogels. Nanoparticles lost only 6% of their stability, microneedles lost 10% of their controlled release, hydrogels lost 7% of their stability, and biodegradable polymers lost 5% of their patient compliance across all of these systems. The stability and precise delivery of biologics have been significantly improved by advancements in drug delivery systems. Hydrogels and microneedles, on the other hand, provide advantages in controlled release and patient compliance. Biodegradable polymers and nanoparticles are promising for maintaining drug integrity and targeting particular sites. In order to overcome the limitations that exist currently and enhance the therapeutic outcomes of biologics, future research ought to concentrate on hybrid strategies that combine the advantages of multiple DDS.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250001"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Pharmacogenomics for Personalized Medicine: Tailoring Drug Therapy to Genetic Profiles.","authors":"Pushpendra Kumar, Ankit Goel, Pooja Malik, Surbhi Sirswal, Poonam Rishishwar, Sanjay Rishishwar","doi":"10.62958/j.cjap.2024.035","DOIUrl":"https://doi.org/10.62958/j.cjap.2024.035","url":null,"abstract":"<p><p>This study means to investigate the capability of pharmacogenetics which can customize drug treatment through altered treatment of male genetic profiles. We finished hereditary profiling utilizing cutting edge sequencing (NGS) to figure out the key hereditary varieties that impact the medications metabolic adequacy and security. Patients were checked for a very long time to evaluate clinical results including ADRs and general wellness. Hereditary assessment uncovered variations in enormous qualities, for example, CYP2C9 CYP2D6 ABCB1 VKORC1 and SLCO1B1 which assume significant parts in drug digestion and transport. These hereditary markers are related with clinical realities to evaluate their effect on drug reactions and unfriendly impacts. The outcomes recommend that customized treatment dependent exclusively upon hereditary profiles could prompt better treatment results. For instance, patients with VKORC1 changes answer better to anticoagulants and drain less while patients with SLCO1B1 transformations have statin-incited myopathy which is more expensive and requires portion changes. This mirrors the useful effect of altered treatment on wellness results. Pharmacogenomics gives a useful asset to customized medication to tailor drug medicines dependent exclusively upon a person's genetic profile.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"40 ","pages":"e20240035"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakthrough Biomarkers in Lung Cancer: Pioneering Early Detection and Precision Treatment Strategies.","authors":"Ruchi Tiwari","doi":"10.62958/j.cjap.2024.034","DOIUrl":"https://doi.org/10.62958/j.cjap.2024.034","url":null,"abstract":"<p><p>There are several biological, genetic, and environmental variables that contribute to lung cancer, which is one of the main causes of cancer-related death globally. In addition to exposure to radon gas, air pollution, and occupational dangers like asbestos, smoking is a major risk factor because it releases carcinogens like nitrosamines and polycyclic aromatic hydrocarbons (PAHs) into the lungs. The risk of developing lung cancer is also influenced by genetic predispositions, such as variations in genes like EGFR, KRAS, and TP53. Additionally, new research emphasises how epigenetic changes, such as DNA methylation and histone acetylation, affect the expression of genes connected to the development of cancer. In determining risk and spotting early indicators of lung cancer, biomarkers have become important instruments. Cell-free DNA (cfDNA), circulating tumour cells (CTCs), and certain microRNAs (miRNAs) in blood are non-invasive biomarkers that indicate tumour heterogeneity and load. Molecular indicators include anaplastic lymphoma kinase (ALK) rearrangements, epidermal growth factor receptor (EGFR) mutations, and programmed death-ligand 1 (PD-L1) expression have proved very important in tailoring the therapy of lung cancer. Inflammatory indicators such as interleukins and C-reactive protein (CRP) are also linked to the prognosis of lung cancer. Finding and confirming these biomarkers is essential for improving early detection, tracking the course of the disease, and directing focused treatments. As research progresses, combining molecular, genetic, and environmental insights might improve lung cancer care, prevention, and early diagnosis, thereby lowering the disease's worldwide burden.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"40 ","pages":"e20240034"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Computational Advancements in ADME: Essential Insights for Drug Disposition.","authors":"D Benito Johnson, Gurinderdeep Singh, Deeksha Sharma, Venkatesan Natarajan, Knv Chenchu Lakshmi, Ram C Dhakar, Sadhana R Shahi, Suresh Velayutham, Ruchi Tiwari","doi":"10.62958/j.cjap.2024.033","DOIUrl":"https://doi.org/10.62958/j.cjap.2024.033","url":null,"abstract":"<p><p>The physicochemical properties of the physiological makeup and the chemical componentof the system make this challenging throughout strenuous procedure. The current review concentrated on in silico modelling of drug disposition, involving absorption process, distribution process, and excretion process and includes thorough knowledge of various database expeditions, the development of a pharmacophore model, molecular docking studies, homology modelling supported sequence similarity and quantitative structure-activity relationships (QSAR)/ quantitative structure-property relationships (QSPR) evaluation along with all information about drug movement and related computational tools for understanding potential chemical and pathophysiological changes. The primary development in ADMET modeling in current times has been the clarification of the function and effective modeling of various transporters. In ADMET modelling, there is still work to be done on including the impact of these transporters into existing models. The present state of modelling different elements of drug disposal at the systemic level will then be discussed, along with recent developments in modelling a wide range of active transporters and their effects on drug pharmacokinetic profiles. A more thorough knowledge of the underlying processes governing different aspects of drug disposition should also lead to an increase in mechanism-based modelling methods that are simple to grasp and put into practice. These developments will hasten the transition of model construction from computational to experimental scientists.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"40 ","pages":"e20240033"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}