Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology最新文献

{"title":"Sunvozertinib A Next-Generation EGFR Exon 20 Insertion Inhibitor Transforming NSCLC Therapy.","authors":"Manoj Kumbhare, Dhiraj Gadekar, Siddhi Chandak, Samiksha Mankar","doi":"10.62958/j.cjap.2026.005","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.005","url":null,"abstract":"<p><p>Sunvozertinib (DZD9008) is an emerging next-generation, highly selective EGFR tyrosine kinase inhibitor (TKI) designed to target EGFR exon 20 insertion (Ex20ins) mutations, a subtype of non-small cell lung cancer (NSCLC) associated with poor response to earlier-generation EGFR TKIs. Patients with these mutations typically exhibit intrinsic resistance to approved standard EGFR inhibitors due to the altered conformation of the kinase domain. Consequently, therapeutic options have remained limited, and platinum-doublet chemotherapy has historically been the primary systemic treatment. Recently developed agents such as amivantamab and mobocertinib have improved response rates, yet challenges related to tolerability, CNS penetration, and durability of benefit persist. Sunvozertinib aims to address these limitations through rational structural design, optimized kinase selectivity, and improved safety-efficacy balance. Preclinical studies have shown potent inhibition of a broad spectrum of EGFR Ex20ins variants while sparing wild-type EGFR, suggesting a reduced risk of dose-limiting toxicities commonly seen with non-selective EGFR blockade. Sunvozertinib has also demonstrated promising CNS activity in animal models-an important feature for NSCLC patients, who frequently develop brain metastases. Early-phase clinical trials, including the WU-KONG series, have reported promising clinical efficacy, including objective response rates ranging from 44-60% in previously treated patients and meaningful activity in treatment-naïve cohorts. The tolerability profile of the drug seems manageable, with diarrhea, rash, and stomatitis among the most commonly observed adverse events; these, however, tend to be milder compared with other agents targeting EGFR Ex20ins.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260005"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Quantum Dots: A Review of Emerging Roles in Technology and Sustainability.","authors":"Fiza Arif Shaikh, Pravin Rangnath Dighe, Manoj Ramesh Kumbhare","doi":"10.62958/j.cjap.2026.010","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.010","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study is to highlight the emerging and advanced applications of quantum dots (QDs) beyond their conventional use, emphasizing their role in modern electronics, healthcare, energy systems, food safety, and smart materials Methods: This work is based on an extensive literature survey of recent research articles, reviews, and technological reports focusing on the optical, electronic, nonlinear, and thermoelectric properties of quantum dots. The collected data were systematically analyzed to understand how size-dependent properties of QDs enable their integration into diverse applications such as photodetectors, display technologies, biosensors, solar devices, and wearable healthcare systems.</p><p><strong>Result and discussion: </strong>Quantum dots exhibit exceptional size-dependent optical and electronic properties that significantly enhance device performance across multiple sectors. In photodetectors, QDs improve sensitivity over a wide spectral range, while in QLED displays they provide high colour purity and energy efficiency. In the food industry, QD-based sensors enable rapid and accurate detection of pathogens, pesticides, and spoilage markers, improving food safety. Their incorporation into solar windows and photovoltaic glass allows sustainable energy generation without loss of transparency. In wearable healthcare devices, QDs facilitate real-time and non-invasive monitoring of vital biomarkers. Additionally, their nonlinear optical properties support advances in laser technology and optical communication, and their thermoelectric behavior contributes to efficient waste heat recovery and thermal management. These findings demonstrate the versatility and multifunctionality of quantum dots.</p><p><strong>Conclusion: </strong>Quantum dots represent a powerful class of nanomaterials with broad and transformative potential. Their unique physicochemical properties enable innovative applications across electronics, healthcare, energy, and smart materials. Continued research and technological development are expected to further expand their practical implementation, making quantum dots key components in next-generation sustainable and high-performance devices.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260010"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Ophthalmic Nanoemulsion Platforms: Design Principles and Translational Applications in Ocular Drug Delivery.","authors":"Vijay R Mahajan, Yuvraj P Kokane, Arshad S Shaikh, Om Shivaji Bodkhe","doi":"10.62958/j.cjap.2026.011","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.011","url":null,"abstract":"<p><p>Due to physiological constraints that negatively affect the efficiency of conventional ocular preparations, such as fast tear turnover, poor corneal penetration, as well as short in-precornereal resident times, ocular drug delivery has long been a technical challenge. Nanoemulsion strategies based on engineering principles have been identified as a promising solution to overcome these challenges for improved solubilization, ocular bioavailability, as well as drug preparation stability. An eye preparation nanoemulsion consists of water, an oil phase, surfactants, as well as a cosurfactant, forming a kinetically stable colloidal system characterized by a mean particle diameter measuring less than 200 nm. The design principles and translation properties of ocular nanoemulsion systems are discussed in this review. Formulation components and the manufacturing methods, along with the stability problems and recent advances, are discussed. The suitability of the systems to both high-energy production methods (such as spontaneous emulsification, ultrasonication, and high-pressure homogenization) and the stability of the ocular nanoemulsions and recent advances on novel methods such as stimuli-sensitive, mucoadhesive, or positive nanoemulsions will be discussed. Despite these advantages, however, some challenges such as stability for a extended period, complexity, and cost of production still exist. In conclusion, customized ocular nanoemulsion delivery systems are quite viable and flexible research strategies for successful ocular drug delivery.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260011"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147277249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electromagnetic Modulation of Biological Systems: Emerging Perspectives in Bioelectronic Healing.","authors":"Akanksha M Kamble, Kiran Kashinath Shinde","doi":"10.62958/j.cjap.2026.008","DOIUrl":"10.62958/j.cjap.2026.008","url":null,"abstract":"<p><p>Bio electromedicine, a dynamic field at the intersection of biology and electromagnetism, has gained prominence in modern healthcare for its diverse applications. This comprehensive review examines the historical development, fundamentals, clinical applications, and challenges of bio electromedicine. The historical journey begins with early pioneers such as Luigi Galvani and Alessandro Volta, progresses through milestones like the invention of the ECG, and unfolds to the cutting-edge applications of today. The fundamentals section explores the collaboration of biological systems with electromagnetic fields, the principles of electrical stimulation, and their cellular and molecular mechanism. Bioelectromagnetic safety guidelines, exposure limits, and environmental concerns are also discussed, ensuring responsible integration into medical practice. Clinical applications encompass a wide array, from pain management and neurological disorders to cardiology, neuropsychiatry, oncology, and regenerative medicine. The field continues to evolve, with emerging research areas and technological advancements shaping the future. Personalized bioelectromedicine stands as an exciting frontier. Despite its promise, bioelectromedicine grapples with ethical considerations, the need for robust clinical evidence, public scepticism, and the integration with conventional medical practices. This review encourages further research and development in bioelectromedicine, fostering its potential to revolutionize healthcare and improve patient outcomes in the years to come.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260008"},"PeriodicalIF":0.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Approaches in Benzimidazole Derivatives Research: Recent Insights.","authors":"Pratiksha Narayan Sonwane, Manoj Ramesh Kumbhare","doi":"10.62958/j.cjap.2026.003","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.003","url":null,"abstract":"<p><p>Benzimidazole remains a privileged heteroaromatic scaffold with broad therapeutic potential, spanning antimicrobial, anticancer, antitubercular, and antiviral domains. In recent years (2020-2025), computational methodologies have significantly accelerated benzimidazole-based drug discovery by elucidating structural determinants of activity and streamlining lead optimization. Molecular docking and dynamics simulations consistently reveal the scaffold's ability to engage in π-π stacking, hydrogen bonding, and hydrophobic interactions within protein active sites. Substituent modifications at C2, C5, and C6 critically modulate affinity and selectivity across diverse targets, including InhA, DprE1, kinases, and viral proteases. Complementary strategies such as QSAR, pharmacophore modeling, and in silico ADMET predictions strengthen early hit prioritization and reduce experimental attrition. Emerging approaches integrating artificial intelligence, machine learning, and free energy perturbation further enhance predictive accuracy and enable multi-target drug design. This short communication highlights recent computational insights, best practices, and future trends in benzimidazole research, emphasizing the value of combining docking, MD, QSAR, ADMET, and AI/ML workflows. Together, these advances provide a robust, cost-effective pipeline for the rational design of next-generation benzimidazole derivatives with improved efficacy and translational potential.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260003"},"PeriodicalIF":0.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-Aminobenzothiazole: A Privileged Scaffold for Tyrosine Kinase-Targeted Anticancer Agents.","authors":"Rani D Navle, Nirmala V Shinde, Arti S Raut, Arshad S Shaikh, Sachin K Bhosle, Avishkar Pawar","doi":"10.62958/j.cjap.2026.007","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.007","url":null,"abstract":"<p><p>2-Aminobenzothiazole's planar structure and tendency to bind to a diverse set of oncogenic targets have made 2-aminobenzothiazole a highly sought heterocyclic in research for anticancer agents. In the past 10 years, intense research in medicinal chemistry has clarified that carefully planned substitution for benzothiazole can yield highly efficient and specific anticancer agents. In this critical assessment, we will specifically evaluate both research and efforts related to 2-aminobenzothiazole-based anticancer agents between 2015 and 2024 for their anticancer targets, SAR relationship, and mechanism of action. In particular, we highlight 2-aminobenzothiazole-based compounds targeting CDKs, Aurora kinase, RAF kinase, and various receptor and non-receptor tyrosine kinases such as EGFR, VEGFR-2, CSF1R, MET, FAK, and DYRK2. Besides inhibition of kinase activity, other non-kinase targets are systematically analysed and introduced in this patent review. These include BCL-2 family members, HDACs, epigenetic modifiers (LSD1, NSD1, FTO), HSP90, mutant p53, and DNA topoisomerases. Substitutions at the C-2, C-5, C-6, and C-7 positions of the benzothiazole ring are examined thoroughly about their anticancer properties and target engagement. Also underscored are the existence of commercially available drugs and patented compounds, as well as translational candidates featuring the 2-aminobenzothiazole pharmacophore. The paper emphasises the dual mechanistic targetability of 2-aminobenzothiazole derivatives as valuable lead compounds targeting both kinases and other targets in an innovative manner aimed at future development of targeted anti-cancer therapies.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260007"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etrasimod: A Next-Generation S1P Receptor Modulator for Ulcerative Colitis - Mechanistic Insights and Clinical Progress.","authors":"Manoj R Kumbhare, Arshad S Shaikh, Bhagwan R Ide, Harshali S Gode, Nishant D Pagere, Rutuja K Porje","doi":"10.62958/j.cjap.2026.006","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.006","url":null,"abstract":"<p><p>Etrasimod, a next-generation oral selective sphingosine-1-phosphate (S1P) receptor modulator, has emerged as a promising treatment for immune-mediated inflammatory diseases (IMIDs), most notably moderate-to-severe ulcerative colitis (UC). Acting primarily on S1PR1, S1PR4, and S1PR5, etrasimod effectively reduces gastrointestinal inflammation by retaining lymphocytes in lymphoid tissues, thereby minimising systemic immunosuppression and associated risks. Etrasimod provides better safety, a favorable pharmacokinetic profile, and a short washout period when compared to first-generation modulators, improving patient adherence and efficacy. Its therapeutic potential has been highlighted by clinical trials, such as the ELEVATE UC 12 and ELEVATE UC 52 studies, which showed notable improvements in clinical remission and mucosal healing when compared to placebo. With a tolerable safety profile and convenience of once-daily oral dosing, etrasimod stands out as an important advancement in the management of UC and holds further potential in other IMIDs, representing a step forward in targeted, patient-friendly immune modulation.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260006"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Autophagy in Maintaining Human Health and Disease Prevention.","authors":"Harsha Icharam Narkhede, Karan Jayantilal Jain, Ishita Sanjay Dalvi, Umesh Bhagaji Gite","doi":"10.62958/j.cjap.2026.004","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.004","url":null,"abstract":"<p><p>Autophagy, a highly conserved catabolic process, plays a fundamental role in maintaining cellular homeostasis by degrading and recycling unnecessary or dysfunctional cellular components through lysosomal pathways. It serves as a vital mechanism for clearing damaged proteins, organelles, and other cytoplasmic constituents, ensuring the cell's functional integrity, especially under stress conditions such as nutrient deprivation. Various forms of autophagy macro-autophagy, micro-autophagy, and chaperone-mediated autophagy are involved in distinct regulatory pathways that respond to different physiological and pathological stimuli. Recent research continues to uncover the molecular underpinnings and biological significance of these pathways, emphasizing their critical contributions to human health and disease.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260004"},"PeriodicalIF":0.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substituted 2-Phenyl Imidazolidines: Synthetic Strategies, Biological Activities, Mechanistic Insights, and Nanocarrier-Based Advancements.","authors":"Arti S Raut, Sachin K Bhosle, Rani D Navle, Nirmala V Shinde, Manoj R Kumbhare, Arshad S Shaikh","doi":"10.62958/j.cjap.2026.001","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.001","url":null,"abstract":"<p><p>Substituted 2-phenyl imidazolidines present a structurally diversified family of heterocycles with several medicinal potentials. Their significance is due mostly to the presence of the phenyl group at the C-2 position, which enhances lipophilicity, rigidity, electronic distribution, and molecular recognition. This review summarises the current advances in the synthesis, biological activity, mechanistic understanding, and nanocarrier-based administration of 2-phenyl imidazolidine derivatives. Amongst the most successful synthetic methodologies described are the classical cyclisation processes, condensation pathways, urea/thiourea-based procedures, green chemistry approaches, and nanocatalyst-assisted techniques. These protocols ensure that highly functionalized derivatives are easily accessible. The biological activities of phenyl imidazolidines encompass anticancer, antibacterial, anti-inflammatory, CNS-modulating, antioxidant, and enzyme-inhibitory properties. Accordingly, a mechanistic study shows these phytochemicals interact with major molecular targets like DNA, tubulin, and other enzymes, leading to cell cycle arrest, induction of apoptosis, regulation of reactive oxygen species, and enzyme inhibition. The computational techniques enhance the optimisation based on SAR through the explanation of electrical behaviour and binding interactions. Recent advances in nanotechnology have enabled the encapsulation of these derivatives within polymeric nanoparticles, lipid-based carriers, metal-doped nano-systems, and hybrid nano-structures. These platforms improve therapeutic effectiveness owing to an increase in solubility, stability, and targeted delivery. This review combines synthetic, biological, mechanistic, and formulation factors to serve as a backbone for logical drug design. It highlights the potential of 2-phenyl imidazolidines as attractive scaffolding in the development of new medicinal compounds.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260001"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiazolidine-2,4-Dione: Bridging the Gap Between Synthesis, SAR, and Biological Activities, and Computational Predictions.","authors":"Nirmala V Shinde, Vrushali P Patole, Siddhi M Chandak","doi":"10.62958/j.cjap.2026.002","DOIUrl":"https://doi.org/10.62958/j.cjap.2026.002","url":null,"abstract":"<p><strong>Introduction: </strong>Thiazolidinedione is one of the most important classes in medicinal chemistry. Thiazolidine-2,4-dione (TZD) is a versatile scaffold, best known for its use in the development of anti-diabetic drugs such as pioglitazone and rosiglitazone. Beyond their well-established antidiabetic properties, TZDs exhibit a wide range of biological activities including anticancer, anti-inflammatory, antibacterial, and neuroprotective effects, making them potential candidates for various therapeutic applications.</p><p><strong>Methodology: </strong>This review focuses on the complete journey of TZD derivatives-from their synthetic design to their inclusion in commercialized pharmaceutical products. Structure-activity relationship (SAR) studies were analyzed to understand how modifications in the TZD core affect binding affinity, selectivity, and therapeutic efficacy. In addition, the review consolidates findings from biological evaluations and computational studies that provide deeper insights into the mechanism of action and pharmacological potential of TZD derivatives.</p><p><strong>Conclusion: </strong>This review highlights the significance of the TZD scaffold as a multifunctional pharmacophore in drug discovery. By integrating synthetic strategies, SAR analysis, and advanced computational tools, TZD derivatives continue to show great potential for the development of new therapeutic agents for various diseases. The combined understanding of chemistry and biological activities of TZDs paves the way for innovative research and future drug design.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"42 ","pages":"e20260002"},"PeriodicalIF":0.0,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}