A Pharmacological Study of Shirisharishta and Its Antihistaminic Effects in Guinea Pigs with Reference to Urticaria.

The effect of Shirisharishta on histamine-induced bronchospasm in guinea pigs was evaluated in this study. Guinea pigs were placed in a histamine chamber, and an aerosol of 0.5% histamine was introduced using a compressor and nebulizer. The antihistaminic activity of the compound formulation of Albizzia lebbeck bark, i.e., Shirisharishta, as well as the extracts of its individual Prakshepa Dravyas, was assessed against histamine aerosol-induced bronchospasm in guinea pigs. Additionally, a clinical trial of Shirisharishta was conducted on a group of patients suffering from urticaria, wherein its antiallergic effects were observed and compared to a standard treatment group. The study demonstrated promising antiallergic and bronchodilator activity of Shirisharishta, supporting its therapeutic potential in allergic and respiratory disorders.