{"title":"Mechanistic Insights and Emerging Applications of Nanogel-Based Topical Drug Delivery Systems.","authors":"Manoj Kumbhare, Prajakta Shinde, Dhanashree Mohite, Vaishnavi Rokade, Siddhi Chandak, Aishwarya Dukare","doi":"10.62958/j.cjap.2025.006","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Nanogels (NGs) represent a new generation of nanoscale hydrogel particles with immense biomedical applications, especially drug delivery System (DDS). Nanogels (NGs) are soft and water-retentive materials that deliver drugs in controlled and sustained release while maintaining high biocompatibility and biodegradability.</p><p><strong>Method: </strong>This review paper primarily focuses on the applications, mechanism, therapies. The capability to react with environmental signals, such as pH, temperature, or enzymatic activity, makes nanogels a promising platform for targeted therapy. Polysaccharide-based nanogels increase biocompatibility and reduce toxicity, allowing for extended therapeutic applications.</p><p><strong>Result: </strong>This reviews the structural properties, drug release mechanisms, and newer developments in nanogel formulations. It also presents the future outlook for nanogels in precision medicine, highlighting their potential in transcending pharmacological obstacles towards enhancing drug delivery and therapeutic efficacies in various branches of medicine.</p><p><strong>Conclusion: </strong>By overcoming existing drawbacks, nanogels have the potential to revolutionize drug delivery and therapeutic interventions in diverse clinical settings.</p>","PeriodicalId":23985,"journal":{"name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","volume":"41 ","pages":"e20250006"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62958/j.cjap.2025.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Purpose: Nanogels (NGs) represent a new generation of nanoscale hydrogel particles with immense biomedical applications, especially drug delivery System (DDS). Nanogels (NGs) are soft and water-retentive materials that deliver drugs in controlled and sustained release while maintaining high biocompatibility and biodegradability.
Method: This review paper primarily focuses on the applications, mechanism, therapies. The capability to react with environmental signals, such as pH, temperature, or enzymatic activity, makes nanogels a promising platform for targeted therapy. Polysaccharide-based nanogels increase biocompatibility and reduce toxicity, allowing for extended therapeutic applications.
Result: This reviews the structural properties, drug release mechanisms, and newer developments in nanogel formulations. It also presents the future outlook for nanogels in precision medicine, highlighting their potential in transcending pharmacological obstacles towards enhancing drug delivery and therapeutic efficacies in various branches of medicine.
Conclusion: By overcoming existing drawbacks, nanogels have the potential to revolutionize drug delivery and therapeutic interventions in diverse clinical settings.
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