Zhongguo gu shang = China journal of orthopaedics and traumatology最新文献

{"title":"[Revealing the role of Hippo pathway in osteoarthritis based on transcriptomic analysis].","authors":"Weixiang Pang, Yang Zheng","doi":"10.12200/j.issn.1003-0034.20240912","DOIUrl":"10.12200/j.issn.1003-0034.20240912","url":null,"abstract":"<p><strong>Objective: </strong>To explore the role of Hippo signaling pathway-related genes in osteoarthritis (OA), identify potential diagnostic biomarkers, and provide a basis for precision diagnosis and targeted therapy.</p><p><strong>Methods: </strong>Transcriptomic data from GSE114007 and GSE57218 in GEO database were analyzed. Differentially expressed genes (DEGs) were identified using DESeq2 and intersected with Hippo pathway genes and weighted gene co-expression network analysis (WGCNA) results to obtain differentially expressed Hippo-related genes (DE-HRGs). Candidate genes were screened using the least absolute shrinkage and selection operator (LASSO) regression, support vector machine-recursive feature elimination (SVM-RFE), and the Boruta algorithm. Their diagnostic value was assessed with receiver operating characteristic (ROC) curves and neural network model. To validate the findings, a rat OA model was established by using Hulth method with control and model groups, 8 rats in each group. The control group received no treatment, while OA group were underwent surgical modeling. Four weeks after modeling, X-ray examinations of knee joints were conducted to observe joint space, the shape of joint surfaces, and the formation of bone spurs. The expression levels of epidermal growth factor receptor (EGFR) and protein kinase AMP-activated non-catalytic subunit beta 2 (PRKAB2) in cartilage tissue were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). Gene set enrichment analysis (GSEA) was employed to analyze functional pathways of EGFR and PRKAB2, and single-sample gene enrichment analysis (ssGSEA) was used to evaluate the relationship between key genes and immune cell infiltration.</p><p><strong>Results: </strong>A total of 3, 996 DEGs were identified, and 11 DE-HRGs were obtained. LASSO regression, SVM-RFE and Boruta algorithms jointly selected 5 candidate genes. Among them, EGFR and PRKAB2 had an area under the curve (AUC) greater than 0.8 in both training set and validation set (0.823 and 0.811 respectively), demonstrating excellent diagnostic performance. Neural network model further demonstrated its discriminative ability (with an AUC of 0.835). In rabbit OA model, X-ray images showed control group had narrowed knee joint space accompanied by bone spurs formation. The results of RT-qPCR showed compared with control group, the expressions of EGFR (1.5±0.8) and PRKAB2 (1.2±0.7) in OA group were lower than those in control group (3.8±1.5), (2.9±1.3), and the differences were statistically significant (<i>P</i><0.05). The functional enrichment analysis revealed both EGFR and PRKAB2 were involved in signaling pathways such as Hippo and adenosine monophosphate-activated protein kinase (AMPK). The analysis of immune infiltration results showed PRKAB2 was positively correlated with Th17 cells (<i>r</i>=0.47, <i>P</i><0.01), while EGFR was negatively correlated with natural killer T cells (<i>r</i>=-0.61, <i","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 6","pages":"603-13"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mid-term efficacy of lateral malleolar osteotomy approach combined with bioabsorbable pins fixation for the treatment of talar body fracture].","authors":"Cheng Wang, Yamin Li, Chenglin Wu, Shutao Zhang, Feng Gu, Jieyuan Zhang, Guangyi Li, Guoxun Song, Wenqi Gu, Lei Wang, Xin Ma, Zhongmin Shi","doi":"10.12200/j.issn.1003-0034.20250808","DOIUrl":"10.12200/j.issn.1003-0034.20250808","url":null,"abstract":"<p><strong>Objective: </strong>To explore surgical technique and mid-term efficacy of treating talar body fractures through lateral malleolus osteotomy approach with absorbable rod fixation.</p><p><strong>Methods: </strong>From January 2021 to April 2023, clinical data of 25 patients with talar body fractures who underwent anatomical reduction with absorbable rods via the lateral malleolus osteotomy were retrospectively analyzed, included 15 males and 10 females;aged from 20 to 54 years old with an average of (34.3±8.2) years;8 patients were typeⅡand 17 patients were type Ⅲ according to Sneppen classification of talar body fractures. Fracture healing time, American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, visual analogue scale (VAS), and the occurrence of complications were evaluated.</p><p><strong>Results: </strong>All 25 patients were followed up after operation, the follow-up period ranged from 24 to 52 months with average of(35.7±6.5) months. All patients were achieved fracture healing, and the healing time ranged from 12 to 18 weeks with an average of(15.1±1.7) weeks. AOFAS ankle-hindfoot score increased from (45.28±4.41) points before operation to (88.96±5.19) points at 2 years after operation;13 feet were excellent, 9 feet were good, and 3 feet were fair. VAS decreased from 8.0 (7.0, 9.0) points before operation to 2.0 (1.0, 2.5) points at 2 years after operation, and the differences at each follow-up time point were statistically significant(<i>P</i><0.05). The imaging examinations showed all patients had good healing of talus body fractures and the osteotomy sites. The absorbable rods gradually degraded over a period of 20 to 24 months after operation, without any failure or displacement of internal fixation. No traumatic arthritis or talus necrosis occurred.</p><p><strong>Conclusion: </strong>The lateral malleolus osteotomy approach could provide a good surgical field, and achieve satisfactory reduction results for talus body fractures combined with absorbable rods for fixation. The postoperative functional recovery is satisfactory, and it avoids the need for secondary surgery to remove internal fixation. The mid-term efficacy is also good.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 6","pages":"554-9"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case report of peroneal nerve injury caused by peripheral nerve block anaesthesia of knee joint].","authors":"Mingchun Li, Zhixuan Nian, Yijia Li, Junwen Liang, Sen Fang, Xudong Yang, Cairang DaoJi, Xiaotai Yue, Xiaoyi Tan, Xiangdong Yun","doi":"10.12200/j.issn.1003-0034.20250428","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20250428","url":null,"abstract":"","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 6","pages":"633-6"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application effect of probing technique on reducing screw cut-out risk during sacroiliac screw placement].","authors":"Chen Huang, Huiyun Yuan, Kaifan Tan, Wei Zhou, Yaming Ren, Dongfa Liao","doi":"10.12200/j.issn.1003-0034.20250510","DOIUrl":"10.12200/j.issn.1003-0034.20250510","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the application effect of the probing technique in reducing the risk of screw cutout during sacroiliac (SI) screw placement and to provide a reference for improving the accuracy and safety of screw insertion.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 46 patients with pelvic fractures who underwent percutaneous SI screw placement from October 2019 to December 2024. Patients were divided into a traditional group (<i>n</i>=24) and a probe group (<i>n</i>=22). The traditional group included 14 males and 10 females, aged 19 to 66 years with a mean of (41.88±14.07) years. The probe group included 12 males and 10 females, aged 21 to 64 years with a mean of (39.91±12.86) years. All patients presented with posterior pelvic ring instability, and fracture types were confirmed by preoperative imaging according to the OTA/AO classification. The traditional group received conventional fluoroscopy-guided screw placement, while the probe group adopted a \"guidewire-cannulated screw-probe\" stepwise insertion technique. Outcome measures included operation time, number of fluoroscopic exposures, screw placement accuracy (assessed by postoperative thin-slice CT using the modified Gras classification), and complications.</p><p><strong>Results: </strong>Across the two groups, 57 sacroiliac screws were placed (30 in the traditional group and 27 in the probe group). All patients completed the follow-up, with a duration ranging from 6 to 24 months with a mean of (16.5±4.8) months. Incision healing was successful in all patients postoperatively. The mean number of fluoroscopic exposures in the probe group (17.8±3.9) times was significantly lower than that in the traditional group (23.6±5.1) times (<i>P</i>< 0.001). The mean operation time in the probe group(19.9±5.8) min was significantly shorter than that in the traditional group (23.8±6.3) min (<i>P</i>=0.021). According to the modified Gras grading, the rate of screw malposition in the probe group was 3.7% (1/27), which was lower than 16.67% (5/30) in the traditional group. No revision surgeries were required in the probe group, whereas one case in the traditional group required revision.</p><p><strong>Conclusion: </strong>The probing technique, utilizing tactile feedback within the osseous canal, reduces intraoperative fluoroscopy frequency and operation time while lowering the risk of screw malposition. This technique demonstrates good applicability in patients with sacral anatomical variations or narrow osseous channels, providing a safe and efficient method for the precise placement of SI screws.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"486-92"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application and efficacy analysis of manual reduction combined with anterior surgery for cervical dislocation with facet locking and spinal cord injury].","authors":"Libin Zheng, Weidong Jiao, Wenli Chen, Houjun Xue, Weixiong Chen, Yu Lei, Jiebin Huang, Baiyong Zhu, Ruikun Huo","doi":"10.12200/j.issn.1003-0034.20250304","DOIUrl":"10.12200/j.issn.1003-0034.20250304","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical outcomes, safety, and indications of manual reduction combined with anterior cervical discectomy and fusion (ACDF) for the treatment of cervical dislocation with facet locking and associated spinal cord injury.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 8 patients with cervical dislocation and facet locking accompanied by spinal cord injury treated between January 2015 and December 2024. The cohort included 6 males and 2 females, aged 27 to 85 years. Injury mechanisms included traffic accidents (3 cases), falls from height (2 cases), ground-level falls (2 cases), and heavy object impact (1 case). All patients underwent attempted closed manual reduction assisted by skull traction. Successful reductions proceeded to anterior cervical discectomy and fusion (ACDF), while failed reductions required conversion to posterior open reduction and internal fixation. Neurological function was assessed using the American Spinal Injury Association (ASIA) impairment Scale, Medical Research Council (MRC) muscle grading, and visual analogue scale (VAS) scores. MRI-based spinal cord compression rates, spinal stability, and complications were recorded. Radiographic parameters (Cobb angle, vertebral slippage distance) and fusion status were observed.</p><p><strong>Results: </strong>Closed reduction was successful in 7 cases and failed in 1 case. Seven patients completed follow-up, ranging from 21 days to 80 months. Postoperatively, ASIA grades improved in 6 patients, muscle strength improved in 6 patients, and pain VAS decreased in 6 patients. Radiographic examination confirmed good spinal stability and solid fusion. Postoperative complications included cerebrospinal fluid leakage, axial symptoms, and pressure sore infection.</p><p><strong>Conclusion: </strong>Under strict adherence to indications and preoperative risk assessment, manual reduction combined with anterior surgery effectively relieves facet locking, decompresses the spinal cord, restores spinal stability, and promotes neurological recovery. This combined strategy is a feasible option for selected patients with cervical dislocation and facet locking.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"515-20"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Predictive value of novel inflammatory indices for sarcopenia in patients with hip fractures].","authors":"Junzhe Lang, Zhiqiang Liu, Cheng Zhang, Lei Chen, Congcong Wu","doi":"10.12200/j.issn.1003-0034.20241119","DOIUrl":"10.12200/j.issn.1003-0034.20241119","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the predictive value of novel inflammatory indices for sarcopenia in elderly patients with hip fractures.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 389 consecutive patients with hip fractures treated between June 2014 and October 2024. The cohort comprised 127 males and 262 females, with a median age of 78 (IQR:70, 84). years. Baseline demographic data and hematological parameters within 24 hours post-injury were collected to calculate novel inflammatory indices. Appendicular skeletal muscle mass index (ASMI) and grip strength were measured. Patients were categorized into a sarcopenia group and a non-sarcopenia group based on grip strength and ASMI criteria. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors.</p><p><strong>Results: </strong>A total of 182 patients (46.8%) met the diagnostic criteria for sarcopenia. Multivariate logistic regression analysis revealed that advanced age [<i>OR</i>=1.051, 95%<i>CI</i>(1.024, 1.080), <i>P</i><0.001], low body mass index [<i>OR</i>=0.805, 95%<i>CI</i>(0.746, 0.869), <i>P</i><0.001], and low lymphocyte-to-monocyte ratio (LMR) [<i>OR</i>=0.278, 95%<i>CI</i>(0.190, 0.407), <i>P</i><0.001] were independent risk factors for sarcopenia. Compared with univariate models, the multivariable combined model demonstrated excellent discrimination, with an area under the curve (AUC) of 0.840 (<i>P</i><0.001).</p><p><strong>Conclusion: </strong>Low lymphocyte-to-monocyte ratio (LMR), as a novel inflammatory index, is an independent risk factor for sarcopenia in elderly patients with hip fractures. It offers favorable predictive efficacy, is inexpensive, and readily accessible, providing a new strategy for the screening and management of sarcopenia in this population.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"510-4"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress in vagus nerve stimulation for the intervention of osteoarthritis].","authors":"Yifan Zheng, Maoxiao Ma, Jiayi Guo, Yapeng Li, Chen Yue","doi":"10.12200/j.issn.1003-0034.20250010","DOIUrl":"10.12200/j.issn.1003-0034.20250010","url":null,"abstract":"<p><p>Osteoarthritis (OA) represents one of the most prevalent forms of chronic joint disease. Although conventional therapeutic strategies offer symptomatic relief to a certain extent, their efficacy and applicability are constrained by notable limitations and deficiencies. Vagus nerve stimulation (VNS), emerging as a novel therapeutic modality, has garnered increasing attention due to its operational simplicity, demonstrated efficacy, and independence from geographical constraints. Accumulating evidence indicates that VNS modulates the autonomic nervous system, thereby suppressing pro-inflammatory cytokines and promoting the polarization of macrophages toward an anti-inflammatory phenotype, ultimately alleviating OA symptoms. However, controversies persist regarding optimal stimulation parameters, potential adverse effects, and the overall therapeutic efficacy of VNS. This review summarizes current research advances and unresolved challenges concerning the application of VNS in OA management. Furthermore, it elucidates the underlying mechanisms by which vagus nerve intervention mitigates OA pathology, providing a reference for future research directions in this field.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"527-32"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Finite element analysis of <i>Wu's</i> bone-setting manipulation for thoracolumbar compression fractures].","authors":"Chao Li, Ziyu Wang, Zhen Tan, Pengfei Yu, Zhijia Ma, Wenchao Li, Zhenyu Tang, Hongwei Li","doi":"10.12200/j.issn.1003-0034.20250337","DOIUrl":"10.12200/j.issn.1003-0034.20250337","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of <i>Wu's</i> bone-setting manipulation compared with other techniques for treating simple thoracolumbar compression fractures (type A1) using finite element analysis, and to investigate its therapeutic validity.</p><p><strong>Methods: </strong>A finite element model of a type A1 thoracolumbar compression fracture was established based on the AO classification. Four mechanical loading scenarios were simulated:simple hyperextension position;simple pressing;hyperextension combined with pressing;Wu's bone-setting manipulation. Stress distribution and displacement of the surrounding tissues were observed and analyzed.</p><p><strong>Results: </strong>Under <i>Wu's</i> bone-setting manipulation, the overall stress was 66.20 MPa with a total displacement of 2.32 mm. Specifically, at the L₁ fractured vertebra, the stress reached 33.00 MPa and displacement was 1.70 mm, outperforming the other three scenarios. In the supine position, the capsular ligaments served as crucial fulcrums for reduction. Under the Wu's bone-setting manipulation load, the primary force-bearing structures were the supraspinous ligament and the anterior longitudinal ligament within the sagittal plane around the vertebra.</p><p><strong>Conclusion: </strong>The Wu's bone-setting manipulation concentrates mechanical stress more effectively on the fractured vertebra and induces significantly greater displacement, thereby achieving superior clinical outcomes for type A1 thoracolumbar compression fractures.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"452-8"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Inheritance and innovative development of traditional Chinese manual techniques].","authors":"Min Fang, Jinghu Li, Lingjun Kong","doi":"10.12200/j.issn.1003-0034.20260477","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20260477","url":null,"abstract":"","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"433-6"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exploring the role of the liver-bone axis in inflammatory and immunomodulation of osteoporosis based on the <i>Shaoyang</i> () pivot theory].","authors":"Xiyue Lu, Hui Pei, Hao Li","doi":"10.12200/j.issn.1003-0034.20260235","DOIUrl":"10.12200/j.issn.1003-0034.20260235","url":null,"abstract":"<p><p>Through theoretical review and literature integration, this paper innovatively proposes the theoretical framework of \"<i>Shaoyang</i> () as the pivot-liver-bone axis-osteoimmunology\" and explores the key pivotal role of the liver in the inflammatory and immune regulation of osteoporosis (OP). The article indicates that the dysfunction of the <i>Shaoyang</i> pivot and the failure of the liver to maintain free flow may be key initiating factors that disrupt the homeostasis of the body's neuro-endocrine-immune network. Based on this, the paper further analyzes and demonstrates how the subsequent release of liver-derived pro-inflammatory factors, bile acid metabolism disorders, and overactivation of the sympathetic nervous system act on the bone marrow microenvironment via the \"liver-bone axis\". These abnormal signals induce local immune imbalance in the bone, abnormally activating the receptor activator of nuclear factor kappa-B and its ligand (RANK/RANKL) signaling axis and inhibiting the Wnt/β-catenin osteogenic pathway, ultimately accelerating bone loss. Meanwhile, existing studies suggest that Chinese herbal formulas designed to harmonize Shaoyang, soothe the liver, and clear heat can precisely intervene in the aforementioned pathological processes, reshaping the homeostasis of the liver-bone microenvironment. By exploring the pathogenesis of OP from the perspective of the \"liver-bone axis\" based on the \"<i>Shaoyang</i> as the pivot\" theory, this paper expands the traditional Chinese medicine (TCM) understanding of the complex pathology of OP and provides novel biological evidence and intervention strategies for the prevention and treatment of OP through integrative medicine.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 5","pages":"521-6"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}