Zhongguo gu shang = China journal of orthopaedics and traumatology最新文献

{"title":"[Study on the influencing factors of vitamin D level in female patients with knee osteoarthritis].","authors":"Xuezong Wang, Hengzhi Wang, Daofang Ding, Yuxin Zheng, Yuelong Cao","doi":"10.12200/j.issn.1003-0034.20240861","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240861","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the characteristics of vitamin D (Vit D) and identify factors influencing Vit D deficiency in patients with knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>Patients diagnosed with KOA between January 2018 and December 2023 were enrolled as study subjects. A total of 260 KOA patients with available Vit D test records were included, consisting of 214 females and 46 males, with a mean age of (71.95±8.35) years and a median disease duration of 5 (4.00, 9.00) years. Differences in the severity of Vit D deficiency between the general population and KOA patients, as well as changes in Vit D levels at different stages of KOA progression, were compared. Multivariate Logistic regression and nested analysis were used to investigate the influencing factors of Vit D in female patients with KOA.</p><p><strong>Results: </strong>A total of 260 KOA patients were included. The median Vit D level was 17.31 (12.45, 25.91) ng·mL-1. The numbers of patients with normal, insufficient, and deficient Vit D were 35, 74, and 151, respectively. Multivariate Logistic regression analysis showed that Vit D levels in KOA patients were influenced by female sex (<i>OR</i>=3.909, 95% <i>CI</i>(0.490, 2.236), <i>P</i>=0.002), imaging grading(<i>OR</i>=17.486, 95%<i>CI</i>(0.220, 5.503), <i>P</i>=0.034), and osteoporosis (<i>OR</i>=0.134, 95% <i>CI</i>(3.381, -0.635), <i>P</i>=0.004). Nested analysis demonstrated that osteoporosis with Vit D supplementation reduced the risk of Vit D deficiency (<i>OR</i>=0.094, <i>P</i>=0.014), while a history of fracture increased the risk of Vit D deficiency (<i>OR</i>=5.750, <i>P</i>=0.015).</p><p><strong>Conclusion: </strong>Female patients with KOA are susceptible to Vit D deficiency, with Vit D levels influenced by imaging grading, osteoporosis status, and fracture history. Regular monitoring and supplementation of Vit D in female KOA patients may delay the progression of the disease.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"343-8"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances and development trends in non-surgical treatment of knee osteoarthritis].","authors":"Rui He","doi":"10.12200/j.issn.1003-0034.20260382","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20260382","url":null,"abstract":"","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"325-8"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of exosome carrying RNA in the treatment of hormone-induced osteonecrosis].","authors":"Yue Meng, Rui Bao, Dongyu Shang, Xilin Xu, Dawei Zhang, Yichang Jiang","doi":"10.12200/j.issn.1003-0034.20250363","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20250363","url":null,"abstract":"<p><p>Osteonecrosis is a metabolic disease commonly induced by glucocorticoid administration, which impedes the blood supply to bone, promotes osteocyte death, and subsequently leads to alterations in bone structure and collapse of the femoral head. Key molecular mechanisms include osteocyte apoptosis, dysregulated autophagy, oxidative stress, and vascular endothelial dysfunction, among others. Although progress has been made in understanding the pathogenesis of steroid-induced osteonecrosis, the development of effective preventive and therapeutic strategies remains an ongoing challenge. Exosomes are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication. Their unique cargo capacity enables them to transport bioactive molecules, including ribonucleic acid (RNA), between cells. Increasing evidence suggests that RNA-loaded exosomes exert dual therapeutic effects:directly promoting osteogenesis and angiogenesis, and modulating pathological processes via the delivery of regulatory RNAs. These properties indicate that exosomes hold immense potential for targeted intervention and therapy in osteonecrosis.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"426-32"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of bone-setting manipulation on lower extremity alignment in patients with varus knee osteoarthritis].","authors":"Xi Li, Jian Zhang, Guohui Liu, Yunhao Liu, Zekun Zhang, Tianci Gao, Jingxi Wang, Yongwang Zhang, Shilin Yin, Lu Liu, Liqing Qi, Shuangqing Du","doi":"10.12200/j.issn.1003-0034.20240350","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240350","url":null,"abstract":"<p><strong>Objective: </strong>To observe the effect of bone setting manipulation on the lower limb alignment in patients with varus knee osteoarthritis (KOA), and to elucidate the underlying therapeutic mechanism.</p><p><strong>Methods: </strong>A total of 100 patients with KOA who received bone-setting manipulation between October 2022 and October 2023 were enrolled. Among them, there were 24 males and 76 females, the age ranged from 47 to 75 years with a mean age of (62.9±8.2) years and a disease course ranging from 0.25 to 20 years . All patients were treated with bone-setting manipulation on spine, hip joint, knee joint, and ankle joint.The Western Ontario and McMaster Universities osteoarthritis index (WOMAC) was adopted to evaluate knee joint function. Full-length weight-bearing X-rays of both lower extremities were performed on each patient before treatment and 2 weeks after treatment. The changes in the hip-knee-ankle (HKA) angle of both lower extremities at 2 weeks after treatment compared with those before treatment, as well as the changes in the gap between the HKA angles of both lower extremities before treatment and 2 weeks after treatment, were observed and recorded.</p><p><strong>Results: </strong>A total of 89 patients were followed up at 2 weeks after treatment. The WOMAC score at 2 weeks after treatment was 23.0 (15.0, 31.0), which was lower than the preoperative score of 42.0 (34.3, 49.0), and the difference was statistically significant (<i>P</i><0.001). There was no statistically significant difference in the HKA angles of the unaffected and affected sides between before treatment and 2 weeks after treatment(<i>P</i>>0.05). However, the absolute value of the HKA angle difference between the unaffected and affected sides at 2 weeks after treatment was 1.8 (0.8, 3.2)°, which was lower than that before treatment 2.1(1.0, 3.5)°, and the difference was statistically significant (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Bone-setting manipulation is effective in reducing pain, stiffness, and improving joint function in patients with KOA. The therapeutic mechanism may be due to the correction of the subtle dislocation across the spine, hip, knee, and ankle, thereby reducing bilateral lower limb mechanical axis discrepancies and balancing weight distribution across both knee joints.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"329-35"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of ultrasound in the treatment of supracondylar fractures of humerus in children complicated with nerve injury].","authors":"Dengshan Chen, Donghui Du, Lei Wang, Chuanwei Zhang, Xingpo Ding","doi":"10.12200/j.issn.1003-0034.20230758","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20230758","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of ultrasound in the treatment of supracondylar fractures of humerus in children complicated with nerve injury.</p><p><strong>Methods: </strong>Between January 2019 and January 2022, a total of 21 patients of supracondylar fracture of humerus in children with nerve injury underwent ultrasound-guided treatment. The patients ranged in age from 2 to 10 years old and included 13 boys and 8 girls. Of these patients, 13 were associated with radial nerve injury, 6 with median nerve injury, and 2 with ulnar nerve injury. Preoperative ultrasonography was used to evaluate nerve injury. According to the classification proposed by ZHU et al., typeⅠand typeⅡ fractures are treated with closed reduction and percutaneous Kirschner wire internal fixation, while type Ⅶ fractures require open exploration to assess nerve injury. The recovery of nerve function was evaluated according to the trial standard for the assessment of peripheral nerve function in the upper limb. The postoperative elbow joint function was evaluated using the Flynn score.</p><p><strong>Results: </strong>All 21 patients were followed up for a period ranging from 6 to 12 months, fracture healing time ranged from 4 to 6 weeks, while the nerve recovery period varied between 1.5 and 4.0 months. The evaluation results of nerve recovery were excellent in 20 cases, good in 1 case, fair in 0 case, and poor in 0 case. None of the children had cubitus varus or cubitus valgus. Elbow joint function Flynn score results:excellent in 20 cases, good in 1 case, fair in 0 case, poor in 0 case.</p><p><strong>Conclusion: </strong>In the treatment of supracondylar fracture of humerus complicated with nerve injury, ultrasound provides a reference for the choice of treatment plan, reducing the probability of re-nerve injury, no radiation, good recovery of elbow joint function and other advantages, and the clinical effect is satisfactory.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"419-25"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the correlation between bony structural abnormalities and clinical symptoms in lumbar disc herniation].","authors":"Shuaiqi Zhou, Jie Yu, Minghui Zhuang, Minshan Feng, Guangqi Lu, Hanze Mao, Zhefeng Jin, Liguo Zhu","doi":"10.12200/j.issn.1003-0034.20250976","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20250976","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between imaging characteristics of the lumbar bony structure (such as scoliosis, instability, ligament ossification, etc.) and lumbocrural pain as well as functional impairment in patients with lumbar disc herniation (LDH).</p><p><strong>Methods: </strong>A national multi-center cross-sectional study was performed, enrolling 1 046 patients with lumbar disc herniation (LDH). Bony structural parameters were assessed using X-ray and computed tomography (CT), including scoliosis (Cobb angle >10°), lumbar curvature (normal/straightened/kyphotic), angular instability (intervertebral angular displacement≥11°), horizontal instability (intervertebral horizontal displacement ≥3.5 mm), ossification of the ligamentum flavum, intervertebral disc calcification, and ossification of the posterior longitudinal ligament. Clinical symptoms were evaluated using the visual analogue scale (VAS) for low back and leg pain, and functional status was assessed using the Oswestry disability index (ODI).</p><p><strong>Results: </strong>Leg VAS was positively correlated with ossification of the ligamentum flavum (<i>r</i>=0.080, <i>P</i>=0.009) and ossification of the posterior longitudinal ligament (<i>r</i>=0.069, <i>P</i>=0.025), and negatively correlated with horizontal instability (<i>r</i>=-0.074, <i>P</i>=0.017). Back VAS was positively correlated with abnormal lumbar curvature (<i>r</i>=0.076, <i>P</i>=0.014), ossification of the ligamentum flavum (<i>r</i>=0.070, <i>P</i>=0.024), and disc herniation with ossification (<i>r</i>=0.104, <i>P</i>=0.001). ODI was positively correlated with leg VAS (<i>r</i>=0.540, <i>P</i>=0.001), back VAS (<i>r</i>=0.585, <i>P</i><0.001), and lumbar scoliosis (<i>r</i>=0.090, <i>P</i>=0.004), and negatively correlated with angular instability (<i>r</i>=-0.110, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>In patients with LDH, bony structural abnormalities (especially ligament ossification and altered lumbar curvature) are partially correlated with low back and leg pain as well as functional impairment. However, pathological changes in bony structures are not the sole factor responsible for severe clinical symptoms. Clinical symptoms in LDH patients are modulated by multiple factors. Future prospective studies are warranted to verify causal relationships, and further exploration should be performed by integrating various imaging modalities and artificial intelligence techniques.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"388-94"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation analysis of degenerative cartilage injury and bone marrow edema with osteoporosis in knee osteoarthritis based on quantitative CT].","authors":"Ning Zhu, Jian Zhai","doi":"10.12200/j.issn.1003-0034.20240513","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240513","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between cartilage injury, bone marrow edema and osteoporosis in patients with knee osteoarthritis (KOA) using quantitative computed tomography (QCT).</p><p><strong>Methods: </strong>A retrospective analysis was performed on chest CT and clinical data of 86 patients with LOA between January 2020 and December 2022. The patients included 23 males and 63 females, aged from 42 to 74 years with a mean age of(57.72±7.97) years. Bone mineral density (BMD) of T₁₂ and L₁ vertebrae was measured using QCT. According to Outerbridge classification, patients were graded into grade 2, grade 3, and grade 4 cartilage injury. Bone marrow edema was evaluated on knee MRI. The differences in BMD among different grades of cartilage injury were compared, and correlation analysis and partial correlation analysis were performed. The incidence of osteoporosis was compared between groups with and without bone marrow edema, and the correlation between BMD values and bone marrow edema was analyzed.</p><p><strong>Results: </strong>There were statistically significant differences in age, T₁₂ and L₁ BMD, and the incidence of osteoporosis among different cartilage injury grades (<i>P</i><0.001). Statistically significant differences were observed in BMD between grade 2 and grade 3, and between grade 2 and grade 4(<i>P</i><0.001), while no significant difference was found between grade 3 and grade 4(<i>P</i>>0.05). The severity of cartilage injury was inversely correlated with T₁₂, T₁₂^*, L₁ BMD, and M-BMD, with <i>r</i> values of -0.377, -0.382, -0.437, and -0.407, respectively(all <i>P</i>< 0.001). After adjusting for confounding factors including age, BMI, and gender using partial correlation analysis, the severity of cartilage injury still showed a certain inverse correlation with M-BMD(<i>r</i>=-0.210, <i>P</i>=0.033). The incidence of osteoporosis was higher in patients with bone marrow edema than in those without bone marrow edema. Bone marrow edema was inversely correlated with T₁₂, T₁₂^* BMD, and M-BMD, with r values of -0.242, -0.246, -0.208, and -0.227, respectively (all <i>P</i><0.05).</p><p><strong>Conclusion: </strong>In patients with KOA, T₁₂ and L₁ BMD gradually decreased and the incidence of osteoporosis gradually increased with the worsening of cartilage injury. T₁₂ and L₁ BMD were lower in KOA patients with bone marrow edema than in those without bone marrow edema.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"349-54"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Significance of staged lateral lumbar interbody fusion in the treatment of degenerative lumbar scoliosis with sagittal imbalance].","authors":"Oujie Lai, Yong Hu, Weixin Dong, Bingke Zhu, Xiaoyang Sun, Jianbin Zhong, Zhenshan Yuan","doi":"10.12200/j.issn.1003-0034.20240265","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240265","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical and radiological outcomes of staged lateral lumbar interbody fusion (LLIF) combined with posterior fusion and fixation in the treatment of degenerative lumbar scoliosis (DLS) with sagittal imbalance, and to quantitatively evaluate the contribution of LLIF to deformity correction in the staged treatment strategy.</p><p><strong>Methods: </strong>Between January 2018 and January 2022, 35 patients with DLS accompanied by sagittal imbalance underwent stageⅠLLIF combined with stageⅡposterior fusion and fixation. There were 13 males and 22 females, aged from 56 to 79 years with a mean of (68.63±7.03) years, with a disease duration of (36.89±14.41) months. The visual analogue score (VAS) and Oswestry disability index (ODI) were used to evaluate changes in low back and leg pain as well as functional status preoperatively and postoperatively. Imaging parameters were assessed preoperatively, after stageⅠsurgery, after stageⅡsurgery, and at the final follow-up.</p><p><strong>Results: </strong>All patients were followed up for a mean of(24.20±7.36) months. The mean operation time was (294.14±35.15) min, and the total blood loss was (584.14±197.58) mL. The mean number of LLIF levels per patient was (3.23±0.55), and the mean number of posterior fixation levels was (6.80±1.84). The low back pain VAS score decreased from (6.29±0.99) preoperatively to(2.54±0.70) at the final follow-up, with a statistically significant difference(<i>P</i><0.01). The leg pain VAS score decreased from (6.14±1.06) preoperatively to (2.03±0.75) at the final follow-up, with a statistically significant difference (<i>P</i><0.01). The ODI score improved from (68.54±12.36)% preoperatively to (26.74±8.37)% at the final follow-up, with a statistically significant difference (<i>P</i><0.01). Compared with preoperative values, sagittal and coronal plane deformities were significantly corrected after staged surgery and were well maintained at the final follow-up. In the staged treatment protocol, stageⅠLLIF contributed 67.17% of the total correction for Cobb angle, 56.65% for lumbar lordosis (LL)angle, 52.69% for sagittal vertical axis (SVA) correction, and 56.21% for pelvic incidence (PI)-LL mismatch correction. Postoperative complications occurred in 12 patients.</p><p><strong>Conclusion: </strong>StageⅠmultilevel lateral LLIF combined with stageⅡposterior fusion and fixation achieves favorable clinical and radiological outcomes in the treatment of DLS with sagittal imbalance. In the staged procedure, stageⅠmultilevel LLIF plays a crucial role in the correction of coronal and sagittal plane deformities and shows potential advantage of simplifying the stageⅡsurgical strategy.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"360-6"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intramedullary augmentation with bone cement for the treatment of osteoporotic proximal humeral fractures in elderly patients].","authors":"Tao Xu, You Zhou, Hongjun Fu","doi":"10.12200/j.issn.1003-0034.20240013","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240013","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare the clinical efficacy of two internal fixation methods in the treatment of osteoporotic proximal humeral fractures(PHF) in elderly patients:anatomical locking plate combined with intramedullary bone cement augmentation versus plate combined with bone grafting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on 59 elderly patients with osteoporotic PHF who underwent open reduction and anatomical locking plate and screw fixation between January 2019 and January 2022. Of these patients, 23 were treated with intramedullary augmentation using bone cement (bone cement group), including 7 males and 16 females, aged from 60 to 83 years with a mean of(66.52±5.30) years, with a time from injury to surgery of 2 (1, 3) days. Thirty-six patients were treated with bone grafting(bone graft group), including 11 males and 25 females, aged from 61 to 85 years with a mean of (69.22±6.55) years, with a time from injury to surgery of 2 (2, 4) days. The operation time, total incision length, number of intraoperative fluoroscopy times, intraoperative blood loss, and length of hospital stay were observed and recorded in both groups. The upper extremity joint function was evaluated using the Constant-Murley score and the disability of the arm, shoulder and hand(DASH) score. The humeral neck shaft angle and adverse imaging findings were also documented.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All patients were followed up for a period of 18 to 54 months, with a mean±standard deviation of (30.8±9.2) months. Operations were successfully performed in all patients of both groups, and no statistically significant differences were observed between the two groups in terms of operation time, total incision length, number of intraoperative fluoroscopies, intraoperative blood loss, or length of hospital stay (all &lt;i&gt;P&lt;/i&gt;&gt;0.05). At the final follow-up, the mean Constant-Murley score was(73.00±5.25) points in the bone cement group and (64.25±5.60) points in the bone graft group, while the mean DASH score was (13.91±4.62) points and (18.47±8.14) points in the two groups, respectively. The bone cement group exhibited significantly better upper extremity joint function than the bone graft group, with statistically significant differences (both &lt;i&gt;P&lt;/i&gt;&lt;0.05). Regarding imaging findings, the humeral neck-shaft angle in the bone graft group was (134.61±1.75)° on the first day postoperatively and (132.86±1.84)° at the final follow-up, showing a statistically significant decrease (&lt;i&gt;P&lt;/i&gt;&lt;0.001). In contrast, the humeral neck-shaft angle in the bone cement group was(135.35±1.47)° on the first day postoperatively and (135.42±1.68)° at the final follow-up, with no statistically significant difference(&lt;i&gt;P&lt;/i&gt;=0.128). At the final follow-up, the humeral neck-shaft angle was significantly smaller in the bone graft group than in the bone cement group(&lt;i&gt;P&lt;/i&gt;&lt;0.001). No statistically significant difference was noted in postoperative adve","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"355-9"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Protecting effect of Quan Duzhong Capsule() on the cartilaginous endplate so as to improve acupuncture-induced intervertebral disc degeneration].","authors":"Songlin Liang, Nianhu Li, Jiawen Zhan, Hongyan Guo, Changjun Tie, Yanjie Zhu, Zhichao Li, Liqing Ke, Peng Zhang, Wenxiang Cheng","doi":"10.12200/j.issn.1003-0034.20240031","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240031","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the protective effect and underlying mechanism of &lt;i&gt;Quan Duzhong&lt;/i&gt; Capsule () on acupuncture-induced caudal intervertebral disc degeneration in rats.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Sixty male Sprague-Dawley rats were weight-stratified and randomly divided into 6 groups (10 rats per group). A 26 G needle was used to puncture the rat coccygeal vertebrae to establish an intervertebral disc degeneration model, while the control group only received acupuncture on the skin lateral to the coccygeal vertebrae. The model groups received either &lt;i&gt;Quan Duzhong&lt;/i&gt; Capsule () at a dose of 300 mg·kg-1 or normal saline via intragastric administration. Samples were collected at 4 and 8 weeks post-modeling, respectively. Longitudinal assessment included weekly 3.0 T MRI scans to dynamically evaluate changes in the nucleus pulposus, with measurements of the nucleus pulposus height, area, signal value, and the disc height index(DHI). Isolated coccygeal segments underwent micro-computed tomography (Micro-CT) to analyze the morphological changes in the vertebrae at both ends of the modeled intervertebral discs, and bone microstructure parameters were analyzed. Coccygeal vertebral tissues were decalcified and embedded in paraffin. Hematoxylin-eosin (HE) staining and Toluidine Blue staining were used to assess the tissue morphology and cartilage damage. Immunohistochemistry was performed to analyze the expression of aggrecan (Acan) and typeⅡcollagen(ColⅡ). Total mRNA was extracted from the nucleus pulposus, and quantitative reverse transcription polymerase chain reaction(qRT-PCR) was used to detect the gene expression of Acan and ColⅡ.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;MRI scan results showed that compared with the control group, the nucleus pulposus signal at the injured site in the model group gradually disappeared with the increase of time after acupuncture modeling, indicating the successful establishment of the acupuncture-induced caudal intervertebral disc degeneration model. Dynamic MRI acquisition data revealed that the T2WI signal value, height, area, and DHI of the nucleus pulposus in rats of the &lt;i&gt;Quan Duzhong&lt;/i&gt; Capsule() administration group were significantly higher than those in the model group(&lt;i&gt;P&lt;/i&gt;&lt;0.05). Micro-CT analysis results demonstrated that after 8 weeks of &lt;i&gt;Quan Duzhong&lt;/i&gt; Capsule() treatment, the bone volume of the vertebrae adjacent to the nucleus pulposus injury site and the trabecular bone thickness were significantly increased compared with the model group (&lt;i&gt;P&lt;/i&gt;&lt;0.05), while the bone surface area to bone volume ratio, structural model index, trabecular separation, and pattern factor were significantly decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Histological staining results indicated that compared with the model group, the intervertebral disc tissue morphology in &lt;i&gt;Quan Duzhong&lt;/i&gt; Capsule () administration group was relatively intact;Toluidine blue staining showed that the chondrocyte layer i","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"39 4","pages":"407-18"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}