Zhongguo gu shang = China journal of orthopaedics and traumatology最新文献

{"title":"[Analysis of clinical characteristics and influencing factors of patients with postmenopausal osteoporosis combined with dyslipidemia].","authors":"Rong Xie, Li-Guo Zhu, Zi-Kai Jin, Tian-Xiao Feng, Ke Zhao, Da Wang, Ling-Hui Li, Xu Wei","doi":"10.12200/j.issn.1003-0034.20250217","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20250217","url":null,"abstract":"<p><strong>Objective: </strong>To explore the co-morbid influencing factors of postmenopausal osteoporosis(PMOP) and dyslipidemia, and to provide evidence-based basis for clinical co-morbidity management.</p><p><strong>Methods: </strong>Based on the 2017 to 2018 Beijing community cross-sectional survey data, PMOP patients were included and divided into the dyslipidemia group and the uncomplicated dyslipidemia group according to whether they were comorbid with dyslipidemia. Demographic characteristics, living habits and disease history were collected through questionnaires, and bone mineral density and bone metabolism biomarkers (osteocalcin, blood calcium, serum typeⅠprocollagen N-terminal prepeptide, etc.) were detected on site. Co-morbidity risk factors were analyzed using binary logistic regression.</p><p><strong>Results: </strong>Three hundred and twenty patients with PMOP were included, including the comorbid group (75 patients) and the uncomplicated group (245 patients). The results showed that history of cardiovascular disease [<i>OR</i>=1.801, 95%<i>CI</i>(1.003, 3.236), <i>P</i>=0.049], history of cerebrovascular disease [<i>OR</i>=2.923, 95%<i>CI</i>(1.460, 5.854), <i>P</i>=0.002], frying and cooking methods[<i>OR</i>=5.388, 95%<i>CI</i>(1.632, 17.793), <i>P</i>=0.006], OST results[<i>OR</i>=0.910, 95%<i>CI</i>(0.843, 0.983), <i>P</i>=0.016], and blood Ca results [<i>OR</i>=60.249, 95%<i>CI</i>(1.862, 1 949.926), <i>P</i>=0.021] were the influencing factors of PMOP complicated with dyslipidemia.</p><p><strong>Conclusion: </strong>Focus should be placed on the influencing factors of PMOP and dyslipidemia co-morbidities, with emphasis on multidimensional assessment, combining lifestyle interventions with bone metabolism marker monitoring to optimize co-morbidity management.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 5","pages":"487-93"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association relation of C₀-C₂ Cobb angle and cervical disc herniation].","authors":"Zhuo-Heng Mai, Yuan-Li Gu, Hai-Ling Wang, Li-Ying Zhang, Sheng-Qiang Zhang","doi":"10.12200/j.issn.1003-0034.20240645","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240645","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Objective To investigate the relationship between cervical disc herniation and C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The clinical data of 301 patients with cervical disc herniation from 2020 to 2024 were retrospectively analyzed. The median value of C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle measurements from 301 patients was used as the boundary, cervical disc herniation patients were divided into two groups, C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle &lt;28.50 group and 151 patients with C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle≥28.50 group. Among them, 150 patients in C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle &lt;28.50 group included 53 males and 97 females, aged 23 to 76 (57.32±12.55) years, with a disease duration of 7 to 19 (13.81±5.32) months;the othor 151 patients with C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle≥28.50 group including 61 males and 90 females, aged 25 to 74 (56.86±12.51) years, with a disease duration of 8 to 18 (14.13±5.56) months. The cervical lordosis angle (C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle and C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; Cobb angle), T&lt;sub&gt;1&lt;/sub&gt; inclination slope (T&lt;sub&gt;1&lt;/sub&gt;S) and cervical sagittal axial distance (C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; SVA) were measured on the lateral cervical radiographs. The correlation between C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle and cervical disc herniation range, protrusion position, average protrusion size and other parameters was analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;When the C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle&lt;28.50°, the average protrusion size was (2.21±0.56) mm, the C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; Cobb angle was (19.92±12.06)° and the C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; SVA was (1.10±1.20) mm. When the C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle≥28.50°, the average protrusion size was (2.38±0.60) mm, the C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; Cobb angle was (12.01±13.09 )°, the C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; SVA was (1.53±1.36) mm, and the difference was statistically significant (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Between the two groups of patients with C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle &lt; 28.50° and C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle≥28.50°, there were significant differences in the size of C&lt;sub&gt;3,4&lt;/sub&gt;, C&lt;sub&gt;4,5&lt;/sub&gt;, C&lt;sub&gt;5,6&lt;/sub&gt;, C&lt;sub&gt;6,7&lt;/sub&gt;, C&lt;sub&gt;7&lt;/sub&gt;, T&lt;sub&gt;1&lt;/sub&gt; disc herniation in single segment (&lt;i&gt;P&lt;/i&gt;&lt;0.05 ). C&lt;sub&gt;0&lt;/sub&gt;-C&lt;sub&gt;2&lt;/sub&gt; Cobb angle was correlated with age(&lt;i&gt;r&lt;/i&gt;=-0.135, &lt;i&gt;P&lt;/i&gt;&lt;0.05 ), C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; Cobb angle (&lt;i&gt;r&lt;/i&gt;=-0.382, &lt;i&gt;P&lt;/i&gt;&lt;0.01 ), C&lt;sub&gt;2&lt;/sub&gt;-C&lt;sub&gt;7&lt;/sub&gt; SVA (&lt;i&gt;r&lt;/i&gt;=0.293, &lt;i&gt;P&lt;/i&gt;&lt;0.01), average protrusion size (&lt;i&gt;r&lt;/i&gt;=0.139, &lt;i&gt;P&lt;/i&gt;&lt;0.05), and the size of C&lt;sub&gt;3,4&lt;/sub&gt; (&lt;i&gt;r&lt;/i&gt;=0.215, &lt;i&gt;P&lt;/i&gt;&lt;0.01 ), C&lt;sub&gt;4,5&lt;/sub&gt; (&lt;i&gt;r&lt;/i&gt;=0.176, &lt;i&gt;P&lt;/i&gt;&lt;0.01 ), C&lt;sub&gt;5,6&lt;/sub&gt; (&lt;i&gt;r&lt;/i&gt;=0.144, &lt;i&gt;P&lt;/i&gt;&lt;0.05 ), C&lt;sub&gt;6,7&lt;/sub&gt; (&lt;i&gt;r&lt;/i&gt;=0.158, &lt;i&gt;P&lt;/i&gt;&lt;0.05 ), C&lt;sub&gt;7&lt;/sub&gt;T&lt;sub&gt;1&lt;/sub&gt; (&lt;i&gt;r&lt;/i&gt;=0.535, &lt;i&gt;P&lt;/i&gt;&lt;0.05) disc herniation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;There is a positive c","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 5","pages":"494-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of Yishen Yangsui formula() on pyroptosis in the spinal cord tissue in rats with degenerative cervical myelopathy].","authors":"Guo-Liang Ma, He Yin, Bo Xu, Min-Shan Feng, Dan Zhang, Dian Zhang, Xiao-Kuan Qin, Li-Guo Zhu, Bo-Wen Yang, Xin Chen","doi":"10.12200/j.issn.1003-0034.20240880","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240880","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To preliminarily investigate the effects and mechanism of action of Yishen Yangsui Formula (, YSYSF)on the recovery of neurological function in rats with degenerative cervical myelopathy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Fifty adult SD female rats were randomly divided into control group, sham group, model group, YSYSF group and positive drug group by using randomized numerical table method. In the model group, YSYSF group and positive drug group, polyvinyl alcohol acrylamide interpenetrating network hydrogel(water-absorbent swelling material) was used to construct a rat spinal cord chronic compression model. The sham group was implanted with the water-absorbent swelling material and then removed without causing spinal cord compression. The control group, the sham group and the model group were given equal amounts of saline by gavage, the group of YSYSF was given Chinese herbal medicine soup by gavage 9.1 g·kg&lt;sup&gt;-1&lt;/sup&gt; once a day, and the positive drug group was given tetrahexylsalicylglucoside sodium monosialate ganglioside by intraperitoneal injection 4.2 mg·kg&lt;sup&gt;-1&lt;/sup&gt; once a day. The motor function of the rats was assessed by the BBB method after 1, 3, 7, and 14 d of drug administration. The spinal cord tissues were taken from rats executed 14 d after drug administration, and the morphological changes of the spinal cord compression site were observed by HE staining, and the expression levels of Caspase-1, GSDMD, NLRP3, PYCARD, IL-1β, and IL-18 were detected in the area of spinal cord injury by Western blot method.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The BBB scores of the control group and the sham group were normal at all time points after modeling, which were higher than the BBB scores of the model group, the YSYSF, and the positive drug group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). From the 3rd day after gavage, at all time points, the BBB scores of rats in the YSYSF group and the positive drug group were higher than those of rats in the model group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The staining pattern of HE spinal cord tissue was normal in the control group and the sham group, and the HE spinal cord in the model group was severely damaged with a large number of neuron deaths, whereas the damage to the spinal cord and neuron cells was reduced in the YSYSF group and the positive drug group. The expression levels of caspase-1, GSDMD, NLRP3, PYCARD, IL-1β and IL-18 in the spinal cord of the model group were significantly higher than those of the sham group (&lt;i&gt;P&lt;/i&gt;&lt;0.0001), and the expression levels of caspase-1, GSDMD, NLRP3, PYCARD, IL-1β, and IL-18 in the YSYSF group and the drug group were significantly lower than those in the model group (&lt;i&gt;P&lt;/i&gt;&lt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;YSYSF can improve the motor function of rats with degenerative cervical spinal cord disease, alleviate the pathological changes, and promote the recovery of spinal cord neurological function. The specific mechanism may be related to the inhibition of the act","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 5","pages":"532-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress in investigating astrocyte heterogeneity after spinal cord injury based on single-cell sequencing technology].","authors":"Lei Du, Yan-Jun Zhang, Tie-Feng Guo, Lin-Zhao Luo, Ping-Yi Ma, Jia-Ming Li, Sheng Tan","doi":"10.12200/j.issn.1003-0034.20240352","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240352","url":null,"abstract":"<p><p>In recent years, the study of single-cell transcriptome sequencing technology in the heterogeneity of astrocytes (astrocytes) after spinal cord injury (SCI) has provided new perspectives on post-traumatic nerve regeneration and repair. To provide a review on the research progress of single-cell sequencing technology in astrocytes after spinal cord injury (SCI), and to more comprehensively and deeply elaborate the application of single-cell sequencing technology in the field of astrocytes after SCI. Single-cell sequencing technology can analyse the transcriptomes of individual cells in a high-throughput manner, thus revealing fine differences in cell types and states. By using single-cell sequencing technology, the heterogeneity of astrocytes after SCI and their association with nerve regeneration and repair were revealed. In conclusion, the application of single-cell sequencing technology provides an important tool to reveal the heterogeneity of astrocytes after SCI, to further explore the mechanisms of astrocytes in SCI, and to develop intervention strategies targeting their regulatory mechanisms in order to improve the therapeutic efficacy of SCI. The discovery of changes in astrocyte transcriptome dynamics has improved researchers' understanding of spinal cord injury lesion progression and provided new insights into the treatment of spinal cord injury at different time points. To date, all of these findings need to be validated by more basic research and sufficient clinical trials. In the future, single-cell sequencing technology, through interdisciplinary collaboration with bioinformatics, computer science, tissue engineering, and clinical medicine, is expected to open a new window for the treatment of spinal cord injury.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 5","pages":"544-8"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical correlation study between bone metabolism level and knee osteoarthritis pain].","authors":"Yong-Qi Sun, Ke-Chun Guo, Ze-Zhong Liu, Jin-Shuai Duan, Bing Xu, Guo-Gang Luo, Xian-Liang Lai, Xiao-Feng Wang","doi":"10.12200/j.issn.1003-0034.20240038","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240038","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the variability of bone metabolism levels among different populations and its association with knee osteoarthritis (KOA) pain.</p><p><strong>Methods: </strong>A total of 50 people (control group) who participated in physical examination from January 2023 to June 2023 were selected, including 26 males and 24 females, wtih a mean aged of (52.14±9.04) years old ranging 41 to 65 years old. The other 50 patients with knee osteoarthritis(case group) who attended the outpatient clinic of the Orthopedics and Traumatology Department in the same time period, including 19 males and 31 females, with a mean age of (53.60±7.76) years old ranging 40 to 65 years. The two groups of Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and bone metabolism markers, such as 25-hydroxy-cholecalciferol[25(OH)D], β-isomerized typeⅠcollagen C-telopeptide breakdown products (β-CTX), total typeⅠprocollagen N-terminal propeptide (t-PINP), osteocalcin (OC), parathormone (PTH) levels were compared. Pearson correlation analysis was used to compare the correlation between two groups of bone metabolism related markers and WOMAC.</p><p><strong>Results: </strong>The WOMAC score of the case group (39.90±2.34) was higher than that of the control group (3.60±0.57), with significant difference (<i>P</i><0.05). There was no significant difference between the two groups of 25 (OH)D, β-CTX and PTH (<i>P</i>>0.05). The t-PINP and OC of the case group were (62.90±52.40) and (19.88±10.15) ng·ml-1, respectively, and those of the control group were (38.86±10.82) and (14.90±3.62) ng·ml^-1, respectively;the t-PINP and OC of the case group were higher than those of the control group, with significant difference (<i>P</i><0.05). Pearson correlation analysis showed that t-PINP was positively correlated with WOMAC pain score in the case group (<i>r</i>²=0.045, <i>P</i><0.01).</p><p><strong>Conclusion: </strong>Bone metabolism levels in the serum of patients with knee osteoarthritis are different from those of healthy people, and the difference between OC and t-PINP is the most obvious, and the concentration of t-PINP levels is positively correlated with pain symptoms in patients with KOA. However, the specific mechanism of correlation between the bone metabolism levels of patients with KOA and their pain symptoms needs to be further elucidated by basic experimental research as well as by enlarging the samples.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 5","pages":"482-6"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of selective nerve block maintaining active finger flexion and extension in the treatment of stenosing tenosynovitis of fingers].","authors":"Li Wang, Xiao-Jun Yu, Fan Yang, Juan Li, Zhi-Qiang Wang","doi":"10.12200/j.issn.1003-0034.20230317","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20230317","url":null,"abstract":"<p><strong>Objective: </strong>To explore the efficacy of ultrasound-guided selective nerve block anesthesia in the distal third of the forearm while maintaining active flexion and extension during surgery for stenosing tenosynovitis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 61 patients including 15 males and 46 females with American Society of Anesthesiologists(ASA)gradesⅠorⅡ, who underwent surgery for stenosing tenosynovitis in our hospital between January 2017 and January 2022. These patients, aged from 16 to 72 years old (weighing 44 to 75 kg), underwent selective nerve blocks targeting the median and ulnar nerves at the middle and distal third of the forearm, and the superficial branch of radial nerve at the dorsal radial side of wrist joint, under ultrasound guidance. A 0.5% ropivacaine solution was used for each nerve block. The anesthetic dosage for each nerve was recorded, and the efficay of each nerve block was monitored by acupuncture every 30 seconds post-administration. The onset time and ability to perform active finger flexion and extension were recorded. Outpatient or telephone follow-up was performed 1, 3 and 6 months postoperatively to evaluate the efficacy of release.</p><p><strong>Results: </strong>The efficacy of anesthesia block was excellent in 60 patients and good in 1 patient. One patient with simple stenosing tenosynovitis of the middle finger reported slight pain intraoperatively, which resolved with additional block of superficial branch of radial nerve of the wrist. Superficial branch of radial nerve was blocked in 20 patients, with a single dose of (1.7±0.3) ml and the onset time of (0.6±0.2) min. Median nerve was blocked in 45 patients, with a single dose of (4.1±1.0) ml and the onset time of (1.2±0.3) min;Ulnar nerve was blocked in 16 patients, with a single dose of (3.9±0.5) ml and the onset time of (1.7±0.3) min. All the patients retained active flexion and extension of the fingers. All 61 patients were followed up for 6 to 10 months with an average of (8.0±2.0) months, and no recurrence was observed.</p><p><strong>Conclusion: </strong>Ultrasound-guided selective nerve block of distal third of the forearm can provide safe, rapid and good anesthesia for patients undergoing surgery for stenosing tenosynovitis of fingers, while maintaining the active finger movement. This technique facilitates intraoperative assessment of release and improves overall surgical outcomes.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 4","pages":"411-4"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vitamin D and bone metabolism characteristics in knee osteoarthritis with osteoporosis patients].","authors":"Xue-Zong Wang, Yu Lu, Dao-Fang Ding, Yu-Xin Zheng, Yue-Long Cao","doi":"10.12200/j.issn.1003-0034.20240743","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20240743","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the characteristics of Vitamin D (VitD) and bone metabolism in patients with knee osteoarthritis (KOA) concurrent with osteoporosis (OP).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was performed on 240 patients who were admitted to the orthopedics department between March 2019 and March 2024. Patients were stratified into four distinct groups according to their respective disease categories.There were 90 patients in the simple KOA group, comprising 13 males and 77 females, age ranged from 50 to 91 years old with an average of (68.48±8.96) years old. There were 90 patients in the simple OP group, comprising 7 males and 83 females, age ranged from 52 to 88 years old with an average of (69.60±8.94 )years old. There were 30 patients in the KOA with OP group, comprising 1 male and 29 females, age ranged from 51 to 91 years old with an average of(69.03±7.93) years old. There were 30 patients in the physical examination group, comprising 5 males and 25 females, age ranged from 53 to 79 years old with an average of(64.93±6.51) years old. The general data and the levels of osteocalcin (OC), β-CrossLaps, parathyroid hormone(PTH) and VitD in each group were observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The level of VitD in KOA with OP group (19.62±10.38) ng·ml&lt;sup&gt;-1&lt;/sup&gt; and OP group (20.65±10.50) ng·ml&lt;sup&gt;-1&lt;/sup&gt; was lower than that in physical examination group (27.46±8.00) ng·ml&lt;sup&gt;-1&lt;/sup&gt; and KOA group (24.01±9.11) ng·ml&lt;sup&gt;-1&lt;/sup&gt; (&lt;i&gt;P&lt;/i&gt;&lt;0.05). There were significant differences in β- CrossLaps and PTH levels among the four groups (&lt;i&gt;P&lt;/i&gt;&lt;0.001, &lt;i&gt;P&lt;/i&gt;=0.019, respectively), while there was no significant difference in OC levels (&lt;i&gt;P&lt;/i&gt;=0.763). Compared with the two simple disease groups, the KOA with OP group had higher levels of β - CrossLaps(0.81±0.30) ng·ml&lt;sup&gt;-1&lt;/sup&gt; (&lt;i&gt;P&lt;/i&gt;&lt;0.001). There were significant differences in β-CrossLaps and PTH between the simple KOA group(0.54±0.22) ng·ml&lt;sup&gt;-1&lt;/sup&gt;, (46.03±18.08) pg·ml&lt;sup&gt;-1&lt;/sup&gt; and the physical examination group (0.44±0.19) ng·ml&lt;sup&gt;-1&lt;/sup&gt;, (36.65±9.63) pg·mL&lt;sup&gt;-1&lt;/sup&gt;(&lt;i&gt;P&lt;/i&gt;=0.038;&lt;i&gt;P&lt;/i&gt;=0.006). There was a significant difference in PTH between the OP group(43.85±14.30) ng·ml-1, and the physical examination group, &lt;i&gt;P&lt;/i&gt;=0.004. There was a significant difference in Kallgren-Lawrence grading between KOA with OP group and KOA group (&lt;i&gt;P&lt;/i&gt;=0.006). Within KOA with OP group, the differences of β-CrossLaps and VitD levels among different K-L grades were statistically significant (&lt;i&gt;P&lt;/i&gt;=0.016). The level of OC, β-CrossLaps and PTH within KOA with OP group was significantly different at different VitD levels (&lt;i&gt;P&lt;/i&gt;=0.013, &lt;i&gt;P&lt;/i&gt;=0.033, &lt;i&gt;P&lt;/i&gt;=0.046).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patients with KOA complicated by OP exhibit greater disturbances in bone metabolism and reduced VitD levels, particularly reflected by elevated β-CrossLaps. These findings underscore the importance of early monitoring of ","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 4","pages":"352-7"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation between bone mass loss and incidence of knee osteoarthritis in the elderly community-based population].","authors":"Chen-Jie Xia, Jin Li, Xiang Li, Ke Zhou, Liang Fang, Hong-Ting Jin, Pei-Jian Tong","doi":"10.12200/j.issn.1003-0034.20231278","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20231278","url":null,"abstract":"<p><strong>Objective: </strong>To explore the epidemiological characteristics of knee osteoarthritis (KOA) among the elderly in the community, and its correlation with bone mass loss.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on elderly community population over 50 year old from 12 community health service centers in Zhejiang province. Their gender, age, body mass index (BMI), T value and KOA diagnosis were collected using face to face questionnaire survey. Univariate regression was used to analyze the influence of age, gender, BMI and bone loss on KOA. Logistic multivariate regression model was used to analyze the independent effect of bone mass loss on KOA.</p><p><strong>Results: </strong>Among 4 173 subjects in this study, 1 710 of them were had a KOA. The prevalence rate was 40.9%. The mean age, the proportion of females and the mean BMI in KOA patients were (65.5±3.8) years old, 67.7%(1 158/1 710) and(24.59±1.28) kg·m^-2, respectively, which were significantly higher than (58.5±3.2) years old, 51.3%(1 263/2 463), and (23.48±1.25) kg·m^-2 in non-KOA subjects (<i>P</i><0.001). In the population aged from 60 to 69 years old, the influence of osteopenia and osteoporosis on the prevalence of KOA was[<i>OR</i>=1.21, 95%<i>CI</i>(1.00, 1.46), <i>P</i>=0.053 2], [<i>OR</i>=1.42, 95%<i>CI</i>(1.14, 1.78), <i>P</i>=0.002 2]. The influence of male and female osteoporosis on the prevalence of KOA was [<i>OR</i>=1.52, 95%<i>CI</i>(1.16, 1.99), <i>P</i>=0.002 7] and [<i>OR</i>=1.87, 95%<i>CI</i>(1.51, 2.32), <i>P</i><0.000 1], respectively. In the population of 24 kg·m^-2≤BMI<28 kg·m^-2, the influence of osteopenia and osteoporosis on the prevalence of KOA was [<i>OR</i>=1.47, 95%<i>CI</i>(1.21, 1.80), <i>P</i>=0.000 1], [<i>OR</i>=2.69, 95%<i>CI</i>(2.11, 3.42), <i>P</i><0.000 1], respectively. After controlling the confounding factors of age, gender and BMI, compared with people with normal bone mass, the effect of osteopenia on the prevalence of KOA was [<i>OR</i>=1.34, 95%<i>CI</i>(1.08, 1.67), <i>P</i>=0.009 2], and the effect of osteoporosis on the prevalence of KOA was [<i>OR</i>=1.38, 95%<i>CI</i>(1.06, 1.79), <i>P</i>=0.017 9].</p><p><strong>Conclusion: </strong>Elderly overweight women are more likely to develop KOA. Bone mass loss is an independent risk factor for KOA, which will significantly increase the prevalence of KOA in people overweight or aged 60 to 69 years old.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 4","pages":"358-63"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Minimally invasive reduction of ulnar bicortex angulation and intramedullary fixation in the treatment of Bado typeⅠchildren with Monteggia fracture].","authors":"Chuan-Wei Zhang, Deng-Shan Chen, Lei Wang, Xing-Po Ding","doi":"10.12200/j.issn.1003-0034.20230329","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20230329","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of minimally invasive reduction and ulna bicortical angulation intramedullary fixation in the management of Bado typeⅠMonteggia fracture in pediatric patients.</p><p><strong>Methods: </strong>Between August 2018 and August 2020, the clinical data of 15 pediatric patients diagnosed with Bado typeⅠfresh Monteggia fracture were retrospectively analyzed. There were 11 males and 4 females. The left side was implicated in 5 cases, while the right side was involved in 10 cases. The age ranged from 4 to 12 years old. There were a total of 10 cases of upper ulna fractures and 5 cases of middle ulna fractures. Among these, the ulnar fracture line presented as transverse or short oblique in 9 cases, and long oblique or spiral in 6 cases. The pediatric patients underwent treatment utilizing minimally invasive reduction and ulna bicortical angulation intramedullary fixation. The effectiveness of the treatment was assessed based on the Mayo elbow scoring system.</p><p><strong>Results: </strong>The follow-up period for all 15 cases ranged from 6 to 24 months. Among them, the occurrence of needle tail irritation was observed in 3 cases, all of which exhibited satisfactory healing following routine disinfection and dressing change. The other children had no re dislocation of the radial capitulum, no epiphyseal injury, no osteofascial compartment syndrome, elbow instability and other complications. The degree of limitation of daily life, range of motion of joints, pain level and appearance of limbs were recorded at the last follow-up. According to Mayo elbow scoring system, 12 cases were excellent and 3 cases were good.</p><p><strong>Conclusion: </strong>The minimally invasive reduction and ulna bicortical angulation intramedullary fixation technique is a simple and effective treatment for Bado typeⅠfresh Monteggia fractures in children.</p>","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 4","pages":"415-9"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Predictive value of combined examination of coagulation and fibrinolysis indexes for deep venous thrombosis after proximal femoral nail anti-rotation in elderly patients with femoral intertrochanteric fracture].","authors":"Hong-Feng Zhang, An-Ji He, Xi-Lin Zhao","doi":"10.12200/j.issn.1003-0034.20231098","DOIUrl":"https://doi.org/10.12200/j.issn.1003-0034.20231098","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the prognostic significance of combined coagulation and fibrinolysis marker analysis in predicting the development of deep venous thrombosis (DVT) following proximal femoral anti-rotation intramedullary nail (PFNA) surgery in elderly patients with intertrochanteric femur fractures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on the clinical data of 80 elderly patients who underwent PFNA treatment for intertrochanteric fractures between April 2019 and April 2023. There were 26 males and 54 females. The patients' ages ranged from 60 to 85 years old, with a mean age of (76.4±5.6) years old. According to the occurrence of DVT following PFNA, patients were categorized into two groups. The DVT group were 29 patients, comprising 10 males and 19 females with a mean age of (76.9 ± 6.1)years old. And the non-DVT group were 51 patients, consisting of 16 males and 35 females with a mean age of (75.3 ± 6.9 )years old. The prothrombin time (PT), activated partial thromboplastin time(APTT), thrombin time(TT), plasma fibrinogen (FIB), plasma thrombin-antithrombin complex(TAT), and D-dimer levels were compared between the two groups immediately post- PFNA surgery, as well as at 3 and 7 days postoperatively. Pearson correlation analysis was conducted to evaluate the relationship between plasma FIB, TAT, and D-dimer levels in patients who developed DVT. Multivariate logistic regression analysis was employed to assess the association between each coagulation and fibrinolysis index following PFNA surgery in elderly patients and the incidence of DVT. The area under the receiver operating characteristic (ROC) curve (AUC) was utilized to determine the predictive value of PT, APTT, TT, FIB, TAT, and D-dimer for postoperative DVT occurrence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There were no statistically significant differences in PT, APTT, and TT between the two groups immediately post-surgery, at 3 days, and at 7 days (&lt;i&gt;P&lt;/i&gt;&gt;0.05). At immediately, 3 days and 7 days postoperatively in DVT group, FIB were (4.68±1.77), (6.73±2.02), (8.81±2.86) g·L&lt;sup&gt;-1&lt;/sup&gt;, TAT were (10.64±2.30), (12.88±3.45), (14.96±4.87) μg·L&lt;sup&gt;-1&lt;/sup&gt; respectively. D-dimer were (635.00±100.88), (720.02±168.09), (810.47±170.19) μg· L&lt;sup&gt;-1&lt;/sup&gt;, respectively.In the DVT group FIB were (3.46±0.47), (3.55±0.52), (3.67±0.48) g·L&lt;sup&gt;-1&lt;/sup&gt;, TAT were (8.58±3.37), (8.69±3.48), (8.80±3.50) g·L&lt;sup&gt;-1&lt;/sup&gt;, D-dimer were (588.36±96.68), (589.58±96.45), (591.11±95.50) g·L&lt;sup&gt;-1&lt;/sup&gt;. The difference between the two groups was statistically significant (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Pearson correlation analysis revealed significant positive correlations between FIB and D-dimer(&lt;i&gt;r&lt;/i&gt;=0.428, 0.523, &lt;i&gt;P&lt;/i&gt;&lt;0.05), FIB and TAT(&lt;i&gt;r&lt;/i&gt;=0.517, 0.411, &lt;i&gt;P&lt;/i&gt;&lt;0.05), as well as TAT and D-dimer(&lt;i&gt;r&lt;/i&gt;=0.602, 0.596, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Multivariate Logistic regression analysis revealed that FIB &lt;i&gt;OR&lt;/i&gt;=3.252, 95% &lt;i&gt;CI&lt;/i&gt;(0.640, 3.975), &lt;i&gt;P&lt;/i&gt;&lt;0.","PeriodicalId":23964,"journal":{"name":"Zhongguo gu shang = China journal of orthopaedics and traumatology","volume":"38 4","pages":"371-7"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}