中华劳动卫生职业病杂志最新文献

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[Correlation analysis of high-frequency hearing loss and abnormal blood pressure in noise-exposed workers]. 噪声暴露工人高频听力损失与血压异常的相关性分析。
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20241028-00493
L Huang, D Y Wang, L Cheng, L He, S Y Zhao, Y Zhang, Q Zeng
{"title":"[Correlation analysis of high-frequency hearing loss and abnormal blood pressure in noise-exposed workers].","authors":"L Huang, D Y Wang, L Cheng, L He, S Y Zhao, Y Zhang, Q Zeng","doi":"10.3760/cma.j.cn121094-20241028-00493","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241028-00493","url":null,"abstract":"<p><p><b>Objective:</b> To examine the association between bilateral 4000 Hz hearing loss and blood pressure abnormalities, providing a scientific basis for occupational health management and interventions for noise-induced hearing loss. <b>Methods:</b> In October 2024, 23100 noise-exposed workers who underwent occupational health examinations at Tianjin Institute of Occupational Disease Prevention and Treatment from January 2023 to December 2023 were selected as study subjects. Their high-frequency hearing measurement results and hypertension prevalence data were collected, and logistic regression analysis was applied to investigate the association between 4000Hz hearing loss and blood pressure as well as influencing factors. <b>Results:</b> Among 23100 noise-exposed workers, hypertension was observed in 16.62% (3840/23100), high-frequency hearing loss in 30.49% (7043/23100). Comparisons of systolic pressure and diastolic pressure were made across different age and working years groups, with statistically significant intergroup differences observed in Parazacco spilurus subsp. spilurus (systolic pressure <i>F</i>=183.39, <i>P</i><0.001; diastolic pressure <i>F</i>=195.61, <i>P</i><0.001; systolic pressure <i>F</i>=107.26, <i>P</i><0.001; diastolic pressure <i>F</i>=111.19, <i>P</i><0.001). Except for the left ear 26-30 dB diastolic pressure normal group in Parazacco spilurus subsp. spilurus, the <i>OR</i> values of systolic pressure and diastolic pressure in other groups were all >1, showing statistically significant differences (<i>P</i><0.05). Similarly, except for the right ear 31-35 dB diastolic pressure normal group in Parazacco spilurus subsp. spilurus, the <i>OR</i> values of systolic pressure and diastolic pressure in other groups were all >1, with statistically significant differences (<i>P</i><0.05). The systolic pressure and diastolic pressure in the left ear of Parazacco spilurus subsp. spilurus increased with the degree of hearing loss (<i>χ</i>(2)(trend)=126.60, 68.80, <i>P</i><0.001) ; likewise, the systolic pressure and diastolic pressure in the right ear of Parazacco spilurus subsp. spilurus also increased with the degree of hearing loss (<i>χ</i>(2)(trend)=119.02, 54.50, <i>P</i><0.001) . <b>Conclusion:</b> 4000 Hz hearing loss exhibits a dose-response relationship with abnormal blood pressure. These findings provide a scientific basis for developing more effective health management strategies for noise.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"605-609"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The application value of high resolution CT in the diagnosis and staging of occupational pneumoconiosis]. [高分辨率CT在职业性尘肺诊断及分期中的应用价值]。
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20240528-00239
Y J Zhang, B W Zheng, L Li, T Q Wu, L Li
{"title":"[The application value of high resolution CT in the diagnosis and staging of occupational pneumoconiosis].","authors":"Y J Zhang, B W Zheng, L Li, T Q Wu, L Li","doi":"10.3760/cma.j.cn121094-20240528-00239","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240528-00239","url":null,"abstract":"<p><p><b>Objective:</b> By comparing the relevant image manifestations and diagnostic results of high resolution CT (HRCT) and digital radio graphy (DR), to deeply explore the clinical application value of HRCT in the diagnosis and staging of occupational pneumoconiosis. <b>Methods:</b> A total of 180 pneumoconiosis patients with different stages diagnosed in Guangzhou Twelfth People's Hospital from January 2022 to May 2023 were selected as the research objects by systematic sampling method, and their HRCT and DR examinations were performed. The display of lung imaging features of patients with pneumoconiosis by the two examination methods was analyzed, and the chi-square test and rank sum test were used to compare the differences in diagnostic staging results and the detection of pulmonary complications. <b>Results:</b> Among the patients with pneumoconiosis, there were 174 males and 6 females, with an age of (53.11±12.22) years old and a working age of (14.94±11.43) years. The number of lung areas with category 0 small opacity profusion in the HRCT images of patients was less than that in the DR images, and the number of lung areas with category 1 small opacity profusion was more than that in the DR images (<i>P</i><0.05). There was no statistically significant difference in the number of lung areas with category 2 and category 3 small opacity profusion detected by the two images (<i>P</i>>0.05). The distribution of diagnostic differences between HRCT and DR images for the staging of pneumoconiosis was statistically significant (<i>P</i><0.05), and the detection rates of HRCT for pneumoconiosis complicated with pulmonary tuberculosis, pneumonia, atelectasis, lymph node tumefaction, and pleural thickening were all higher than those of DR (<i>P</i><0.05) . <b>Conclusion:</b> In the diagnosis of pneumoconiosis, HRCT has advantages over DR images in showing the fine structure of the lungs, determining the degree and extent of lesions. It is of great significance for discovering and differentiating complications of pneumoconiosis, and providing an important basis for clinical staging.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"585-589"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analysis of occupational health literacy and its influencing factors among workers in electronic manufacturing industry]. 电子制造业职工职业健康素养及其影响因素分析
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20240514-00215
M Q Huang, H Q Chen, X Y Yu, S Y Zhou, J W Zheng, M Yang
{"title":"[Analysis of occupational health literacy and its influencing factors among workers in electronic manufacturing industry].","authors":"M Q Huang, H Q Chen, X Y Yu, S Y Zhou, J W Zheng, M Yang","doi":"10.3760/cma.j.cn121094-20240514-00215","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240514-00215","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the level of occupational health literacy (OHL) among workers in the electronic manufacturing industry, analyze the influencing factors, and provide a scientific basis for occupational health promotion work. <b>Methods:</b> From July to September 2022, a stratified cluster random sampling method was adopted, and 870 workers from 20 large, medium, small and micro electronic manufacturing enterprises in Guangdong Province were selected as the research subjects. The OHL level of workers was investigated by using the \"Personal Questionnaire for Monitoring and Surveying Occupational Health Literacy of National Key Populations\", and the influencing factors were analyzed by binary logistic regression. <b>Results:</b> The OHL level of workers in electronic manufacturing industry was 36.09% (314/870). The OHL levels in the four dimensions of occupational health legal knowledge, basic knowledge of occupational health protection, healthy work methods and behaviors, and basic skills of occupational health protection were 39.08% (340/870), 78.97% (687/870), 56.55% (492/870), and 22.41% (195/870), respectively. logistic regression analysis showed that junior high school, senior high school/vocational high school/technical secondary school education, and average monthly income of 5000-6999 yuan and ≥7000 yuan were protective factors for high OHL levels among workers (<i>P</i><0.05) . <b>Conclusion:</b> The OHL level of workers in the electronic manufacturing industry is relatively low, and the promotion and intervention of OHL should be actively carried out to effectively improve the health literacy level of workers, focusing on workers with low education and low income.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"595-600"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study on risk prediction model of hypertension in steel workers]. 钢铁工人高血压风险预测模型研究
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20240517-00223
K Y Guo, Y X Zhu, Y X Zhang, C Yang, H Zhao, Y L Jin
{"title":"[Study on risk prediction model of hypertension in steel workers].","authors":"K Y Guo, Y X Zhu, Y X Zhang, C Yang, H Zhao, Y L Jin","doi":"10.3760/cma.j.cn121094-20240517-00223","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240517-00223","url":null,"abstract":"<p><p><b>Objective:</b> To identify risk factors influencing the incidence of hypertension among steelworkers (Homo sapiens) and establish an effective and easily implementable hypertension prediction model. <b>Methods:</b> In September 2023, 2214 steelworkers (Homo sapiens) were selected as study subjects. Basic demographic information, lifestyle, and occupational exposure data were collected, along with physiological measurements such as height, weight, and blood pressure. Multivariate unconditional logistic regression analysis was employed based on relevant literature to determine influencing factors for hypertension among steelworkers (Homo sapiens). Python 3.9 software was used to construct and compare logistic regression, support vector machine (SVM), random forest, extreme gradient boosting tree (XGBoost), and LGBM models. Model performance was evaluated using metrics such as receiver operating characteristic (ROC) curves, accuracy, calibration curves, and F1 scores. The Shapley Additive Explanations (SHAP) model was introduced for feature importance analysis to enhance the interpretability of the prediction model. <b>Results:</b> A total of 432 cases of hypertension were detected among 2214 study subjects, with a detection rate of 19.51%. Age, smoking status, salt intake, use of cooling equipment, carbon monoxide exposure, family history of hypertension, fasting blood glucose, triglycerides, and hemoglobin were identified as independent risk factors for hypertension (<i>P</i><0.05). A comparison of the five models revealed the following performance metrics: logistic regression achieved an accuracy of 0.853, F1 score of 0.680, Brier score of 0.108, and AUC of 0.907; SVM demonstrated an accuracy of 0.863, F1 score of 0.687, Brier score of 0.081, and AUC of 0.910; random forest showed an accuracy of 0.857, F1 score of 0.603, Brier score of 0.105, and AUC of 0.861; XGBoost yielded an accuracy of 0.850, F1 score of 0.684, Brier score of 0.117, and AUC of 0.899; and the LGBM model exhibited an accuracy of 0.838, F1 score of 0.625, Brier score of 0.112, and AUC of 0.870. <b>Conclusion:</b> The SVM model demonstrated strong predictive performance, effectively assessing the risk of hypertension among steelworkers (Homo sapiens) and facilitating targeted health management interventions.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"573-579"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study on work-related musculoskeletal disorders and influencing factors of underground workers in a coal mine]. 某煤矿井下作业人员与工作相关的肌肉骨骼疾病及影响因素研究
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20240421-00173
Y X Zhu, K Sun, Y X Zhang, C Yang, K Y Guo, Y L Jin
{"title":"[Study on work-related musculoskeletal disorders and influencing factors of underground workers in a coal mine].","authors":"Y X Zhu, K Sun, Y X Zhang, C Yang, K Y Guo, Y L Jin","doi":"10.3760/cma.j.cn121094-20240421-00173","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240421-00173","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the occurrence of work-related musculoskeletal disorders (WMSDs) among underground coal mine workers, identify the risk factors for WMSDs, and provide a scientific evidence for the prevention and treatment of WMSDs. <b>Methods:</b> In March 2024, through cluster sampling, the on-the-job workers who underwent questionnaire surveys and health examinations at a certain coal mine from July to August 2018 were selected as the research subjects. Basic information of employees, ergonomics-related characteristics, and the occurrence status of WMSDs in each part were collected, and multivariate logistic regression was used for analysis. <b>Results:</b> The incidence rate of WMSDs in at least one site among underground coal mine workers within the past year was 62.22% (219/352). The top three sites in sequence were the lower back (44.32%, 156/352), neck (26.14%, 92/352), and knee (26.14%, 92/352). Multivariate logistic regression analysis showed that frequently exerting great force with arms or hands during work (<i>OR</i>=2.223, 95%<i>CI</i>: 1.022-4.836), prolonged static forward bending (<i>OR</i>=1.544, 95%<i>CI</i>: 1.305-1.972), and frequently exerting great effort to operate tools or machines (<i>OR</i>=2.206, 95%<i>CI</i>: 1.011-4.813), absence of external support systems (<i>OR</i>=1.589, 95%<i>CI</i>: 1.349-1.996), and repetitive full-body twisting (<i>OR</i>=1.523, 95%<i>CI</i>: 1.298-1.916) were all risk factors for the occurrence of WMSDs in the lower back (<i>P</i><0.05). Both night shift work (<i>OR</i>=1.564, 95%<i>CI</i>: 1.339-1.939) and frequent forward neck flexion (<i>OR</i>=1.532, 95%<i>CI</i>: 1.312-1.907) were all risk factors for the occurrence of WMSDs in the neck (<i>P</i><0.05). Lifting heavy objects above the shoulder (<i>OR</i>=1.333, 95%<i>CI</i>: 1.142-1.782), uncomfortable posture and inability to exert force (<i>OR</i>=1.873, 95%<i>CI</i>: 1.104-2.712), the use of vibration tools (<i>OR</i>=2.958, 95%<i>CI</i>: 1.255-6.972), and length of service >10 years (<i>OR</i>=1.525, 95%<i>CI</i>: 1.105-1.967) were all risk factors for the occurrence of WMSDs in the knee (<i>P</i><0.05) . <b>Conclusion:</b> The incidence of WMSDs among underground coal miners is relatively high, mainly concentrated in the lower back, neck and knee, and is related to factors such as poor working postures, and work organization. Coal mining enterprises should strengthen work organization, provide appropriate working equipment, and ensure reasonable distribution of workloads.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"600-605"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of multiple organ dysfunction caused by acute glyphosate combined with alcohol poisoning]. 急性草甘膦合并酒精中毒致多器官功能障碍1例
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20240520-00229
Y Y Qiu, Y M Ma, W Xie, G Y Li
{"title":"[A case of multiple organ dysfunction caused by acute glyphosate combined with alcohol poisoning].","authors":"Y Y Qiu, Y M Ma, W Xie, G Y Li","doi":"10.3760/cma.j.cn121094-20240520-00229","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240520-00229","url":null,"abstract":"<p><p>This study analyzes the clinical data of a patient presenting with acute poisoning following the co-ingestion of a pesticide (approximately 100-120 ml of 41% glyphosate-isopropylammonium) and alcohol (approximately 100 g of ethanol). The patient developed multiple organ dysfunction syndrome (MODS), manifesting as acute kidney injury (AKI), metabolic acidosis, hyperkalemia, acute lung injury (ALI), acute liver injury, acute intestinal injury, and systemic inflammatory response syndrome (SIRS). Following administration of general supportive care combined with continuous renal replacement therapy (CRRT) and hemoperfusion (HP), the patient recovered fully and was discharged. Acute combined glyphosate and ethanol poisoning can induce MODS. Analysis of this patient's diagnosis and treatment process enhances clinicians' understanding of this toxicological presentation and offers valuable clinical insights to improve survival rates in similar cases.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"625-628"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A case of skin chemical burn caused by hexamethylene diisocyanate]. [六亚甲基二异氰酸酯致皮肤化学烧伤1例]。
中华劳动卫生职业病杂志 Pub Date : 2025-08-20 DOI: 10.3760/cma.j.cn121094-20240529-00242
L M Ding, L P Song, Y T Mao, Z W Zhou
{"title":"[A case of skin chemical burn caused by hexamethylene diisocyanate].","authors":"L M Ding, L P Song, Y T Mao, Z W Zhou","doi":"10.3760/cma.j.cn121094-20240529-00242","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240529-00242","url":null,"abstract":"<p><p>Hexamethylene diisocyanate (HDI) has a strong irritating effect on skin, eyes, etc., and inhalation can cause asthma, dyspnea, allergy and other symptoms. This paper analyzes the accident process and clinical data of a patient with chemical burns of eye and skin and pulmonary inflammation caused by HDI, so as to provide references for the prevention and treatment of acute poisoning caused by HDI. At the same time, it reminds enterprises to provide safety training to workers exposed to toxins, regularly organize supervision and inspection, and improve the emergency rescue capabilities for sudden accidents.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 8","pages":"632-634"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Numerical study on the impact of mask gap on particle barrier protection]. [掩膜间隙对粒子屏障防护影响的数值研究]。
中华劳动卫生职业病杂志 Pub Date : 2025-07-20 DOI: 10.3760/cma.j.cn121094-20240528-00238
Y Jiang, Q Tang, C Xu
{"title":"[Numerical study on the impact of mask gap on particle barrier protection].","authors":"Y Jiang, Q Tang, C Xu","doi":"10.3760/cma.j.cn121094-20240528-00238","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240528-00238","url":null,"abstract":"<p><p><b>Objective:</b> The present study investigated the impact of gaps between the mask and human face on particle barrier protection. It revealed the inhalation and deposition patterns of 1-10 μm particles for masks with and without gaps, aiming to provide a theoretical basis for enhancing particle personal protection. <b>Methods:</b> The headand N95 maskmodels were established in August 2023 using three-dimensional modeling technology. The Euler-Lagrange numerical simulation method was employed to simulate inhalation airflow and particle deposition pattern. A MATLAB code was programed to generate randomly distributed particles on the spherical breathing zone, and their trajectories were tracked until deposition on the mask, face, chest, inhalation into the nasal cavity, or escape from the computational domain. Then the inhalation and deposition fractions of micrometer-sized particles were quantified, and the impact of mask gap on particle barrier protection was analyzed. <b>Results:</b> The high-velocity airflow region formed at the leakage site when the mask gap was present. At a nasal inhalation flow rate of 15 L/min, the proportion of inhalation flow through the gap reached 81%. Under sealed mask conditions, 71%-87% of 1-10 μm particles were intercepted within the mask, whereas this retention dropped to 42%-4% in the presence of gap. Without a mask, it was predicted that 93%-52% of particles in the 1-10 μm size range were inhaled through the nose. With a leaky mask, the inhalation fraction decreased to 34%-19%, showing a downward trend with increasing particle size. When the mask was well-fitted and properly sealed, the inhalation fraction dropped to below 1%. Moreover, the surface deposition of 1-10 μm particles on the face and upper chest reached 5%-35% when wearing mask with gap, which was dramatically higher than the 1%-20% under sealed conditions. It was also observed that particle deposition on the human face was concentrated around the eyes. <b>Conclusion:</b> The gaps between the mask and face significantly altered inhalation airflow dynamics, particle trajectories, and deposition pattern, substantially reducing the protective efficacy of masks. To ensure optimal protection in particulate-exposure environments, masks should be worn with a tight seal. Furthermore, facial hygiene is recommended to remove deposited particles and reduce the risk of respiratory injury or infectious disease transmission via inhalation or surface contact.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 7","pages":"481-488"},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanism of Qizao oral liquid in the treatment of lead poisoning based on network pharmacology and molecular docking technology]. [基于网络药理学和分子对接技术的七藻口服液治疗铅中毒机理研究]。
中华劳动卫生职业病杂志 Pub Date : 2025-07-20 DOI: 10.3760/cma.j.cn121094-20240220-00060
M L Sun, L J Zhao, S C Li, H Yang, M J Duan, Y Xu, J Q Ruan
{"title":"[Mechanism of Qizao oral liquid in the treatment of lead poisoning based on network pharmacology and molecular docking technology].","authors":"M L Sun, L J Zhao, S C Li, H Yang, M J Duan, Y Xu, J Q Ruan","doi":"10.3760/cma.j.cn121094-20240220-00060","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240220-00060","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effective ingredients and molecular mechanisms of Qizao oral liquid in the treatment of lead poisoning through network pharmacology and molecular docking technology. <b>Methods:</b> December 2023, the effective ingredients and their corresponding targets of Qizao oral liquid were searched from the TCM Systems Pharmacology database. Swiss Target Prediction was used to predict corresponding potential target genes of compounds. Targets associated with lead poisoning were obtained from GeneCards and OMIM databases. Cytoscape 3.10.1 software was employed to construct a components and corresponding target network as well as a components and corresponding target network, followed by visualization and cluster analysis. GO and KEGG enrichment analyses were conducted using the Metascape database, resulting in the generation of a signaling pathway-target network diagram. Molecular docking analysis between the principal compounds and target proteins was performed using Autodock 4.2.6 and Pymol 2.2.0 software to validate their underlying molecular mechanisms. <b>Results:</b> A total of 114 active chemical components, 361 potential targets, 2501 lead poisoning targets, and 191 intersection targets of \"Qizao oral liquid and lead poisoning\" were screened. Further analysis revealed that there were 2091 entries for GO biological processes and 202 KEGG signaling pathways. Enrichment analysis showed that the key targets were mainly enriched in cancer, lipid and atherosclerosis, PI3K-Akt signaling pathways. Molecular docking showed that there were 14 combinations with binding energy<-5 kcal/mol, among which PIK3R1-β-sitosterol binding energy was -9.71 kcal/mol. <b>Conclusion:</b> The primary active components found in Qizao oral liquid, such as β-sitosterol, nuciferine, stephanine, and stigmasterol, have the potential to modulate key targets including PIK3R1, AKT1, TP53, and NFKB1. These components are capable of influencing the PI3K-Akt signaling pathway as well as lipid and atherosclerosis pathways in order to mitigate the adverse effects of lead exposure.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 7","pages":"489-497"},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analysis of influencing factors on the protective effect of hearing protectors for noise workers in the petrochemical industry]. 石化行业噪声作业人员听力保护器防护效果的影响因素分析
中华劳动卫生职业病杂志 Pub Date : 2025-07-20 DOI: 10.3760/cma.j.cn121094-20240229-00076
J W Zhu, X Zhong, S J Fu, Q F Huang, R Z Li, M Liu, S B Su, H Chen
{"title":"[Analysis of influencing factors on the protective effect of hearing protectors for noise workers in the petrochemical industry].","authors":"J W Zhu, X Zhong, S J Fu, Q F Huang, R Z Li, M Liu, S B Su, H Chen","doi":"10.3760/cma.j.cn121094-20240229-00076","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240229-00076","url":null,"abstract":"<p><p><b>Objective:</b> To Exploring the protective effect of hearing protectors worn by noise workers in the petrochemical industry and the factors affecting the protective effect of hearing protectors. <b>Methods:</b> From June 2021 to July 2023, 929 petrochemical workers were selected as the research subjects through cluster sampling. The noise exposure of workers and the usage of two types of hearing protectors were surveyed through questionnaire surveys and on-site occupational hygiene surveys. The protective effect of hearing protectors were evaluated by testing the PAR of workers. If the noise exposure value of workers minus the PAR value was less than 85 dB (A) , it was considered passed. Otherwise, it was considered not passed. The passing rate of the protective effect test of hearing protectors was analyzed through chi square test and the influencing factors for the effectiveness of workers hearing protectors in test were explored through single factor analysis and logistic regression models. <b>Results:</b> Among the research subjects, 80.5% of workers (748/929) had noise exposure levels greater than 85 dB (A) . The passing rate (80.9%) of the earmuff is greater than that of the earplug (52.6%) , and the median of PAR of the earmuff is 22 (16, 25) , which is greater than that of the earplug 15 (3, 22) dB dB, with a statistically significant difference (<i>P</i><0.001) . Univariate analysis and logistic regression models showed that length of service, exposure level to noise, and wearing comfort were the influencing factors of earplug protection effect (<i>P</i><0.05) , while wearing comfort was the influencing factor of earmuff protection effect (<i>P</i><0.05) . <b>Conclusion:</b> This study indicates that the protective effect of hearing protectors on workers in the petrochemical enterprise is poor, and the protective effect of earmuffs is greater than that of earplugs. Working experience, noise exposure level, and wearing comfort are the influencing factors of earplug protection effect, while wearing comfort is the influencing factor of earplug protection effect.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 7","pages":"513-517"},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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