中华劳动卫生职业病杂志最新文献

{"title":"[Determination of isopropyl acetate, tert-butyl acetate and sec-butyl acetate in workplace air by solvent desorption-gas chromatography].","authors":"G L Chen, J W Hu, J Yuan, J H He, W F Rong, B H Wu","doi":"10.3760/cma.j.cn121094-20241111-00518","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241111-00518","url":null,"abstract":"<p><p><b>Objective:</b> To establish a method for the determination of isopropyl acetate, tert-butyl acetate and sec-butyl acetate in the air of workplace by gas chromatography. <b>Methods:</b> In November 2023, the air in the workplace was collected using activated carbon tubes for isopropyl acetate, tert-butyl acetate and sec-butyl acetate. The samples were desorbed with carbon disulfide, separated on a capillary chromatographic column, detected by a hydrogen flame ionization detector (FID), and the detection limits, precision, desorption rates, etc. of the method were analyzed. <b>Results:</b> The linear ranges for the determination of isopropyl acetate, tert-butyl acetate, and sec-butyl acetate were 4.44-2222.00 μg/ml, 4.33-2165.00 μg/ml, and 4.36-2180.00 μg/ml, respectively. The regression equations were <i>y</i>=0.981<i>x</i>+5.075, <i>y</i>=1.285<i>x</i>+6.972, and <i>y</i>=1.203<i>x</i>+7.380, respectively. The correlation coefficients were all 0.99994. The detection limits were 0.21 μg/ml, and the minimum detection concentration was 0.14 mg/m(3) (air volume calculated as 1.50 L). The within-run precisions were 0.94%-2.67%, 1.03%-2.63%, and 1.13%-2.66%, respectively, and the between-run precisions were 2.12%-2.48%, 2.20%-2.71%, and 2.38%-3.09%, respectively. The desorption rates were 94.66%-102.58%, 96.45%-103.92%, and 94.79%-102.58%, respectively. The samples could be stored at room temperature for at least 7 days. <b>Conclusion:</b> The solvent desorption-gas chromatography method has good precision, high sensitivity, and simple operation, and is suitable for the simultaneous determination of isopropyl acetate, tert-butyl acetate, and sec-butyl acetate in the air of the workplace.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 4","pages":"309-313"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the causal relationship between serum albumin and carpal tunnel syndrome and the mediating role of leptin].","authors":"J X Zheng, S W Zhong, Y Yang, Z H Peng, Y N He, S H Zhu, F Y X Huang, Z Wang","doi":"10.3760/cma.j.cn121094-20250704-00267","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20250704-00267","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the causal association between serum albumin and carpal tunnel syndrome (CTS) and to investigate the mediating role of leptin in this relationship. <b>Methods:</b> In April 2025, data on serum albumin, leptin (adjusted for body mass index), and CTS from Genome-Wide Association Studies (GWAS) and FinnGen public databases were collected for a two-way, two-sample Mendelian randomization (MR) analysis. Causal analyses were performed using inverse variance weighted (IVW), weighted median estimator, MR-Egger, simple mode, and weighted mode methods. The robustness of the results was tested using Cochran's <i>Q</i> statistic, MR-Egger intercept test, Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test. A two-step approach was used to analyze the mediating effect of leptin between serum albumin and CTS. <b>Results:</b> The IVW analysis showed that elevated serum albumin levels significantly increased the risk of CTS (<i>OR</i>=1.18, 95%<i>CI</i>: 1.00-1.38, <i>P</i>=0.045), and the results from the weighted median estimator and weighted mode method were consistent with the IVW direction and the differences were statistically significant (<i>P</i><0.05). Mediation analysis revealed a significant negative causal effect between serum albumin and leptin (<i>OR</i>=0.44, 95%<i>CI</i>: 0.28-0.68, <i>P</i><0.001), and elevated leptin levels significantly reduced the risk of CTS (<i>OR</i>=0.79, 95%<i>CI</i>: 0.68-0.94, <i>P</i>=0.006). Leptin played a key mediating role in the path of serum albumin affecting CTS (<i>β</i>(indirect)=0.190, <i>P</i>=0.027), with a mediation proportion of 118%. Reverse MR analysis showed that the causal effect of CTS on serum albumin was not statistically significant (<i>OR</i>=1.00, 95% <i>CI</i>: 0.97-1.04, <i>P</i>=0.889). There were no statistically significant differences in the heterogeneity test (Cochran's <i>Q</i>=20.68, <i>P</i>=0.079) and multi-effect test (MR-Egger intercept value -0.004, <i>P</i>=0.684; MR-PRESSO global <i>P</i>=0.067) . <b>Conclusion:</b> There is a positive causal relationship between serum albumin level and the risk of CTS, and leptin level plays an important mediating role in this pathway, suggesting that albumin may indirectly increase the risk of CTS through the modulation of leptin, and provide new genetic clues for the identification of people at high risk of CTS.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 4","pages":"241-246"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the status and correlation of occupational burnout and professional identity in the optometrists].","authors":"Z H Chu, L H Li, Z Y Deng, N N Luo","doi":"10.3760/cma.j.cn121094-20241028-00491","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241028-00491","url":null,"abstract":"<p><p><b>Objective:</b> To explore the current status of occupational burnout and professional identity among optometrists, and to examine the relationship between them. <b>Methods:</b> In September 2024, using the convenience sampling method, a questionnaire survey was conducted on 235 optometrists from two Class Ⅲ Grade A eye hospitals in Tianjin City. Data were collected on their general demographic characteristics, occupational burnout (including emotional exhaustion, depersonalization, and personal accomplishment), and professional identity (including occupational belonging, occupational benefit, and occupational motivation). Correlation analysis was used to explore the relationship between occupational burnout and professional identity, and a regression model was constructed to analyze the main influencing factors of professional identity. <b>Results:</b> The score of occupational belonging for optometrists was (4.20±0.79) points, the score of occupational benefit was (4.32±0.75) points, and the score of occupational motivation was (4.13±0.78) points. Among the optometrists, 59 were positive for occupational burnout (25.1%), including 43 with mild burnout (18.3%), 10 with moderate burnout (4.3%), and 6 with severe burnout (2.6%). Occupational belonging, occupational benefit, and occupational motivation of optometrists were negatively correlated with emotional exhaustion and depersonalization (<i>r</i> ranging from -0.460 to -0.390, <i>P</i><0.01), and positively correlated with personal accomplishment (<i>r</i> ranging from 0.365 to 0.426, <i>P</i><0.01). Emotional exhaustion and depersonalization had significant negative predictive effects on occupational belonging, occupational benefit, and occupational motivation (<i>P</i><0.05). Personal accomplishment had significant positive predictive effects on all three (<i>P</i><0.05) . <b>Conclusion:</b> The overall professional identity of optometrists is generally at a moderately high level. Emotional exhaustion and depersonalization are risk factors that weaken professional identity, whereas personal accomplishment is a protective factor. Attention should be paid to the alleviation of occupational stress and career development support for optometrists.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 4","pages":"274-280"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the effect of occupational radiation exposure on peripheral blood lymphocyte micronucleus frequency based on distributed lag non-linear model].","authors":"X L Qin, Q Huang, Y Zeng, J Guo, J Diao, J L He, W Li, Y Y Xia","doi":"10.3760/cma.j.cn121094-20241008-00456","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241008-00456","url":null,"abstract":"<p><p><b>Objective:</b> To explore the lag effects of occupational exposure doses on the peripheral blood lymphocytes micronucleus frequency in the radiation workers. <b>Methods:</b> In October 2024, 191 radiation workers who participated in occupational health examination in Chongqing Center for Disease Control and Prevention from 2017 to 2020 were selected as the research objects to detect the micronucleus rate of peripheral blood lymphocytes. The 4-year exposure dose (mSv) was obtained. The distributed lag non-linear model (DLNM) combined with the generalized Linear model (GLM) model was used to analyze the exposure lag response relationship between the average annual exposure dose and the micronucleus rate of peripheral blood lymphocytes in 2020. Relative Risk (<i>RR</i>) was used to quantify the risk of radiation exposure to micronucleus in peripheral blood lymphocytes. <b>Results:</b> The median annual exposure doses of radiation workers in 2017, 2018, 2019 and 2020 were 0.42 mSv, 0.50 mSv, 0.28 mSv and 0.20 mSv, respectively, and the maximum values were 7.72 mSv, 5.41 mSv, 4.09 mSv and 2.82 mSv, respectively. The median annual exposure dose decreased by 0.09 mSv (<i>R</i>(2)=0.707), and the maximum annual exposure dose showed a significant downward trend (<i>R</i>(2)=0.976, <i>P</i>=0.012), showing an overall downward trend year by year. The micronucleus rate of lymphocytes in 2020 was less than 6 ‰, and there was no micronucleus abnormality. Micronucleus rate higher than 1 ‰ accounted for 10 %. Based on the analysis of the DLNM model, the cross-base of the annual exposure dose was associated with an increase in the lymphocyte micronucleus rate <i>RR</i> after adjusting for gender and age (<i>P</i><0.05). The RR of lag 3 years was 1.30 (95%<i>CI</i>: 1.16~1.45) at 0.40 mSv annual exposure dose. The annual exposure dose of lag effect was nonlinear with the micronucleus rate of lymphocytes, and the exposure-response curve was \"J\" type. When the annual exposure dose was higher than 3.00 mSv, <i>RR</i> increased exponentially. <b>Conclusion:</b> This study found that low-dose radiation increased micronuclei occurrence after 3 years, and the annual exposure dose with lag effects on the lymphocyte micronucleus frequency was nonlinear, suggesting that to better protect the radiological occupational population, the annual exposure dose should be reduced as much as possible.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"204-208"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of trends and typology of craniofacial features in Central Chinese adults].","authors":"J K Zhang, X J Ding, Z M Chen, Y X Hu, S J Yang, W H Chen, M Zhou","doi":"10.3760/cma.j.cn121094-20250311-00091","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20250311-00091","url":null,"abstract":"<p><p><b>Objective:</b> To identify the change trend of craniofacial features in Central China over the past 18 years, identify representative craniofacial features in Central China, and develop an updated typology of craniofacial features. <b>Methods:</b> From May to November 2023, a stratified random sampling method was employed to recruit 3 547 adults from Central China. A total of 4 human body indexes and 19 craniofacial indexes were measured and established a craniofacial characteristic database. Hierarchical clustering algorithms were used to screen representative craniofacial indicators. Weighted generalized linear models were used to recognize the influence factors and change trends for craniofacial indicators. The binary panel was updated based on the bivariate distribution of face width and face length among Central China adults in 2023, while the principal component analysis (PCA) panel was updated based on the 10 craniofacial indicators. <b>Results:</b> Hierarchical clustering analysis identified five categories of craniofacial indexes with one representative craniofacial index in each category, namely, head circumference, bitragion chin arc, lip length, face width, and face length. Weighted generalized linear models showed that age, gender, birthplace, and obesity status were important influential factors. Trend analyses demonstrated that compared with participants during 2005-2007 and 2010-2011, men in 2023 showed larger head circumference, bitragion chin arc, and lip length, but smaller face width, and no statistically significant difference in face length; while women in 2023 showed smaller bitragion chin arc, face length, and face width, and no statistically significant difference in head circumference or lip length. Results from typology study indicated that the existing craniofacial panel was no longer applicable to the current adults in central China. The newly constructed binary panel in central China divided the craniofacial region into 10 cells, with a total coverage of 97.24% (96.26% for males and 98.33% for females) and cell coverages ranging from 4.60% to 17.20%. The newly constructed PCA panel partitioned the craniofacial region into 8 cells, with a total coverage of 96.14% (94.28% for males and 98.21% for females) and cell coverages ranging from 9.42% to 14.91%. <b>Conclusion:</b> Statistically significant changes in craniofacial characteristics were observed among adults in Central China, with age, gender, birthplace, and obesity status identified as key influencing factors. This study updated the binary panel and the PCA panel, which can be applied to the design and fit test of respiratory protection products.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"161-170"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the role of non-coding RNAs in the pathogenesis of pulmonary fibrosis].","authors":"Y J Wei, S W Wang, F Li","doi":"10.3760/cma.j.cn121094-20240905-00417","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240905-00417","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease. It is the most common form of irreversible interstitial pneumonia. The etiology of IPF is not fully understood, its detection, diagnosis and treatment options are limited, and its morbidity and mortality are high. Therefore, elucidating the molecular pathological mechanism of the occurrence and progression of IPF can provide theoretical basis for finding new targets for diagnosis and treatment of IPF. Non-coding RNAs have been confirmed to be involved in a variety of physiological and pathological processes and play important roles in the occurrence and progression of many different diseases, including lung diseases. In this review, the role of the non-coding RNAs in the occurrence and progression of IPF and the exploration of them as clinical diagnostic markers of IPF are reviewed, with a view to provide new ideas for the diagnosis and treatment of IPF at the molecular level.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"235-240"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reactive airway dysfunction syndrome caused by acute inhalation of inorganic acids: a case report].","authors":"T T Ye, Y J Ruan, J B Zhang","doi":"10.3760/cma.j.cn121094-20240730-00355","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240730-00355","url":null,"abstract":"<p><p>We report a case of reactive airway dysfunction syndrome (RADS) induced by occupational acute inhalation of mixed nitric and hydrofluoric acid vapors. The clinical manifestations, imaging and pulmonary function changes, pathological features and therapeutic course were mainly analyzed. The case illustrated that a single high level exposure to inorganic acid fumes could lead to RADS, underscoring the need for standardized glucocorticoid protocols and long-term follow-up to improve the prognosis of patients.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"222-225"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on miRNA-204 inhibits silica-induced lung fibrosis in mice the inhibition of miRNA-204 on silica-induced lung fibrosis in mice].","authors":"X Wang, Y Gao, X Wu, M M A X Qumu, P Li, Y Bai, T Zhang, Q Zeng","doi":"10.3760/cma.j.cn121094-20241227-00586","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241227-00586","url":null,"abstract":"<p><p><b>Objective:</b> To observe the effect of Lv-miR-204 on the expression of DVL3 and the inhibition of silicosis fibrosis in mice with silicosis, and to provide experimental evidence for the molecular mechanism of silicosis fibrosis. <b>Methods:</b> In October 2023, 72 BALB/c mice were randomly divided into 4 groups: the control group, the SiO(2) model group, the recombinant lentivirus (SiO(2)+Lv-miR-204) intervention group, and the lentivirus (SiO(2)+Lv-NC) control group, with 18 mice in each group. The mice were killed after 7, 14, and 28 days of dust exposure. HE and Masson stain showed pathological changes in lung tissue, and the content of hydroxyproline in lung tissue was determined using a hydroxyproline kit, and the expression levels of miRNA-204 and DVL3 in lung tissue were detected by Realtime-PCR. One-way ANOVA was used to compare the statistical differences among groups; when statistically significant differences were found, further pairwise comparisons were conducted using the SNK method. <b>Results:</b> On days 7, 14, and 28 after exposure to dust, the degree of lung fibrosis in the SiO(2)+Lv-miR-204 group was significantly reduced; the determination of hydroxyproline content showed that the hydroxyproline content in the SiO(2)+Lv-miR-204 group was significantly lower than that in the SiO(2) model group and the SiO(2)+Lv-NC group, with statistically significant differences (<i>P</i><0.05) ; Realtime-PCR results showed that the expression level of miRNA-204 in the SiO(2)+Lv-miR-204 group was significantly higher than that in the remaining three groups, and the expression of DVL3 in this group was significantly lower than that in the SiO(2) model group and the SiO(2)+Lv-NC group, with statistically significant differences (<i>P</i><0.05) . <b>Conclusion:</b> Overexpression of miR-204 can target and regulate the down-regulation of DVL3 expression level, thereby slowing down the progression of mouse silicosis fibrosis.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"181-185"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study of the effects of long-term exposure to chrysotile on rDNA copy number and DDR in MeT-5A cells].","authors":"X Su, Y X Li, J Q Liu, J Huang, Z Q Jiang, J L Lou","doi":"10.3760/cma.j.cn121094-20241230-00590","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241230-00590","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effects of chrysotile asbestos exposure on ribosomal DNA (rDNA) copy number variation and DNA damage response (DDR) in human pleural mesothelial cells (MeT-5A) . <b>Methods:</b> In April 2024 MeT-5A cells were exposed to chrysotile asbestos at doses of 2.5 μg/cm(2), 5 μg/cm(2) once a week for four weeks, and the cells were collected at weeks 1 and 4 (P1 and P7). The 45S rDNA copy number, 5S rDNA copy number, ACER2, PA2G4, and ZNF385A mRNA expression were determined by quantitative real-time PCR (qPCR) assay. Cell cycle, apoptosis, and DNA damage in the cells were detected using a Muse cell analyzer. The data were statistically anayzed using SPSS 24.0 software. Measurement data conforming to normal distribution were expressed as mean±standard deviation. One-way analysis of variance was used for comparisons among multiple groups, and the least significant difference (<i>LSD</i>) <i>t-</i>tset was used for further pairwise comparisons. <b>Results:</b> Compared with the control group, the 45S and 5S rDNA copy number in the 5 μg/cm(2) exposed group increased at both P1 and P7 generations (<i>P</i><0.05). Compared with the control group, the mRNA expression level of the nucleolar protein ACER2 decreased in the chrysotile asbestos exposed groups at both P1 and P7 generations (<i>P</i><0.05), while the mRNA expression level of ZNF385A increased in the 5μg/cm2 exposed group (<i>P</i><0.05). The mRNA expression level of PA2G4 increased in the chrysotile asbestos exposure group at P7 (<i>P</i><0.05) but decreased in the exposure group at P1 (<i>P</i><0.05). Compared with the control group, the early, late and total apoptosis rates in the chrysotile asbestos exposure groups showed statistically significant differences at different time points (<i>P</i><0.05). Compared with the control group, the proportion of cells in the G0/G1 phase decreased in the chrysotile asbestos exposure group at P7 (<i>P</i><0.001), while the proportion of cells in the S phase increased (<i>P</i><0.05), and the proportion of G2/M phase increased in the 5 μg/cm2 exposure group (<i>P</i><0.05), with statistically significant differences. Compared with the control group, the DNA double-strand break rate in the exposure groups at P1 and P7 and the H2A.X phosphorylation rate in the exposed group at P7 increased, with statistically significant differences (<i>P</i><0.05) . <b>Conclusion:</b> Chrysotile asbestos exposure caused changes in rDNA copy number and mRNA expression levels of related nucleolin genes in Met-5A cells, inducing apoptosis, cell cycle arrest, and DNA damage.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"186-192"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Determination of methylcyclohexanol in workplace air by solvent desorption-gas chromatography].","authors":"H J Lan, P B Li, X M Wu, Y J Feng, S Y Li, G L Chen","doi":"10.3760/cma.j.cn121094-20250214-00061","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20250214-00061","url":null,"abstract":"<p><p><b>Objective:</b> To establish a gas chromatography method with solvent desorption for the determination of methylcyclohexanol in workplace air. <b>Methods:</b> In February 2024, the workpace air samples were collected through Neutral silicone tubes, desorbed with ethanol, separated by a polyethylene glycol capillary column modified with nitrophenyl terephthalic acid (DB-FFAP), and then determined by a hydrogen flame ionization detector (FID) . <b>Results:</b> 1-methylcyclohexanol, 3-methylcyclohexanol and 4-methylcyclohexanol show good linear relationships when the mass concentrations are between 1.15-1840.00 μg/ml, and 2-methylcyclohexanol shows good linear relationship when the mass concentration is between 1.16-1860.00 μg/ml (the correlation coefficient r was better than 0.9999) ; the limit of detection (LOD) was 0.23 μg/ml, and the limit of quantification (LOQ) was 0.77 μg/ml, The lowest detection and lowest quantification concentrations were 0.15 and 0.51 mg/m(3) (measured by 1.5 L air sample). The method showed a good average desorption efficiency which was 96.71%-99.47%, and the relative standard deviation (<i>RSD</i>) of within-batches and between-batches were 0.51%-1.25% and 1.20%-2.45%. The air samples could be saved at least 14 d at room temperature and 4 Celsius degree without obvious loss. <b>Conclusion:</b> This method has the characteristics of high precision, high desorbent efficiency, high sensitivity, and simple operation. It is suitable for the determination of methylcyclohexanol in the air in the workplace.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"44 3","pages":"226-231"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}