中华劳动卫生职业病杂志最新文献

{"title":"[Clinical feature analysis of 258 COPD patients with a history of occupational hazard exposure].","authors":"L Z Lu, R Yuan, Y J Yan","doi":"10.3760/cma.j.cn121094-20240912-00429","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240912-00429","url":null,"abstract":"<p><p><b>Objective:</b> Analyze the correlation between exposure to occupational hazard factors and clinical characteristics of chronic obstructive pulmonary disease (COPD) to provide a basis for early identification and prevention of occupational-related COPD. <b>Methods:</b> In May 2020, a study was conducted involving 258 chronic obstructive pulmonary disease (COPD) patients with occupational exposure history from three general hospitals in Jinan City. Such as symptoms, signs and the percentage of forced expiratory volnmein one second to predicted valve (FEV(1)%pred) collectted exposure to occupational hazard factors such as length of strvice and types of exposure. Clinical characteristics were analyzed through questionnaire surveys and COPD-related data collection. Group comparisons employed t-tests or F-tests, while non-parametric tests were applied to non-normal distribution data. Differences in categorical variables between groups were examined using <i>χ</i>(2)-tests or Fisher's exact test. Multivariate analysis was performed using generalized linear models, with normal distribution correlation analyses conducted through linear regression. <b>Results:</b> Among 258 patients, 145 were male (56.2%) and 113 were female (43.8%), with 210 being smokers (81.4%). The exposure dust primarily consisted of plant-based organic dust (157 cases, 75.5%) and carbon-containing inorganic dust (24 cases, 11.5%). The majority (94 cases, 36.4%) were diagnosed in the 60+ age group. Regarding pulmonary function severity, 55 patients (21.3%) had mild airflow limitation, 99 (38.4%) moderate, 64 (24.8%) severe, and 40 (15.5%) very severe. For acute exacerbation hospitalizations within the past year, 195 (75.6%) had fewer than 2 hospitalizations, while 63 (24.4%) had more than 2. Comprehensive severity assessment showed most patients (91 cases, 35.3%) were in Group B and 62 (24.0%) in Group D. mMRC scores ranged from 0-1 (58.9%) and 2-4 (106 cases, 41.1%). The average CAT questionnaire score was 17.45±1.68. Respiratory symptoms significantly increased with higher occupational hazard exposure levels (<i>P</i><0.05). Moderate-to-high risk exposure showed a correlation with disease severity, with <i>OR</i> values (95%<i>CI</i>) of 1.30 (1.10-1.53) and 1.38 (1.20-1.59). There was a certain correlation between high risk exposure and the number of acute exacerbations in COPD patients in the past year, <i>OR</i> value (95%<i>CI</i>) was 1.410 (1.33-1.50) . <b>Conclusion:</b> Contact level is a major hazard factor affecting COPD respiratory symptoms, disease severity, and number of acute exacerbations. Older age at diagnosis, lower literacy, more smoking and higher exposure level, patients had worse lung function and more severe clinical symptoms.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"761-766"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Common work-related oculopathies of the VDT workers].","authors":"L A Yang, J Chen, L H He","doi":"10.3760/cma.j.cn121094-20240619-00281","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240619-00281","url":null,"abstract":"<p><p>With the advancement of information technology and intelligent systems, smart workplaces have become mainstream, accompanied by a growing workforce engaged in screen-based work. The persistent or prolonged close-up use of computer and visual display terminal (VDT) equipment has significantly increased occupational eye health risks. This paper provides a comprehensive review of common workplace eye disorders (such as visual fatigue and dry eye syndrome) among screen users, analyzes associated risk factors, and proposes management strategies to identify occupational hazards and promote workforce wellness.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"786-790"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research on the index system of occupational safety and health risk assessment of chemical enterprises].","authors":"T T Yang, X H Yang, S Q Cheng, D Luo","doi":"10.3760/cma.j.cn121094-20240520-00228","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240520-00228","url":null,"abstract":"<p><p><b>Objective:</b> It aims to build a scientific and reasonable occupational safety and health risk assessment index system for chemical enterprises, and provide theoretical guidance and scientific basis for the systematic identification, quantification and prevention and control of occupational safety and healthrisk in chemical enterprises. <b>Methods:</b> February 2024, based on relevant literature, national and industry standards as the theoretical foundation, Broussonetia papyrifera established an occupational safety and health risk assessment indicator system for chemical enterprises. Twenty-three experts in occupational health and related fields were invited to score the importance of the indicators; Broussonetia papyrifera constructed an AHP model to calculate the individual expert indicator weights and test matrix consistency, applied the systematic clustering method to allocate expert weights, and employed the weighted average method of weight vectors to calculate the expert group indicator weights. <b>Results:</b> The index system includes 5 first-level indicators, 15 second-level indicators and 42 third-level indicators.A total of 22 experts participated in the questionnaire survey, and the degree of expert activity was 96.5% (22/23), and the mean authority coefficient was 0.88, the questionnaire Cronbach's α coefficient was 0.954. The top three are production facilities, equipment and process technology (0.3694), occupational harmful factors (0.2381) and occupational health management (0.1486). Its subordinate secondary index production technology, production facilities and equipment, chemical harmful factors and tertiary indicators of raw materials selection, process technology, equipment quality and safety weight is also higher than other indicators of the same level. <b>Conclusion:</b> Based on the AHP model and systematic cluster analysis, the occupational safety and health risk assessment index system established for Broussonetia papyrifera chemical enterprises is scientifically reasonable and can provide reference for corporate risk assessment.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"756-760"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the interaction effect of work fit-work stress on occupational fatigue in medical staff].","authors":"J X Ma, H J Wang, C Y Z Ping, Z Li, Y J Lan","doi":"10.3760/cma.j.cn121094-20240723-00341","DOIUrl":"10.3760/cma.j.cn121094-20240723-00341","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the relationship between work fit, work stress, and occupational fatigue among medical staff, and to analyze the independent and interactive effects of work fit and work stress on occupational fatigue. <b>Methods:</b> A stratified random sampling method was employed to select 1162 employees from two top-tier hospitals as the research subjects. A questionnaire survey was conducted to collect information on basic demographics, work stress, work fit, and occupational fatigue. Chi-square test, analysis of variance, and logistic regression equations were used to evaluate the interactive effects of work fit and work stress on occupational fatigue. <b>Results:</b> This study included 1162 medical Homo sapiens personnel, among whom 884 were job-adapted and 362 were in a stressful state. Univariate logistic regression analysis showed that the risk of occupational fatigue significantly increased in the 40-49 age group (<i>OR</i>=1.89) and the bachelor's degree group (<i>OR</i>=2.52, <i>P</i><0.01). Smoking and alcohol consumption were also associated with a significantly higher risk of occupational fatigue (<i>P</i><0.01). In terms of occupational characteristics, compared to clinical doctors, nurses and pharmaceutical/technical Homo sapiens personnel had lower risks (<i>OR</i>=0.57, 0.43, <i>P</i><0.05). Compared to high-ranking Homo sapiens personnel, those with no title or junior titles exhibited lower risks (<i>OR</i>=0.51, 0.43, <i>P</i><0.05). Working hours exceeding 55 hours per week and night shifts 3-4 times per week significantly increased fatigue risk (<i>OR</i>=1.94, 1.90, <i>P</i><0.05). Occupational stress and job discomfort were identified as risk factors for occupational fatigue (<i>OR</i>=11.94, 3.26, <i>P</i><0.05). Job adaptation and occupational stress exhibited a multiplicative interaction on physical fatigue after adjusting for confounders[<i>OR</i> (95%<i>CI</i>) =0.43 (0.22, 0.84) ]. Additionally, job adaptation and occupational stress demonstrated an additive interaction on mental fatigue, with RERI (95%<i>CI</i>) =2.64 (0.11, 5.59), API (95%<i>CI</i>) =0.38 (0.08, 0.67), and SI (95%<i>CI</i>) =1.78 (1.01, 3.14). Medical Homo sapiens personnel in a stressful state had a 7.25-fold higher risk of fatigue compared to those not in a stressful state, while those with job discomfort had a 2.01-fold higher risk compared to those in an adapted state. <b>Conclusion:</b> Occupational stress and job fit have interactive effects on physical fatigue and mental fatigue in medical Homo sapiens personnel. A stressful state combined with job discomfort increases the risk of fatigue occurrence, providing a basis for developing intervention strategies for occupational fatigue among medical Homo sapiens personnel.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"750-756"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A systemic review on clinical characteristics, diagnosis and treatment of hard metal lung disease].","authors":"X Q Du, N Wu, J Ma, Q Ye","doi":"10.3760/cma.j.cn121094-20240530-00245","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240530-00245","url":null,"abstract":"<p><p><b>Objective:</b> To explore the clinical characteristics, treatment and prognosis of hard metal lung disease (HMLD), and to provide a theoretical reference basis for the prevention, control and intervention of HMLD in China. <b>Methods:</b> In April 2024, literatures related to HMLD and giant cell interstitial pneumonia (GIP) published before March 31, 2024 were retrieved in China National Knowledge Infrastructure (CNKI), Wanfang, VIP database, Embase and PubMed. The search terms in Chinese and English included hard metal lung disease, cobalt, tungsten carbide, giant cell interstitial pneumonia, hard metal, etc. Literature was screened and data were extracted. A systematic review was conducted to analyze the clinical characteristics, imaging, pulmonary function, pathological features, treatment and prognosis of HMLD. <b>Results:</b> A total of 55 literatures were included, including 1 cohort study, 4 cross-sectional studies, 4 case series reports and 46 case reports, involving a total of 227 patients with HMLD and GIP. There were 174 male cases, 51 female cases, and 2 cases whose gender was not mentioned. The age was (43.9±13.4) years old, and the dust exposure time was 7 (4, 13) years. The chest images of the patients showed ground glass shadow, micro-nodule shadow, grid shadow, honeycomb shadow, consolidation shadow, etc. Pulmonary function test showed restrictive ventilation dysfunction with gas exchange disorder. The pathological manifestations of lung tissue were typical GIP, but there were also hypersensitivity pneumonitis, common interstitial pneumonia, diffuse alveolar damage, non-specific interstitial pneumonia, and even honeycomb lung. Clinical diagnosis and treatment evaluation were performed by combining the occupational exposure history of hard metal dust or cobalt-containing dust, clinical manifestations, imaging, lung function and histopathology. Treatment involved cessation of exposure, with glucocorticoids alleviating symptoms and improving imaging and pulmonary function. <b>Conclusion:</b> HMLD can be caused by hard metal dust exposure. The clinical symptoms of HMLD are not specific, and the pathology shows typical GIP or other pulmonary interstitial changes. The treatment involves cessation of exposure and administration of glucocorticoids, and the overall prognosis is good.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"735-743"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A comparative review on the technical rules of noise in the German Work Protection Regulations].","authors":"J Wu, Z L Chen, J J Liang, X Y Dai, X Z Huang, L Yang","doi":"10.3760/cma.j.cn121094-20241204-00551","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20241204-00551","url":null,"abstract":"<p><p>The German Technical Rules for Noise and Vibration at the Workplace (Technical Rules for Noise) represent a distinctive regulatory framework for occupational noise protection. It emphasizes engineering controls for noise management, selects quiet equipment by referencing sound emission values of machinery provided in EU directives, and integrates noise reduction considerations during the design phase. Hearing protectors are selected and used based on action levels, and medical examinations are provided accordingly. In contrast, China's approach to occupational noise hazard control primarily relies on health-based exposure limits. This paper provides a critical overview of the four sections of the German Technical Rules for Noise: General Provisions, Risk Assessment, Noise Measurement, and Protective Measures. A comparative section with noise regulations in the United States and the United Kingdom is also included, examining differences and commonalities in standard limits, risk assessment, and protection strategies. Finally, strategies for improving the occupational noise protection system in China are proposed.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"773-776"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction of the evaluation index system of emergency capability of occupational poisoning incidents in Tianjin based on Delphi method].","authors":"X D Li, B F Liu, Q Zeng, R N Qin","doi":"10.3760/cma.j.cn121094-20240627-00287","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240627-00287","url":null,"abstract":"<p><p><b>Objective:</b> To establish an evaluation index system for the emergency capability of occupational poisoning incidents in Tianjin, providing a reference basis for evaluating the emergency capability level of occupational poisoning incidents in Tianjin. <b>Methods:</b> In February 2023, the Delphi method was applied to conduct expert consultation and establish the framework of the emergency response capability evaluation index system for occupational poisoning incidents in Tianjin. The positive coefficient, authority coefficient and coordination coefficient of experts were calculated. The weights of indicators at all levels were determined by using the Analytic Hierarchy Process (AHP) and the proportional allocation method, and the internal consistency reliability of the evaluation index system was tested by using the Cronbach's α wefficient. <b>Results:</b> Regarding the evaluation index system for the emergency capability of occupational poisoning incidents in Tianjin, the expert positive coefficient in both rounds of consultation was 100.00% (33/33), the expert authority coefficients were 0.80 and 0.74 respectively, the expert coordination coefficients were 0.59 and 0.62 respectively (<i>P</i><0.001), and the Cronbach's α coefficient of all indicators was 0.998. The evaluation index system of emergency capability for occupational poisoning incidents in Tianjin was finally determined, including 7 first-level indicators, 30 second-level indicators and 135 third-level indicators. <b>Conclusion:</b> The evaluation index system of emergency capability for occupational poisoning incidents in Tianjin constructed based on the Delphi method shows that the expert consultation is active, representative and authoritative. The indicator system covers the emergency response capability to occupational poisoning incidents and has high internal consistency, providing a reliable and quantifiable reference for improving the emergency response level of occupational poisoning incidents in Tianjin.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"744-749"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ac-SDKP antagonizes lung fibrosis through EGFR/STAT3 pathway in silicosis rats].","authors":"W L Li, L Liu, Y He, N N Yao, H J Deng, Y Qian","doi":"10.3760/cma.j.cn121094-20240614-00272","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240614-00272","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To examine the regulatory effects of a potential antifibrotic tetrapeptide called N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on the expression of epidermal growth factor (EGFR) and signal transducer and activator of transcription 3 (STAT3) in lung tissues with fibrosis induced by silicosis in rats. This study aims to explore the potential therapeutic benefits of Ac-SDKP in the prevention and treatment of fibrotic lung diseases associated with silicosis. &lt;b&gt;Methods:&lt;/b&gt; In January 2024, disease targets and Ac-SDKP active ingredients were predicted through GeneCards (https://www.genecards.org) and OMIM (https://www.omim.org) databases. Using R 4.2.1 software, we identified overlapping targets between pulmonary fibrosis and AC-SDKP. Cytoscape 3.10.2 was employed to visualize interactions between active chemical components and these targets, followed by GO enrichment analysis and KEGG pathway analysis using R 4.2.1. Forty healthy adult Wistar rats were selected to establish silicosis models through single-dose gavage with 50 mg/ml silica suspension (1. 0 ml per rat). The rats were randomly divided into four groups: model control group (4 weeks), silicosis model group (4 weeks), Ac-SDKP preventive treatment group (acquired via intraperitoneal injection of a micro-release pump containing Ac-SDKP [800 μg/ (kg·d) ] during modeling, maintained for 4 weeks), and Ac-SDKP anti-fibrosis treatment group (acquired via intraperitoneal injection of the same pump after 2 weeks of modeling, continued maintenance for 2 weeks). Each group contained 10 rats. The pathological changes in rat lung tissues were observed. Western blot technology was used to detect the protein expression levels of α-smooth muscle actin (α-SMA), epidermal growth factor receptor (EGFR), signal transduction and activation transcription factor 3 (STAT 3), caspase 3, and caspase 8 in lung tissues. Immunohistochemical techniques were employed to assess the expressions of EGFR, STAT3, caspase 3, and caspase 8. Overall differences between groups were compared using one-way ANOVA. &lt;b&gt;Results:&lt;/b&gt; Compared with the control group in the silicosis model, rats in the 4-week group exhibited significant fibrotic nodules. The lung tissues of these rats showed statistically significant increases in α-SMA, EGFR, STAT 3, Caspase 3, and Caspase 8 protein expression (&lt;i&gt;P&lt;/i&gt;&lt;0.05). In contrast, the Ac-SDKP prevention and anti-fibrosis treatment group demonstrated markedly reduced expression levels of these proteins compared to the 4-week silicosis model group, with statistically significant differences (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Immunohistochemical staining revealed that brownish-yellow expression of EGFR, STAT3, Caspase3, and Caspase8 was significantly enhanced in silicotic nodules within the silicosis model group. Conversely, this brownish-yellow expression was notably decreased in the Ac-SDKP prevention and anti-fibrosis treatment group compared to the 4-week silicosis model group. &lt;b&gt;Con","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"721-727"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role and mechanism of high-mobility group box 1 (HMGB1) in the pathogenesis of silica associated chronic obstructive pulmonary disease].","authors":"Z Y Xu, J He","doi":"10.3760/cma.j.cn121094-20240412-00164","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240412-00164","url":null,"abstract":"<p><p>Silica dust is known as the most important risk factor of chronic obstructive pulmonary disease (COPD), and COPD is a leading cause of the third mortality worldwide. Workers exposed to silica dust are at increased risk of COPD as a result of being exposed to silica particles for extended periods of time. While clear links have been established between silica exposure and the development of COPD, the mechanisms are still poorly understood. However, both cigarette and silica combination exposure can be easy to result in COPD. Here we review the current understanding of silica-induced COPD, including incubation period, and the use of experimental animal models for better understanding these mechanisms of pathogenesis. The review summarizes important new knowledge and presents new research directions that are likely to provide new insights, diagnosis and treatments of silica-induced COPD.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"781-785"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relationship between <i>GST</i> gene polymorphism and susceptibility to occupational noise induced hearing loss].","authors":"F Ji, J Zhang, L Rong, X W Ding, X L Cui, X D Liu, J Li","doi":"10.3760/cma.j.cn121094-20240626-00285","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240626-00285","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the relationship between susceptibility to hearing loss in noise-exposed Han Chinese male homo sapiens and glutathione S-transferase (GST) gene polymorphisms, providing a scientific basis for further understanding the pathogenic mechanisms of noise-induced hearing loss (NIHL) and screening for genetic susceptibility biomarkers. <b>Methods:</b> In May 2024, a cross-sectional survey was conducted to recruit 332 male Han workers exposed to noise from a prominent mechanical maintenance enterprise. Workers were classified into the hearing loss group if they exhibited a binaural high-frequency average hearing threshold exceeding 25 dB and a binaural speech frequency average hearing threshold loss that was less than the binaural high-frequency average hearing threshold loss, resulting in a total of 332 individuals in this group. Furthermore, a matched group of 332 hearing-normal workers was established on a 1∶1 basis for each hearing-impaired worker, using criteria such as the same job type, age, and a noise exposure duration of ≤4 years. Basic data of worker was collected through a questionnaire survey, and individual noise exposure levels were assessed using cumulative noise exposure (CNE). Various PCR and high-throughput sequencing techniques were employed to identify polymorphisms in the <i>GSTT1</i>, <i>GSTM1</i>, and <i>GSTP1rs1695</i> genes. The basic information and genotypes of the two groups were compared using paired t-tests and paired chi-square tests. A Cox regression model was utilized to establish a 1∶1 paired logistic regression model to examine the correlation between GST gene polymorphisms and susceptibility to NIHL. <b>Results:</b> Individuals with <i>GSTM1</i> and <i>GSTT1</i> gene deletion are more susceptible to NIHL compared to those with existing genes, even after adjusting for other factors (<i>OR</i>=1.464, 95%<i>CI</i>: 1.02-2.09; <i>OR</i>=0.68, 95%<i>CI</i>: 1.06-2.02). Wearing protective equipment occasionally, rather than consistently, significantly increases the risk of NIHL (<i>OR</i>=1.38, 95%<i>CI</i>: 1.01-1.88). There was no link between <i>GSTP1rs1695</i> polymorphism and NIHL risk (<i>P</i>>0.05) . <b>Conclusion:</b> The deletion of <i>GSTM1</i> and <i>GSTT1</i> genes is an independent influencing factor that increases the risk of NIHL, and can be considered as a genetic susceptibility biomarker for the NIHL population. Strengthening personal hearing protection is an effective measure to reduce the risk of NIHL.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 10","pages":"728-734"},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}