中华劳动卫生职业病杂志最新文献

{"title":"[Structural equation analysis and modeling of fect and ankles WMSDs and its adverse ergonomic factors].","authors":"X Zhang, N Jia, X Sun, M B Zhang, Q Xu, H D Zhang, R J Ling, Y M Liu, Z Li, G Yin, Y Shao, H Zhang, J Qi, H D Qiu, Y M Liu, B Wang, T B Zeng, D Y Ye, J Xiao, R G Zou, Y Chen, B Li, H Liu, J C Liu, D X Jiang, Y Q Qi, Q H Mei, J X Li, E F Yang, J Guo, L Y Wang","doi":"10.3760/cma.j.cn121094-20240703-00297","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240703-00297","url":null,"abstract":"<p><p><b>Objective:</b> To explore the structural equation model to explore the levels of work-related musculoskeletal disorders (WMSDs) and various risk factors in the feet and ankle of China's occupational population, providing scientific basis for for preventing WMSDs in feet and ankles. <b>Methods:</b> Data of 73497 national occupational epidemiological cases were selected from June 2018 to December 2023 used the Chinese version of the Electronic Questionnaire on Musculoskeletal Disorders. The adverse ergonomic factors and their source classification standard and confirmatory factor analysis were used to investigate foot and ankle WMSDs and their related risk factors (including individual factors, work organization, work posture, work type, fatigue, etc.) in key occupational groups in China, and structural equation model hypothesis, fitting, verification, and path and intermediary effect analysis were carried out. The model fit evaluation indexes included Chi-square specific degrees of freedom (<i>χ</i>(2)/<i>df</i>), gauge fit index (NFI), Tucker Lewis index (TLI), goodness of Fit index (GFI), adjusted Goodness of Fit index (AGFI) and approximate root mean square error (RMSEA) . <b>Results:</b> A total of 73497 occupational workers were surveyed, with local muscle fatigue and WMSDs incidence rates in the feet and ankles being 17.17% and 12.06%, respectively. The fitting index of the adjusted structural equation model basically meets the standard (GFI=1, AGFI=1, RMESA=0.042, NFI=0.716, TLI=0.663). The top three factors affecting feet and ankle WMSDs are feet and ankle muscle fatigue, work type, and work organization, with standardized path coefficients of 0.221, 0.105, and 0.095, respectively. The top two factors affecting feet and ankle muscle fatigue are work organization and work type, with standardized path coefficients of 0.548 and 0.383, respectively. Feet and ankle muscle fatigue, work type, work organization, and work posture have a direct effect on feet and ankle WMSDs, with effect values of 0.221, 0.105, 0.095, and 0.077, respectively. The organization and type of work can also have indirect effects through feet and ankle muscle fatigue, with effect values of 0.121 and 0.084, respectively. <b>Conclusion:</b> Feet and ankle muscle fatigue has a direct impact on WMSDs, and plays a mediating role between ankle and ankle WMSDs caused by work organization and work type. Feet and ankle muscle fatigue is an important pathway leading to feet and ankle WMSDs. It is recommended that employers and managers detect job fatigue early and take corresponding prevention and intervention measures, which can play a key role in preventing feet and ankle WMSDs.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"101-109"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Studies on the role of iron death in paraquat-induced mesenchymalization of alveolar epithelial cells].","authors":"Y W Su, W X Fang, S H Tang, G Z Li, Z Wang","doi":"10.3760/cma.j.cn121094-20240515-00219","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240515-00219","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of iron death in paraquat (PQ) -induced alveolar epithelial mesangialization (EMT) . <b>Methods:</b> In August 2023, the appropriate PQ staining concentration as well as the intervention concentration of lipoinhibitor-1 (Lip-1) were screened by CCK8 method. The RLE-6TN cells were divided into three groups, which were control group, PQ group and iron death inhibition group, 200 μmol/L PQ solution was given to the PQ group, and PQ 200 μmol/L and 0.1 μmol/L Lip-1 solution was given to the iron death inhibition group, the control group was added the same amount of cell medium. morphological changes and migratory viability of the cells in each group were observed at 12 h, 24 h and 48 h after the poisoning, and the contents of ferrous ions (Fe(2+)), reactive oxygen radicals (ROS), glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA) were detected in each group; meanwhile, qRT-PCR and western-blot were used to determine the molecular expression of E-cadherin, α-smooth muscle actin (α-SMA), and Collagen I in the cells in each group. The difference between group was compared by ANOVA, and the further pairwise comparison was conducted by Bonferroni method. <b>Results:</b> Cell viability was detected using CCK8, and the results showed that the cell survival rate of RLE-6TN cells treated with 200 μmol/L PQ+0.1 μmol/L Lip-1 solution was 56.6%. The migration activity of RLE-6TN cells in the iron death inhibition group was weaker than that in the PQ group after 24 and 48 hours of exposure, and the degree of EMT changes in the cells was reduced compared to the PQ group. After 12, 24, and 48 hours of exposure, the Fe(2+) concentration, ROS fluorescence intensity, and MDA content in the iron death inhibition group decreased compared to the corresponding time points in the PQ group (<i>P</i><0.05/3), while compared with PQ group, the GSH concentration and SOD concentration increased compared to the corresponding time points in the PQ group (<i>P</i><0.05/3). The results showed that compared with the control group, the expression levels of E-cadherin mRNA and protein in PQ group and iron death inhibition group were both decreased (<i>P</i><0.05/3), while compared with PQ group, the expression levels of E-cadherin mRNA and protein in iron death inhibition group were increased (<i>P</i><0.05/3) ; Compared with the control group, the expression levels of α-SMA, Collagen I mRNA and protein in PQ group and iron death inhibition group cells increased (<i>P</i><0.05/3), while compared with PQ group, the expression levels of α-SMA, Collagen I mRNA and protein in iron death inhibition group cells decreased (<i>P</i><0.05/3) . <b>Conclusion:</b> Ferroptosis is involved in the EMT process of alveolar epithelial cells induced by PQ. Inhibiting ferroptosis can reduce cellular oxidative damage and alleviate the degree of cellular EMT.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of Ergonomic Principle for the Prevention of Work-Related Musculoskeletal Disorders Part 1: General Principles (T/WSJD 14.1-2020)].","authors":"Q Xu, N Jia, R J Ling, G Li, Y M Liu, H D Zhang, Q S Chen, Q L Zhang, Z Wang, Y Qu, X Y Zhang, Y Yang, Z X Wang","doi":"10.3760/cma.j.cn121094-20240507-00200","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240507-00200","url":null,"abstract":"<p><p>Ergonomic Principle for the Prevention of Work-Related Musculoskeletal Disorders Part 1: General Principles (T/WSJD 14.1-2020) is the first guideline standard for the prevention of work-related musculoskeletal disorders provided to employers and occupational health technical service institutions in China, which covers ergonomic risk factors and their hazard definition, ergonomic prevention principles, risk assessment process, risk control process and risk evaluation principles. The standard specifically clarify the specific types of adverse ergonomic risk factors and control strategies and the standard process of systematic ergonomic risk assessment, providing implementation paths and practical guidance for eliminating/reducing adverse ergonomic risks and enhance workplace environments to prevent work-related musculoskeletal disorders. This paper interprets and analyzes the background of standard establishment, formulation process, fundamental basis, and main content, etc., to provide scientific and accurate technical support for enterprise managers, labours and technical personnel of occupational health institutions to optimize the use of this standard.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ergonomic evaluation and effectiveness analysis of improvement measures in the assembly position of an automotive parts production company].","authors":"B Shen, P F Liu, J H Liu, X Y Xu, M F Zheng, Z X Wang, N Jia","doi":"10.3760/cma.j.cn121094-20240418-00171","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240418-00171","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the improvement effect of ergonomics in the assembly position of an automotive parts production company. <b>Methods:</b> From February to December 2023, the assembly positions and 8 operators of an automobile brake parts production company were selected as the research objects. The Swedish Ergonomic Hazard Identification Method and rapid upper limb assessment (RULA) were used to identify and evaluate the adverse ergonomic factors of work-related musculoskeletal disorders (WMSDs) in different parts of the body before and after the improvement. Through field investigation, observation and personnel interviews, three ergonomic problems were identified that need to be solved, namely, the height of the assembly table did not match the height of the operator, the storage space for small accessories was not set reasonably, and empty boxes were difficult to be placed. Technical improvements were made by designing an adjustable height assembly table, improving the layout of the workbench, and designing a mechanical pedal automation device. Statistical analysis was performed by <i>t</i>-test and paired rank sum test to evaluate the effectiveness of ergonomic improvements. <b>Results:</b> The operation of the assembly position could be divided into 13 actions, and the time to complete 1 cycle was (83.0±2.7) s. The Swedish Ergonomic Hazard Identification Method identified 28 adverse ergonomic factors of WMSDs in different parts before improvement, and 15 adverse ergonomic factors after improvement. Before ergonomics improvement, the RULA scores were 5 to 7 points, and the risk levels of 6 workers were Ⅳ (very high risk) and 2 workers were Ⅲ (moderate risk). After ergonomics improvement, the RULA score was 4 points, and the risk level was reduced to Ⅱ (low risk). Paired rank sum test results showed that there were statistically significant differences in upper arm, A-part (upper arm, lower arm and wrist) exertion and load, A-part muscle use, neck, total score, and risk level before and after improvement (<i>P</i><0.05). Per capita productivity of assembly post was (40.1±1.4) pieces/ (person·hour) before the improvement and (44.0±1.7) pieces/ (person·hour) after the improvement, the difference was statistically significant (<i>t</i>=50.35, <i>P</i><0.001) . <b>Conclusion:</b> The ergonomic improvement measures can reduce the adverse ergonomic factors in the assembly position of an automotive parts production company, reduce the risk of WMSDs, and improve the production efficiency.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the pollution and influencing factors of legionella pneumophila in industrial circulating cooling tower].","authors":"M Yu, Y Tang, C Y Tao, Y Ning, Y Xu, X Zhang","doi":"10.3760/cma.j.cn121094-20240429-00193","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240429-00193","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the pollution status of legionella pneumophila of industrial circulating cooling towers, and explore the factors affecting the positive rate and quantity of legionella pneumophila, in order to provide data support for the risk assessment and hierarchical management of legionella pneumophila in workplaces. <b>Methods:</b> In February, May, August and October 2023, the cooling water samples were collected from a total of 20 industrial circulating cooling towers of 9 enterprises in an industrial park in Shanghai. The water temperature, free residual chlorine, total residual chlorine, turbidity, chroma, pH, conductivity, chemical oxygen consumption, iron content and total plate count in the water samples were detected. Meanwhile, the legionella pneumophila in the water samples were qualitatively and quantitatively analyzed, and the influence of water quality indexes on the positive rate and number of legionella pneumophila detected was analyzed by logistic regression and linear regression respectively. <b>Results:</b> The positive rates of legionella pneumophila in the first to fourth quarters of 20 industrial circulating cooling towers of 9 chemical enterprises were 35% (7/20), 45% (9/20), 45% (9/20), and 85% (17/20). The serotypes of legionella pneumophila detected in the cooling tower were mainly legionella pneumophila type 1 (95.2%, 40/42), and the number of legionella pneumophila ranged from 0.2 to 316.8 cfu/ml. Circulating cooling water temperature (<i>OR</i>=1.36, 95%<i>CI</i>: 1.12-1.64, <i>P</i>=0.001) and conductivity (<i>OR</i>=1.02, 95%<i>CI</i>: 1.00-1.03, <i>P</i>=0.026) were independent risk factors affecting the detection of legionella pneumophila. There was a positive correlation between chemical oxygen consumption and the detected amount of legionella pneumophila (<i>β</i>=8.08, <i>P</i>=0.002) . <b>Conclusion:</b> The positive rate of legionella pneumophila in industrial circulating cooling water system is high, and the detected quantity fluctuates greatly, which may have health risks, suggesting that it is necessary to pay attention to the water quality management such as water temperature, conductivity and chemical oxygen consumption of industrial circulating cooling water and the monitoring and control of legionella pneumophila.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"122-128"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Structural equation analysis of the incidence of shoulder WMSDs and individual and work-related factors].","authors":"S Zhou, Z X Wang, R J Ling, Q Xu, H D Zhang, Y M Liu, G Li, Y Yin, H Shao, J Li, H D Zhang, B Qiu, D Y Wang, Q Zeng, Y Ye, B Xiao, H Zou, J C Chen, D X Li, Y Q Liu, J X Liu, E F Jiang, J Qi, L Y Mei, X F Zhao, M M Yang, N Jia","doi":"10.3760/cma.j.cn121094-20240701-00291","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240701-00291","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the incidence of shoulder work-related musculoskeletal disorders (WMSDs) among occupational population in China, and to explore their intrinsic association with personal and work-related factors. <b>Methods:</b> In April 2024, 73497 valid questionnaires of the Chinese version of the Musculoskeletal Disorders Electronic Questionnaire were retrospectively analyzed from June 2018 to December 2023 in 22 provinces and 29 key industries in China, and the general information, occurrence of WMSDs and related risk factors of key occupational populations in different regions in China were collected. By using Chi-square test and confirmatory factor analysis, the relationship between shoulder fatigue and pain in key occupational groups and individual factors, work type, work posture and work organization was discussed, and the internal relationship was analyzed based on structural equation model. <b>Results:</b> Higher incidence of shoulder fatigue and pain were associated with female, lack of physical exercise, uncomfortable working posture and neck leaning forward (<i>P</i><0.05). Structural equation model analysis showed that work type, work posture and work organization were strongly correlated (<i>r</i>=0.58, 0.55). Work organization and work type were strongly correlated with shoulder fatigue (<i>r</i>=0.65) and moderately correlated with shoulder fatigue (<i>r</i>=0.21). Shoulder fatigue was moderately associated with shoulder pain (<i>r</i>=0.40). Individual factors, work type, work posture and shoulder fatigue could directly affect shoulder pain (<i>OR</i>=0.07, -0.09, 0.17 and 0.40), and work type and work posture could also indirectly affect shoulder pain through shoulder fatigue (<i>OR</i>=0.08, 0.03). Work organization only indirectly affected shoulder pain through shoulder fatigue (<i>OR</i>=0.26) . <b>Conclusion:</b> The main influencing factor of shoulder pain is shoulder fatigue, followed by work posture and individual factors. Structural equation model can better reflect the complex relationship between work type, work posture and work organization and shoulder WMSDs. Improving work posture and work organization may be an effective way to control the influence of shoulder fatigue on shoulder pain.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Standard interpretation of the Ergonomic Guidelines for the Prevention of Work-related Musculoskeletal Disorders Part 3 in Shipbuilding Manufacturing Work].","authors":"Z H Peng, P X Chen, H Zhang, F Yang, Y Yin, N Jia, Z Wang, Z X Wang","doi":"10.3760/cma.j.cn121094-20240423-00183","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240423-00183","url":null,"abstract":"<p><p>The \"Guidelines for the Ergonomic Prevention of Work-related Musculoskeletal Disorders Part 3 in Shipbuilding Operations\" (T/WSJD 14.3-2024) was published and implemented in March 2024, providing a basis for scientific prevention and control of musculoskeletal disorders in shipbuilding operations. In this paper, the background, formulation process, basis and main content of the standard project are interpreted and analyzed, so as to help relevant practitioners and managers more fully understand and implement the ergonomic program proposed by the standard, and provide scientific and accurate technical support for enterprises.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"146-149"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the application of immature platelet and thromboelastography in assessing the risk of hemorrhage after blood-poisonous snake bite].","authors":"X Wu, S Q Lan, E L Gong, H Z Ye, P Lan","doi":"10.3760/cma.j.cn121094-20240322-00112","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240322-00112","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the value of immature platelets and thromboelastography (TEG) in evaluating bleeding tendency in patients bitten by blood venomous snakes. &lt;b&gt;Methods:&lt;/b&gt; In December 2023, a bleeding scoring system was used to grade the bleeding score and degree of bleeding in 147 patients with blood venomous snake bites. Immature platelets and TEG were also tested to analyze the correlation between the bleeding degree of patients and indicators such as TEG, immature platelet ratio (IPF), and absolute value of immature platelets (A-IPF). The measurement data were represented by Mean±SD, and ANOVA was used for comparison among groups. Statistical data were analyzed using &lt;i&gt;χ&lt;/i&gt;(2) test. Spearman correlation was used to analyze the correlation between bleeding degree and the platelet count (PLT), immature platelet and TEG. Pearson linear correlation was used to analyze the correlation of PLT, immature platelets and TEG. The indexes of immature platelets and TEG were analyzed by receiver operating characteristic curve. &lt;b&gt;Results:&lt;/b&gt; The 147 patients were graded for bleeding severity based on their bleeding scores, and divided into mild (22 cases), moderate (119 cases), and severe groups (6 cases), and the clinical data such as age, gender and the time from bite to visit were compared among the three groups. The differences were not statistically significant (&lt;i&gt;P&lt;/i&gt;&gt;0.05). The coagulation reaction time (R), clot formation time (K), and immature platelet parameters (IPF, A-IPF) in TEG parameters increased with the degree of bleeding. PLT decreased with the degree of bleeding, and the difference was statistically significant (&lt;i&gt;P&lt;/i&gt;&lt;0.05). Blood venomous snake bite patients have a negative correlation between PLT and IPF (&lt;i&gt;r&lt;/i&gt;=-0.301, &lt;i&gt;P&lt;/i&gt;=0.012), but no correlation with A-IPF (&lt;i&gt;r&lt;/i&gt;=0.072, &lt;i&gt;P&lt;/i&gt;=0.461) ; PLT was positively correlated with coagulation Angle (αAngle) and maximum thrombus amplitude (MA) of TEG (&lt;i&gt;r&lt;/i&gt;=0.220、0.243, &lt;i&gt;P&lt;/i&gt;=0.028、0.015), but negatively correlated with R value and K value (&lt;i&gt;r&lt;/i&gt;=-0.368、-0.362, &lt;i&gt;P&lt;/i&gt;&lt;0.001). IPF is positively correlated with R and K values (&lt;i&gt;r&lt;/i&gt;=303、271, &lt;i&gt;P&lt;/i&gt;=0.0020、0.035) ; IPF is not correlated with MA value and Angle angle, while A-IPF is positively correlated with R value (&lt;i&gt;r&lt;/i&gt;=0.162, &lt;i&gt;P&lt;/i&gt;&lt;0.001). The degree of bleeding in patients is positively correlated with R value (&lt;i&gt;r&lt;/i&gt;=0.237, &lt;i&gt;P&lt;/i&gt;&lt;0.001), but not with K value, MA value, and Angle angle (&lt;i&gt;P&lt;/i&gt;&gt;0.05) ; The degree of bleeding in patients is correlated with PLT (&lt;i&gt;r&lt;/i&gt;=-0.411, &lt;i&gt;P&lt;/i&gt;&lt;0.001). The ROC curve analysis results show that the R value, K value, and MA value are effective in evaluating the bleeding risk of blood venomous snake bites in patients, and the PLT combined with A-IPF has the best efficacy in evaluating the bleeding risk of blood venomous snake bites in patients. &lt;b&gt;Conclusion:&lt;/b&gt; The combination of PLT and A-IPF, TEG's R value, K value, MA value indicato","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"134-138"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nano-ITO induce pulmonary alveolar proteinosis through oxidative stress and activation of NF-κB/Nrf2 signaling pathway].","authors":"Y Q Lin, Y Zhang, X Y Chen, W K Li, Y J Niu, X F Wang, N Liu, G Li","doi":"10.3760/cma.j.cn121094-20240313-00094","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240313-00094","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role of the nuclear factor-kappa B (NF-κB) /nuclear factor E2 related factor 2 (Nrf2) pathway in the occurrence of lung tissue in the pulmonary alveolar proteinosis (PAP) model of rats induced by indium tin oxide nanoprticles (Nano-ITO) . <b>Methods:</b> In October 2019, 120 SD rats were divided into 3, 7, 14, 28, 56, and 84 day Nano ITO exposure groups and corresponding time point control groups, with 10 rats in each group; the exposure group was treated with 6 mg/kg·bw Nano-ITO via non exposed tracheal injection, twice a week. Time-course studies were performed to examine the pulmonary toxicity induced by Nano-ITO. At the end of the experiment, cytokines levels and oxidative stress were analyzed in the bronchoalveolar lavaged fluid (BALF). Rat lung tissues were also harvested for staining with HE, PAS, Masson, and Oil Red O. Ultrastructure of lung tissue cells was observed by transmission electron microscope. The localization and expression of NF-κB p65, IκB-α, IKK-β, Nrf2, NQO1, HO-1 were observed by immunohistochemistry, Western blot and real-time fluorescent quantitative PCR. The comparison between the two groups was analyzed by independent sample T test, and the comparison between the multiple groups was analyzed by one-way ANOVA. <b>Results:</b> Nano-ITO intratracheal instillation caused pulmonary toxicity by inducing acute inflammation, granuloma (nodule) formation, and alveolar proteinosis. ELISA analysis showed that, compared with the corresponding time points control groups, the levels of superoxide dismutase (SOD), total antioxidant capacity (T-AOC), malondialdehyde (MDA), interleukin (IL) -1β, IL-6, tumor necrosis factor alpha (TNF-α), IL-10, total protein (TP), and lactate dehydrogenase (LDH) in BALF of rats exposed to Nano ITO were all increased (<i>P</i><0.05) ; The protein expression of Nrf2 and NF-κB p65 was upregulated in rat lung tissue, while the protein expression of KK-β was increased (<i>P</i><0.01). Nrf2 and its downstream proteins NQO1 and HO-1 were highly expressed in Nano-ITO-induced PAP rat. <b>Conclusion:</b> NF-κB/Nrf2 signal pathway is involved in the process of Nano-ITO induced pulmonary alveolar proteinosis in rats.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"81-90"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The correlation between WMSDs and thyroid indicators in male large-scale mechanical maintenance workers].","authors":"M L Bi, X Y Cui, X F Wang, X X Peng, J Li, H N Wang, X S Wang, X W Ding","doi":"10.3760/cma.j.cn121094-20240122-00033","DOIUrl":"https://doi.org/10.3760/cma.j.cn121094-20240122-00033","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the status of work-related musculoskeletal disorders (WMSDs) in male large-scale mechanical maintenance workers, and to explore the relationship between WMSDs and thyroid indexes. <b>Methods:</b> From April to July 2022, male front-line maintenance workers in a large-scale mechanical maintenance enterprise who participated in occupational health examination were selected as the study subjects (<i>n</i>=2036). The occurrence of WMSDs was investigated by questionnaire. The levels of triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) in serum were detected. <i>χ</i>(2) test, <i>t</i>-test and Mann-Whitney U test were used to detect thyroid diseases and hormone levels of workers in WMSDs group and non-WMSDs group, and binary logistic regression model was used to analyze the relationship between thyroid disease, T3, T4, TSH and WMSDs. <b>Results:</b> The incidence of WMSDs among the male large-scale mechanical maintenance workers was 73.18% (1490/2036). The rate of thyroid disease in WMSDs group was higher than that in non-WMSDs group [8.26% (123/1490) vs. 4.95% (27/546), χ(2)=6.42, <i>P</i>=0.011], and the TSH value was lower than that in non-WMSDs group[1.66 (1.23, 2.26) μIU/ml vs. 1.75 (1.30, 2.42) μIU/ml, <i>Z</i>=-2.40, <i>P</i>=0.019]. There were no significant differences in the levels of T3, T4 and abnormal levels of 3 hormones between the two groups (<i>P</i>>0.05). After accounting for individual and occupational factors, workers with thyroid disease had an increased risk of WMSDs (<i>OR</i>=1.656, 95%<i>CI</i>: 1.072-2.559, <i>P</i>=0.023), while workers with increased TSH had a decreased risk of WMSDs (<i>OR</i>=0.897, 95% <i>CI</i>: 0.823-0.977, <i>P</i>=0.013) . <b>Conclusion:</b> The incidence of WMSDs in male workers of large-scale mechanical maintenance is high, and its incidence may be related to thyroid index. Thyroid disease may be a risk factor for WMSDs, and increased TSH may be a protective factor for WMSDs.</p>","PeriodicalId":23958,"journal":{"name":"中华劳动卫生职业病杂志","volume":"43 2","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}