World Journal of Urology最新文献

{"title":"Sand clearance vs. flowrate during ureteroscopy: studies in an in-vitro transparent kidney model.","authors":"Leilane Glienke, Timothy L Hall, William W Roberts","doi":"10.1007/s00345-025-05708-z","DOIUrl":"10.1007/s00345-025-05708-z","url":null,"abstract":"<p><strong>Purpose: </strong>Suction has recently been introduced into the ureteroscopic armamentarium to improve stone fragment and debris clearance. However, the benefits of suction appear to be limited by current irrigation systems. This study aimed to measure the time to clear sand ureteroscopically from a transparent silicone kidney-ureter model at different flowrates and compare with results with conventional pressurized irrigation and intermittent suction.</p><p><strong>Methods: </strong>A LithoVue™ Elite ureteroscope was inserted through a Clear Petra 11/13 Fr 46 cm or 12/14 Fr 50 cm FANS device into a transparent silicone kidney model. Irrigation was delivered from a peristaltic pump at rates of 18-90 ml/min with pump assisted outflow or from a pressurized source with suction assisted outflow. Intrarenal pressure (IRP) was maintained between 30-40 cmH₂O. Trials were conducted to measure the time required to completely aspirate 0.5 g of sand from the mid and upper calyces.</p><p><strong>Results: </strong>Sand was cleared more quickly from the kidney model as flowrate increased up to ~ 70-80 ml/min. Use of continuous flowrate was more efficient at clearing sand than variable flowrate produced by bursts of intermittent suction.</p><p><strong>Conclusions: </strong>Flowrate is a primary variable affecting efficiency of sand clearance in in vitro studies. Current clinical methods that utilize intermittent suction during ureteroscopy are likely less efficient than configurations that provide continuous flowrates. Incorporation of IRP feedback into irrigation systems may facilitate high flowrate while maintaining stable low IRP, thereby enhancing efficiency and safety of ureteroscopy.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"319"},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxycitric acid inhibits ferroptosis and ameliorates benign prostatic hyperplasia by upregulating the Nrf2/GPX4 pathway.","authors":"Dayong Yang, Chengxi Zhai, Junyu Ren, Jinran Bai, Tao Li, Mingyao Lu, Yongjie Tang, Liangsheng Wei, Rongyao Luo, Fachun Tong","doi":"10.1007/s00345-025-05637-x","DOIUrl":"10.1007/s00345-025-05637-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Benign prostatic hyperplasia (BPH) poses a significant public health challenge, affecting a substantial portion of aging men worldwide. Current therapeutic options offer limited efficacy. The pathogenesis of BPH is multifactorial, involving ferroptosis, oxidative stress, and chronic inflammation. Hydroxycitric acid (HCA) is a natural compound with diverse pharmacological activities, including the inhibition of ferroptosis, anti-inflammatory, anti-oxidative stress, and anti-tumor effects. However, its role in BPH remains unexplored. This study aimed to investigate the effects of HCA on BPH and elucidate the underlying mechanisms, with the goal of providing novel therapeutic insights for BPH treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;C57BL/6J mice were used to establish a BPH model induced by testosterone propionate (TP). Animals were then randomly assigned to the following groups: Sham, BPH, BPH + Lip-1, BPH + Bru, BPH + HCA + Bru, and BPH + HCA. Prostate index (PI) was determined, and histopathological changes were evaluated by hematoxylin and eosin (HE) staining. Mitochondrial morphology was analyzed by TEM. The levels of Fe&lt;sup&gt;2+&lt;/sup&gt;, MDA, and GSH in prostate tissues were measured. Western blot analysis was performed to assess the protein expression of Nrf2 and GPX4.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared to the Sham group, the prostate tissues of the BPH group exhibited typical histopathological features of hyperplasia, including epithelial cell proliferation, increased glandular lumen size. Concurrently, the levels of ferroptosis markers Fe&lt;sup&gt;2+&lt;/sup&gt; (P &lt; 0.01) and MDA (P &lt; 0.001) were significantly elevated, while the expression of GSH (P &lt; 0.01) and GPX4 (P &lt; 0.05) was downregulated. Furthermore, mitochondrial morphology showed abnormalities. HCA treatment significantly reduced PI (P &lt; 0.01) and attenuated epithelial cell proliferation and glandular lumen enlargement (P &lt; 0.01, P &lt; 0.001, respectively). HCA also reduced the levels of Fe&lt;sup&gt;2+&lt;/sup&gt; (P &lt; 0.05) and MDA (P &lt; 0.05), and elevated GSH levels (P &lt; 0.01). Furthermore, HCA upregulated the expression of Nrf2 (P &lt; 0.01) and GPX4 (P &lt; 0.01). The Nrf2 inhibitor Brusatol increased the levels of Fe&lt;sup&gt;2+&lt;/sup&gt; (P &lt; 0.05) and MDA (P &lt; 0.05), and downregulated the expression of Nrf2 (P &lt; 0.05) and GPX4 (P &lt; 0.05), thereby attenuating the protective effects of HCA. However, co-administration of HCA and Brusatol partially reversed changes in Fe&lt;sup&gt;2+&lt;/sup&gt; (P &lt; 0.05) and MDA (P &lt; 0.05) levels, and increased the expression of Nrf2 (P &lt; 0.05) and GPX4 (P &lt; 0.05), indicating reduction in Brusatol-induced effects. Furthermore, HCA treatment did not significantly affect liver and kidney function markers (AST, ALT, SCR, and UR) (P &gt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;HCA inhibits ferroptosis by activating the Nrf2/GPX4 pathway, thereby ameliorating the pathological changes in BPH induced by TP. This study suggests a novel therapeutic strategy for BPH.&lt;","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"318"},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can ureteral stents be omitted from radical cystectomy with continent diversion? An ACS-NSQIP analysis of the early postoperative outcomes.","authors":"Yara Ghandour, Baraa AlJardali, Towfik Sebai, Marwan Zein, Jad Najdi, Albert El Hajj","doi":"10.1007/s00345-025-05685-3","DOIUrl":"https://doi.org/10.1007/s00345-025-05685-3","url":null,"abstract":"<p><strong>Purpose: </strong>Radical cystectomy with continent diversion is the standard treatment for muscle-invasive bladder cancer. Evidence supporting the necessity of ureteral stent use after this procedure is limited. This study compares 30-day postoperative outcomes of radical cystectomy with continent diversion using neobladder reconstruction in patients managed with and without ureteral stents.</p><p><strong>Methods: </strong>A retrospective cohort study using the 2019-2022 ACS-NSQIP database included 1,318 patients who underwent radical cystectomy with continent diversion using neobladder reconstruction. We compared baseline characteristics and perioperative factors between the stented (n = 1,216) and stentless group (n = 102). Univariate and multivariate analyses assessed the relationship between stent use and perioperative outcomes, as well as 1:1 propensity score matching.</p><p><strong>Results: </strong>Patient demographics and comorbidities were comparable between the two groups. Similarly, preoperative and intraoperative factors showed no significant differences, except for a higher drain placement rate in the stented group (98.6% vs. 89.2%, p < 0.001). Postoperatively, the stented cohort exhibited higher odds of minor complications (CD grade 1-2; OR 1.66, p = 0.018), and an increased incidence of progressive renal insufficiency (8.7% vs. 1.3%, p = 0.024) and bleeding requiring transfusion (29.8% vs. 19.6%, p = 0.030). Ureteral obstruction, urinary leak, anastomotic leak rates, hospital stay, and readmission and reoperation rates remained similar between the two groups. Propensity score matching (1:1) for patients with and without stents supported the results of the multivariate logistic regression.</p><p><strong>Conclusion: </strong>Stent omission after radical cystectomy with continent diversion using neobladder reconstruction was not associated with significant differences in major complications, ureteral obstruction, readmission, or reoperation rates. It is potentially a safe alternative associated with fewer minor complications.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"314"},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organizational impact of systematic urine culture before Bacillus Calmette Guerin (BCG) induction instillations.","authors":"Quentin Jock, Laura I Levi, Matthieu Lafaurie, Annabelle Goujon, Pierre Mongiat Artus, Paul Meria, Francois Desgrandchamps, Alexandra Masson Lecomte, Emilien Seizilles de Mazancourt","doi":"10.1007/s00345-025-05671-9","DOIUrl":"https://doi.org/10.1007/s00345-025-05671-9","url":null,"abstract":"<p><strong>Purpose: </strong>There are conflicting recommendations concerning the performance of a systematic urine culture (UC) prior to Bacillus Calmette Guerin (BCG) bladder instillations for non-muscle-invasive bladder tumor. The objective was to study the organizational impact of the UC performed before bladder instillations, defined as the number and proportion of BCG instillations postponed due to a positive urine culture result.</p><p><strong>Methods: </strong>Induction BCG records in a single academic center between 2015 and 2020 were retrospectively reviewed. All patients had a UC prior to each instillation, treated if positive. Risk factors associated with the occurrence of a positive UC, an adverse event or postponement of instillation were studied.</p><p><strong>Results: </strong>A total of 156 patients were included, among which 68.9% of patients had at least one risk factor of UTI and 33% of patients presented at least one positive UC at induction. During BCG induction, 76/909 (8.4%) urine cultures performed were positive and 33% of patients had at least one postponement of BCG instillation. There were 64 instillations postponed, caused by untreated positive urine culture for 40 (62.5%) and absence of urine culture performed for 6 (9.4%) In multivariate analysis, only the presence of lower urinary tract symptoms was significantly associated with a risk of positive UC.</p><p><strong>Conclusion: </strong>Positive UC during BCG instillations is a frequent event and a source of disorganization in BCG induction, with possible oncological consequences. A strategy of performing UC only in selected patients, could facilitate proper BCG administration and avoid unreasonable use of antibiotics.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"316"},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Is flexible navigable suction ureteral access sheath (FANS) safer and more efficient than conventional sheaths? Italian multicentric experience\".","authors":"Daniele Castellani, Angelo Cormio, Khi Yung Fong, Steffi Kar-Kei Yuen, Vineet Gauhar","doi":"10.1007/s00345-025-05697-z","DOIUrl":"https://doi.org/10.1007/s00345-025-05697-z","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"315"},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between urinary pH and efficacy of Bacillus Calmette-Guérin treatment in patients with carcinoma in situ of the bladder.","authors":"Ryo Yamashita, Takashi Sugino, Akifumi Notsu, Yuichiro Nakaya, Kana Ito, Yuma Sakura, Hideo Shinsaka, Masato Matsuzaki, Masashi Niwakawa, Eiji Kikuchi","doi":"10.1007/s00345-025-05700-7","DOIUrl":"https://doi.org/10.1007/s00345-025-05700-7","url":null,"abstract":"<p><strong>Purpose: </strong>Bacillus Calmette-Guérin (BCG) is the standard treatment for carcinoma in situ (CIS) in patients with urothelial bladder carcinoma. We aimed to determine whether average urinary pH before BCG instillation affects the BCG response.</p><p><strong>Methods: </strong>Between August 2003 and January 2023, 203 patients with CIS received BCG treatment (Tokyo strain, 80 mg, ≥ 5 times) at our hospital. Average urinary pH was calculated by summing each urinary pH measurement before BCG instillation and dividing by the number of instillations. The Fine-Gray method was used to assess the relationship between average urinary pH (as a continuous variable) and intravesical recurrence. We also analyzed the cumulative incidence of intravesical recurrence after BCG treatment using different cutoff values for average urinary pH (median and trisection of the cohort).</p><p><strong>Results: </strong>The median follow-up period was 45 months (interquartile range (IQR): 14-83 months). The median urinary pH was 6.07 (IQR: 5.68‒6.50). In multivariate analysis, average urinary pH before BCG was significantly associated with intravesical recurrence (hazard ratio: 0.53, 95% confidence interval 0.32-0.89, p = 0.017). The cumulative incidence of intravesical recurrence differed significantly when categorized by average urinary pH (median and trisection), with patients having higher urinary pH showing lower intravesical recurrence rates.</p><p><strong>Conclusion: </strong>This is the first study to examine the relationship between BCG response and average urinary pH in patients with CIS. Patients with higher urinary pH had lower intravesical recurrence rates after BCG treatment.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"317"},"PeriodicalIF":2.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do patients with intermediate-risk renal carcinoma who receive adjuvant pembrolizumab really benefit in recurrence-free survival? Analysis of a cohort of nephrectomies over 10 years.","authors":"Pablo A Rojas, David Carracedo, Pietro Moscatiello, Laura González, Helena Gimbernat, Marta Santiago, Miguel Toledo, Nathalie Pereira, Miguel Sánchez-Encinas","doi":"10.1007/s00345-025-05599-0","DOIUrl":"https://doi.org/10.1007/s00345-025-05599-0","url":null,"abstract":"<p><strong>Purpose: </strong>Pembrolizumab has shown benefits as adjuvant therapy in the Keynote-564 trial, improving disease-free survival (DFS) across broad patient subgroups. However, it remains unclear if all patients, including those potentially cured by surgery alone, derive real benefits or are unnecessarily exposed to adverse effects and costs. This study aimed to evaluate DFS in Keynote-564-like patients who underwent nephrectomy without adjuvant pembrolizumab.</p><p><strong>Methods: </strong>We included nephrectomy patients meeting Keynote-564 criteria. Clinical and pathological features were analyzed, and Cox regression was used to identify predictors. DFS and overall survival (OS) were assessed.</p><p><strong>Results: </strong>Forty-three patients met Keynote-564 criteria (100% intermediate risk). Among them, 12 patients (28%) experienced recurrence. Significant differences between recurrent (Re+) and non-recurrent (Re-) patients were observed in ECOG ≥ 1 frequency (25% vs. 0%; p < 0.05), tumour size (9.4 vs. 6.9 cm; p = 0.02), and renal pelvis invasion (50% vs. 19%; p = 0.04). Cox regression identified ECOG ≥ 1 as a predictor of recurrence (HR = 17.97, 95% CI 1.76-187.16; p = 0.016). After a median follow-up of 59.5 months, 2-year DFS and OS were 86% and 93%, respectively. Treating only relapsed patients with pembrolizumab would have saved €1,254,167.</p><p><strong>Conclusion: </strong>Our recurrence rate was lower than Keynote-564, whereby no strong predictors of recurrence were identified. Although ECOG ≥ 1 was statistically significant, its clinical utility remains limited. Further research is needed to determine if adjuvant pembrolizumab provides a true benefit in intermediate-risk patients.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"307"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the learning curve of total ultrasound guided percutaneous nephrolithotomy in complex renal stones using\"30-degree triangulation\"technique.","authors":"Bo Xiao, Yang Chen, Shen Lin, Xue Zeng, Yubao Liu, Yangyang Xu, Haiwen Huang, Zhichao Luo, Wenjie Bai, Jianxing Li","doi":"10.1007/s00345-025-05674-6","DOIUrl":"https://doi.org/10.1007/s00345-025-05674-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the learning curve of in the training of total ultrasound(US) guided percutaneous nephrolithotomy(PCNL) in complex renal stones using \"30-degree principle\" technique.</p><p><strong>Patients and methods: </strong>A total of 80 patients were included in this study to evaluate the learning curve of US guided PCNL in an inexperienced novice. They were divided into 8 groups based on timing of the surgery to evaluate the outcomes within the groups. The operator has mastered the\"30-degree triangulation\" technique for US-guided percutaneous renal puncture by education and theoretical study. Two important parameters were reviewed, namely US screening time and puncture time. Other peri-operative data were also recorded.</p><p><strong>Results: </strong>The mean US screening time was 509.3 s for the first 10 cases. It decreased significantly to an average of 226.3 s through 30 to 40. Although the US screening time gradually shortened with accumulated experience and stabilized at an average of 152.5 s through 70-80 cases, there was no significant difference between the following groups. Puncture time declined from 558.8 s in the first group to a mean of 202.3 s in the patients 30 to 40. Consistent with the trend in US screening time, although puncture time continued to decrease, there was no significant difference between them in subsequent patient groups. There were no significant differences in the hemoglobin drop, stone-free rate(SFR), post-hospitalization, or severe complication rate between each groups.</p><p><strong>Conclusions: </strong>The acceptable outcome of PCNL guided by total ultrasound in complex stones could be achieved after 40 cases under the premise of mastering the \"30-degree triangulation\"technique. The US screening time and puncture time dropped to a relative steady level after 40 times of practice.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"312"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and self-confidence of healthcare workers to perform transurethral catheterization: a matter deserving attention!","authors":"Gokhan Calik, Zeynep Bahadır, Berk Madendere, Ozgur Arikan, Vahit Guzelburc, Engin Evci, Suleyman Sami Cakir, Bulent Altay, Pilar Laguna, Mehmet Kocak, Selami Albayrak, Rahim Horuz, Kubilay Sabuncu, Mustafa Boz, Bulent Erkurt, Mohamad Aosama Alrifaai, Abdullah Al Chaabawi, Mahmoud Alrais, Ibrahim Abdi Ali, Shaban M S Ashour, Jean de la Rosette","doi":"10.1007/s00345-025-05677-3","DOIUrl":"10.1007/s00345-025-05677-3","url":null,"abstract":"<p><strong>Background: </strong>Patients may suffer from the sequela of complicated transurethral catheterization (TUC) such as urethral injury, infection, and stricture formation. We assessed the self-confidence, knowledge, and experience of healthcare professionals performing TUC.</p><p><strong>Methods: </strong>A multi-center, prospective, cross-sectional questionnaire-based study was performed among healthcare workers from 5 university hospitals. Data was transferred to an online Data Management System and self-confidence, knowledge, and experience levels among different healthcare roles were compared.</p><p><strong>Findings: </strong>Of all 747 participants, 8% did not feel confident, had enough knowledge or preparation skills regarding TUC. 23% never asked for help while performing TUC whereas 42% always asked for assistance (p < 0.0001). Healthcare roles did not differ statistically in terms of TUC knowledge and understanding. However, healthcare workers in surgical specialties felt more confident in their knowledge (29% vs 21%). Confidence in male catheterization skills rated as 'well' and 'very well' were reported highest by paramedics (71%, 20%) followed by nurses (48%, 20%), physicians (53%, 30%) and residents (50%, 36%). In the event of difficult catheterizations, physicians mostly preferred the assistance of \"urologists and urology residents\" (64%) while nurses mostly reached out to other nurses (39%). Paramedics were the least likely to ask for assistance (40%) followed by nurses (26%), doctors (24%), and residents (13%) (p < 0.0001).</p><p><strong>Conclusion: </strong>A significant proportion of healthcare workers do not have the necessary knowledge and understanding of TUC and do not feel confident in their catheterization and preparation skills when challenged by a difficult TUC, which requires the reassessment of the training programs pre- and post-graduation. This will facilitate and create a safer environment for both the patient and the healthcare professionals.</p><p><strong>Trial registry: </strong>ClinicalTrials.gov NCT05334225.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"311"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on:'' A systematic review and meta-analysis of alpha-adrenergic antagonists for the treatment of pain in chronic prostatitis''.","authors":"Yun Deng, Changhong Xu, Li Yang","doi":"10.1007/s00345-025-05693-3","DOIUrl":"https://doi.org/10.1007/s00345-025-05693-3","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"308"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}