Alejandro Calvillo-Ramirez, Lauren Chew, Jessica Edith Acevedo-Rodriguez, Andrea G Palacios-Navas, Carlos E Vidal-Valderrama, Lee Ponsky, Randy Vince
{"title":"Robot-assisted partial nephrectomy for localized renal masses in elderly and younger patients: a systematic review and meta-analysis of perioperative outcomes.","authors":"Alejandro Calvillo-Ramirez, Lauren Chew, Jessica Edith Acevedo-Rodriguez, Andrea G Palacios-Navas, Carlos E Vidal-Valderrama, Lee Ponsky, Randy Vince","doi":"10.1007/s00345-025-05712-3","DOIUrl":"https://doi.org/10.1007/s00345-025-05712-3","url":null,"abstract":"<p><strong>Purpose: </strong>Robot-assisted partial nephrectomy (RAPN) is an established treatment modality for localized renal masses (LRMs). Nevertheless, its applicability in aging populations presents unique challenges, with limited existing evidence. This meta-analysis aims to evaluate the safety and feasibility of RAPN for LRMs in elderly patients compared to younger individuals.</p><p><strong>Methods: </strong>Databases were searched until August 2024 to identify articles comparing RAPN outcomes in elderly and younger patients. Studies were stratified based on age cutoffs for older individuals. Three primary cutoffs were employed for subgroup analysis: 70-74, 75-79, and ≥ 80 years old. Primary outcomes included the incidence of any grade and major complications (Clavien-Dindo ≥ 3) and trifecta achievement. Odds ratios (OR) and mean differences (MD) were used for statistical comparisons.</p><p><strong>Results: </strong>Seven studies comprising 5,937 patients were included. A significantly higher incidence of any grade complications was observed in elderly patients (OR 1.38 [95%confidence interval [CI] 1.03, 1.84], p = 0.02). However, there was no difference in major complications (OR 1.32 [95%CI 0.79, 2.18], p = 0.28) or trifecta achievement (OR 1.02 [95%CI 0.83, 1.25], p = 0.84) between elderly and younger patients. Similarly, estimated blood loss, transfusion rates, positive surgical margins, and operative time were comparable between groups. Notably, elderly individuals had a shorter warm ischemia time (MD -1.59 [95%CI -2.40, -0.79], p < 0.001).</p><p><strong>Conclusions: </strong>RAPN appears to be a viable treatment option for well-selected elderly patients with LRMs who are candidates for active treatment. While elderly patients experienced higher rates of minor complications, major complications and trifecta achievement were comparable to those of younger patients.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"335"},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ferhat Yakup Suçeken, Şeref Coşer, Duygu Kurtuluş, Murat Akgül, Kamil Kül, Mehmet Sevim, Mithat Ekşi, Eyüp Veli Küçük, Bekir Aras
{"title":"Transcutaneous electrical nerve stimulation (TENS) therapy in rehabilitating erectile dysfunction after bilateral nerve sparing robotic assisted radical prostatectomy.","authors":"Ferhat Yakup Suçeken, Şeref Coşer, Duygu Kurtuluş, Murat Akgül, Kamil Kül, Mehmet Sevim, Mithat Ekşi, Eyüp Veli Küçük, Bekir Aras","doi":"10.1007/s00345-025-05707-0","DOIUrl":"https://doi.org/10.1007/s00345-025-05707-0","url":null,"abstract":"<p><strong>Aim: </strong>Erectile dysfunction (ED) represents one of the most clinically significant and detrimental quality-of-life complications in prostate cancer (PCa) patients following treatment. Different modalities are applied to improve and rehabilitate functional results, especially erectile function after radical prostatectomy (RP). We aimed to evaluate the effect of transcutaneous electrical nerve stimulation (TENS) on postoperative erectile function in patients who underwent bilateral nerve sparing robot-assisted radical prostatectomy (RARP).</p><p><strong>Methods: </strong>The data of patients who underwent RARP for PCa were retrospectively examined. Patients were divided into two groups: those who underwent TENS to improve ED status after RARP (TENS(+)) and those who did not (TENS(-)). The patients' demographic data, surgical data, pre-op/post-op 3rd month International Prostate Symptom Score (IPSS), and pre-op/post-op 6th and 12th month International Index of Erectile Function (IIEF-5) data were evaluated.</p><p><strong>Results: </strong>Of the 80 patients included in the study, 40 were allocated to the TENS(+) group and 40 to the TENS(-) group. The demographic and operative characteristics of the groups were similar. Preoperative and postoperative IPSS were statistically similar in both groups (p = 0.07 and p = 0.12, respectively). While, the mean preoperative IIEF-5 scores were similar for two groups, they were found to be statistically higher in the TENS(+) group in post-operative 6th months (p < 0.001). However, the improvement in IIEF score in the TENS(-) group was more pronounced during the second six months post-operatively, and no statistically significant difference was observed between the two groups at the 12th postoperative month (p = 0.12).</p><p><strong>Conclusion: </strong>TENS therapy administered following RARP may be efficacious in penile rehabilitation 6 months post-surgery. TENS may be an alternative therapy for patients seeking early erectile recovery after RARP.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"337"},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sierra N Tolbert, Bridget L Findlay, Garrett N Ungerer, Yeonsoo S Lee, Boyd R Viers, Katherine T Anderson, Jonathan N Warner
{"title":"Transmeatal urethral surgery (TraMUS): technique and one-year outcomes in the management of penile urethral strictures.","authors":"Sierra N Tolbert, Bridget L Findlay, Garrett N Ungerer, Yeonsoo S Lee, Boyd R Viers, Katherine T Anderson, Jonathan N Warner","doi":"10.1007/s00345-025-05718-x","DOIUrl":"https://doi.org/10.1007/s00345-025-05718-x","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the technique and early outcomes of transmeatal urethroplasty for penile urethral strictures.</p><p><strong>Methods: </strong>We retrospectively reviewed a database of patients who underwent transmeatal urethral surgery for penile urethral strictures using an extended Nikolavsky technique with buccal graft at a single institution. The study includes patients with lichen sclerosis and hypospadias and outlines a comprehensive surgical and postoperative care protocol.</p><p><strong>Results: </strong>13 patients were treated for penile strictures and included in this study. The etiology of stricture included iatrogenic (n = 6), lichen sclerosis (n = 2), and hypospadias (n = 3). The average graft length was 6.5 cm (range 3-15 cm). Two patients were lost to follow up at 4 months and 8 months respectively. Median follow up duration was 14 months (range 11-28 months). Of the 11 patients with data at one year, there was one failure, which occurred at 3 months (91% primary success rate). Only 1 patient (9%) developed de novo incontinence following the procedure. There were no other reported complications directly related to the procedure.</p><p><strong>Conclusions: </strong>Penile urethral strictures present significant challenges in urological practice due to their complex etiology and high complication rate. These strictures frequently recur after traditional treatments leading to the recommendation to offer urethroplasty at diagnosis. We describe a novel, transmeatal technique for managing penile urethral strictures, aimed at reducing the risks associated with conventional surgery, which was successful in 91% of patients at one year. Further studies are necessary to confirm the long-term efficacy and compare this approach to traditional surgical methods.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"338"},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of three urethral stent types on outcomes following one-stage hypospadias repair: a multi-center retrospective controlled study.","authors":"Hualin Cao, Pin Li, Yuandong Tao, Xiaoyu Yi, Honghong Liu, Xiaoye Chen, Songbai Liao, Hongshuai Jia, Xiaowei Zhang, Xincheng Jiang, Weijing Ye, Huixia Zhou","doi":"10.1007/s00345-025-05724-z","DOIUrl":"https://doi.org/10.1007/s00345-025-05724-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether the double cannula urethral stents (DCUS) are superior to traditional silicone Foley catheters (FC) or gastric tubes (GT) in hypospadias repair to decrease complications.</p><p><strong>Patients and methods: </strong>This retrospective cohort study included 224 patients with hypospadias who underwent placement with DCUS (group DCUS), FC (group FC), and GT (group GT) after hypospadias repair between August 2019 and June 2023. The occurrence of early and late complications was assessed. The occurrence of complications in the three groups was compared, and the important contributing factors of urinary fistula and glans dehiscence were determined.</p><p><strong>Results: </strong>A total of 224 patients, 86 in FC, 59 in GT, and 79 in the DCUS group, met the inclusion criteria. Postoperative early complications in the DCUS group were significantly lower than those in the FC group (P = 0.002), but there was no significant difference between the GT and FC group (P = 0.390), or between the GT and DCUS group (P = 0.065). Postoperative late complications in the DCUS group were significantly lower than those in the FC group (P = 0.040), and there was no significant difference between the GT and FC group (P = 0.422), or between the GT and DCUS group (P = 0.325). Logistic regression showed that age (p = 0.030) and stent type (p = 0.048) were important risk factors for urethral fistula, while glans width (p = 0.016) was an important risk factor for glans dehiscence.</p><p><strong>Conclusions: </strong>DCUS reduced the occurrence of complications compare to FC and GT after hypospadias repair, offering practical value for clinical application.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"334"},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziv Savin, Reuben Ben-David, Vinay Durbhakula, Kavita Gupta, Eve Frangopoulos, Blair Gallante, Sarah Lidagoster, Kyrollis Attalla, Peter Wiklund, Reza Mehrazin, John P Sfakianos, William M Atallah, Natasha Kyprianou, Mantu Gupta
{"title":"Does having an asymptomatic renal stone increase morbidity after radical cystectomy?","authors":"Ziv Savin, Reuben Ben-David, Vinay Durbhakula, Kavita Gupta, Eve Frangopoulos, Blair Gallante, Sarah Lidagoster, Kyrollis Attalla, Peter Wiklund, Reza Mehrazin, John P Sfakianos, William M Atallah, Natasha Kyprianou, Mantu Gupta","doi":"10.1007/s00345-025-05720-3","DOIUrl":"https://doi.org/10.1007/s00345-025-05720-3","url":null,"abstract":"<p><strong>Background: </strong>Asymptomatic renal stones identified before radical cystectomy (RC) and urinary diversion (UD) pose a potential treatment dilemma. This study aims to evaluate the outcomes of these asymptomatic stones managed by observation and their natural history after surgery.</p><p><strong>Methods: </strong>This longitudinal cohort study included patients referred for RC and UD between 2015 and 2023 at a single institution. Preoperative CT scans were reviewed to identify patients with asymptomatic renal stones. Exclusion criteria included prior stone treatment, additional ureteric stones, and lack of postoperative radiological follow-up. 90-day postoperative complications, stone-related adverse events and spontaneous stone passage (SSP) were the primary endpoints over a postoperative follow-up. Kaplan-Meier curves and regression models were performed.</p><p><strong>Results: </strong>Among 606 RC patients, 47 patients with 52 renal units met the inclusion and exclusion criteria. The mean stones burden was 4.5 mm (SD ± 2.75). The lower pole was the most frequent location to harbor stones (48%), while renal pelvis was the least one (12%). There were no differences in baseline characteristics or postoperative complication rates between patients with and without asymptomatic renal stones (Overall complications: 60% vs. 61%; Major complications: 17% vs. 18%). The 1-year cumulative incidence of stone-related adverse events and SSP were 10% and 47%, respectively. Higher BMI was a significant predictor of SSP (p < 0.001), with an optimal cutoff of 28 kg/m<sup>2</sup>. Larger stones were associated with stone-related adverse events (p = 0.03).</p><p><strong>Conclusion: </strong>Observation is a viable strategy for preoperative asymptomatic renal stones among RC and UD patients, with most stones passing spontaneously and few adverse events after the surgery.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"336"},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical efficacy and predictors of outcome in varicocelectomy: a meta-analysis of multivariable studies.","authors":"Hong Xiao, Rui-Jie Yao, Hao-Nan He, Yi-Lang Ding, Peng Yang, Qiang Chen, Hai-Lin Huang, Xi Chen, Mao-Yuan Wang, Song-Xi Tang, Hui-Liang Zhou","doi":"10.1007/s00345-025-05702-5","DOIUrl":"https://doi.org/10.1007/s00345-025-05702-5","url":null,"abstract":"<p><strong>Background: </strong>Varicocele is a common cause of male infertility. Varicocelectomy can effectively improve semen quality, but it does not improve semen quality in all patients.</p><p><strong>Methods: </strong>Prior to conducting this meta-analysis, we registered the protocol in PROSPERO (CRD42024574608). Our meta-analysis by searching databases such as Web of Science, Embase, PubMed, and Cochrane Library. Only studies utilizing multivariable logistic regression were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the effect size.</p><p><strong>Results: </strong>The analysis comprised 11 studies with 1,498 patients and encompassed 14 outcomes. The overall efficacy rate of varicocelectomy was 62.8% (95% CI 55.6-69.9%). Compared to other surgical methods and approaches, microsurgical varicocelectomy and subinguinal varicocelectomy demonstrated higher surgical efficacy rates. Higher preoperative sperm concentration (OR = 1.04, 95% CI 1.01-1.06) and total motile sperm count (OR = 3.00, 95% CI 1.04-8.67) were predictive of better post-varicocelectomy outcomes. Furthermore, a positive correlation existed between wider spermatic vein diameter and improved efficacy post-varicocelectomy (OR = 2.41, 95% CI 1.36-4.26).</p><p><strong>Conclusion: </strong>Microsurgical subinguinal varicocelectomy achieves higher surgical efficacy rates. Varicocele patients with better preoperative sperm concentration, total motile sperm count, and wider spermatic vein diameter are more likely to benefit from varicocelectomy. This provides andrologists with a reference basis for advising varicocele patients on the surgical efficacy and potential benefits post-varicocelectomy.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"331"},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Montorsi, Paolo Capogrosso, Federico Dehò, Giorgio Gandaglia, Alberto Briganti, Andrea Salonia
{"title":"RE: holep versus thuflep in men with very large prostates (> 175 ml).","authors":"Francesco Montorsi, Paolo Capogrosso, Federico Dehò, Giorgio Gandaglia, Alberto Briganti, Andrea Salonia","doi":"10.1007/s00345-025-05646-w","DOIUrl":"https://doi.org/10.1007/s00345-025-05646-w","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"332"},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications, benefits, and challenges of adopting teleurology: a scoping review.","authors":"Khadijeh Moulaei, Hadi Kazemi-Arpanahi","doi":"10.1007/s00345-025-05706-1","DOIUrl":"10.1007/s00345-025-05706-1","url":null,"abstract":"<p><strong>Background: </strong>Urological diseases present substantial challenges for patients, including restricted access to specialized care, prolonged wait times, and geographical barriers, particularly in underserved and rural regions. Teleurology leverages telecommunication technologies to enable remote consultations, improve patient monitoring, and enhance access to specialized care. This scoping review aims to systematically examine the applications, benefits, and challenges associated with teleurology, offering a comprehensive analysis of its role in contemporary urological practice.</p><p><strong>Methods: </strong>The PRISMA-ScR guidelines was followed to perform this scoping review. Systematic searches were performed in PubMed, Scopus, and Web of Science, covering publications from 2010 until January 19, 2025. Two trained reviewers independently retrieved, screened, and extracted the data.</p><p><strong>Results: </strong>The initial search identified 2,080 studies. After removing 500 duplicates, 1,577 unique studies remained for title and abstract screening. Ultimately, 49 articles were selected for data extraction. The most frequent teleurology communication interventions were Telephone (n = 12) and Videoconferencing (n = 11). Teleurology services were predominantly delivered through synchronous modalities (77%), followed by a combination of synchronous and asynchronous approaches (18%). Tele-consultation (n = 18), Tele-visit (n = 15), and Tele-care, in that order (n = 8) were the most common applications. A total of 339 benefits (n = 216) and challenges (n = 123) for teleurology were identified, with 28 benefits and 13 challenges remaining after consolidation. \"Reducing patient treatment expenditures, travel costs and time\" (n = 30), \"Increasing patient satisfaction with telemedicine services\" (n = 23), \"Access to care for patients in rural or underserved areas\" (n = 17), and \"Curbing disease spread and sustaining care during pandemics while maintaining distancing\" (n = 17) were the most common benefits of teleurology. The most important challenges were \"Lack of physical examination of patients during telemedicine visits\" (n = 30), \"Need for robust digital infrastructure (inaccessible to technology, computer and internet)\" (n = 23), and \"Patient concerns about confidentiality and privacy\" (n = 18).</p><p><strong>Conclusions: </strong>Teleurology improves access, reduces costs, and enhances patient satisfaction, especially in underserved areas. However, physical exam limitations, infrastructure gaps, and privacy concerns remain challenges. Future efforts should refine teleurology frameworks and strengthen digital infrastructure for secure, high-quality care.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"330"},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joren Vanthoor, Thomas R W Herrmann, Vincent De Coninck
{"title":"Can preoperative transurethral catherization reduce the risk of urethral stricture after endoscopic treatment of the prostate?","authors":"Joren Vanthoor, Thomas R W Herrmann, Vincent De Coninck","doi":"10.1007/s00345-025-05474-y","DOIUrl":"https://doi.org/10.1007/s00345-025-05474-y","url":null,"abstract":"<p><p>Urethral strictures are a well-known complication following endoscopic treatment of benign prostatic hyperplasia (BPH). Although the exact cause remains unclear, repetitive instrument movement and pressure-induced ischemia are likely contributing factors. While the incidence seems lower after enucleation compared to transurethral resection of the prostate, it remains important to prevent this iatrogenic complication. A small randomized trial suggested a benefit from preoperative urethral dilatation, though findings were constrained by limited sample size and follow-up. Similarly, studies comparing resectoscope sizes have not yet demonstrated significant differences in stricture rates. Drawing parallels with ureteral stricture prevention, where prestenting with a ureteral catheter is commonly used, we hypothesize that preoperative transurethral catheterization may relax and dilate the urethra, potentially lowering the risk of stricture formation. Clinical observations support this: patients with preoperative indwelling catheters before endoscopic treatment of BPH often display a more compliant urethra during surgery. While mechanical irritation remains a theoretical concern of placing a catheter, the relaxing effect may outweigh potential harm, much like DJ-stent use in the ureter. A prospective study will be conducted within the EAU Endourology Consortium to evaluate this hypothesis, incorporating force-sensing dilators and standardized follow-up with uroflowmetry and cystoscopy at 3 and 6 months. If successful, preoperative catheterization may offer a simple, low-risk strategy to reduce urethral strictures in BPH surgery, particularly in patients with a narrow urethra.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"325"},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}