Wiener Klinische Wochenschrift最新文献

筛选
英文 中文
Incidence and epidemiology of out-of-hospital cardiac arrest in Upper Austria : A multicenter, retrospective cohort study. 上奥地利州院外心脏骤停的发病率和流行病学:一项多中心、回顾性队列研究
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-17 DOI: 10.1007/s00508-026-02818-5
Marius Knöll, Romana Erblich, Andreas Manigatterer, Matthias Aujesky, Harald Ecker, Sigrun Angerhofer, Markus Brunner, Wolfgang Voelckel, Daniel Staribacher, Matthias Noitz, Konstantin Bräu, Jens Meier, Martin W Dünser
{"title":"Incidence and epidemiology of out-of-hospital cardiac arrest in Upper Austria : A multicenter, retrospective cohort study.","authors":"Marius Knöll, Romana Erblich, Andreas Manigatterer, Matthias Aujesky, Harald Ecker, Sigrun Angerhofer, Markus Brunner, Wolfgang Voelckel, Daniel Staribacher, Matthias Noitz, Konstantin Bräu, Jens Meier, Martin W Dünser","doi":"10.1007/s00508-026-02818-5","DOIUrl":"https://doi.org/10.1007/s00508-026-02818-5","url":null,"abstract":"<p><strong>Objective: </strong>To determine the incidence and epidemiology of out-of-hospital cardiac arrest (OHCA) with resuscitation attempts by emergency physician teams in Upper Austria.</p><p><strong>Methods: </strong>This multicenter, retrospective study included all OHCA cases attended by all 22 physician-staffed emergency medical service units operating in Upper Austria between 2017 and 2024. The primary endpoint was the annual incidence of OHCA with resuscitation attempts per 100,000 inhabitants. Secondary endpoints included the proportion of cases in which resuscitation was not attempted, patient demographics, OHCA etiology and OHCA location.</p><p><strong>Results: </strong>During the study period, 15,200 OHCA cases were attended by emergency physician teams. Resuscitation was attempted in 9343 patients (61.5%), while death was pronounced without resuscitation in 5857 (38.5%). The median (interquartile range, IQR) annual incidence of OHCA with resuscitation attempts was 78.9 (76.9-81.9)/100,000 inhabitants. Adults accounted for 98.5% of OHCA cases with 77.8 (76.0-80.5)/100,000 inhabitants/year. Of these 91.9% were due to medical etiologies with 71.1 (69.8-74.5)/100,000 inhabitants/year, while external (mostly traumatic) etiologies accounted for 8.1% (6.3 (5.7-6.8)/100,000 inhabitants/year). Pediatric OHCA constituted 1.5% of all cases with 1.1 (1.1-1.3)/100,000 inhabitants/year and was equally distributed between medical and external causes.</p><p><strong>Conclusion: </strong>In this first systematic assessment of OHCA epidemiology in Upper Austria, OHCA with resuscitation attempts by emergency physician teams occurred at a median annual incidence of 78.9 per 100,000 inhabitants. Adult OHCA of medical origin accounted for the vast majority of cases. These findings provide a comprehensive epidemiological overview of OHCA in Upper Austria and highlight the potential value of establishing a prospective, nationwide OHCA registry to facilitate benchmarking, quality improvement initiatives and future outcome analyses.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Entrustable professional activities for medical students and graduates of Austrian medical universities : Results of a national development and harmonization process. 奥地利医科大学的医科学生和毕业生可信赖的专业活动:国家发展和协调进程的结果。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-16 DOI: 10.1007/s00508-026-02810-z
Paul Zajic, Carolin Herzog, Martina Zöbl, Erwin Petek, Ursula Kiechl-Kohlendorfer, Bernd Lamprecht, Katharina Steininger-Kaar, Wolfgang Weninger, Regina Roller-Wirnsberger
{"title":"Entrustable professional activities for medical students and graduates of Austrian medical universities : Results of a national development and harmonization process.","authors":"Paul Zajic, Carolin Herzog, Martina Zöbl, Erwin Petek, Ursula Kiechl-Kohlendorfer, Bernd Lamprecht, Katharina Steininger-Kaar, Wolfgang Weninger, Regina Roller-Wirnsberger","doi":"10.1007/s00508-026-02810-z","DOIUrl":"https://doi.org/10.1007/s00508-026-02810-z","url":null,"abstract":"<p><strong>Background: </strong>Entrustable professional activities (EPAs) translate competency-based medical education into observable clinical work and can clarify expectations at the undergraduate-postgraduate transition. In Austria, undergraduate EPA implementation has been heterogeneous, limiting transparency and comparability across medical universities.</p><p><strong>Methods: </strong>We conducted a national, multiphase development and harmonization process to define EPAs for students entering and completing the clinical practical year (KPJ). International EPA frameworks were identified by literature review and mapped to the Austrian Clinical Learning Objectives Catalogue (KLK). Draft EPAs were formulated using descriptors recommended by the Association for Health Professions Education (AMEE), linked to CanMEDS roles, assessment profiles and supervision levels and validated through a two-round national consultation process with expert groups from all Austrian public medical universities/faculties. Consensus was predefined as ≥ 75% agreement.</p><p><strong>Results: </strong>The process yielded a nationally endorsed set of 11 EPAs covering key tasks along the patient-care continuum, including history taking, clinical examination, clinical reasoning, diagnostics, common procedures, recognition of emergencies and first measures, evidence-based treatment planning, documentation and interprofessional communication, patient safety/quality and prevention counselling. Assessment profiles prioritized workplace-based assessment (e.g., Mini-CEX, DOPS, OSCE components) supported by structured feedback and complementary approaches (e.g., handovers, ward rounds, multisource feedback). Expected supervision levels were specified for KPJ entry and completion, with progression from predominantly direct supervision to mainly indirect supervision, differentiated by EPA.</p><p><strong>Conclusion: </strong>Austria's harmonized undergraduate EPA catalogue endorsed by all public Austrian medical universities/faculties provides a practice-oriented national qualification profile that can support curricular mapping, more comparable workplace-based assessment, mobility between Austrian universities, and clear expectations for students and supervisors.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Viennese neurologist Richard Stern and the discrimination and persecution of Jewish physicians in Austria and Slovakia. 维也纳神经学家理查德·斯特恩以及奥地利和斯洛伐克对犹太医生的歧视和迫害。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-15 DOI: 10.1007/s00508-026-02812-x
Katharina Sigismund, Dominik Groß, Nico Biermanns
{"title":"The Viennese neurologist Richard Stern and the discrimination and persecution of Jewish physicians in Austria and Slovakia.","authors":"Katharina Sigismund, Dominik Groß, Nico Biermanns","doi":"10.1007/s00508-026-02812-x","DOIUrl":"https://doi.org/10.1007/s00508-026-02812-x","url":null,"abstract":"<p><p>This article reconstructs the life and career of the Viennese neurologist and neuropathologist Richard Stern (1878-1942) and situates his trajectory within the longue durée of antisemitic discrimination against Jewish physicians in Austria. Drawing on archival sources and contemporary scientific publications, it examines Stern's academic training in the largely forgotten tradition of Lothar Frankl-Hochwart (1862-1914), his clinical and scientific work, and his professional activities in social insurance medicine. The study emphasizes that the exclusion of Jewish physicians in Austria did not begin with the Anschluss in 1938 but rather built upon pre-existing and increasingly radicalized forms of antisemitism within the medical profession, academic institutions, and public health administration since the late nineteenth century. Stern's career exemplifies both the structural constraints faced by Jewish physicians and the unequal career opportunities, which were severely limited in university medicine but more accessible within social insurance institutions. By tracing Stern's marginalization after the First World War, the article highlights the gradual transition from discrimination to total exclusion. Following the Anschluss, this process culminated in the systematic expulsion of Jewish physicians from Austrian medicine. Stern's forced migration to Slovakia exposed him to a new phase of persecution under conditions of political dependency on Nazi Germany. His subsequent deportation and murder in Auschwitz illustrate the transnational dimension of antisemitic violence and the precariousness of escape routes in Central Europe.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paroxysmal finger hematoma affecting the thumb. 影响拇指的阵发性手指血肿。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-12 DOI: 10.1007/s00508-026-02811-y
Andrea M Lutz, Matthias Möhrenschlager
{"title":"Paroxysmal finger hematoma affecting the thumb.","authors":"Andrea M Lutz, Matthias Möhrenschlager","doi":"10.1007/s00508-026-02811-y","DOIUrl":"https://doi.org/10.1007/s00508-026-02811-y","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of a multidisciplinary lifestyle intervention in adults with Down syndrome : A retrospective observational study. 多学科生活方式干预成人唐氏综合征的结果:一项回顾性观察研究。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-09 DOI: 10.1007/s00508-026-02814-9
Barbara Bauer, Alexandra Thajer
{"title":"Outcomes of a multidisciplinary lifestyle intervention in adults with Down syndrome : A retrospective observational study.","authors":"Barbara Bauer, Alexandra Thajer","doi":"10.1007/s00508-026-02814-9","DOIUrl":"https://doi.org/10.1007/s00508-026-02814-9","url":null,"abstract":"<p><strong>Background: </strong>Adults with Down syndrome are at increased risk of obesity and cardiometabolic disease; however, evidence regarding effective lifestyle interventions remains limited. This study evaluated the outcomes of a multidisciplinary lifestyle program incorporating nutritional therapy in adults with Down syndrome attending a specialized outpatient clinic.</p><p><strong>Methods: </strong>This retrospective observational study included adults with genetically confirmed Down syndrome aged ≥ 18 years with overweight or obesity (body mass index, BMI> 25 kg/m<sup>2</sup>) who participated in a multidisciplinary lifestyle intervention between October 2016 and October 2017. The program combined individual nutritional counselling, nutrition and cooking workshops, supervised physical activity, psychological support, and caregiver involvement. Anthropometric measurements, body composition, dietary intake, and biochemical parameters were assessed at baseline, 5 months and 10 months.</p><p><strong>Results: </strong>In this study nine participants met the inclusion criteria and five completed the intervention and follow-up assessments. Mean baseline BMI was 36.0 ± 6.0 kg/m<sup>2</sup>. Mean body weight decreased from 81.5 to 78.9 kg, and 3 participants achieved clinically relevant weight loss (> 5% of baseline body weight). No statistically significant changes were observed in anthropometric, body composition, dietary, or biochemical outcomes. Descriptive analyses indicated reductions in fat mass and visceral fat among participants achieving weight loss. Participants also reported improvements in nutritional awareness, healthier food choices, and meal preparation practices.</p><p><strong>Conclusion: </strong>This retrospective study demonstrates the feasibility of implementing a multidisciplinary lifestyle intervention incorporating nutritional therapy for adults with Down syndrome and obesity in a specialized outpatient setting. The findings provide preliminary clinical experience regarding the provision of a tailored interventional approach in this population. Larger prospective studies are required to further evaluate multidisciplinary lifestyle programs and their long-term relevance for metabolic health and quality of life.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of myofascial release technique in patients with partial rotator cuff tear : A single-blind randomized controlled trial. 肌筋膜释放技术对部分肩袖撕裂患者的影响:一项单盲随机对照试验。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-07 DOI: 10.1007/s00508-026-02809-6
Nazlican Erdin Stoyanov, Tugce Coban, Zeynep Hazar, Ulunay Kanatli
{"title":"The effects of myofascial release technique in patients with partial rotator cuff tear : A single-blind randomized controlled trial.","authors":"Nazlican Erdin Stoyanov, Tugce Coban, Zeynep Hazar, Ulunay Kanatli","doi":"10.1007/s00508-026-02809-6","DOIUrl":"https://doi.org/10.1007/s00508-026-02809-6","url":null,"abstract":"<p><strong>Background: </strong>The myofascial release technique is applied to improve symptoms by releasing fascial tissues. The aim of this study was to determine the effects of the myofascial release technique on proprioception, range of motion, pain, shoulder function, and flexibility in patients with rotator cuff tear.</p><p><strong>Material and methods: </strong>In this study 29 patients with partial rotator cuff tear were randomly divided into 2 groups. The control group received conventional physiotherapy including hot pack, transcutaneous electrical nerve stimulation and exercise program, while the treatment group received the same conventional physiotherapy along with the myofascial release technique. All procedures were performed for 4 weeks. Proprioception, pain severity, range of motion, shoulder functional level, and flexibility were assessed before and after the treatment.</p><p><strong>Results: </strong>Improvement in proprioception was significant in all directions in the treatment group and only in flexion in the control group (p < 0.05). Flexibility significantly increased only in the treatment group (p < 0.05); however, no significant between-group differences were found in proprioception and flexibility (p > 0.05). Both groups showed significant improvement in pain severity, range of motion, and functional level (p < 0.05); however, compared to control group, the treatment group demonstrated significantly greater improvements in pain severity during activity, internal rotation, and functional level (pain and total scores) (p < 0.05), whereas no significant between-group difference was found for the functional level (disability score) (p > 0.05).</p><p><strong>Conclusion: </strong>The addition of the myofascial release technique to conventional physiotherapy could contribute to improvements in pain severity during activity, internal rotation, and functional level (pain and total scores) in patients with partial rotator cuff tear, and its inclusion in physiotherapy programs could optimize treatment outcomes.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noninvasive test patterns across vascular and parenchymal liver diseases. 血管性和实质性肝脏疾病的无创检查模式。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-03 DOI: 10.1007/s00508-026-02808-7
Lorenz Balcar, Lucie Simonis, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Benedikt Simbrunner, Georg Kramer, Nina Dominik, Michael Schwarz, Albert Friedrich Stättermayer, Michael Trauner, Mattias Mandorfer, Bernhard Scheiner, Thomas Reiberger, Georg Semmler
{"title":"Noninvasive test patterns across vascular and parenchymal liver diseases.","authors":"Lorenz Balcar, Lucie Simonis, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Benedikt Simbrunner, Georg Kramer, Nina Dominik, Michael Schwarz, Albert Friedrich Stättermayer, Michael Trauner, Mattias Mandorfer, Bernhard Scheiner, Thomas Reiberger, Georg Semmler","doi":"10.1007/s00508-026-02808-7","DOIUrl":"https://doi.org/10.1007/s00508-026-02808-7","url":null,"abstract":"<p><strong>Background and aims: </strong>Vascular liver diseases such as porto-sinusoidal vascular disorder (PSVD), Budd-Chiari syndrome (BCS), and non-cirrhotic portal vein thrombosis (NCPVT) are rare causes of portal hypertension (PH) but share the same phenotype with parenchymal chronic liver disease (CLD). We assessed whether blood-based and elastography-based noninvasive tests (NITs) can: (i) differentiate vascular from parenchymal liver disease, (ii) detect specific signs of portal hypertension within etiologies and (iii) identify portal vein thrombosis.</p><p><strong>Methods: </strong>Consecutive patients with PSVD, NCPVT, BCS, or CLD treated at a tertiary referral center between January 2022 and December 2024 were included. Assessed NITs included platelet count, liver stiffness measurement (LSM), spleen stiffness measurement (SSM), the SSM to LSM ratio, ANTICIPATE, and NICER.</p><p><strong>Results: </strong>This study included 411 patients: PSVD n = 43, NCPVT n = 38, CLD n = 309, and BCS n = 21. Among patients without PVT, NIT patterns differed between etiologies. The PSVD showed low LSM despite elevated SSM, resulting in the highest SSM to LSM ratio. This ratio best discriminated PSVD from CLD and BCS (AUC ≥ 0.870); the proposed cut-off of > 2 showed good diagnostic performance. The ANTICIPATE also differentiated PSVD from CLD/BCS, whereas SSM alone did not. Detection of specific PH signs was etiology dependent. In PSVD, platelet count showed the highest accuracy (AUC 0.823). In CLD, several NITs were associated with specific PH signs but accuracy was limited. In BCS, differences of the tested NITs for specific PH signs were not statistically significant. Across etiologies, NITs showed limited accuracy for detecting PVT.</p><p><strong>Conclusion: </strong>Combined assessment of LSM and SSM, particularly the SSM to LSM ratio, supports differentiation of PSVD from parenchymal and posthepatic liver disease, whereas platelet counts was most informative to detect specific PH signs within PSVD.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The College of Physicians in Vienna and its Jewish members after Austria's annexation (Anschluss) to Nazi Germany in 1938. 1938年奥地利被纳粹德国吞并后,维也纳内科医师学院及其犹太成员。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-01 Epub Date: 2026-03-10 DOI: 10.1007/s00508-026-02723-x
Josef Hlade, Beatrix Volc-Platzer, Hermann Zeitlhofer, Teresa Lang, Herwig Czech
{"title":"The College of Physicians in Vienna and its Jewish members after Austria's annexation (Anschluss) to Nazi Germany in 1938.","authors":"Josef Hlade, Beatrix Volc-Platzer, Hermann Zeitlhofer, Teresa Lang, Herwig Czech","doi":"10.1007/s00508-026-02723-x","DOIUrl":"10.1007/s00508-026-02723-x","url":null,"abstract":"<p><p>This text outlines the process by which Jewish members of the College of Physicians in Vienna (Gesellschaft der Ärzte in Wien) were disenfranchised and excluded subsequent to Austria's annexation to the German Reich (euphemistically called the Anschluss) in March 1938. At the beginning of 1938, 60% of the members and about one third of the board were of Jewish origin. The provisional director, Adolf Irtl (1867-1947), along with members of the Medical Faculty at the University of Vienna and the Nazi Party, discussed how to deal with and expel the Jewish members. Their membership rights were restricted from the outset. Following the Anschluss, the College of Physicians retroactively demanded \"unpaid membership fees\" from Jewish members, threatening their already precarious financial situation. In February 1939, the Medical Society of Vienna (Wiener Medizinische Gesellschaft) was founded as a Nazi replacement organization. Jewish members were no longer accepted. As part of the project \"History of the College of Physicians in Vienna: the critical years 1930-1960\", the names of all those who were expelled for antisemitic or political reasons have been documented. Some of these victims are presented here as examples.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"517-532"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare inflammatory myofibroblastoma of duodenal papilla in an adult. 成人十二指肠乳头罕见的炎性肌成纤维细胞瘤。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-01 Epub Date: 2026-02-27 DOI: 10.1007/s00508-026-02724-w
Ling Xiao, Wei-Hui Liu
{"title":"A rare inflammatory myofibroblastoma of duodenal papilla in an adult.","authors":"Ling Xiao, Wei-Hui Liu","doi":"10.1007/s00508-026-02724-w","DOIUrl":"10.1007/s00508-026-02724-w","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"575-577"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147310783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Austrian Society of Gastroenterology and Hepatology (ÖGGH) consensus on primary biliary cholangitis. 奥地利胃肠病学和肝病学会(ÖGGH)对原发性胆管炎的共识。
IF 2.6 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2026-09-01 Epub Date: 2026-09-09 DOI: 10.1007/s00508-026-02798-6
Emina Halilbasic, Elisabeth Tatscher, Elmar Aigner, Lukas Burghart, Ivo Graziadei, Stephanie Hametner-Schreil, Benedikt Silvester Hofer, Harald Hofer, Andreas Maieron, Mattias Mandorfer, Markus Peck-Radosavljevic, Benedikt Schaefer, Wolfgang Sieghart, Martin Stradner, Stefan Traussnigg, Martin Wagner, Heinz Zoller, Peter Fickert, Michael Trauner
{"title":"Austrian Society of Gastroenterology and Hepatology (ÖGGH) consensus on primary biliary cholangitis.","authors":"Emina Halilbasic, Elisabeth Tatscher, Elmar Aigner, Lukas Burghart, Ivo Graziadei, Stephanie Hametner-Schreil, Benedikt Silvester Hofer, Harald Hofer, Andreas Maieron, Mattias Mandorfer, Markus Peck-Radosavljevic, Benedikt Schaefer, Wolfgang Sieghart, Martin Stradner, Stefan Traussnigg, Martin Wagner, Heinz Zoller, Peter Fickert, Michael Trauner","doi":"10.1007/s00508-026-02798-6","DOIUrl":"10.1007/s00508-026-02798-6","url":null,"abstract":"<p><p>This consensus document of the Austrian Society of Gastroenterology and Hepatology (ÖGGH) is intended to provide practical guidance for the management of individuals with primary biliary cholangitis (PBC).PBC is a chronic inflammatory, autoimmune-mediated disease of the intrahepatic bile ducts that can lead to fibrosis and ultimately cirrhosis. Middle-aged women are significantly more frequently affected than men. The pathogenesis is currently not fully understood. Based on the presence of disease-specific autoantibodies, it is classified as an autoimmune liver disease, although a combination of genetic predisposition and environmental factors contribute to disease development and progression.The diagnosis of PBC is based on a cholestatic enzyme pattern together with the presence of anti-mitochondrial antibodies (AMA) or PBC-specific anti-nuclear antibodies (sp100, gp210). A liver biopsy is rarely required to establish the diagnosis; exceptions are the suspicion of a PBC autoimmune hepatitis (AIH) variant syndrome or the absence of the abovementioned antibodies.The therapeutic goal is to reduce cholestatic injury thereby preventing disease progression and to reduce symptoms. Approximately 60-70% of patients achieve clinical and biochemical remission with first-line treatment, i.e., ursodeoxycholic acid (UDCA). Recently, the therapeutic paradigm has shifted from achieving certain predefined response criteria to a normalization of alkaline phosphatase (ALP) together with a low-normal bilirubin level, as the latter was linked to improved outcomes in some subgroups. For patients who do not sufficiently respond to UDCA, the newly approved peroxisome proliferator-activated receptor (PPAR) agonists elafibranor and seladelpar, as well as bezafibrate (off-label use), should be used as a combination treatment with UDCA. In patients with decompensated cirrhosis, liver transplantation has been associated with good long-term outcomes, albeit disease recurrence occurs in up to 50% by 15 years.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"831-858"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书