Wiener Klinische Wochenschrift最新文献

{"title":"Conservative treatment of knee arthrofibrosis according to a cellular cytokine-based model : A retrospective pilot evaluation.","authors":"Robert Wakolbinger-Habel, Jakob Gaudernak, Brigitte Elisabeth Scheffold, Rainer Fiala, Robert Breuer, Martin Bittner-Frank, Clemens Lang, Helena Zehetner-Nics, Ana Oljaca, Mehdi Mousavi, Tatjana Paternostro-Sluga","doi":"10.1007/s00508-024-02497-0","DOIUrl":"10.1007/s00508-024-02497-0","url":null,"abstract":"<p><strong>Background: </strong>Arthrofibrosis (AF) is a relatively frequent complication after knee surgery, leading to painful limitation of joint mobility. Currently, intense stretching is performed in many patients, without improvements in mobility. A novel concept, established on a cellular, cytokine-based model, advocates to consider the warning function of pain and to terminate forced joint mobilization to disrupt the cycle of arthrofibrosis. Based on these findings, our clinic developed a comprehensive antifibrotic treatment protocol. The aim of this analysis was to evaluate the patients treated so far.</p><p><strong>Methods: </strong>Patients treated at the Clinic Donaustadt, an academic teaching hospital of the Medical University of Vienna, Austria, according to the clinic's AF protocol, were evaluated by reviewing their records. Patellar mobility, range of motion, tightness, overheat, pain, general mobility, assistive devices, working status and the necessity of additional surgery were assessed at baseline, after 2 months and after 12 months (follow-up).</p><p><strong>Results: </strong>Four patients were treated according to the AF protocol. After two months, patellar mobility and range of motion clearly increased in three out of four patients. At the follow-up examination, patella mobility further increased, extension was complete, flexion at least 120°, and symptoms such as tightness, overheating, nocturnal pain and pain after activity had disappeared in three out of four patients. None of the patients had analgesics or walking aids and three out of four patients had returned to work. Out of the four patients, three expressed high satisfaction with the AF protocol and reported no limitations in daily life, including recreational activities.</p><p><strong>Conclusion: </strong>Based on this pilot evaluation, the comprehensive conservative AF program seems to have high potential. Therefore, larger future studies should be conducted to validate this concept.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"551-556"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of anti-HBc positivity on clinical outcomes and treatment response in immune thrombocytopenia.","authors":"Özlem Beyler, Cengiz Demir, Ali Doğan","doi":"10.1007/s00508-025-02563-1","DOIUrl":"10.1007/s00508-025-02563-1","url":null,"abstract":"<p><strong>Purpose: </strong>Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts due to the destruction of platelets by autoantibodies. The presence of hepatitis B core antibodies (anti-HBc) is a marker of previous or occult hepatitis B virus (HBV) infection, which may influence the clinical course and treatment outcomes in ITP patients.</p><p><strong>Methods: </strong>This retrospective study investigated the impact of anti-HBc positivity on the clinical outcomes and response to treatment in ITP patients. A total of 116 patients with ITP were divided into 2 groups: those who were anti-HBc positive (n = 31) and those who were anti-HBc negative (n = 85). Clinical data, including platelet counts at diagnosis and during follow-up, response to corticosteroid treatment and remission rates were analyzed.</p><p><strong>Results: </strong>The results indicated that anti-HBc positive patients had significantly lower platelet counts at diagnosis (p = 0.009) and a longer hospital stay (p = 0.042). Additionally, these patients demonstrated lower complete response rates to initial corticosteroid treatment at 1 month (p = 0.001) and 6 months (p = 0.021) compared to anti-HBc negative patients; however, there were no significant differences in overall response or durable response rates between the groups at 12 months. The risk of relapse was higher in anti-HBc positive patients (p = 0.041).</p><p><strong>Conclusion: </strong>These findings suggest that anti-HBc positivity may be associated with a more severe disease course and reduced treatment efficacy in ITP, highlighting the importance of assessing hepatitis B serological markers when managing ITP patients.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"579-584"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding Gampenrieder et al., A comparison of breast cancer incidence and cancer stages before and after the introduction of the Austrian national breast cancer screening program in the federal state of Salzburg.","authors":"Pascal A T Baltzer, Paola Clauser","doi":"10.1007/s00508-025-02555-1","DOIUrl":"10.1007/s00508-025-02555-1","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"593-594"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adequate bowel preparation of patients undergoing screening colonoscopy : Does educational status matter? A retrospective data analysis.","authors":"Anna K Hinterberger, Susanne Mayer, Lena Jiricka, Elisabeth A Waldmann, Jasmin Zessner-Spitzenberg, Barbara Majcher, Lisa M Rockenbauer, Michael H Trauner, Monika Ferlitsch","doi":"10.1007/s00508-024-02468-5","DOIUrl":"10.1007/s00508-024-02468-5","url":null,"abstract":"<p><strong>Background: </strong>In order to achieve a high-quality screening colonoscopy, a high-quality bowel preparation is essential. To perform an adequate bowel cleansing patients need to understand and act on medical information, also known as health literacy. This study aimed to analyze the relationship between the patients' educational status as a proxy for health literacy and adequate bowel preparation.</p><p><strong>Methods: </strong>A retrospective analysis of data collected within the Austrian national colorectal cancer screening program from 2012 to 2022 was conducted. The database contains information on the quality of bowel preparation as well as the academic degree of the patients. Variables were used to perform a logistic regression analysis, with bowel preparation quality (based on the Aronchick scale) as the dependent variable and completed tertiary education as independent variable, and sex and age as control variables.</p><p><strong>Results: </strong>A total of 329,778 patients aged 30-99 years were included in the analysis. Within the group of academics, 88.46% (n = 21,883) were adequately prepared whereas in the group of non-academics, 84.79% (n = 258,641) were found to have a high bowel preparation quality. The odds ratio (OR) for academics to have an adequate bowel preparation quality was 1.37 (95% confidence interval, CI 1.32-1.43; p < 0.001).</p><p><strong>Conclusion: </strong>Patients with a tertiary education showed better bowel preparation quality than non-academics in Austria. Therefore, it is important to improve strategies on how to inform also less educated persons to facilitate a better screening colonoscopy quality and to optimize the use of resources from a clinical as well as a public health perspective.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"557-562"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"100 Jahre Chirurgie der Primären Nebenschilddrüsenüberfunktion.","authors":"","doi":"10.1007/s00508-025-02618-3","DOIUrl":"https://doi.org/10.1007/s00508-025-02618-3","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":"137 17-18","pages":"600"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periprosthetic seromas and a third space effect after high-dose methotrexate.","authors":"Claudia Prattes, Andreas Leithner, Joanna Szkandera, Georg Prattes, Ernst-Christian Urban, Andrea Eder-Halbedl, Volker Strenger","doi":"10.1007/s00508-024-02467-6","DOIUrl":"10.1007/s00508-024-02467-6","url":null,"abstract":"<p><strong>Background: </strong>Besides surgery, chemotherapy including high-dose methotrexate is a mainstay of osteosarcoma treatment. Methotrexate is known to accumulate in tissues and cavities, so-called third spaces (e.g., periprosthetic seromas) leading to local toxicity and delayed elimination (third space effect). We compared the concentrations of methotrexate in serum and periprosthetic seromas to evaluate a potential toxic risk based on a third space effect.</p><p><strong>Methods: </strong>In 45 osteosarcoma patients who were treated with endoprosthesis and high-dose methotrexate (HDMTX) between 1991 and 2011 we retrospectively analyzed methotrexate concentrations in periprosthetic seromas and serum. Differences were assessed by means of the Wilcoxon test.</p><p><strong>Results: </strong>A total of 112 periprosthetic seroma punctures were performed in 18 out of 45 patients. At 24 h the periprosthetic seroma concentrations were in median 14.86-fold (range 1.49-42.97-fold, p = 0.001), at 48 h in median 8.50-fold (range 1.36-52.56, p < 0.001) and at 72 h in median 2.66-fold (range 0.66-5.82, p = 0.015) of the corresponding serum concentrations. At 24 h highly toxic concentrations (≥ 20 μmol/l) were observed in 30% of all analyzed seromas (median 109.83 μmol/l, range 4.91-170.71 μmol/l). A significantly higher serum concentration (range 0.16-0.75 μmol/l, median 0.36 µmol/l) was found in patients with prior puncture than patients without puncture at 45 h after HDMTX.</p><p><strong>Conclusion: </strong>Methotrexate concentrations of periprosthetic seromas are significantly higher than corresponding serum concentrations possibly contributing to a third space effect. To avoid severe adverse effects punctures of these effusions should be considered.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"537-543"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal to add a second Christmas holiday in the USA.","authors":"Gary P Wormser","doi":"10.1007/s00508-025-02500-2","DOIUrl":"10.1007/s00508-025-02500-2","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"585-586"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUW researcher of the month: Dr.in Juliane Winkler.","authors":"","doi":"10.1007/s00508-025-02620-9","DOIUrl":"https://doi.org/10.1007/s00508-025-02620-9","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":"137 17-18","pages":"596-597"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUW researcher of the month: Dr.in Carla Tripisciano und Ap. Prof. PD Dr. Johannes Thaler.","authors":"","doi":"10.1007/s00508-025-02621-8","DOIUrl":"https://doi.org/10.1007/s00508-025-02621-8","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":"137 17-18","pages":"598-599"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thelazia callipaeda infestation in an 8-month-old male infant in Hubei, China.","authors":"Xiaomei Wang, Changzhen Li","doi":"10.1007/s00508-025-02533-7","DOIUrl":"10.1007/s00508-025-02533-7","url":null,"abstract":"<p><p>Thelazia callipaeda, a zoonotic nematode, primarily infests the ocular tissues of mammals, occasionally humans. Infestations in infants under 1 year of age are rarely reported. This case describes an 8‑month-old male infant diagnosed with ocular T. callipaeda infestation in Hubei, China. The infant was brought to the hospital by his mother, who reported that he had been rubbing his right eye for 3 days, accompanied by increased ocular discharge and mild tearing. Upon examination, a whitish, motile, thread-like worm was observed in the conjunctival sac of the right eye. During ophthalmological surgical exploration, a total of 10 worms were removed from the right eye, with 8 sent for identification. All 8 adult nematodes collected were morphologically identified as T. callipaeda, consisting of 4 females and 4 males. Following the removal of the nematodes, the infant's ocular symptoms rapidly resolved, with no recurrence noted during a 2-month follow-up.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":"589-592"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}