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Boots in summer vs sandals in winter? The dilemma that makes cancelling daylight saving time tricky. 夏天穿靴子还是冬天穿凉鞋？让取消夏令时变得棘手的难题。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2024-01-26 DOI: 10.1007/s00508-024-02322-8
José María Martín-Olalla, Jorge Mira
{"title":"Boots in summer vs sandals in winter? The dilemma that makes cancelling daylight saving time tricky.","authors":"José María Martín-Olalla, Jorge Mira","doi":"10.1007/s00508-024-02322-8","DOIUrl":"10.1007/s00508-024-02322-8","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective use of molecular minimal residual disease for risk stratification in children and adolescents with acute lymphoblastic leukemia : Long-term results of the AIEOP-BFM ALL 2000 trial in Austria. 前瞻性使用分子极小残留病对儿童和青少年急性淋巴细胞白血病患者进行风险分层：奥地利AIEOP-BFM ALL 2000试验的长期结果。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2023-08-03 DOI: 10.1007/s00508-023-02249-6
Leila Ronceray, Michael Dworzak, Karin Dieckmann, Georg Ebetsberger-Dachs, Evgenia Glogova, Oskar A Haas, Neil Jones, Karin Nebral, Reinhard Moser, Thomas Lion, Bernhard Meister, Renate Panzer-Grümayer, Sabine Strehl, Christina Peters, Ulrike Pötschger, Christian Urban, Georg Mann, Andishe Attarbaschi
{"title":"Prospective use of molecular minimal residual disease for risk stratification in children and adolescents with acute lymphoblastic leukemia : Long-term results of the AIEOP-BFM ALL 2000 trial in Austria.","authors":"Leila Ronceray, Michael Dworzak, Karin Dieckmann, Georg Ebetsberger-Dachs, Evgenia Glogova, Oskar A Haas, Neil Jones, Karin Nebral, Reinhard Moser, Thomas Lion, Bernhard Meister, Renate Panzer-Grümayer, Sabine Strehl, Christina Peters, Ulrike Pötschger, Christian Urban, Georg Mann, Andishe Attarbaschi","doi":"10.1007/s00508-023-02249-6","DOIUrl":"10.1007/s00508-023-02249-6","url":null,"abstract":"<p><p>Since 1979 Austrian children and adolescents with acute lymphoblastic leukemia (ALL) have been treated according to protocols of the Berlin-Frankfurt-Münster (BFM) study group. The Associazione Italiana di Ematologia e Oncologia Pediatrica and BFM (AIEOP-BFM) ALL 2000 study was designed to prospectively study patient stratification into three risk groups using minimal residual disease (MRD) on two time points during the patient's early disease course. The MRD levels were monitored by detection of clone-specific rearrangements of the immunoglobulin and T‑cell receptor genes applying a quantitative polymerase chain reaction-based technique. The 7‑year event-free survival (EFS) and overall survival rates for all 608 Austrian patients treated between June 1999 and December 2009 within the AIEOP-BFM 2000 study were 84 ± 2% and 91 ± 1%, respectively, with a median observation time of 6.58 years. Event-free survival for patients with precursor B‑cell and T‑cell ALL were 84 ± 2% (n = 521) and 84 ± 4% (n = 87; p = 0.460), respectively. The MRD assessment was feasible in 94% of the patients and allowed the definition of precursor B‑cell ALL patients with a low, intermediate or high risk of relapse even on top of clinically relevant subgroups. A similar finding with respect to MRD relevance in T‑ALL patients was not possible due to the small number of patients and events. Since this pivotal international AIEOP-BFM ALL 2000 trial, molecular response to treatment has been continuously used with additional refinements to stratify patients into different risk groups in all successive trials of the AIEOP-BFM ALL study group.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Summertime, wintertime, a biannual shift or what? : A polylemma! 夏季、冬季、一年两次的转变还是什么？
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2024-01-26 DOI: 10.1007/s00508-024-02324-6
Michael Kundi
{"title":"Summertime, wintertime, a biannual shift or what? : A polylemma!","authors":"Michael Kundi","doi":"10.1007/s00508-024-02324-6","DOIUrl":"10.1007/s00508-024-02324-6","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspective: legal, ethical, and medical perspectives of the landscape of assisted suicide in Austria. 视角：从法律、伦理和医学角度看奥地利协助自杀的前景。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI: 10.1007/s00508-024-02344-2
Eva Katharina Masel
{"title":"Perspective: legal, ethical, and medical perspectives of the landscape of assisted suicide in Austria.","authors":"Eva Katharina Masel","doi":"10.1007/s00508-024-02344-2","DOIUrl":"10.1007/s00508-024-02344-2","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-density lipoprotein (HDL) has an impact on myeloma outcome: Lower HDL associates with worse progression-free survival. 高密度脂蛋白（HDL）对骨髓瘤的预后有影响：高密度脂蛋白越低，无进展生存期越短。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2023-07-04 DOI: 10.1007/s00508-023-02239-8
Işıl Erdoğan Özünal, Emrah Kılıçaslan, Tayfun Elibol, Erman Öztürk
{"title":"High-density lipoprotein (HDL) has an impact on myeloma outcome: Lower HDL associates with worse progression-free survival.","authors":"Işıl Erdoğan Özünal, Emrah Kılıçaslan, Tayfun Elibol, Erman Öztürk","doi":"10.1007/s00508-023-02239-8","DOIUrl":"10.1007/s00508-023-02239-8","url":null,"abstract":"<p><strong>Background: </strong>Multiple myeloma (MM) staging is based on beta‑2 MG, albumin, LDH levels, and the presence of chromosomal abnormalities. We aimed to evaluate the impact of high-density lipoprotein (HDL) on myeloma outcomes.</p><p><strong>Materials and methods: </strong>This study included 148 individuals; 68 patients diagnosed with MM and 80 age, sex, comorbidity-matched controls. The relationship between HDL and myeloma stage and the association between HDL and progression-free survival (PFS) were analyzed.</p><p><strong>Results: </strong>Sixty-five percent of patients were male in each group. Mean HDL level was higher in the control group than myeloma group (52.6 ± 15.02 mg/dl versus 33.79 ± 12.71) (p < 0.001). According to ISS, 39 patients (57%) had advanced stage (ISS-III) disease. To assess the optimal cut-point for HDL that makes a difference in PFS, the X‑tile software program was used and in line with the created plots, the myeloma cohort was divided into two groups as HDL < 28 and ≥ 28 mg/dl. Twenty-two patients (32.4%) were in HDL < 28 group. According to the ISS, HDL < 28 group had more advanced disease than the HDL ≥ 28 group (p = 0.008). Twenty-nine patients (42.6%) progressed or died during the follow-up and 15 of these were in the HDL < 28 group. Time to progression was shorter in patients who were in the HDL < 28 group (median, 22 versus 40 months, p = 0.03). There was no statistically significant difference between these groups in terms of overall survival (p = 0.708).</p><p><strong>Conclusion: </strong>Myeloma patients have lower HDL than controls and HDL < 28 mg/dl associates with advanced-stage disease and shorter PFS. Therefore, HDL can be a surrogate prognostic marker in myeloma.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"A star is born"-A unique case of an intranasal foreign body. "一颗新星诞生了"--一个独特的鼻内异物病例。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2024-01-04 DOI: 10.1007/s00508-023-02320-2
Alexandros Andrianakis, Peter Valentin Tomazic
{"title":"\"A star is born\"-A unique case of an intranasal foreign body.","authors":"Alexandros Andrianakis, Peter Valentin Tomazic","doi":"10.1007/s00508-023-02320-2","DOIUrl":"10.1007/s00508-023-02320-2","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathologie goes digital. 病理学走向数字化。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 DOI: 10.1007/s00508-024-02398-2
{"title":"Pathologie goes digital.","authors":"","doi":"10.1007/s00508-024-02398-2","DOIUrl":"https://doi.org/10.1007/s00508-024-02398-2","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MUW researcher of the month. MUW 月度研究员。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 DOI: 10.1007/s00508-024-02394-6
{"title":"MUW researcher of the month.","authors":"","doi":"10.1007/s00508-024-02394-6","DOIUrl":"10.1007/s00508-024-02394-6","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Treatment of haemophilia in Austria]. [奥地利的血友病治疗]。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1007/s00508-024-02370-0
Christoph Male, Cihan Ay, Richard Crevenna, Sabine Eichinger, Clemens Feistritzer, Robert Füller, Alexander Haushofer, Andreas Kurringer, Peter Neumeister, Stephan Puchner, Joachim Rettl, Thomas Schindl, Gerhard Schuster, Rudolf Schwarz, Michael Sohm, Werner Streif, Katharina Thom, Barbara Wagner, Eva Wissmann, Karl Zwiauer, Ingrid Pabinger
{"title":"[Treatment of haemophilia in Austria].","authors":"Christoph Male, Cihan Ay, Richard Crevenna, Sabine Eichinger, Clemens Feistritzer, Robert Füller, Alexander Haushofer, Andreas Kurringer, Peter Neumeister, Stephan Puchner, Joachim Rettl, Thomas Schindl, Gerhard Schuster, Rudolf Schwarz, Michael Sohm, Werner Streif, Katharina Thom, Barbara Wagner, Eva Wissmann, Karl Zwiauer, Ingrid Pabinger","doi":"10.1007/s00508-024-02370-0","DOIUrl":"10.1007/s00508-024-02370-0","url":null,"abstract":"<p><p>This guideline is intended to provide practical guidance for the diagnosis and treatment of haemophilia in Austria. Few randomized controlled interventional trials are available addressing the treatment of haemophilia, therefore recommendations are usually based on low level of evidence and represent expert consensus.This guideline is based on the WFH guideline, published in 2020, and adapted according to the national circumstances and experience.It includes recommendations and suggestions for diagnosis and follow-up visits and pharmacological therapies for treatment and prophylaxis. Further topics comprise special aspects in children and adults with severe haemophilia, outcome measurement, and management of trauma, special bleedings and interventions, including dental procedures, inhibitors, management of haemophilia carriers, and psychosocial aspects.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intramuscular botulinum toxin-A in complex regional pain syndrome resistant to standard treatment: a case report. 肌肉注射肉毒杆菌毒素-A 用于标准治疗无效的复杂性区域疼痛综合征：病例报告。
IF 1.9 4区 医学
Wiener Klinische Wochenschrift Pub Date : 2024-07-01 Epub Date: 2024-01-19 DOI: 10.1007/s00508-023-02317-x
Yasemin Tombak, Ozgur Zeliha Karaahmet, Ece Unlu Akyuz
{"title":"Intramuscular botulinum toxin-A in complex regional pain syndrome resistant to standard treatment: a case report.","authors":"Yasemin Tombak, Ozgur Zeliha Karaahmet, Ece Unlu Akyuz","doi":"10.1007/s00508-023-02317-x","DOIUrl":"10.1007/s00508-023-02317-x","url":null,"abstract":"<p><strong>Objective: </strong>To present a patient with complex regional pain syndrome type 1 (CRPS-I) and improvement of contracture of hand muscles and grip strength after successful treatment with botulinum neurotoxin‑A (BoNT-A).</p><p><strong>Case: </strong>A 53-year-old woman with CRPS‑I experienced severe allodynia, swelling and autonomic changes in the left hand after a distal radius fracture. Over the succeeding months, she developed contracture of the left hand muscles which was treated with injection of BoNT‑A into the hand muscles (10 points).</p><p><strong>Results: </strong>In the patient treatment with BoNT‑A an improvement was seen in the hand range of motion (ROM) and grip strength.</p><p><strong>Conclusion: </strong>Successful results can be obtained with BoNT‑A injection in treatment-resistant CRPS‑I cases which may develop joint contracture.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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