Wiener Klinische Wochenschrift最新文献

{"title":"Bone transport nails for reconstruction of lower limb diaphyseal defects in patients with bone sarcomas : A case series.","authors":"Maria Anna Smolle, Silvia Zötsch, Dimosthenis Andreou, Marisa Valentini, Andreas Leithner, Philipp Lanz","doi":"10.1007/s00508-025-02527-5","DOIUrl":"https://doi.org/10.1007/s00508-025-02527-5","url":null,"abstract":"<p><strong>Purpose: </strong>Bone transport nails (BTN) are increasingly being used for defect reconstruction in orthopedic surgery, including orthopedic oncology. Herein, we report on preliminary outcomes in three adult sarcoma patients undergoing bone defect reconstruction of the lower limbs with a BTN.</p><p><strong>Methods: </strong>In this study three patients were retrospectively included; ID1 male, 18 years, Ewing's sarcoma of the right tibial diaphysis; ID2 female, 30 years, G2 periosteal osteosarcoma of the left femoral diaphysis; ID3 female, 28 years, epithelioid malignant peripheral nerve sheath tumor (MPNST) originating from the right proximal tibial metaphysis. All patients had been treated at a university hospital for primary sarcomas of the lower limbs and underwent defect reconstruction with a BTN (Precice® System, NuVasive GmbH, Globus Medical, Audubon, PA, USA).</p><p><strong>Results: </strong>Bone defect lengths were 8.5 cm, 14.1 cm and 14.4 cm, respectively. Bone transport time amounted to 5.3 months, 9.1 months and 10.3 months, and time to bony consolidation to 9.1 months, 12.3 months and 14.7 months, respectively (in ID1 and ID3 partially). Patient ID1 required revision surgery for a wire breakage (used for two-level transport) and one screw avulsion. Patient ID2 developed a peri-implant infection that was successfully treated with prolonged antibiotics. In ID3, an occult intraoperative distal femoral fracture was initially treated conservatively. A consecutive varus/flexion deformity and residual ipsilateral limb length discrepancy was addressed via distal femoral osteotomy and retrograde femoral growing nail implantation.</p><p><strong>Conclusion: </strong>The Precice® BTN can be used for reconstruction of diaphyseal long bone defects in patients with primary malignant tumors; however, candidate patients have to be thoroughly counselled regarding the prolonged immobilization and partial weight-bearing period associated with the lengthening procedure as well as risk for complications and revision surgery.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's satisfaction with breast reconstruction after mastectomy and a survey on the decision process for type of reconstructive surgery.","authors":"Ingrid Jelinek, Rupert Koller, Michael Kundi","doi":"10.1007/s00508-025-02526-6","DOIUrl":"https://doi.org/10.1007/s00508-025-02526-6","url":null,"abstract":"<p><strong>Background: </strong>Breast reconstruction is an option for women after breast cancer surgery to improve the quality of life. While data about satisfaction after reconstruction are available, little is known about the decision process and about factors shaping this process.</p><p><strong>Methods: </strong>From 100 selected women, 72 women between 30 and 65 years of age (median 50.3 years, interquartile range 44-57 years) with breast reconstruction conducted in a single center in Vienna (Austria) consented to take part in this study. The role of family, social environment and healthcare providers during decision making, body image, thoughts about hospital stay and potential complications were assessed by a questionnaire. The decision for autologous tissue versus silicone implants was analyzed by structural equation modelling.</p><p><strong>Results: </strong>Overall, 69% of the women chose autologous tissue either alone or in combination with a silicone prosthesis. Visual appearance was the most important reason (86%) for choosing reconstruction. Thoughts about the stay in hospital and possible complications were important for the mediating role of healthcare providers in deciding on the type of reconstruction. If women had no concerns about complications they made the choice on their own and favoring autologous tissue reconstruction. In contrast, if such concerns existed women tended to seek help from healthcare providers and tended to choose silicone implants.</p><p><strong>Conclusion: </strong>Counselling of women after breast cancer surgery and during decision making for breast reconstruction should include an esthetic outcome but also possible complications and related length of hospital stay.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of breast cancer incidence and cancer stages before and after the introduction of the Austrian national breast cancer screening program in the federal state of Salzburg : Real-world data from the Tumor Registry Salzburg.","authors":"Simon Peter Gampenrieder, Marc Vaisband, Gabriel Rinnerthaler, Lukas Weiss, Bernhard Jaud, Martin Sprenger, Richard Greil","doi":"10.1007/s00508-025-02508-8","DOIUrl":"https://doi.org/10.1007/s00508-025-02508-8","url":null,"abstract":"<p><strong>Background: </strong>In January 2014 a national, quality-assured breast cancer screening program was introduced in Austria. To investigate if the program reduced the incidence of advanced breast cancer stages, we evaluated data from the Tumor Registry Salzburg, which records all cancer cases diagnosed in the federal state of Salzburg, Austria. Secondary objectives were changes in nodal status and the influence of age and urban or rural residence on stage distribution.</p><p><strong>Methods: </strong>Female patients resident in the federal state of Salzburg with a first diagnosis of breast cancer in 2010-2022 were included. For the main objectives, patients aged 45-69 years with known tumor stages were evaluated. Age-standardized incidence rates were compared between 2010-2013 and 2016-2019 by normal approximation of Poisson rates and stage distributions by ordinal logistic regression.</p><p><strong>Results: </strong>The distribution of stages 0-IV did not differ significantly between 2010-2013 and 2016-2019 (P = 0.380). The percentage of stage IV breast cancer decreased numerically from 9.4-4.5% (P = 0.141). No statistically significant differences between early stages (0-I), advanced stages (II-IV, P = 0. 524) and between lymph node negative and positive cases (P = 0.538) were detected. Neither age nor urban/rural residence had a substantial influence on tumor stage. Interestingly, the breast cancer incidence rates in Salzburg decreased nonsignificantly after the introduction of screening: annual 245.7 vs. 229.8 cases per 100,000 standard population (P = 0.483).</p><p><strong>Conclusion: </strong>Our findings do not support the assumption that the introduction of the Austrian breast cancer screening program significantly reduced advanced stage breast cancer in the federal state of Salzburg compared to the opportunistic screening established before.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of pentoxifylline for major depressive disorder : A systematic review and meta-analysis of randomized controlled trials.","authors":"Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Zhiyun Wong, Kaeshaelya Thiruchelvam","doi":"10.1007/s00508-025-02519-5","DOIUrl":"https://doi.org/10.1007/s00508-025-02519-5","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a widespread mental health issue; however, despite various antidepressant treatments many patients do not achieve full remission or continue to experience residual symptoms. This systematic review and meta-analysis evaluated the efficacy of pentoxifylline for MDD.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted to identify randomized controlled trials (RCT) that evaluated the efficacy of pentoxifylline as an adjunctive therapy in the treatment of MDD. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were pooled using a random effects meta-analysis model due to the expected heterogeneity among studies.</p><p><strong>Results: </strong>Four studies met the inclusion criteria and were included. The included studies comprised a total of 292 participants diagnosed with MDD. Participants' ages ranged from 18 to 65 years, and all had a Hamilton Depression Rating Scale (HAM-D) score of at least 18. The pooled analysis showed a significant improvement in response rates for the pentoxifylline group compared to the control group (pooled odds ratio [OR] 6.85, 95% confidence interval, CI: 3.42, 13.73), indicating a much higher likelihood of treatment response. Remission rates favored the pentoxifylline group, with a pooled OR of 6.09 (95% CI: 3.11, 11.91), suggesting a significantly higher likelihood of achieving remission with pentoxifylline.</p><p><strong>Conclusion: </strong>Our findings support the potential of pentoxifylline as an effective treatment for MDD; however, further research is needed to fully establish its efficacy across different patient populations.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus and IgA nephropathy: coexistence or coincident?","authors":"Rahime Duran, Derya Yıldırım, Rıza Can Kardaş, İbrahim Vasi, Burcugül Kaya, Yahya Çakır, İbrahim Karaduman, Hamit Küçük, Berna Göker, Mehmet Akif Öztürk, Abdulsamet Erden","doi":"10.1007/s00508-025-02512-y","DOIUrl":"https://doi.org/10.1007/s00508-025-02512-y","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus is a multisystem autoimmune disease primarily manifesting as lupus nephritis. While lupus nephritis is the most common renal pathology in lupus, non-lupus nephropathies such as IgA nephropathy occasionally occur. This study aims to evaluate the clinical features and outcomes of lupus patients with IgA nephropathy, comparing them with those of primary IgA nephropathy and lupus nephritis.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using the PubMed and Google Scholar databases to identify cases of systemic lupus erythematosus with IgA nephropathy reported between 1995 and December 2023. A total of 16 cases were identified and 2 additional cases from our clinic were included. These cases were compared with 47 lupus nephritis patients from our clinic and 215 primary IgA nephropathy patients from the literature. Data were collected on demographics, serology, renal biopsy findings, treatment, progression to renal failure and mortality.</p><p><strong>Results: </strong>We identified 18 cases of lupus with IgA nephropathy with a median age of 41.6 years and a female predominance (72.2%). In comparison to the primary IgA nephropathy cohort, lupus with IgA nephropathy group exhibited a lower rate of renal failure (11.1% vs. 34%) and mortality (5.6% vs. 20%). Additionally, the lupus-IgA nephropathy group showed a slightly lower mortality rate compared to the lupus nephritis cohort (5.6% vs. 10.6%).</p><p><strong>Conclusion: </strong>Lupus with predominantly IgA deposits often follows a more indolent course than primary IgA nephropathy but severe cases with crescentic glomerulonephritis can still progress to renal failure.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound combined with radiographic localization assisting in emergency foreign body removal surgery.","authors":"Haibo Xie, Dianyi Zhang, Zhixin Liu, Bifeng Fu","doi":"10.1007/s00508-025-02511-z","DOIUrl":"https://doi.org/10.1007/s00508-025-02511-z","url":null,"abstract":"<p><p>This case report presents a successful retrieval of a metallic foreign body located in the soft tissue of the patient's posterior thigh using a combination of ultrasound and radiography localization in an emergency setting. The combined use of ultrasound and radiography localization facilitated precise localization, reduced surgical trauma, decreased radiation exposure, and contributed to the rapid recovery of the patient.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility, acceptance and effects of pulsed magnetic field therapy in patients with post-COVID-19 fatigue syndrome : A randomized controlled pilot study.","authors":"Mohammad Keilani, Margarete Steiner, Julia Sternik, Jim Schmeckenbecher, Ralf Harun Zwick, Barbara Wagner, Richard Crevenna","doi":"10.1007/s00508-025-02522-w","DOIUrl":"https://doi.org/10.1007/s00508-025-02522-w","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this randomized, single-blinded, placebo-controlled pilot study was to explore the feasibility, acceptance and effects of pulsed electromagnetic field therapy (PEMF) in patients with post-COVID-19 fatigue syndrome.</p><p><strong>Methods: </strong>A total of 20 patients were included in the study. They were randomly assigned to an intervention group (n = 10, male:female = 4 : 5, age = 45 ± 9 years) and a placebo group (n = 10, m:f = 4:6, age: 39 ± 23 years). A Papimi™ Delta professional electromagnetic field therapy device was used for treatment. Controls received a placebo PEMF. In total 10 PEMF sessions (30 min., 2× per week) were applied. Physical performance, health-related quality of life, fatigue, work ability, sleep, pain, anxiety and depression were assessed at baseline, posttreatment and at follow-up 5 weeks after treatment. Feasibility and acceptance were assessed posttreatment.</p><p><strong>Results: </strong>The intervention group showed a notable improvement in the 6 minutes walking test. The use of PEMF improved fatigue (measured with the Brief Fatigue Inventory and the Multidimensional Fatigue Inventory). Also, the depression subscale of the Hospital Anxiety and Depression Scale, the Insomnia Severity Index, the Work Ability Index and most subscales of the Short Form (SF) 36 questionnaire showed improvement. From the placebo group three patients dropped out. There were no drop-outs in the intervention group. In the intervention group, PEMF was well-accepted and patients showed very good adherence.</p><p><strong>Conclusion: </strong>The results of this pilot study indicate that PEMF is feasible and well accepted. Furthermore, this study population showed improvements in physical and mental health in the intervention group. This study is a promising contribution to this growing research field and provides the required evidence for future efficacy studies on PEMF for post-COVID-19 patients.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a nurse-led intervention on number of falls and acceptance of disability in patients with Parkinson's disease.","authors":"Yanli Cheng, Zishuang Liu, Na Zhang","doi":"10.1007/s00508-025-02518-6","DOIUrl":"https://doi.org/10.1007/s00508-025-02518-6","url":null,"abstract":"<p><strong>Background: </strong>Falling is one of the possible complications of Parkinson's disease (PD). Also, Parkinson's patients become disabled due to the gradual progression of the disease; however, acceptance of the disability (AOD) can help in managing the illness. The aim of this study was to evaluate the effect of a nurse-led intervention on the prevention of falls and AOD in patients with PD.</p><p><strong>Methods: </strong>In this study 240 patients over 60 years of age were selected from specialized clinics and randomly divided into 2 experimental and control groups. Both groups received their usual care; however, the experimental group also received a separate nurse-led intervention twice a month for 6 months. The number of falls and the AOD were measured (using a modified Chinese version of the AOD scale).</p><p><strong>Results: </strong>During the 6‑month follow-up, falls in the control group were more than the experimental group (165 vs. 92 falls). The AOD of the experimental group had increased significantly in the postintervention period and the 6‑month follow-up compared to the preintervention (from 60.4 ± 19.25 preintervention to 65.125 ± 18.52 postintervention and 65.433 ± 18.30 in follow-up, p < 0.05). Also, the AOD of the experimental group was significantly higher than the control group in the two time periods of postintervention and follow-up (postintervention: 65.125 ± 18.52 in experimental group and 58.78 ± 19.32 in control group; follow up: 65.433 ± 18.30 in experimental group and 57.52 ± 18.97 in control group, p < 0.05).</p><p><strong>Conclusion: </strong>The nurse-led intervention can be an effective noninvasive method to reduce the number of falls and increase the AOD in patients with PD.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating physicians' knowledge of assisted suicide and palliative sedation therapy in Austria : An exploratory survey study.","authors":"Lukas Fischer, Nguyen-Son Le, Stefanie Kirchner, Angelika Feichtner, Angelina Falkner, Eva Katharina Masel, Jan Gärtner, Dietmar Weixler, Gudrun Kreye","doi":"10.1007/s00508-025-02509-7","DOIUrl":"https://doi.org/10.1007/s00508-025-02509-7","url":null,"abstract":"<p><strong>Background: </strong>Since January 2022, assisted suicide (AS) has been legal in Austria under specific conditions, allowing medical AS for individuals with incurable, life-ending diseases or severe, enduring illnesses that significantly impact their lives. Palliative sedation therapy (PST) involves the controlled use of drugs to induce unconsciousness and alleviate otherwise untreatable suffering. This study evaluates Austrian physicians' knowledge of AS and PST, comparing the knowledge levels of palliative care (PC) and non-PC physicians.</p><p><strong>Methods: </strong>In this explorative study, an online survey was distributed primarily to physicians in Lower Austria through the State Healthcare Agency Lower Austria (Landesgesundheitsagentur Niederösterreich, LGA) and to PC physicians across Austria via the Austrian Association for Palliative Care (Österreichische Palliativgesellschaft, OPG). Questions in this survey focused on basic knowledge of the principles of AS and PST. Participants included physicians who have expertise in PC and physicians from other medical specialties.</p><p><strong>Results: </strong>In this study, 223 physicians completed the survey. The PC physicians displayed significantly more specialized training, with 74.2% holding a PC diploma compared to 17.9% of non-PC physicians (p < 0.001). Regarding PST, PC physicians were more likely to follow guidelines, using midazolam (97.8% vs. 77.6%, p < 0.001), propofol (56.2% vs. 38.1%, p = 0.009), and levomepromazine (23.6% vs. 11.2%, p = 0.016). In AS, PC physicians emphasized the decision-making capacity more frequently (p = 0.006) and were better informed about the legal requirements.</p><p><strong>Conclusion: </strong>Overall, Austrian physicians demonstrate insufficient knowledge of AS and PST, underlining the need for enhanced education on PC principles to ensure informed practice post-AS legalization. Nonetheless, PC physicians in Austria demonstrate superior adherence to guidelines in managing life-limiting conditions, PST and AS compared to non-PC physicians, highlighting the importance of specialized PC education.</p>","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal white plaques on the tongue: isolated oral manifestation of secondary syphilis.","authors":"Yuri de Lima Medeiros, Maria Emília Mota, Daniel Amaral Alves Marlière","doi":"10.1007/s00508-025-02515-9","DOIUrl":"https://doi.org/10.1007/s00508-025-02515-9","url":null,"abstract":"","PeriodicalId":23861,"journal":{"name":"Wiener Klinische Wochenschrift","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}